重化學工業機械의 國産化方案에 關한 硏究 : 特히 窯業에 있어서의 燒成爐, 粉碎機, 排風機, 冷却機, 電氣集마器 自動枰量供給器 等의 製作을 目的으로

趙哲衡,朴碩喆,丁太權,宋鐵,桭達福,金基玉,朴煥奎,趙煥從,朴善鐘,金種一,李茂錫 朝鮮大學校 1977 綜合論文集 Vol.1977 No.-

This is to investigate the posibility of home manufacturing of heavy chemical industry machines, such as rotary kiln, crusher, blower, cooler, electrostatic precipitator and weighing feeder of cement plant. It is concluded that even though we can not make all of them (some of them are made now and some others are going to be made in the near future, some of them are made whole and some others are made partially), we can build or export the cement plant by importing the important machines which we can not make now and by substituting them with ours gradually.

Systemic administration of low dosage of tetanus toxin decreases cell proliferation and neuroblast differentiation in the mouse hippocampal dentate gyrus

Bing Chun Yan,In Hye Kim,Joon Ha Park,Ji Hyeon Ahn,Jeong-Hwi Cho,Bai Hui Chen,Jae-Chul Lee,Jung Hoon Choi,Ki-Yeon Yoo,Choong Hyun Lee,Jun Hwi Cho,Jong-Dai Kim,Moo-Ho Won 한국실험동물학회 2013 Laboratory Animal Research Vol.29 No.3

In the present study, we investigated the effect of Tetaus toxin (TeT) on cell proliferation and neuroblast differentiation using specific markers: 5-bromo-2-deoxyuridine (BrdU) as an exogenous marker for cell proliferation, Ki-67 as an endogenous marker for cell proliferation and doublecortin (DCX) as a marker for neuroblasts in the mouse hippocampal dentate gyrus (DG) after TeT treatment. Mice were intraperitoneally administered 2.5 and 10 ng/kg TeT and sacrificed 15 days after the treatment. In both the TeT-treated groups, no neuronal death occurred in any layers of the DG using neuronal nuclei (NeuN, a neuron nuclei maker) and Fluoro-Jade B (F-J B, a high-affinity fluorescent marker for the localization of neuronal degeneration). In addition, no significant change in glial activation in both the 2.5 and 10 ng/kg TeT-treated-groups was found by GFAP (a marker for astrocytes) and Iba-1 (a marker for microglia) immunohistochemistry. However, in the 2.5 ng/kg TeT-treated-group, the mean number of BrdU, Ki-67 and DCX immunoreactive cells, respectively, were apparently decreased compared to the control group, and the mean number of each in the 10 ng/kg TeT-treated-group was much more decreased. In addition, processes of DCX-immunoreactive cells, which projected into the molecular layer, were short compared to those in the control group. In brief, our present results show that low dosage (10 ng/kg) TeT treatment apparently decreased cell proliferation and neuroblast differentiation in the mouse hippocampal DG without distinct gliosis as well as any loss of adult neurons.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

專門家시스템 開發을 위한 知識獲得의 方法論

曺基祚,李鍾仁 慶南大學校 産業經營硏究所 1991 産業經營 Vol.14 No.-

Knowledge acquisition is the process of gathering knowledge about a domain, usually from expert, and transforming it to be executed in a program. It is a part of the knowledge- engineering process, which includes defining a problem, designing an architecture, building an knowledge base, and testing and refining the program. Knowledge acquisition is the bottleneck in this process. Knowledge acquisition methodologies are divided into three categories: knowledge- driven, expert-drieven, and machine-driven. To evaluate knowledge acquisition methodologies, a framework is proposed by addressing the nature of knowledge and problem domains. Different methodologies in each category are described and evaluated for their ability to support various kinds of problem domain and type of knowledge they are designed to elicit.

고온 용융염에서 Fe-Base 합금의 부식거동

조수행,윤기석,임종호,박성원 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.10

In the development of the advanced spent fuel management process based on the molten salt technology, it is essential to choose the optimum material for the process equipment handling molten salt. The corrosion behaviors of 304 S.S., 321 S.S., 316 LN S.S. and Incoloy 800 H in a molten salt of LiCI-Li₂O were investigated in the temperature range of 650-800℃. The oxide scales consisting of Fe₃O₄i FeCr₂O₄and Cr₂O₃ were formed in the 304 S.S., 321 S.S., 316 LN S.S. and Incoloy 800 H regardless of reaction temperature and time. The order of corrosion rate was Incoloy 800 H < 316 LN S.S. < 321 S.S. < 304 S.S.. Incoloy 800 H showed uniform corrosion behavior, whereas 304 S.S., 321 S.S. and 316 LN S.S. showed intergranular corrosion behavior. Incoloy 800 H with high Ni content exhibited the highest corrosion resistance among the examined alloys. (Received February 27, 2004)

FET형 포도당 센서를 위한 PVP/DAST/GOD 고정화막 형성기술

조병욱,이수근,박이순,이종덕,손병기 경북대학교 센서기술연구소 1992 센서技術學術大會論文集 Vol.3 No.1

고등학교 물리실험의 효율적 지도방안

조상순,이기종 全北大學校 科學敎育硏究所 1988 과학과 과학교육 논문지 Vol.13 No.-

School science laboratory has been considered as the most effective and essential in practising students scientific inquiry skills. In physics education yet our reality has such problems as exciting system of entrance exam, crowded classroom, lack of exeperimental instruments, heavy teaching loads and very little known about the teaching-learning models which reflect these problems. In this study which is based on these prevailing necessities and the experiences of teaching, I'll offer four kinds of models such as observation, classification, measurement, experiment which are used in Physics class to improve adequate inquiry methods for High school students. The number of experiments in the new Physics course of the high school is more than that in the old one and the experiments are of higher level. In the Physics teaching, student experiment is desirable but considering our situation which is running the large class, the laboratory demonstration may be more useful. Realizing the inquiring teaching method, I have endeavored to bridge the gap between laboratory demonstrations and experiments and debated on selecting and sequencing the guidelines of subject matter in consistent with the modern philosophy of science education. Also, I attempted to draw the inquiring experiment activities systematically. Finally, several suggestions to improve teaching materials and test items for inquiring science laboratory were made as a conclusion.

대학교 신입생의 특성에 관한 실태조사(Ⅱ) : 1995학년도 조선대학교 신입생을 대상으로 1995 chosun University Entrants

조용래,박상학,김상훈,표경식,김학렬,김양옥,김기순,박종 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.2

스키장 이용자의 라이프스타일과 이용의도 간의 인과관계

조기형,박종성 명지대학교 예체능연구소 2001 藝體能論集 Vol.12 No.-

To develop the causual relationship among population, social variables, perceived quality of service, and intention of ski consumer's behavior, this study was foused to explore most optimal relationship between lifestyle of participants, perceived quality of service and intention of ski consumer's behavior in ski leisure sports After seting up hypothetical relationship. Subjects for this study consisted of the population from 18 to over 60 years who are participating in ski leisure sport in ski resort near by Seoul and Yongpyung, which were a total of 1000 using multi-stage stratified random sampling. Of these 1000 subject, 636 of these were used as data analysis. The Questionnaire about lifestyle, perceived quality of service and intention of consumer's behavior scales are based on the scale of domestic previous studies using in referencing scale of lifestyle conducted by Park(1999), Well and Tigert(1971), Cosmas(1981), Venkatesh(1977), Arnott(1972), Roberts(1979), , perceived quality of service conducted by Chelladurai etc(1987), Martin(1987), Sandomir(1988), Lee(2000) &Joo etc(1998), and intention of consumer's behavior conducted by Geva &Goldman(1991) and Ko(1998). The methods of statistics used to analyze the collected dates are Multiple Regression analysis. Results of this research are as follows: There was showed the significant relationship among the lifestyle of participants, perceived quality of service and intention of consumer's behavior by the relationship model.

급성충수돌기염으로 발현된 방선균증 2예

조진원,송진영,김창억,민영훈,최창순,우흥정,현인규,김종현,유기철,채승완,손진희 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1

The Actinomyces species are normal flora of oral cavity and upper intestine characterized as gram-positive, non-spore-forming anaerobic or mjcroaerophilic rods. Actinomycosis is a chronic suppurative and granulomatous disease characterized by abscess, sinus, abundant granulation and mass. The appendix is the commonly involved site among abdominal actinomycosis. Abdominal actinomycosis is often difficult to diagnose before operation because of no reliable clinical features and infrequency of the disease. We report two cases of abdominal actinomycosis which were manifested as acute appendicitis. Those were detected Incidentally tv the pathologist after routine appendectomy. Both patients were successfully treated with appendectomy followed by proper antibiotics use.