홍민어 Sciaenops ocellatus에서의 바이러스성 신경괴사증 viral nervous necrosis

김진도,김석렬,정성주,김영진,정태성,최태진,박성우,오명주 한국어병학회 2001 한국어병학회지 Vol.14 No.2

1999년 10월에서 11월 사이에 남해안 일대의 홍민어 종묘 생산장에서 20~30열령의 치어가 척추만곡 및 이상유영을 하며 대량 폐사하였다. 병어는 특이 외부 증상이 없었고, 높은 누적폐사량이 바이러스 질병으로 의심되어, 조직학적 및 분자생물학적인 검사를 행하여 폐사원인을 확인하였다. 폐사개체의 조직을 H-E 염색하여 관찰한 결과 뇌와 안구의 신경세포에서 공포와 괴사가 관찰되었고, 전자현미경 관찰에서는 안구와 뇌에서 바이러스 입자가 관찰되었다. RT-PCR 결과에서는 ≒426 bp의 DNA 단편을 확인할 수 있었다. 이러한 결과로 홍민어에서 발생한 대량폐사는 바이러스성 신경괴사증(VNN)으로 진단되었다. Mass mortalities occurred among red drum lavae, 20 to 30 days old, culturing at hatcheries on southern costal area. No specific external signs were observed except abnormal swimming and spinal deformity. It was, however, suspected as a viral etiology due to high mass mortalities so that histopathological and molecular biological study was performed to evaluate the agent. Both vacuoles and necrosis were observed on nerve cells of brain and eye by H-E staining, and viral particles were observed on electronmicroscopic examination. On the other hand, DNA fragment, approximately 426 bps, was amplified with RT-PCR. The above results were able to diagnosis the etiological agent of mass moralities in red drum larvae as VNN(viral nervous necrosis)virus.

중·고등학생들의 체지방 측정방법 및 총지방량에 관한 연구

손태열,홍관이,김기진,정정진,김학렬,김태영 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.1

본 연구에 대한 목적은 현재까지 국내외에서 사용되어온 추정방정식과 본 연구의 추정방정식을 밀도법에 의한 체지방량을 기준으로 비교분석하고 각종 신체계측치와 신체밀도에 의한 체지방량과의 상관관계를 토대로 한국 중·고등학생들에게 적합한 체지방 추정방정식을 산출함과 동시에 본 연구에서 개발된 추정방정식을 토대로 한국 중·고등학생들의 체지방량과 제지방량을 산출하는 것이었다. 본 연구의 밀도법으로 얻은 값과 선행방정식으로 얻은 값을 비교하여 보았을 때 MSF에 있어서는 BD2와 BD3, MSM의 경우는 BD1과 BD3, HSF에서는 BD2에서만 통계적으로 유의한차(P>0.05)가 없는 것으로 나타났다. 또한 수중체중 측정법으로 얻은 신체밀도와 가장 관련성이 높은 변인으로서는 피부두겹 측정으로서 장골경사, 무릎, 안면부, 견갑하부, 장곡옆면, 복부, 옆가슴, 삼두근의 순서로 나타났으며, 허리둘레와 발목둘레도 중요한 영향을 미치는 것으로 나타났다. 한편 남자 중학생들의 %FAT와 LBM은 각각 12.60±3.93%와 41.75±4.85KG을 나타났으며, 여자 중학생들은 14.56%와 45.14±50KG으로 나타났다. 또한 남자 고등학생 및 여자 고등학생들의 %FAT와 LBM은 각각 11.69±4.77%, 12.01±5.26%와 46.57±4.47KG, 53.32±8.01KG으로 나타났다. 이상과 같은 결과를 고려하여 볼 때, 본 연구에서 개발된 방정식을 사용함으로서 기존의 외국인을 대상으로 개발된 선행방정식을 이용하여 산출하였을 때 나타나는 오차범위를 보다 크게 줄임으로서 정확한 체지방량을 산출할 수 있을 것으로 평가된다.

정신분열병 환자에서 얼굴 영상의 작동기억 장애 : 기능자기공명영상연구

이창욱,김태석,주라형,박주미,박여진,김종진,전신수,배치운,김정진,이수정,이철,백인호 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : Impaired processing of facial information is one of the broad ranges of cognitive deficits seen in patients with Schi-zophrenia. We aimed to elucidate the differences in brain activities involved in the process of facial working memory between schizophrenic patients and healthy comparison subjects. Methods : Twelve patients with schizophrenia were recruited along with twelve demographically matched healthy volunteers as a comparison group. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the Perfor-mance of a 2-back working memory paradigm using images of neutral faces as mnemonic content. Rcsults : The patient group performed the tasks with reduced accuracy. Group analysis revealed that the left fusiform gyrus, the right superior frontal gyrus, the bilateral middle frontal gyri/insula, the left middle temporal gyrus, the precuneus, the quadrangular lobules and the vermis of cerebellum showed decreased cortical activities in the patient group. On the other hand, an increased level of activation in the lateral prefrontal cortex and the pahetal lobule was observed from the patient group, all in the right hemisphere. Conulusion : A decreased level of activity in the left fusiform gyrus among the patient group implicates inefficient processing of facial information. An increased level of activation in prefrontal and parietal neural networks from the patient group confirms earlier findings on the impaired working memory of patients with schizophrenia.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

小兒의 齒周疾患 活動性과 oral-black-pigmented Bacteroides와의 相關關系에 關한 硏究

鄭鎬吉,金鎭泰 大韓小兒齒科學會 1985 大韓小兒齒科學會誌 Vol.12 No.1

For the study of the relationship between oral-black-pigmented Bacteroides and periodontal disease activity in children, 28 children of 8~12 ages were examined with 4 groups (S.B.I: 0, 1, 2, 3). The periodontal disease activity of each site was evaluated using S.B.I, G.C.F, and periodontal pocket depth. The proportion of coccid cells, motile rods, nonmotile rods and spirochetes was determined by dark-field microscopy. The subgingival plaque samples were plated onto blood agar plate and incubated in an anaerobic chamber. After 7 days of incubation, total number of colonies and the total number of black-pigmented colonies were enumerated. Pure culture colonies were identified by biochemical test. The experiment showed that. 1. As the S.B.I score increased, the G.C.F flow and the proportion of motile rods was increased significantly but the proportion of nonmotile rods and coccid cells was decreased. 2. When the S.B.I score was 1, the mean percentage of aerobic microflora was 72.6% and anaerobic microflora was 27.4%, the mean percentage of black pigmented Bacteroides among total subgingival microflora was 2.4% and other anaerobic microflora was 25.0%. 3. When the S.B.I score was 2, the mean percentage of aerobic microflora was 59.7% and anaerobic microflora was 40.3%, the mean percentage of black pigmented bacteroides among total subgingival microflora was 2.9% and other anaerobic microflora was 37.4%. 4. When the S.B.I score was 3, the mean percentage of aerobic microflora was 17.2% amd anaerobic microflora was 82.8%, the mean percentage of black pigmented Bacteroides among total subgingival microflora was 13.3% and other anaerobic microflora was 69.5%. 5. When the S.B.I score was o, the mean percentage of aerobic microflora was 79.5% amd anaerobic microflora was 20.5%, the mean percentage of black pigmented Bacteroides among total subgingival microflora was 1.1% and other anaerobic microflora was 19.4%. 6. As the S.B.I score increased, the proportion of aerobic microbic microflora was decreased but the proportion of anaerobic microflora and black pigmented Bacteroides was increased significantly.

자동차 배출가스 정화용 Pd/γ-AI_(2)O_(3) 촉매의 인 피독에 있어서 La_(2)O_(3)의 첨가효과에 대한 연구

정태훈,정석진 慶熙大學校 材料科學技術硏究所 1990 材料科學技術硏究論集 Vol.3 No.-

In order to suggest an efficient catalyst system for automotive emission control, Pd-La_(2)O_(3) catalyst was characterized before and after phosphorus contact. By H_(2) chemisorption experiment, it was found that the particle size of Pd was decreased and dispersion of it was increased by promotion of La_(2)O_(3) After phosphorus poisoning, it was found that amounts of H_(2) chemisorbed were decreased largely up to certain value (ca. 5wt%). However, there was small changes in the amount of H_(2) chemisorbed between 5wt% and 10wt% phosphorus poisoned catalysts. That is to say, phosphorus of high loading doesn't affect the loss of H_(2) chemisorption site by formation of multilayers on the catalyst. By engine exhaust gas test, it was observed that Pd-La_(2)O_(3) catalyst was pretty sensitive against the phosphorus poisoning.

MANET 라우팅 프로토콜 QoS 지원서비스의 성능평가에 관한 연구

鄭燦赫,金鉉郁,李光培,姜景仁,朴京培,劉忠烈,吳世德,裵振勝,趙榮泰 明知大學校 産業技術硏究所 2004 産業技術硏究所論文集 Vol.23 No.-

In this paper, we evaluated two main QoS supporting routing protocol on wireless ad hoc network. At presence, wireless mobile communication focuses on how to efficiently support mobility of users more than QoS guarantee. However, in order to satisfy requirement of various applications which have been or will be served, QoS support service between source and destination becoming a very important issue. Of all routing protocols, DSR and AODV are very important routing protocol in MANET. So we simulated DSR and AODV QoS Routing Protocol Through simulation evaluation tool NS(Network Simulation) based on various environments.

Pd/titania 촉매에 의한 아세틸렌 Cyclotrimerization

정용화,이태진,김기석 한국화학공학회 2004 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.42 No.1

Pd/titania 촉매에 의한 아세틸렌 cyclotrimerization의 반응성과 생성물 분포의 변화를 상압조건하의 373K에서 flow reaction 실험에 의해서 연구하였다. 주요 생성물로서 에틸렌과 벤젠이 얻어졌으나 시간이 경과함에 따라서 촉매의 피독으로 인하여 아세틸렌 전화율이 급격히 감소하였다. 일정한 반응기체 유속(공간속도 4,000hr^(-1))에서 아세틸렌 농도를 50, 25, 12.5 vol%로 감소시켰을 경우 벤젠 생성량은 감소하였으나 촉매의 피독은 완화되었다. 아세틸렌 농도 변화에 대한 벤젠 생성량의 비교에 의해서 벤젠 생성반응이 아세틸렌 농도에 대해 1차 반응임을 확인하였다. 또한 일정한 아세틸렌 농도 (25 vol%)에 대하여 공간속도를 4,000 hr^(-1)에서 6,000 hr^(-1)로 증가시켰을 경우 촉매의 피독이 완화되었으며 벤젠 생성량도 증가하였다. Flow reaction에 의한 아세틸렌 cyclotrimerization에 있어서 촉매 피독을 완화시키고 벤젠 수율을 증대시키기 위해서는 반응기체 흐름의 아세틸렌 농도와 유속의 최적화가 필요해 보인다. 본 연구에 있어서 palladium-titania 계면의 oxygen anion vacancoies와 환원된 titania 표면이 종전의 연구자들 보다 100K 낮은 온도에서의 벤젠 생성에 기여한 것으로 추정된다. Cyclotrimerization of acetylene was studied by means of atmospheric flow reaction at 373 K on Pd/titania catalyst to investigate variations of catalytic reactivity and product distribution. While ethylene and benzene were obtained as the major products, rapid decrease in acetylene conversion resulted from catalyst poisoning with the lapse of reaction time. For a fixed flow rate(space velocity 4,000hr^(-1)), as acetylene concentrations decreased from 50 to 25, to 12.5 vol%, benzene yields decreased, whereas catalyst poisoning was attenuated. Comparison of benzene evolution signals from the variation of acetylene concentrations showed that the rate of benzene formation is first-order in acetylene pressure. In addition, for a fixed concentration(25 vol%) of acetylene, as space velocity increased from 4,000 to 6,000hr^(-1), benzene yields also increased and catalyst poisoning was attenuated. Optimization of acetylene concentration and flow rate may be necessary to accomplish the attenuation of catalyst poisoning as well as enhancement of benzene yield from acetylene cyclotrimerization by flow reaction. It can be deduced from this study that oxygen anion vacancies at palladium-titania interface and reduced titania made contributions toward catalytic activity for benzene formation at the temperature 100 K lower than those reported by previous researchers.

신성고혈압 흰쥐에서 측뇌실내 Captopril이 Bradykinin의 중추승압효과에 미치는 영향

정태호,양민준,오승호,전제열,염철호,윤평진 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Effects of intracerebroventricular captopril on the central pressor response to bradykinin were examined in normotensive and 2-kidney, 1 clip (2KIC) Goldblatt hypertensive rats. The experiment was done under pentobarbital (50 ㎎/㎏. IP) anesthesia. Captopril (1 ㎎)and bradykinin (5 nmol) were administered into the right lateral cerebral ventricle, while arterial blood perssure and heart rate were continuously monitored throughout the experiment. Intracerebroventricular captopril did not affect the blood pressure within 10 minutes in both normotensive and 2KIC hypertensive rats, while it significantly augmented the central pressor response to bradykinin in the hypertensive rats. These observations suggest that an elevation in endogenous kinin levels is without effect on arterial pressure in normotensive and 2KIC hypertensive rats. However, the kallikreinkinin system in the central nervous system plays a role in the regulation of blood pressure, possibly maintaining the hypertension, in 2KIC hypertensive rats.