정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

출생전 흰쥐 콩팥에서 콩팥소체 벽상피 분화에 대한 아포프토시스의 역할

이승헌,김영희,김완영,차정호,김진,정진웅 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.6

제주도 연안 갈치, Trichiurus lepturus 채낚기 어구의 생력화 : 3. 집어등의 수중조도

오승훈,서익조,김병엽,이창헌,정용진,서두옥,김동근 제주대학교 해양연구소 2001 해양자원연구소연구보고 Vol.25 No.-

Umbilicaria esculenta가 생산하는 Depside계 화합물의 구조 및 Phospholipase A₂ 저해활성

김진우,송경식,장현욱,유승헌,유익동 영남대학교 약품개발연구소 1996 영남대학교 약품개발연구소 연구업적집 Vol.6 No.-

Phospholipase A₂(PLA₂) is lipolytic enzyme that has known to be involved in inflammation. In the course of our screening for antiinflammatory compounds from natural products, a compound having PLA₂ inhibitory activities was isolated from the methanol extract of Umbilicaria esculenta. The compound was identified as lecanoric acid based on various NMR studies including DEPT, HETERO-COSY and HMBC experiments. Lecanoric acid inhibited human rheumatoid synovial PLA₂ activity with IC_(50) of 0.17 mM and also exhibited antitumor activity (ED_(50)=2.7μg/ml) against skin tumor cell line (LOX-IMVI).

원발성 척추 악성 신경초종 : 증례보고 3례 Case Report

김진국,송재욱,박우민,장지수,이창훈,이승훈 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.5

反應性 加熱 蒸着法에 依한 水素化된 非晶質 게르마늄의 電氣的 特性

李原鎭,梁承勳,朴奉斗,羅炳旭 慶北大學校 師範大學 1985 敎育硏究誌 Vol.27 No.-

Reactive thermal evaporation of high purity polycrystalline germanium was carried out in an atmosphere of hydrogen plasma. Deposition temperature (T_s) and hydrogen pressure (P_(H_2)) were proved to be important parameters to determine the electrical properties of samples, as expected, and the optimum T_s was determined as 200℃. Evaporation onto a substrate at 200℃ in an atmosphere of 1 torr hydrogen plasma has been shown to yield a film which shows a low RT conductivity (10^-6Ω^-1㎝^-1) and an activation type conduction (with an activation energy of 0. 38 0. 42eV) in measuring temperature (above RT). And for optimized samples, germanium hydrogen bonds were proved to be stable even after annealing at 400℃.

水素化된 非晶質 게르마늄의 特性調査(Ⅱ)

李原鎭,梁承勳 慶北大學校 1987 論文集 Vol.44 No.-

Reactive thermal evaporation(RTE) was developed as a new method to deposit hydrogenated amorphous germanium(a-Ge:H) films. The RTE was carried out by the evaporation of high purity polycrystalline germanium(nominally 6N) in an atmosphere of hygrogen plasma produced by high voltage AC(3 KV) discharge of molecular hydrogen gas of nominal purity 4N. The addition of hydrogen during the thermal evaporation of germanium has been shown to improve the electrical and optical properties of the resulting amorphous germanium(a-Ge) films considerably by saturation of dangling bonds, if the dissociation of molecular hydrogen takes place. Electrical conductivity and its annealing behavior, optical absorption coefficient and optical band gap (E^opt_g), electron probe microanalyzer(EPMA) and X-ray diffraction were used to characterize the samples. Variables preparing and treating samples were hydrogen plasma pressure, P_H(0.2 Torr, 0.5 Torr, 1 Torr and 2 Torr) and annealing temperature, T_a(200 to 400℃). The electrical conductivities were measured as a function of inverse temperature(10^3/T) and hydrogen plasma pressure for the a-Ge and the a-Ge:H. The sample prepared at optimum conditions show the activated type conduction(with an activation of 0.38-0.39eV) in measuring temperature range(above RT) and contain the stable germanium-hydrogen bonds which are not broken even after annealing at 400℃. The samples prepared below or above 1 Torr have shown the hopping conduction to higher temperature than the samples prepared at 1 Torr. These were interpreted as insufficient hydrogenation below 1 Torr or as impurity incorporation above 1 Torr, respectively. Optical properties of a-Ge:H were measured as a function of deposition temperature (T_s) and hydrogen plasma pressure. Optical band gap decreases with T_s for a-Ge : H(1.58 to 0.9 eV for T_s of RT to 300℃) and increases with P_H (1.1 to 1.27 eV for P_H of to 2 Torr) The content of hydrogen in samples was proved to be effectively controlled by changing T_s and P_H. Optimal conditions of sample preparation from the view point of electrical and optical properties were determined to be substrate temperature of 200℃ and hydrogen plasma pressure of 1 Torr. From this study, we have shown that the RTE is the effective, safe and simple method to produce a-Ge:H films.

석이로부터 분리한 페놀성 화합물의 phospholipase A_2 저해활성

김진우,송경식,유익동,장현욱,유승현,배강규,민태진 충남대학교 생물공학연구소 1997 생물공학연구지 Vol.5 No.-

호알카리성 진균 Cephalosporium sp. RYM-202가 생산하는 alkaline xylanase (CX-III)의 작용에 의해 xylan 기질로부터 생성되는 주요 가수분해 산물은 xylobiose와 중합도가 4 이상인 xylooligosaccharides이었다. 이 효소는 xylobiose에 대한 분해능을 가지고 있지 않지만 xylotriose로부터는 xylobiose를, xylotetraose로부터는 xylobiose와 xylotriose를 주산물로 형성하였다. 이러한 결과들은 CX-III가 transglycosidase 활성을 소유하는 전형적인 endo-type xylanase임을 보여준다. N-bromosuccinimide에 의한 CX-III의 화학적 변화 실험 결과 효소 1분자 당 2개의 tryptophan 잔기가 활성에 관여하는 것으로 나타났다. 그러나 iodoacetamide 및 diethylpyrocarbonate에 의한 효소활성의 저해효과는 나타나지 않음으로써 이 효소의 활성부위에 cysteine과 histidine 잔기가 필수적이지 않음이 확인되었다. The hydrolysis products formed from birchwood xylan by the action of an alkaline xylanase (CX-III) from alkalophilic Cephalosporium sp. RYM-202 were xylobiose and xylooligosaccharides polymerized with more than 4 sugar molecules. This enzyme was not active on xylobiose but readily attacked xylotriose accumulating xylobiose as a major product. The predominant end-products from xylotetraose by CX-III were xylobiose and xylotriose. These results indicate that the enzyme is typically endo-type xylanase possessing transglycosidase activity. Chemaical modification of CX-III with N-bromosuccinimide revealed that two tryptophan residues per molecule of CX-III were essential for its catalytic activity on xylan. On the other hand, iodoacetamide and diethylpyrocarbonate did not influence the activity of the enzyme, suggesting that cysteine and histidine residues are not involved in the active site of this alkaline xylanase.

GIS 및 지진취약도 분석기법을 활용한 창원시 교통망의 내진위험도 분석

이형진,김성훈,최승용 국립7개대학공동논문집간행위원회 2005 공업기술연구 Vol.5 No.-

Recently seismic fragility analysis method has been widely used for the seismic probabilistic risk assessment of infrastructures such as nuclear power plants, buildings and bridges because of its probabilistic characteristics. Furthermore, this technique has been applied to large-scale social system consisted of each infrastructures by combing GIS. In this paper, the applicability of this technique to domestic infrastructure system. Example studies were performed about Changwon city. Nonlinear time history analysis, with a maximum likelihood approach were analysis of whole infrastructure systems. The results shows that it can be very useful to predict seismic probabilistic risk assessment of this domestic transportation network. However, it is also shown that further studies such as more suitable damage criterion to domestic structure and precise nonlinear analysis techniques should be developed to predict more precise results.

톨루엔의 一回 및 反復吸入 露出이 白鼠에 미치는 影響 : 血中 濃度 및 細胞外性 아미노酸 神經傳達物質의 濃度變化 Blood concentration and extracellular amino acid neurotransmitter levels

백승경,신윤열,박용훈,이진훈,최태혁,이완구 內務部 國立科學搜査硏究所 1996 國立 科學 搜査 硏究所 年報 Vol.28 No.-