정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

도시지역 합류식 하수관거 월류수의 오염부하 특성

윤현식,이두진,이영대 漢陽大學校 環境科學硏究所 2003 環境科學論文集 Vol.24 No.-

합류식 하수관거 월류수(Combined sewer overflow, CSOs)는 도시 인근 방류선 수체의 주요한 오염원의 하나로 알려져 있으며, 특히 강우초기 월류수의 경우 높은 오염부하가 일시에 방류되어 심각한 문제를 야기시킨다. 본 연구에서는 도시지역 합류식 하수관거 월류수의 발생 및 오염부하 특성을 분석하고, 초기강우에 의한 세척효과, 오염원 기여도 평가 등을 수행하였다. 강우사상에 따라 다소 차이가 있었으나, 합류식 하수관거 월류수가 건기하수에 비하여 오염부하가 전반적으로 높았으며, 특히 월류초기에는 매우 고농도로 측정되었다. 근사적인 오염물질 수지식을 통하여 관거퇴적물의 재부유에 의한 오염기여도가 가장 높았다. 무차원 L(V)곡선이 초기세척현상(First flush)을 잘 표현하였으며 SS, CODcr, T-P, T-N의 순으로 초기세척효과가 크게 나타났다. Combined sewer overflows(CSOs) have been considered as a major cause of water quality deterioration of natural water-courses in the vicinity of the heavily urbanized areas. The factors defining the magnitude and occurrence of CSOs are site specific. It is important to know exact properties of pollutants contained in CSOs to address water quality impacts that are caused by CSOs inputs to the receiving waters. This should be accompanied with an integrated analysis, evaluation programs, thus allowing us to an appropriate technology to alleviate the impacts. Pollutant concentrations measured during the storm events were generally higher than those of dry weather conditions except for T-N parameter and observed significant higher concentrations at the initial phase of CSOs. Based on the rough estimation by the proposed pollutant mass balance, it was found that a main part of wet weather pollutional loads originates from the resuspension of sewer bottom sediments. The dimensionless L(V) curves for determining whether first flush phenomenon occur or not were well described the pollutant flushing. These results show that a given fraction of volume contains a load of SS higher than CODcr, T-P, T-N in the initial phase of wet weather runoff.

工夫하며 運動하는 選手像 定立을 위한 調査硏究

尹益善,金振杓,金斗敬 龍仁大學校 1995 용인대학교 논문집 Vol.11 No.-

The purpose of physical education is to bring up the whole-man individual, physically, spiritually, intellectually, and socially balanced, who contributes to an individual life. In connection with the measure to allow the student to grow up as the one studying and exercising in their own way to prepare for the education of internationalization and opening, the following conclusion was drawn : (1) The matter of course that the athlete ought to receive the record of 70~80 points, though not studying, by imposing the privilege only on the athlete should be eliminated by revising the school record management regulation in each school boldly, and the athlete should be guided so that the athlete with any specialty can attend school, take for on examination justly, and acquire records soundly and squarely. (2) By distinguishing the specialty-athlete from the non-specialty athlete, either athlete should be instructed about both theory and practice matching the standard of mathematical ability for the college that they want. Accordingly, the athletic student should be instructed by establishing the college preparatory instruction plan systematically, mapping out the practical curricular instruction plan, and schooling should be accomplished so that the athletic students may improve their quality and ability. (3) As the specific-purpose school or the vocational high school secures the number of the curricular hours of cultural sciences to a maximum(216 credits), the basic and practical elements of learning matching the actual condition of the athletic students should be excluded, and teaching material be reorganized. And the curricular instruction plan should be hammered out, and its understanding should be promoted. The number of the lost hours of school should be resolved through the exhaustive supplementary lessens and the student-initiated lessons, and the climate that the student study on their own should be promoted. (4) Sports activities should be managed for the purpose of pursuing education for the whole man with the notion that the sport activity is an extension of education, and the state of physical exhaustion from hard training should be emotionally purified through reading, or music or art appreciation. And the promotion of the spirit of cooperation and harmony through special activities could impose on the athletic student their abilities to study on their own. (5) The quality of education stems from teachers. The image of the educator is desperately required that the teacher instructs students by studying teaching materials all the time and endeavoring through education, training, seminar, and the like endlessly. The trinity of school, society and household is strongly required that treat the excellent teacher and the climate that the new education improvement is guided by cultivating the student's ability to think high-dimensionally and the student's ability to participate in intellectual society, and by devising the curricular improvement scheme.

12-O-Tetradecanoylphorbol-13-Acetate에 의한 HL-60 세포 분화유도중 Vimentin 유전자 전사조절에 대한 AP-1의 역할

임규,김진희,권도원,김승민,이명선,윤경아,손미영,박종일,윤완희,황병두 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-

Purpose: To gain insight on the role of AP-1 in transcriptional regulation of vimentin gene during differentiation of HL-60 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA), the levels of vimentin mRNA and AP-1 have been investigated with Northern blot hybridization and DNA mobility shift assay. Materials and Methods: HL-60 cells were grown in RPMI 1640 medium supplemented with 10% heat-inactivated fetal calf serum and antibiotics in a humidified 5% CO_2 at 37℃. Total RNA was prepared by a modification of the method of Karlinsey et al. Northern blot hybridization was performed by the method of Virca et al. EcoRI fragment of pVIM-GEM was used as probe for vimentin mRNA. DNA mobility shift assay was performed by the method of Lim et al. End labeled DNA probe(Upper strand, 5'-CGCTTGATGAGTCAGCCG- 3') for AP-1 binding activity was mixed with nuclear extracts in a 20 μl reaction volume containing 300 mM KCI, 60 mM HEPES, pH 7.9, 25 mM MgCI_2, 1 mM EDTA, 1 mM DTT, 60% glycerol, and 2 ㎍ of poly[dI-dC]. Results: TPA increased vimentin mRNA levels, with maximal stimulation reached at 24 hr. The level of vimentin mRNA was induced in proportion to the concentration of TPA. TPA-induced vimentin mRNA was almost reduced by actinomycin-D pretreatment. TPA-induced stimulation of vimentin gene was completely reduced by staurosporin pretreatment. In DNA mobility shift assay, AP-1 newly appeared at 24 hr during TPA-induced differentiation and was almost not detected after the pretreatment of staurosporin. Conclusions: These results suggest that the induction of vimentin mRNA during TPA-dependent differentiation in HL-60 cells may be mediated by protein kinases C signal transduction and AP-1 is important to transcriptional regulation.

질 측벽에 발생한 평활근종 1예

박성철,이두진,이승호,박윤기 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Leiomyomas are common in the myometrial layer of the uterus, though they are rarely found in other reproductive organs. Leiomyomas are benign, hormone-sensitive smooth muscle tumors. They develop during the reproductive years and regress after menopause. Preoperative diagnosis is difficult to make. We present a case of a 54-year-old woman with a vaginal wall tumor. The management in this case included surgical excision Histologic examination definitively confirmed the diagnosis of a vaginal leiomyoma. We report the details of this case along with a brief review of the literature.

12-O-Tetradecanoylphorbol-13-Acetate에 의한 HL-60 세포 분화유도중 Vimentin 유전자 전사조절에 대한 AP-1의 역할

임규,김진희,권도원,김승민,이명선,윤경아,손미영,박종일,윤완희,황병두 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Purpose: To gain insight on the role of AP-1 in transcriptional regulation of vimentin gene during differentiation of HL-60 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA), the levels of vimentin mRNA and AP-1 have been investigated with Northern blot hybridization and DNA mobility shift assay. Materials and Methods: HL-60 cells were grown in RPMI 1640 medium supplemented with 10% heat-inactivated fetal calf serum and antibiotics in a humidified 5% CO_(2) at 37°C. Total RNA was prepared by a modification of the method of Karlinsey et al. Northern blot hybridization was performed by the method of Virca et al. EcoRI fragment of pVIM-GEM was used as probe for vimentin mRNA. DNA mobility shift assay was performed by the method of Lim et al. End labeled DNA probe(Upper strand, 5'-CGCTTGATGAGTCAGCCG- 3') for AP-1 binding activity was mixed with nuclear extracts in a 20 μl reaction volume containing 300 mM KC1, 60 mM HEPES, pH 7.9, 25 mM MgCl_(2), 1 mM EDTA, 1 mM DTT, 60% glycerol, and 2μg of poly[dI-dC]. Results: TPA increased vimentin mRNA levels, with maximal stimulation reached at 24 hr. The level of vimentin mRNA was induced in proportion to the concentration of TPA. TPA-induced vimentin mRNA was almost reduced by actinomycin-D pretreatment. TPA-induced stimulation of vimentin gene was completely reduced by staurosporin pretreatment. In DNA mobility shift assay, AP-1 newly appeared at 24 hr during TPA-induced differentiation and was almost not detected after the pretreatment of staurosporin. Conclusions: These results suggest that the induction of vimentin mRNA during TPA-dependent differentiation in HL-60 cells may be mediated by protein kinases C signal transduction and AP-1 is important to transcriptional regulation.

The development of a bycatch reduction device for offshore dredging and the performance estimation of model net

Doo-Jin HWANG,Ok-Sam KIM,Hyun-Chool SHIN,Eun-A YOON,Hae-Hoon PARK,Chang-Doo PARK,Gwang-Je PARK 한국수산과학회 양식분과 2014 한국수산과학회 양식분과 학술대회 Vol.2014 No.7

Hospitalized Cases of Adolescent and Adult H1N1 Influenza in a University Hospital in Korea, September 2009-January 2010

Yoon, So Yoon,Ryu, Yon Ju,Kang, Hye Won,Baek, Doo Hyun,Kim, Soo Hyun,Choi, Min Young,Park, Hye Sung,Lee, Jin Hwa,Chun, Eun Mi,Chang, Jung Hyun,Cho, Young Joo,Jun, Yoon Hee,Shim, Sung Shine,Lee, Mi Ae 이화여자대학교 의과학연구소 2010 EMJ (Ewha medical journal) Vol.33 No.2

연구배경:2009년 4월 새로운 인플루엔자 A(H1N1) 바이러스에 의한 감염은 전세계적으로 대유행이 시작되었다. 본 연구에서는 대한민국의 한 대학병원에서 발생한 H1N1 인플루엔자 감염환자 중에서 청소년과 성인 입원 환자를 대상으로 임상적 특성과 예후에 대하여 2009년 9월부터 2010년 1월까지 조사하여 알아보고자 하였다. 방 법:대유행 H1N1 인플루엔자로 확진된 13세 이상의 환자의 의무기록을 후향적으로 분석하였으며 대유행 H1N1 인플루엔자는 real-time reverse transcriptase-polymerase chain reaction 시행하여 확진하였다. 결 과:43명의 대유행 인플루엔자 입원 환자 중에서 7명(16%)은 중환자실 치료를 받았으며 이중 1명(2%)은 사망하였다. 평균 연령은 45세였고 기저질환으로 천식, 당뇨, 허혈성 심장질환, 기관지 확장증, 암의 순서로 많은 빈도수를 보였다. 임상증상으로 발열이 가장 주된 증상이었으며 그 외에 기침, 호흡곤란, 콧물, 근육통 또는 관절통, 인후통을 호소하였다. 입원 시 42명 중 25명의 환자에서 흉부 방사선 검사 결과 폐렴을 동반하였고 만성호흡기 질환의 악화를 보인 경우가 11명의 환자에서 관찰 되었다. 또한 23명의 Fish환자에서 산소공급이 필요하였으며 이중 2명은 급성 호흡부전으로 인하여 기계 환기가 필요하였다. 중환자실 입원을 요한 7명의 환자들은 모두 기저질환을 가지고 있었으며 이중 5명은 천식, 3명은 허혈성 심장 질환이 있었고 임신 상태와 당뇨가 각각 1명으로 나타났다. 확진된 모든 환자들은 증상 발현으로부터 평균 2일 내에 항바이러스제를 처방 받았다. 결 론:천식은 입원치료를 요하는 대유행 인플루엔자 감염환자에서 가장 흔하게 동반된 내과적 질환이었으며 특히 허혈성 심장질환 동반하는 환자의 경우 중환자실 입원을 필요로 함을 알 수 있으며 연구 결과 대부분의 환자에서 항바이러스제 치료에 효과적인 것으로 나타났다.

Effect of Ultrasonic Process of Electroless Ni-P-Al₂O₃ Composite Coatings

Jin-Doo Yoon,Bon-Heun Koo,Hwan-Il Hwang,Sun-Kyo Seo,Jong-Kyu Park 한국표면공학회 2021 한국표면공학회지 Vol.54 No.6

In general, surface treatments of electroless Ni-P coating are extensively applied in the industry due to their excellent properties for considerable wear resistance, hardness, corrosion resistance. This study aims to determine the effect of ultrasonic conditions on the morphology, alumina content, roughness, hardness, and corrosion resistance of electroless Ni-P-Al₂O₃ composite coatings. The characteristics were analyzed by Energy-dispersive X-ray spectroscopy (EDX), x-ray diffractions (XRD), and atomic force microscopy (AFM), etc. In this study, the effect of ultrasonic condition uniformly distributed alumina within Ni-P solution resulting in a smoother surface, lower surface roughness. Furthermore, the corrosion resistance behavior of the coating was analyzed using tafel polarization curves in a 3.5 wt.% NaCl solution at 25 ℃. Under ultrasonic, Al₂O₃ content in Ni-P composite solution increased from 0.5 to 5.0 g/L, Al₂O₃ content at 3.0 g/L was showed a significantly enhanced corrosion resistance. These results suggested that ultrasonic condition was an effective method to improve the properties of the composite coating.

Fishing experiment using a developed offshore dredge bycatch reduction device

Doo-Jin HWANG,Ok-Sam KIM,Hyun-Chool SHIN,Eun-A YOON,Hae-Hoon PARK,Chang-Doo PARK,Gwang-Je PARK 한국수산과학회 양식분과 2014 한국수산과학회 양식분과 학술대회 Vol.2014 No.7