http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
최영락,정혜원,최영기,김시욱,이기만,최강현,안진영 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.3
Effective treatment for community-acquired pneumonia (CAP) requires administration of appropriate empirical therapy based on etiologic, clinical, and radiological features. However, in Korea, CAP is poorly characterized, and data on viral CAP are particularly sparse. Therefore, improper use of antibiotics is common, and is detrimental the potential for development of bacterial. Thus, we investigated clinical and radiological findings for discrimination of viral CAP from bacterial CAP. Etiologic, clinical, and radiological data from 467 patients with CAP at Chungbuk National University Hospital from October 2010 to September 2011were analyzed retrospectively. Viruses were identified in 23cases (11.4%); the influenza virus A was the most common virus detected (N=18, 25.4%), followed by the respiratory syncytial virus A (N=14, 17.9%). Bacteria were identified in 48 cases (23.8%); Streptococcus-pneumonia was the most common (N=24, 25.5%), followed by Staphylococcus aureus (N=20, 21.3%). Depending on hospitalization time, the following significant differences were observed between viral and bacterial CAP: on admission, (1) high fever (≥ 38.5°C),(2) purulent sputum, (3) white blood cell count, (4) Creactive protein levels, (5) and bilateral lung involvement on chest X-ray were higher in bacterial CAP; and at discharge,(1) duration of high fever and (2) radiologic improvement within three days were higher in viral CAP. Regarding seasonal patterns, both viruses and bacteria have been identified with relative frequency in the winter season. This study described the etiological, clinical, and radiological findings of viral and bacterial CAP. Conduct of additional largescale,prospective investigations will be required in order to improve the appropriate treatment of CAP.
Establishment of normal canine thoracic radiograph database in small breed dogs
Jinhwa Chang,Wooshin Choi,Jinyoung Song,Youngjae Lee,Donghoon Lee,Juhyung Kim,장동우 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.3
Inter-breed and individual variations in thoracic conformation often resulted in incorrect diagnosis during interpreting canine thoracic radiographs. Therefore, it may be helpful to build up a collection of normal thoracic radiographs of different breeds for useful reference. The aim of this study is to establish the normal canine thoracic radiograph database according to breed, age and body weight. Medical records and thoracic radiographs of Veterinary Medical Center, Chungbuk National University were reviewed retrospectively. Normal thoracic radiographs of 170 dogs out of 640 patients that had thoracic radiographs were obtained. In 170 normal dogs, Maltese, Shih-tzu, Yorkshire Terriers, and Miniature Poodle were the most prevalent breeds with the number of 90 dogs. In this study, the normal canine thoracic radiograph database was established in the four breed, and it can be used for normal references when interpreting canine thoracic radiographs.
Evaluation for the Safety of Bee Venom in ICR Mice
Hu Jang Lee, Chun-Nam Cha, Yeo-Eun Lee, In-Jin Kang, Suk Kim 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.1
This study was conducted in order to examine the safety of bee venom as an alternative for antibiotics using male ICR mice. Five-week-old male mice received a single intravenous injection of a dried honey bee venom at the concentration of 0.25 mg/kg (a clinical dose) or 0.5 mg/kg through the tail vein and various pathophysiological analyses were performed after three days. No significant differences in changes of body weight were observed between the saline-treated control group and the experimental groups. In the hematological analysis, none of the parameters were affected by bee venom. In blood biochemistry analysis, none of the markers were affected by administration of bee venom. Similarly, there were no significant effects on markers for liver, kidney, and skeletal muscle functions in all treated- groups. On macroscopic examination, no remarkable lesions were detected in these organs. Because there were no adverse effects of the bee venom in a single intravenous toxicity test for three days, it was concluded that bee venom could be a candidate for a safe natural antibiotic for use in the animal production industry.
Retrospective study on fractures in dogs
마루프 미나르,최석화,오정진,김소민,박민혁,황야원,김근형 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.3
Patients referred to the Veterinary Medical Center at Chungbuk National University were analyzed. This study aimed to provide information to clinicians in Korea on the factors affecting fracture incidence in patients adapted to Korean companion animal culture. Eighty cases showingbone fractures were investigated from January, 2005 to December,2011. Fractures were mainly observed in miniature dogs such as Yorkshire terrier (12%), Poodle (12%), and Maltese (9%). Almost 50% of all cases were less than 1 year old. Total bone fractures in summer and fall constituted 62%. Fracture incidence was higher in male dogs (54%)than female dogs (46%). Hindlimb fracture (37%) was the most common. Distribution of limb fractures was higher in the femur (19), followed by the tibia/fibula (15), radius/ulna (13), humerus (11), and mandible (8). Pelvic fracture was observed in 19 cases. Simple fracture (84%) was the most common fracture type, followed by comminuted fracture (16%). Distal portion was the most common fracture site in long bones (67%), followed by middle (26%) and proximal bones (7%). Fractures were mainly caused by traffic accidents (43%), whereas 28.5% of fractures were due to falling down. Plate & screw (26%) was the most common method of fracture repair, followed by intramedullary pin (24%), wire (11%), external skeletal fixation (10%), screw (9%), amputation (7%), cross pin (6%), IM pin and wire (5%), and rush pin (1%). Among 80 patients, 79%of patients showed a good prognosis after surgery, whereas 13%patients did not experience a good result. This study shows that miniature dogs are prone to falling and fractures, especially in the distal part of long bones.
A light microscopic study on tongue development in Korean native goats (Capra hircus)
Chungkil Won, Munki Kim. Gyu-Hyen Cho, Chong-Sup Kim, Gon-Sup Kim 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.4
The purpose of this study was to identify the composition and organization of lingual tissues underlying the histo-structural change of developing tongue in Korean native goats by light microscopy (LM). Tongues of the fetuses on days 60, 90, 120 and neonate were examined for the morphological development. In the 60-day-old fetuses, the tongue tissues were differentiated into epithelium, lamina propria and muscle layer. Primordia of filiform, conical, lentiform, fungiform and vallate papillae appeared and rudiments of taste bud were observed in the epithelia of the primordia of the gustatory papillae. The dorsal surface of the lingual epithelia showed a weak PAS positive reaction. Collagenous fibers and small blood vessels were shown in the connective tissues. In the 90-day-old fetuses, Von Ebner’s glands were moderately PAS positive while the muscle fibers and connective tissue were strongly positive for PAS. The collagenous fibers increased and came to have a more complex arrangement in the tongue. The muscle fibers were spread out at various directions and developed in striated muscle bundles. In the 120-day-old fetuses, taste buds were observed in the epithelia of the gustatory papillae, and several well-developed tissues visible such as blood vessels, collagenous fibers, muscle fiber bundles and Von Ebner’s glands. In the neonates, many taste buds were found in a transverse section of the vallate papilla. The muscle layers, Von Ebner’s glands, collagenous fibers and blood vessels were more developed than those of the 120-day old fetuses. These findings indicate that goat tongues have a variety of different shapes during prenatal development
Age and gender-associated metabolic characteristics of urinary stone patients
Sang Keun Lee,Young-Won Kim,Ho Won Kang,Won Tae Kim,Yong-June Kim,Seok-Joong Yun,Wun-Jae Kim,Sang-Cheol Lee 충북대학교 동물의학연구소 2015 Journal of Biomedical and Translational Research Vol.16 No.4
The aim of the present study was to investigate sex- and age-associated clinico-metabolic characteristics of urinary stone patients. A retrospective review was performed on data from 2,009 consecutive patients presenting with their first urinary stone episode between 2005 and 2013. Of the 2,009 patients, 1,426 (71.0%) satisfied the inclusion criteria and were enrolled in the study. Patients were grouped by age (<60, ≥60 years old) and sex. The medical history and 24 hr urinary chemistry results of each patient were obtained. The mean age of the 165 (11.6%) patients aged 60 or over was 65.5 ± 4.2 years. Body mass index was greater in elderly females than in younger females (p=0.031). After stratification by sex and age, lower urinary excretion of calcium and uric acid was a protective factor for both sexes among the elderly (p<0.05, each, respectively). Low urine pH was a common risk factor for both sexes among the elderly (p=0.013 in males, p=0.047 in females, respectively), whereas lower citrate excretion was a risk factor for only the elderly female group (p=0.004). With regard to urinary metabolic abnormalities, elderly females showed higher incidence of hypocitraturia compared to younger females (p=0.049). In conclusion, this study demonstrated the sex- and age-associated clinico-metabolic characteristics of urinary stone patients. Thus, it is important to tailor metabolic evaluation and medical prevention therapies for patient according to sex and gender characteristics.
Chungkil Won, Gyuhyen Cho, Munki Kim, Gonsup Kim, Chongsup Kim 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.3
The purpose of this study was to explore the morphological characteristics of developing lentiform papilla (LP) in Korean native goats by scanning electron microscopy (SAM). Tongues were removed from fetuses on days 90, 120, neonates, and juveniles on days 30, 60, 90, 120, 150, and 180. In prenatal development, the primordia of LP in 90-day-old fetuses were round and spotted on the inner most part of the torus linguae of the tongue. Primordia of LP in 120-day-old fetuses also had a lens-like shape. In neonates, LP displayed similar features as the adult one. In postnatal juveniles on days 30 and 60, LP continually increased in size without much difference in structure compared to that of neonates. By postnatal day 90, detached pieces of keratinized superficial epithelia were observed. Microridges and microplicae were well developed on the epithelial surface of LP in 60- to 120-day-old goats. The lengths of LP were 476~514 μm in neonates, 687~962 μm in the weaning period of 60-dayold goats, and 1,068~1,567 μm in the maturing period of 180-day-old goats. These findings indicate that goat LP has different sizes and shapes from those of other species during development
Anti-obesity and Anti-lipidemic effects of linalool in high-fat diet-induced obese mice
Hyung-Seon Baek,Sung Hwan Kim,이인철,강성수,유진철,윤원기,김영국,Hyoung Chin Kim,김종춘 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.3
This study investigated the anti-obesity and anti-lipidemic ability of linalool (LL) in ApoE deficiency mice fed with a high-fat diet (HFD). Four experimental groups of 8 mice each were constructed: a control group received a basic diet and oral repeated dose of the vehicle only for 12 weeks; a HFD group received a HFD and oral repeated dose of the vehicle only for 12 weeks; and the HFD&LL25 and HFD&LL50 groups received a HFD and oral repeated dose of LL 25 and 50 mg/kg/day for 12 weeks, respectively. HFD produced a significant increase in body weight, spleen weight, and adipose tissue weight compared with the control group. An increase in the serum levels of aspartate aminotransferase and alanine aminotransferase activities, total cholesterol (T-CHO), triglyceride (TG), and low density lipoprotein cholesterol was also found in the HFD group. Histopathological examinations showed severe liver injuries, characterized by extensive fatty changes and hepatocyte degeneration/necrosis. On the contrary, oral administration with LL significantly improved HFD-induced obesity and hyperlipidemia, evidenced by a decrease in the adipose tissue weight, T-CHO, TG, and histopathological lesions. The results indicate that LL suppressed HFD-induced obesity, hyperlipidemia, hypercholesterolemia, and hepatic steatosis, suggesting that LL might be a promising adjuvant therapy for the treatment of these metabolic disorders related to corpulence.