精神身體障碍와 泌尿器疾患

김창윤 藥業新聞社 1990 (月刊) 醫藥情報 Vol.1990 No.7

Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2

김창윤,이승재,이혜진,Eliezer Masliah 한국뇌신경과학회 2016 Experimental Neurobiology Vol.25 No.3

Synucleinopathies are a collection of neurological diseases that are characterized by deposition of α-synuclein aggregates in neurons and glia. These diseases include Parkinson's disease (PD), dementia with Lewy bodies, and multiple system atrophy. Although it has been increasingly clear that α-synuclein is implicated in the pathogenesis of PD and other synucleinopathies, the precise mechanism underlying the disease process remains to be unraveled. The past studies on how α-synuclein exerts pathogenic actions have focused on its direct, cell-autonomous neurotoxic effects. However, recent findings suggested that there might be indirect, non-cell-autonomous pathways, perhaps through the changes in glial cells, for the pathogenic actions of this protein. Here, we present evidence that α-synuclein can cause neurodegeneration through a non-cell-autonomous manner. We show that α-synuclein can be secreted from neurons and induces inflammatory responses in microglia, which in turn secreted neurotoxic agents into the media causing neurodegeneration. The neurotoxic response of microglia was mediated by activation of toll-like receptor 2 (TLR2), a receptor for neuron-derived α-synuclein. This work suggests that TLR2 is the key molecule that mediates non-cell-autonomous neurotoxic effects of α-synuclein, hence a candidate for the therapeutic target.

정신건강복지법 이대로는 안 된다

김창윤 대한의사협회 의료정책연구소 2017 의료정책포럼 Vol.15 No.3

안와벽재건술 시행 후 평가방법으로서 초음파의 효용성

김창윤,양정열,천지선,문재원 대한성형외과학회 2009 Archives of Plastic Surgery Vol.36 No.4

Purpose: Blow out fracture resulting from facial trauma is of high frequency among facial bone fractures, and can cause severe complications. So, proper post-operative management and close observation are needed. So far, Computed tomography has been the best method in evaluating following orbit wall reconstruction. However, cost-effectiveness, accessibility to patients and hazard of radiation exposure of computed tomography require supplementary measure for the evaluation following orbit wall reconstruction. This study was performed to describe the effectiveness of ultrasonography in the evaluation following orbit wall reconstruction. Methods: A retrospective study was performed on 40 patients who underwent orbit wall reconstruction from June, 2008 to July, 2008. The patients' ages ranged from 13 to 65 years with the mean of 27.5 years. The patient group was composed of 27 males and 13 females. The follow up period ranged from 2 weeks to 28 weeks with the mean of 11 weeks. Preoperatively, all fractures were diagnosed using computed tomography. Ultrasonography for all cases, and computed tomography for 2 cases were performed for evaluation following orbit wall reconstruction. Results: Reduction of herniated orbital soft tissue and orbit implant was identified by using ultrasonography in 38 cases out of 40 cases. In other cases which we could not identify the orbit implant, computed tomography was performed. Conclusion: Compared to computed tomography, ultrasonography is a simple, inexpensive and convenient method. Ultrasonography can be used as supplementary measure to computed tomography in the evaluation following orbit wall reconstruction for elective patients.

윤락여성의 혈청 HBsAg 및 Anti-HBs 양성율

김창윤,Kim, Chang-Youn 대한예방의학회 1983 예방의학회지 Vol.16 No.1

성적접촉에 의한 B형간염의 전파가능성을 조사하고 그 정도를 파악할 목적으로 1982년 3월 1일부터 7월 31까지 대구시내 윤락여성 435명을 대상으로 B형간염감염율과 그들의 연령, 종사기간, 교육수준, 수혈 및 수술력을 조사하였다. B형간염 virus 보유율이 높은 한국인을 상대로 하는 중구보건소에 등록된 윤락여성의 경우 B형간염 감염율이 41.7%였고 B형간염 virus 보유율이 낮은 주한미군을 상대로 하는 동 남구보건소에 등록된 윤락여성에서는 30.2%의 감염율을 나타내어 중구보건소에 등록된 윤락여성이 통계적으로 유의하게 높은 잠염율을 보였다(p<0.025). 동 남구보건소에 등록된 윤락여성에서는 종사기간 별로 별다른 차이를 보이지 않았으나 중구보건소에 등록된 윤락여성에서는 2년 이상의 경우 B형간염 감염율이 49.3%였고 2년 미만의 경우 38.9%로 차이는 있으나 통계적 유의수준에는 미치지 못하였다. 교육수준, 수술력 및 수혈력과 B형간염, 감염율 사이에는 일정한 상관관계를 보이지 않았다. 이상의 결과로 미루어 보아 성적접촉으로 B형간염이 어느정도 전파되기는 하나 주전파 경로는 아닌 것으로 생각된다. This study was attempted to define epidemiologically the possibility and the magnitude of sexual transmission of HBV in Korea. Two groups of prostitutes; one group (309) deals with Koreans, the other group (126) deals with American soldiers stationing in Korea, were tested for the presence of HBsAg and anti-HBs. The prevalence rate of HBsAg or anti-HBs was significantly higher in prostitutes who deal with Koreans (41.7%) than in prostitutes who deal with American soldiers (30.2%) (p<0.025). Among the prostitutes who deal with American soldiers, there was no appreciable difference in the prevalence rate of HBsAg or anti-HBs by the duration of prostitution. However, among the prostitutes who deal with Koreans, the prevalence rate was increased with the duration of prostitution, although it did not reach the statistically significant level (p=0.12). There was no remarkable association between the prevalence rate of HBsAg or anti-HBs and educational level, history of operation or history of transfusion. The data support the possibility of sexual transmission of viral hepatitis B but it seems seems sexual transmission does not contribute significantly to the prevalence rate of HBsAg or andi-HBs in Korea.

조선시대의 치안정책과 조직에 관한 연구

김창윤 한국공안행정학회 2014 한국공안행정학회보 Vol.23 No.4

본 연구는 500년이 넘는 긴 역사를 자랑하던 조선시대 경찰의 성리학적 유교이념에 의한 치안정책과 특징 그리고 조직체계를 분석함으로써 다원화된 조선시대 치안체제를 이해하고 그 역할을 고찰하는데 목적이 있다. 조선전기의 통치철학은 외교면에서는 친명정책(親明政策)을 표방하고, 정치사회적인 면에서는 신진사대부를 중심으로 고려의 문벌귀족사회를 타파하였으며, 경제적인 면에서는 전제개혁(田制改革)을 단행하고, 사상면에서는 숭유억불(崇儒抑仏) 정책을 추진하였다. 이러한 통치철학에 따라서 조선전기의 치안정책은 다원적 경찰권 행사에 의한 방도금란 정책과 예방적 순찰정책이었다. 조선후기의 통치철학은 변화된 사회질서를 성리학적 원리에 따라 재정립하기 위해 정통유학인 정주학(程朱學)과 예학(禮學)이 발전하면서 중앙집권적인 붕당정치가 발달되었다. 18세기에는 유교의 근대지향과 조선중화주의를 통치철학으로 강조하였다. 조선후기의 치안정책은 혼란한 시대상황을 반영하여 매우 다양한 방도금란 및 순찰 정책과 체제유지 정책을 수행하였다. 즉, 붕괴된 사회질서를 회복하기 위해서 훈련도감과 삼군문과 같은 군사조직과 기존의 포도청 조직을 모두 활용하여 치안유지에 노력하였다. 기존의 오위(五衛)와 순청(巡廳), 의금부(義禁府), 삼군문(三軍門) 그리고 전문경찰기관인 좌·우포도청(左捕·右盜廳)이 조선후기 수도치안을 맡게 되었다. 즉, 임진왜란을 계기로 오위(五衛)가 군사조직으로 쓸모없게 되면서 훈련도감(訓練都監)과 삼군문(三軍門) 그리고 포도청에서 그 임무를 담당하였다. This article is a primarily study on Police Policies and Police Organization in Chosun Dynasty. It is argued that Podocheung(Police Bureau of Chosun Dynasty) is the unique Police in Chosun Dynasty. But there are many police forec in Chosun Dynasty. This study attempts to analyze the characters of Police policies and their effects on the Police systems in Chosun Dynasty. For the purpose of this study, it uses a historical Method on the Police policies and Police organization in Chosun Dynasty. The conclusions of this study are summarized as follows. Firstly, the police policies of the early days of the Chosun Dynasy (1392-1592) are the crime prevention and proactive patrol policy. These policies have been effected on an pursue-confucianism and oppressingbuddhism. Secondly, the police policies of the latter part of the Chosun Dynasy (1592-1876) are the crime prevention, proactive patrol policy and maintenance of a system. These policies have been effected on the modern inclination and a successor of Chinese civilization. In Choson Dynasty, the policies of crime prevention and proactive patrol had contributed to stabilize the national system. The diversified police forces of Chosun Dynasty had played the principal role in setting up and building the government of Choson Dynasty.

토목현장에서의 무인비행장치 기반 현장정보 취득 및 분석 시스템 개발

김창윤,윤준희 대한토목학회 2022 대한토목학회논문집 Vol.42 No.4

Due to harsh conditions of construction site, understanding of current feature of terrain and other infrastructures is critical issue for site managers. However, because of difficulties in acquiring the geographical information of the construction sites such as large sites and limited capability of construction workers, comprehensive site investigation of current feature of construction site is not an easy taskfor construction managers. To address these circumstances of construction sites, this study deduce difficulties and applicabilities of unmanned aerial vehicle in the area of construction site management. To confirm applicability of UAV in civil construction project,case study have been conducted on the road construction project. The result of case study proved that the developed system is one of promising technologies that has been studied in construction site management. To improve applicability of UAV for construction and process management information, law and technical issues will be an important area of future study. 건설 현장, 특히 토목 분야 시공 프로젝트의 경우 다양한 요인에 따라 프로젝트 진척상황을 파악하고 공사/공정을 모니터링 하는데 어려움이 따른다. 본 연구에서는 건설 프로젝트, 특히 토목 시공 프로젝트의 생애주기 중 주요 과정 중 하나인 공사/공정관리 모니터링 단계에서의 무인비행장치의 활용가능성에 대하여 분석하고 그 방법에 대하여 고찰하고자 한다. 먼저, 본 연구에서 도출한 건설 현장의 특징을 극복하기 위하여 공사/공정관리 모니터링 과정에 대하여 먼저 분석을 수행하고, 현재 드론 기기의 특성에 맞는 활용 방법에 대하여 분석을 수행하였다. 이를 바탕으로 하여 토목 현장 관리를 위한 필수 데이터인 정사영상 및 포인트 클라우드 데이터를 취득하기 위한 시스템을 개발하였으며 시스템 적용가능성에 대한 분석을 수행하였다. 대표적인 토목 현장인 도로 프로젝트를 대상으로 테스트베드를 수행하여 무인비행장치의 현장 활용가능성에 대한 검토 역시 진행하였다. 테스트 베드 수행 결과 개발된 시스템의 건설 현장 관리 적용 가능성 및 실용성을 확인할 수 있었다. 향후 연구에서는 무인비행장치를 활용하여 취득하고 분석한 데이터가 실질적으로 시공/공정 관리 정보로서 활용될 수 있도록 기반을 마련될 수 있도록 제도적, 기술적 보완을 위한 연구가 요구된다.

소설 「조만득 씨」의 영화 <나는 행복합니다> 되기

김창윤 한국언어문학교육학회 2015 한어문교육 Vol.32 No.-

This study analyzed a novel's becoming a film with Deleuze's 'becoming' concept as a foundation for seeking a way for a novel and a film to acquire mutual valuable, artistic performances. Novel's becoming a film marks the point which a novel is changed at from previous itself after its meeting with a film, and at the same time marks the point that the film is changed at from previous itself after its meeting with a novel. Until now, the studies about the novel 「Mr. Man-Deuk, Jo」 and the film <I'm happy> have focused on the narrative differences being revealed from the media difference of novel and film, but this paper developed the research with more focusing on the theme aspect. Because that was considered to be a more appropriate research method in the creation's becoming a film, rather than the difference. In its beginning section, the novel 「Mr. Man-Deuk, Jo」 largely asks two questions: 'Does Mr. Man-Deuk, Jo want or doesn't want that (treating the delusion of grandeur)?' and 'It is up to Mr. Man-Deuk, Jo to make Dr. Min treating him as a real fortune or as a unfortune.' And the novel answers the two question through the section of conclusion and Dr. Min's speech. The film <I'm happy> tries to draw its thematic consciousness through its answer about the second question, 'It is up to Mr. Man-Deuk, Jo to go through the real matter after his treatment.' The film constructs a different narrative framework from that of the novel 「Mr. Man-Deuk, Jo」 by focusing on expanding the characters in order to draw such answer, and produces an expanded meaning structure rather than the meaning of film itself. And the expansion of characters draws Su-Gyeong and Man-Su's another conclusion. The film suggests an open ending different from the novel's closed ending, and makes the audience grasp the chain of symbols. The novel 「Mr. Man-Deuk, Jo」 could newly sew the chains of the symbols having floated through the film <I'm happy>'s creation of a new meaning structure, and that led to the expansion of meanings. Also, the film <I'm happy> could let the audience grasp the chains of symbols in open ending by getting the answer about the second question through the first question as the meaning structure focused on the novel 「Mr. Man-Deuk, Jo」.

한국의 범죄특성에 관한 연구 - 지난 10년간 5대 범죄발생 분석을 중심으로 -

김창윤 원광대학교 경찰학연구소 2011 경찰학논총 Vol.6 No.1

본 연구는 2000년에서 2009년까지 지난 10년간의 시기에 발생한 5대 범죄의 추세분석을 중심으로 범죄발생현황과 경찰의 대응활동 그리고 향후발전방안을 제시하는데 목적을 두고 있다. 지난 10년 동안 5대 범죄는 2000년 228,394건에서 2009년 478,815건으로 증가하였는데 이는 209.6%나 증가한 것이다. 살인범죄의 경우, 2000년의 964건에서 2009년의 1,349건으로 385건이 늘어난 38.3%가 증가하였으며, 강도사건은 2000년의 5,349건에서 2009년의 5,904건으로 555건이 늘어나 10.3%가 증가하였다. 강간사건은 2000년의 6,082건에서 2009년의 16,156건으로 10,074건이 늘어나 165.6%로 매우 높은 증가율을 보였다. 폭행․상해사건은 2000년의 49,838건에서 2009년의 198,210건으로 4배 가까운 397.7%가 증가하였으며, 절도사건은 2000년의 165,261건에서 2009년의 256,680건으로 55.3%가 증가하였다. 또한 지난 10년간 인구10만 명당 범죄발생률이 평균 2.75%씩 증가하고 있었음에도 불구하고, 이에 대한 체계적인 범죄예방활동과 대응이 우리가 알고 있는 것과는 다르게 매우 미흡했던 시기로 나타났다. 따라서 5대 범죄문제 해결을 위한 국가정책과 치안정책이 제시되어야함을 알 수 있다. 본 연구에서는 5대 범죄를 해결하기 위한 세부방안으로 첫째 수사경찰체제 정비, 둘째 과학적 수사체제 확립, 마지막으로 경찰관련 학자와의 협력체제 구축 등을 제시하였다. This Study concerned with the trends and the characteristics of 5 Index Crime in Korea from 2000-2009. It described the curves and the component ratio of 5 Index Crime, major crimes-violent crime, sexual violence crime, felony, property crime. The data that this study has analysed were obtained from official crime statistics, "Analytical Report on Crime," which is published by the Supreme Public Prosecutor's Office in Korea. The analysis period are from 1999 to 2010. By using the Analytical Report on Crime, annually published by the Korean Supreme Public Prosecutors' Office, this study examines 10 Years Korean crime trends and patterns in the following five Index Crimes: murder, robbery, forcible rape, assault, and property crime. Although the official statistics provide information on crime only reported to the police, it is useful in capturing and analyzing crime trends and patterns over the 2000-2009. The conclusions of this study are summarized as follows. Firstly, crime rate per 100,000 in Korea was higher than average of Japan in the period of 2000-2009. Secondly, the police power didn't effect on the crime rate in the period of 2000-2009. In Korea, the study of the 5 Index crime and behavioral characteristics of offenders is needed for the detailed analysis on the 5 Index crime characteristics and police policy against 5 Index Crime.

토목/건축 분야에서의 ICT융합 기술의 활용

김창윤 한국정보통신설비학회 2013 한국정보통신설비학회 학술대회 Vol.2013 No.1