정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

고등학교 지구과학 실험·실습 요목 비교 분석

정원우,이윤종,기우항,김영호,양승영,강용희,안병호,임성규,윤일희,김중욱,윤성효,강동진 경북대학교 과학교육연구소 1997 科學敎育硏究誌 Vol.21 No.-

The purpose of this study is to investigate the status of the experimental and practical education in high school earth. The present status and reasonable management of the experimental and practical education in high school earth science have been grasped from the questionaires. To do this, eighty eight earth science teachers in Korea are administered questionaires. The frequency of the experimental and practical items in the seven kind of earth science text books were investigated. The problems and the reasonable management for experimental and practical education were proposed in this paper.

수술후 경막외강에 주입한 ketamine의 진통효과에 관한 연구

정기호,조남수,임경준,유병식,정종달,김용일 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Author divided 60 patients who got lower abdomen or lower extremity surgical operation into three groups. Each group consisted of 20 patients. We injected ketamine 10㎎, 20㎎, and 30㎎ respectively into the epidural space when the patient complained of pain postoperatively and observed the postoperative analgesic effect of ketamine. Finally, we concluded the following : 1) The onset time of analgesic effect. : The analgesic effect appeared within 10 minutes in 3 groups and the significant difference among them was not seen. 2) The duration of analgesic effect : The duration of analgesia was relatively short with less than 1 hour on an average in all 3 groups and was not constant. 3) Cardiopulmonary system. : The significant change of blood pressure, pulse and respiratory rate was not seen in all three groups and and the difference among them also was not seen. 4) Side effects. : Sedative action(16%), nausea(10%), dizziness(5%), headache(3.3%) From above results, the epidural administration of ketamine is not suitable for postoperative pain management because of a lot of side effects as well as short and inconstant duration of analgesic effeet.

게르마니움화합물이 암세포 증식 및 림파구에 미치는 영향 : MOLT-4, L1210, Sarcoma180와 림파구에 대하여 MOLT-4, L1210 and Sarcoma180

정용자,성영기 慶星大學校 1996 論文集 Vol.17 No.4

I could take carboxyethylgermanium sesquioxide from ASAI Germanium Institute. It was experimented in cytotoxicity on carcinoma cell : Sarcoma180,L1210 and Molt-4, and in mitogenecity of lymphocytes in vitro. in vitro WBC contents were observed by Wright's staining under microscope after injected it, and the spleen and tumor size were measured by weight. Molt-4 is a suspension culture derived from the peripheral blood of acute lymphoblastic leukemia patient. L1210 is lymphocytic mouse leukemia and grows in suspension cultures or spinner cultures. Sarcoma 180 was derived from Swiss Webster Sarcoma 180 ascites. These cell lines have been used extensively for routine screening programs of chemical agents and natural products for cytotoxicity activity. These are also utilized in preliminary testing for antitumor activity in cancer chemotherapy screening studies. In order to test in vivo cytotoxicity of germanium compound, BALB/C mice were used. Sarcoma 180 cells were harvested by brief treatment with trypsin-EDTA and then inoculated in abdominal cavities of mice by intraperitoneal transplantation of 2×?cell/mouse. Germanium-30 ㎕ or nomal saline were injected intraperitoneally once a day for 6 weeks. The survival of treated sarcoma mice and the growth of tumor were observed during 6 weeks. At sixth week, sarcoma mice were decapitated and tumors and spleens were weighted. Into each well (0.2ml capacity) of 10³, 5×10³,2×10⁴,?cells/well were inoculated at Day-0. After culture during various time interval, the absorbances measured by MTT. At Day-2 or Day-3 after culture, and 5×10³and 10⁴cells/well, we can take the appropriate value in L1210 and Molt-4. Sarcoma cells were show the lower value compared with the other cells(Fig 1,2,3) To estimate the effect of germanium compound as a mitogen to lymphocytes, the absorbance of human lymphocytes cultured in medium containing germanium compound for 3days was measured by MTT method. Germanium compound increased it significantly at the concentration of 10㎍ and 30㎍/ml. When germanium compound compared with concanavalin A, that has higher ability of mitogenecity than concanavalinA on human lymphocytes.(Fig.4,5) The direct cytotoxicity of germanium compound was estimated by comparing absorbaned to the control which was cultivated without germanium compound. Fig 6,7 show that the absorbances of Sarcoma 180, L1210 of MOLT-4 cultured in medium containing germanium compound was decreased dose-dependently. It means that germanium compound exhibits direct cytotoxicity. However in the case of Molt-4, the absorbance was lower than the other, respectively of administered dose. Following injection of germanium compound of 2mg/kg/day for 2 weeks, whole blood was obtained in vivo. the leukocytes stained with wright's staining solution compared with the control to be injected normal saline instead of germanium compound. As shown in table 1, there was increase in lymphocytes, basophils and monocytes. At long-term treatment, LMP% was increased a little, but the tumor weight decreased or increased on individuality.

진화 알고리듬을 위한 객체지향 모델링과 클래스 라이브러리 구현

정호연,이수연,곽재승,김용주,박기태,현철주 한국경영과학회 2000 經營 科學 Vol.17 No.2

In evolutionary algorithm, there exist various models for the evolution of the population with respect to schemes and strategies for reproduction, in the application of the algorithm to a specific problem, one model suitable to the problem is to be properly chosen and a program expert or a software is needed to help implement and test a designed algorithm. In this study, object oriented modeling and the class library for simple evolutionary algorithms(SEA) with one population is developed. The library proposed here can be used as a generalized tool for solving problems in a wide range of domains.

다발성 골수종으로 이행한 단일형질세포종 1예

정재용,모성환,기장도,문철호,김창욱,전용준,박유환,정춘해,오윤경 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.2

구륜 이동 로보트의 궤한 제어를 위한 동력학 모델링

정용욱,김기열,박종국 慶熙大學校 大學院 院友會 1996 高凰論集 Vol.19 No.-

We presents a systematic method for the dynamic modeling of Wheeled Mobile Robot. We treats the dynamic modeling for describes relationship between the wheel actuator force/torque and WMR motion through the use of Newton's equilibrium laws. To calculate the WMR position in real time, we introduced the Dead-Reckoning algorithms and the simulation results show that the proposed dynamic modeling is useful. We can easily extend the proposed WMR modeling to mobile robot of similar type and this type of methodology is useful to analyze, design and control any kinds of rolling robots.

첨가물에 의한 석고스케일의 억제

정기용 梨花女子大學校 韓國生活科學硏究院 1971 韓國生活科學硏究院 論叢 Vol.6 No.-

This expsriment showed that the additives such as sodium dihyrogen phosphate,polyoxyethylene sorbitan monostearate, sodium hexamtaphosphate and tetrasodium pyrophosphate presented the inhibition effdct to calcium sulfate and especially tetrasodium pyrophosphate was s predominant inhibiting agent. Also this experiment tetrasodium pyrophosphate which concentrations were 0.05ppm respectivel,at pH8 even in high concentration such as 0.03M CaSO_4 solution could almost completely be inhibited the calcium sulfate scale deposition.

갑상선암의 진단과 치료

정기용 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.4

갑상선단독결절에서 악성여부를 감별하는 완벽한 검사방법은 없으나 세침흡입세포검사가 현재까지 알려진 최선의 검사이나 약 10%의 위음성율을 보이고 악성의 진단율은 약40%에 지나지 않아 한계점을 보이고 있다. 따라서 갑상선암의 의심이 있다면 다각적인 임상적 검사 및 환자의 추적검사가 필요할것으로 생각된다. 갑상선단독결절의 치료선택에 있어 가장 중요한 점은 역시 결절의 악성여부라는 사실은 이론의 여지가 없다. 양성결절의 수술 후 합병증이나 수술에 따른 절개선 반흔 역시 최소화 할 수 있어 악성종양의 부담감을 가질 필요없이 또한 수술의 적응증을 너무 좁게 결정하여 악성종양을 놓치거나 종양을 가지고 생활한다는 환자의 심리적 부담감을 가중시킬 필요없이 수술을 권장하는 것이 좋다고 생각되며 갑상선 악성종양의 경우 수술방법의 선택은 수술전 평가 혹은 수술시 육안적 소견에 따라 결정되어야 할것으로 사료된다. 따라서 갑상선수술 특히 악성종양인 경우에는 경험이 많은 갑상선수술 전문의에 의해 시행 되어 져야 한다고 생각된다.

유전자정보은행의 운영과 인권의 보호

정용기 용인대학교 2007 용인대학교 논문집 Vol.25 No.-

DNA information can be used for a variety of purposes. The introduction of DNA information system can elevate usefulness of criminal investigation to prevent second offense of violent crimes. However, the gene has a lot of information on individuals so that disclosure, misuse and abuse of the information may be much likely to infringe on human rights. And a population- wide DNA information system could be a 'Big Brother' in this technology era. Now the Korean Government has also admitted of needs of DNA database so that the National Assembly is deliberating on the bill of DNA database. The most important subject in controlling DNA database is that the possibility of violation of human rights must be ruled out. Therefor DNA information should be managed strictly not to make use of it for other purposes than criminal investigation. An organization that is independent from either the police or the prosecution shall manage DNA information to prevent disclosure, misuse and abuse of the information as much as possible.