Anti-inflammatory and Anti-oxidant Effects of PHBV/Collagen (PHCP) on Lipopolysaccharide-Induced Skin Inflammation

Jin-Yi Han3*, Xu Zi Guang, Jyung-Sik Kwak, Ki-Wan Oh, Han-Ik Bae 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.1

The anti-inflammatory effect of PHBV/Collagen (PHCP) was examined in a mouse model of lipopolysaccharide (LPS)-induced skin inflammation. Vascular permeability on the back skin was measured by the local accumulation of Evan’s blue dye after subcutaneous injection of LPS (30 μg site-1). Dye leakage in the skin showed a significant increase at 2 h after injection of LPS. This LPS-induced dye leakage was also completely inhibited by HO-1 inhibitor, ZnPP, and antioxidants, including methyl gallate, trolox, and mannitol. To study the possible mechanisms underlying the in vivo anti-inflammatory effect of PHCP against LPS-induced inflammation, we also examined the effects of PHCP on malondialdehyde (MDA) and glutathione levels in skin tissues and found that pretreatment with PHCP resulted in inhibited MDA elevation and a remarkable reduction of glutathione level. In addition, similar results were obtained after pretreatment with antioxidants, including trolox and mannitol, and HO-1 inhibitor, ZnPP. Histopathologically, an influx of neutrophils into the skin dermis was detected between 24 h and 72 h after LPS injection (30, 100 μg site-1), compared to control animals after injection of saline. This increase was greater in mice treated with 100 μg of LPS than in those treated with 30 μg of LPS and was significantly suppressed by pretreatment with PHCP, antioxidants, and HO-1 inhibitor. These results collectively suggest that PHCP has an anti-inflammatory effect against LPS-induced inflammation model in vivo and may be a good candidate for the skin tissue engineering biomedical application primarily through manipulation of the redox state.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

15番 空間群의 6가지 다른 表現

吳美蘭,金勁翰,李珍昊,徐日煥 충남대학교 기초과학연구소 1996 忠南科學硏究誌 Vol.23 No.2

The space group number 15 can be expressed in six different ways as C2/c, A2/a, A2/n, C2/n, I2/a, and I2/c according to the setting of unit cell axes. The International Union of Crystallography has chosen C2/c for a standard space group of the space group number 15. In this paper, it has been shown that the six space groups are mutually transformed.

객체 지향 데이타 모델에서 질의 처리 결과의 신뢰성 보장을 위한 퍼지 질의 연산 규칙의 설계

吳廉德,金鎭漢 충주대학교 1997 한국교통대학교 논문집 Vol.32 No.2

There are a lot of fuzzy information which can be used effectively in the real world.An object-oriented data model presents a possibility of information application of more diverse methods and areas such as CAD,OIS(Office Information System),and multimedia database. To represent the degree of incompleteness, we suggest fuzzy information with certainty factor. A query model is also proposed to efficiently process fuzzy information. The G-relation concept in OSAM can be used in OSAM to represent fuzzy information, association between instances in a class, and certainty factors (C.F) for each instance object. However the representations of object C.F,C.F between objects ,association using G-relation are not suitable for storing classes

택시운전기사의 불안정도와 교통사고 발생 양상

오한진,이동배,박암 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

To find out the relationship between anxiety scales and traffic accidents of the taxi drivers, the author investigated 588 taxi drivers randomly selected from 70 taxi companies in Taejon city from Oct. 1 to Oct. 31 in 1991. The major findings of this study were as follows: 1. The mean indices of self-rating anxiety scale(SAS) were found to be 0.63 for all surveyed drivers, 0.66 for accident drivers and 0.61 for non-accident drivers(p<0.001). 2. Younger drivers and unmarried drivers, showed relatively higher accident rates than other groups and the difference was statistically significant (p<0.01). 3. Drivers, who drived small taxi worked, more than 21 days per months, worked for more than 10 hours per day and complained for his job, showed relatively higher SAS index than other groups and the their differences were statistically significant(p<0.01). Drivers who drived small taxi, had worked for fewer years and worked for more than 10 hours per day experienced relatively higher accident rates than other groups and the difference was statistically significantly(p<0.001). 4. Drivers who had poor health habits showed relatively higher SAS index and higher accident rates than other groups(p<0.05). 5. The accident rate of the above 0.75 SAS index group, 35.2%, was the highest. That of the 0.50 to 0.74 SAS index group was 26.8%. But that of the below 0.40 SAS index group, 6.6%, was the lowest. The difference among the groups was statistically significant(p<0.001).

교육대학원에 있어서 초등 과학교육 영역의 중요성과 그 운영방안

오진태,옥치율,한영욱,이형철,김용권,임채성 釜山敎育大學校 1994 부산교육대학 논문집 Vol.30 No.1

The future society is expected to be rapidly change in all areas, that is, the length of change time is becoming much smaller than that of generation time. It is very important to prepare the citizens who possess scientific literacy which actively cope with the rapid changes and specialization of society. The sources of rapid changes may be due to the developments in science and technology. Therefore, the importance of science education will be increasingly high. Scientific literacy should be improved basically and systematically from the early stages of formal education. Teachers who are responsible to educate children should be able to research in the areas of science education as well as science itself, and to have capacity to transmit them to the classroom. To do this, the graduate course and the science education within the system beyond the level of college education are essential parts of teacher education. In the graduate course, it is important that science itself and pedagogy of science should be balanced.

절골술을 이용한 안면교정

오석희,한기환,강진성 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.5

The most important factor in the beauty of the face is the harmony of the facial skeleton and soft tissue. The postoperative result is not always satisfying after only classic soft tissue surgery. The reason for dissatisfaction is disharmony of the facial skeleton. Recently, the development of maxillofacial surgical techniques enable disharmony of the facial skeleton to be successfully corrected. The authors have had experience with 33 cases of congenital and acquired facial deformities, from March of 1986 to February of 1989, and have followed them from 6 months to 2 years. We used an intraoral approach in most cases and got good results. There were four wound disruptions which were treated conservatively and resolved without sequelae.

토지이용패턴에 따른 하천수질과 식생분포

오영주,강병화,김병우,김성필,한민수,김진호,나영은 한국환경농학회 2006 한국환경농학회지 Vol.25 No.1

첫 입원치료 받은 정신분열병 환자들의 삶의 질 추적 연구

한오수,이철,최지욱,홍진표,김창윤 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.6

울산의대 서울중앙병원 정신과에서 첫 입원 치료를 받고 퇴원하여 2년 혹은 5년이 경과한 정신분열병과 기타 정신병 108명 중 최종 73명(응답을 66%)을 대상으로 Heinrichs등이 고안한 삶의 질 척도(Quality of Life Scale)를 사용하여 현재의 삶의 질을 평가하여 다음과 같은 결과를 얻었다. 첫째, 삶의 질 측면 4가지 측면인 대인관계, 직업적 역할, 정신내적 요소, 및 일상적인 물건 및 행동 모두에서 삶의 질이 전반적으로 저하되어 있음을 관찰할 수 있었다. 대인 관계 영역 중 가족 구성원과의 인적 관계 항목은 다른 항목에 비해 상대적으로 만족도가 높았다. 둘째, 정신분열병군의 삶의 질은 기타 정신병군에 비해 대부분의 삶의 질 항목에서 유의하게 낮은 것으로 나타났다. 셋째, 2년 경과군과 5년 경과군 사이 삶의 질은 유의한 차이를 보이지 않았다. 발병 초기 삶의 질 저하가 상당기간 유지됨을 시사하였다. 넷째. 퇴원 후 삶의 질에 영향을 미치는 변인으로는 첫 입원 치료 기간이 유의한 역상관관계를 보였으며 또한 다변량 회귀 분석에 있어서도 같은 결과를 보였다. 이는 초기 치료에 대한 반응 정도가 부분적으로는 향후 삶의 질을 예측할 수 있음을 시사한다. 기타 첫 입원 당시의 연령, 교육 수준. 사회경제적 수준, 첫 입원하기까지의 이환 기간, 첫 입원 당시 Global Assessment of Functioning 입원 치료시 약물용량 등은 삶의 질과 유의한 상관관계를 보이지 않았다. Objectives : One object of this study is to provide a descriptive level of qua1ity of life(QOL) in a group of the first admired schizophrenic patients through interviews being performed after two or five yeah of fo11ow-up, and comparing them with patients in psychotic disorders other than schizophrenia. Another object is to identify clinical variables on the first admission which correlate to QOL factors, after two or five years of fo11ow up. Methods : A total of 73 subjects of the first admitted patients with schizophrenia(n=57) and psychotic disorders other than schizophrenia(other psychotic disorders group, n= 16) were selected. A Quality of Life Scale(QLS) measuring 21 items of life variables was used. Demographic and psychiatric data were obtained through medical records and psychiatric interviews. Results : Schizophrenia group(n=57) showed moderate decrease(mean 3.7 of 6) in all aspect of quality of life. However, the schizophrenia group displayed a relatively high score in relations with household members(mean=5.2) only among 21 QOL items. Comparison to other psychotic disorders group(n= 16), schizophrenia group showed a significant decrease in almost all aspects of QOL. No significant difference was obtained between the 2 year(n=27) and the 5year(n= 30) group. Duration of the first admission showed a significant correlation with current quality of life in the schizophrenic group. Conclusions : The significantly decreased score of quality of life suggests the need for careful observation and therapeutic concern for the early stage of schizophrenia. The schizophrenic group's relatively high score in relations with household members in this period may provide the importance of rehabilitation to improve their quality of life. Duration of the first admission may be a useful predictor of their subsequent quality of life.

전계자격에 따른 Arac.acid박막의 전류특성

오재한,송진원,이경섭 東新大學校 1999 論文集 Vol.11 No.-

We give pressure stimulation into organic thin films and then manufacture a device under the accumulation condition that the state surface pressure is 30[mN/m]. In processing of a device manufacture, we can see the process is good from the change of a surface pressure for organic thin films and transfer ratio of area per molecule. The structure of manufactured device is Au/arachidic acid/Al; the number of accumulated layers is 17, 19 and 21. Also, we then examined of the MIM device by means of Ⅰ-Ⅴ. Then Ⅰ-Ⅴcharacteristic of the device is measured from 0 to +2[V]. In the cyclicvoltammetry, stable up to 0.9[V] vs. Ag/AgCl. The insulation property of a thin film Is better as the distance between electrodes is larger.