Evaluation of Agronomic Stability of North Korean Rice Varieties using Statistical Models

O-Young Jeong,Jeom-Ho Lee,Ha-Cheol Hong,Eung-Gi Jeong,Jin-Soo Paek,Chang-Ihn Yang,Yong-Hee Jeon,Myeong-Ki Kim,Kyu-Seong Lee,Sae-Jun Yang,Young-Tae Lee 韓國作物學會 2008 한국작물학회지 Vol.53 No.1

This experiment was carried out to evaluate the agronomic stability of North Korean rice varieties using the statistical model developed by Grafius, Finlay, and Ever hart. The lowest yearly variation based on coefficients of variation was found in Hannam 29 for number of panicles per hill, in Sijoong 9 for number of grains per panicle, in Pyeongyang 3 for ripened grain ratio, in Sijoong 16 for 1,000 grain weight, and in Yeomju 1 for grain yield. By Grafius's model, Pyeongbook 3, Weonsan 66 in early maturing groups and Seohaechalbyeo in medium maturing groups show stable for 3 years. Weonsan 66 in early maturing groups and Seohaechalbyeo in medium maturing groups were found to be highly stable as analyzed by both Finlay and Wilkinson's model and Everhart & Russell's model. With reference to three models, Weonsan 66 was highly stable for 3 years with showing more yield than Odaebyeo in early maturing groups while Seohaechalbyeo was highly stable for 3 years with showing high yield than Hwaseongbyeo in medium maturing groups above 5~;t~;ha-1 of milled rice respectively.

Evaluation of Agronomic Stability of North Korean Rice Varieties using Statistical Models

Jeong, O-Young,Lee, Jeom-Ho,Hong, Ha-Cheol,Jeong, Eung-Gi,Paek, Jin-Soo,Yang, Chang-Ihn,Jeon, Yong-Hee,Kim, Myeong-Ki,Lee, Kyu-Seong,Yang, Sae-Jun,Lee, Young-Tae The Korean Society of Crop Science 2008 한국작물학회지 Vol.53 No.1

This experiment was carried out to evaluate the agronomic stability of North Korean rice varieties using the statistical model developed by Grafius, Finlay, and Ever hart. The lowest yearly variation based on coefficients of variation was found in Hannam 29 for number of panicles per hill, in Sijoong 9 for number of grains per panicle, in Pyeongyang 3 for ripened grain ratio, in Sijoong 16 for 1,000 grain weight, and in Yeomju 1 for grain yield. By Grafius's model, Pyeongbook 3, Weonsan 66 in early maturing groups and Seohaechalbyeo in medium maturing groups show stable for 3 years. Weonsan 66 in early maturing groups and Seohaechalbyeo in medium maturing groups were found to be highly stable as analyzed by both Finlay and Wilkinson's model and Everhart & Russell's model. With reference to three models, Weonsan 66 was highly stable for 3 years with showing more yield than Odaebyeo in early maturing groups while Seohaechalbyeo was highly stable for 3 years with showing high yield than Hwaseongbyeo in medium maturing groups above $5\;t\;ha^{-1}$ of milled rice respectively.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

저전력의 플립-플롭과 클럭 드라이버 설계

양윤주,하영철,송정근,홍창희 東亞大學校 附設 情報通信硏究所 1999 情報通信硏究所論文誌 Vol.7 No.1

본 논문에서는 VLSI 전체 전력소비에 있어 비중이 높은 클럭 시스템의 전압 스윙 폭을 줄여 전력소비를 감소시킬 수 있는 저전압 클럭용 플립플롭을 제안한다. 제안된 플립플롭이 저전압 스윙 클럭으로도 동작함을 증명하고 이 플립플롭과 연계하기 위한 실제 전압 폭 감소 클럭 드라이버를 설계하였으며, 이 클럭 드라이버에 의해 기존의 클럭 드라이버에서 발생하는 전력소비를 1/4가량 감소시킬 수 있음을 설명했다. 본 논문에서 제시하는 플립플롭과 클럭 드라이버간의 연계동작과 소비전력 감소 효과는 SPLICE simulation을 통해 검증하였다.

SPICE를 이용한 다이나믹 D 플립플롭의 성능 연구

하영철,양광진,임영도,홍창희 동아대학교 공과대학 부설 한국자원개발연구소 1995 硏究報告 Vol.19 No.1

In this paper, we analyze two D flip-flop generally considered to be fastest (and most widely used), and compare their speed performance and their speed performance and their robustness against clock skew when a two-phase clocking scheme is applied. The effect of click skew on their speed and proper logic operation is analyzed and verified with SPICE simulation.

노인 외상 환자의 중증도 분류 시 Triage-revised Trauma Score의 의의

양영모,하영록,정성필,김승환,유인술 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Backgrouds: The mortality of geriatric trauma patients is higher than that of other age groups. However, little research has been done the methods or criteria of triage for geriatric trauma patients. This study evaluated a clinical significance of the triage-revised trauma score(t-RTS) for triage of geriatric trauma patients. Methods: We retrospectively analyzed clinical data on 528 trauma patients over 65 years of age who were treated from Jan 1999 to Dec 2000. The t-RTS was calculated utilizing the RR(respiratory rate), SBP(systolic BP), and GCS scores and the ISS was abstracted from the final diagnosis. The obtained t-RTS and ISS were evaluated using the measures of sensitivity, specificity, accuracy, and AUC curve. Results: The overall mortality rate was 9%, and there was no significant differences between the survival group and the mortality group according to age and sex. The mean scores of SBP, RR and GCS of the survival group were significantly higher than those of mortality group(p=0.001). The mean of t-RTS and RTS of the survival group were also significantly higher(p=0.001), but the ISS was significantly higher in the mortality group(p=0.001). The t-RTS, RTS, and ISS showed good prediction rates on the ROC curve(p=0.001), and the AUC value was higher in the ISS than in the t-RTS and the RTS. The sensitivity and the accuracy were high in the t-RTS and the RTS, and the specificity was high in the ISS. The t-RTS is less than 10 for a survival probability of 50% or less Conclusions: Implementation of the t-RTS in the triage of geriatric trauma patients in the field and in emergency room would be very useful. The probability of death in geriatric trauma patients is high when the t-RTS is less than 10.

자궁경부암에서 Glutathione S Transferase-π의 분포에 관한 연구

양승하,김의한,강영근,김대중,강상균 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

Uterine cervical carcinoma is the most common malignant tumor of woman in korea. GST-π is multifunctional and is implicated to detoxication of drug and carcinogenesis. This enzyme is expressed in many tumors of human. Relationship between GST-π and drug resistence on uterine cervical carcinoma is not known, but condyloma accuminatum, CIN and invasive carcinoma express this isoenzyme, and it is regarded as a useful marker in preneoplasia and neoplasia. To observe the expression of GST-π in CIN and invasive carcinoma, we analyzed CIN 26 cases and invasive squamous cell carcinoma 61 cases by immunohistochemical stain using monoclonal mouse anti-human GST-π. The results are as followings: 1) The GST-π showed positive reactionin normal and metaplastic epthelium adjacent to CIN and invasive carcinoma in forty-three cases(62.3%) of sixty-nine cases. 2) The GST-π showed positive reactionin CIN in eighteen cases(69.2%) of twenty-six cases. Positive rates of CIN Ⅰ, CIN Ⅱ and CIN Ⅲ are 66.7%, 71.5%, 68.8%, respectively. 3) The GST-π showed positive reaction in invasive squamous cell carcinoma in fifty-one cases(83.6%) of sixty-one cases. Positive rates of microinvasive and invasive squamous cell carcinoma are 84.6% and 83.3%, respectively. According to cell type, keratinizing and nonkeratinizing type are 81.8% and 84.6%, respectively. Above results revealed that GST-π may be significance as a immuohistochemical marker in CIN and invasive SCC, and may be implicated in intrinsic resistance for anticancer drug.

비점막(鼻粘膜) 섬유세포에서의 RANTES와 MCP의 발현 조절

하용찬,조정재,유영처,양원용 Official Journal of the Korean society for immunol 2003 Immune Network Vol.3 No.1

급성충소돌기염의 임상 : 병리학적 고찰

양기화,조준필,하영천,한진우,정학재,손수창,이성희,황재훈,신철호 최신의학사 1989 最新醫學 Vol.32 No.4

Aspergillus nidulans 에서의 핵전이에 의한 종내잡종 형성

양영기,박열,이영하,맹필재 충남대학교부설 생명공학연구소 1991 생물공학연구지 Vol.1 No.-

The nuclear transfer technique was employed to obtain intraspecific hybrids in Aspergillus nidulans. Nuclei isolated from either a wild type or an auxotrophic mutant strain (FGSC 475) were transferred into the protoplasts of a recipient strain (FGSC 514). The frequency of hybrid formation (4.8% and 10.1%, respectively) by nuclear transfer was higher than the frequency (0.6%) by protoplast fusion. Furthermore, most of the hybrids formed showed increased activity of some components of cellulase system, xylanase system, and mannanase. The hybrids were analyzed to be either diploid or aneuploid. These results suggest that nuclear transfer technique is more efficient in the formation of intraspecific hybrids than protoplast fusion method and is useful for the improvement of Aspergillus strains.