증식당뇨망막증에서 아르곤레이저 광응고술의 치료 효과

안병헌,민병무,최시환,서병로,박우찬 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

Vitreous hemorrhage, which is the major cause of blindness in proliferative diabetic retinopathy, has been prevented clinically with laser photocoagulation. We reviewed 57 cases(98 eyes) of proliferative diabetic retinopathy which were treated by argon laser and followed up for more than 6 months. Of these 98 eyes, 81 eyes(83%) showed a satisfactory response after standard panretinal photocoagulation. 14 eyes(14%) revealed the vitreous hemorrhage after panretinal photocoagulation and higher incidence of vitreous hemorrhage in the cases of new vessel on the optic disc. In the cases(26 eyes) of new vessel on the optic disc, 2000 laser burns revealed lower incidence of vitreous hemorrhage(1/5, 20%) in comparison with 1500 laser burns(8/21, 38%). These results indicate that initial augmented laser therapy prevented the vitreous hemorrhage effectively.

The prediction of the tooth size in the mixed dentition for Korean

Moon, Sung-Hwan,Kim, Seong-Oh,Yu, Hyung-Seong,Choi, Byung-Jai,Choi, Hyung-Jun,Lee, Jae-Ho 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.2

이번 연구의 목적은 혼합치열기 아동에서 미맹출된 견치와 소구치의 크기를 예측하는데 있어서 한국인에 맞는 방정식을 만들기 위함이다. 미맹출 치아의 크기를 예측하는 것은 혼합치열기 교정 진단과 치료계획 수립에 있어서 매우 중요하다. 미맹출된 견치와 소구치 크기를 예측하는 방법은 몇가지가 있지만 그중에서도 가장 흔하게 쓰이는 것이 모이어의 예측표와 다나카와 존스턴의 방정식이 있다. 하지만 그것들은 백인을 위해서 제작된 것이고 치아 크기는 인종에 따라서 다르다고 알려져 있다. 이번 연구에서는 치아크기를 측정하여 하악 영구 절치의 크기 합과 견치 및 소구치의 크기 합 사이의 상관관계를 구하고 회귀방정식을 이용해서 한국인에 맞는 예측표를 만들었다. 연세대학교 치과대학에 재학중인 178명의 한국 학생(남 108명, 여 70명, 평균연령 21.63)을 대상으로 실험하였다. 영구치의 근원심 폭경을 석고모형상에서 calipers를 이용해서 측정하였다. 성별간의 치아 크기는 차이가 있었다(p<0.05). Correlation coefficient는 0.57에서 0.64의 범위였고, standard errors of the estimates 는 여성에서 0.6으로써 남성보다 우수하였다. r^(2)값은 0.27에서 0.41의 범위를 나타내었다. Estimating the size of unerupted teeth is an essential aspect of orthodontic diagnosis and treatment planning in the mixed dentition. Several methods were introduced and used for the prediction. The most common methods among these would be Moyers probability chart and Tanaka and Johnston equations. These are currently used widely, but they were developed for Caucasians. Because there are clear racial differences in teeth size, the objectives of this study were to produce correlation coefficients between the combined mesiodistal widths of the permanent mandibular incisors and those of the canines and premolars for each quadrant, and prediction tables with regression equations, specifically for Korean. 178 young adults (70 women, 108 men, mean age 21.63 years) were selected from the College of Dentistry, Yonsei University, Seoul, Korea. The mesiodistal crown diameters of the permanent teeth were measured with calipers. Significant sexual dimorphism was found in tooth sizes. The correlation coefficients between the total mesiodistal width of the mandibular permanent incisors and those of the maxillary and mandibular canines and premolars were found to be between 0.52 and 0.64. The standard error of the estimatation was better (0.60) for women and the r^(2) values ranged from 0.27 to 0.41 for both sexes, Prediction tables were prepared for Korean. This study showed larger canine and premolar diameters than Tanaka and Johnston's and Moyers' studies which might be due to the racial differences. Further investigations with a larger sample size will be needed for more representative data on the Korean population.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

중이진주종에서 플라스미노젠 활성인자 발현의 임상적 의의

김형종,김진환,임현준 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.2

Tacrolimus LC-MS/MS 분석법과 신생 쥐 전혈에서의 약물동태학 연구

이병요,백인환,권광일 충남대학교 약학대학 의약품개발연구소 2011 藥學論文集 Vol.26 No.-

혈소판 응집 억제제의 효과 측정법에 대한 고찰과 지원자에서 Triflusal의 혈소판 응집 억제능 평가

이병요,장힘찬,백인환,윤휘열,권광일 충남대학교 약학대학 의약품개발연구소 2010 藥學論文集 Vol.25 No.-

The anti-platelet agent is a member of a class of pharmaceuticals that decreases platelet aggregation and inhibits thrombus formation. They are effective in the arterial circulation and widely used in primary and secondary prevention of thrombotic cerebrovascular or cardiovascular disease. As a method for estimating the effects of anti-platelet agent, platelet aggregation was conventionally measured using the optical method or the impedance method. Several alternate methods currently in development or recently developed were considered, including luminescence method, flow cytometry, laser-light scattering method, and Verify Now-P2Y12 assay. Principles, advantages, and disadvantages of the optical method, impedance method, and the other alternate platelet aggregation methods were discussed in this report. 15 human volunteers were recruited for the evaluation of the efficacy of triflusal using the optical method. After the oral administration of a single dose of 900mg, 15 subjects received eight doses administered at 24-hour intervals of 600mg triflusal. Using platelet rich-plasma from above subjects, we performed baseline platelet aggregation test induced by adenosine diphosphate(ADP), collagen, and arachidonic acid. The results of platelet aggregation test after triflusal administration were compared with the baseline study. Triflusal significantly inhibited platelet aggregation induced by ADP (33.0±21.3%) and arachidonic acid (99.1±1.2%), respectively. Therefore, we concluded that anti-platelet aggregation effect of triflusal can be studied successfully with the optical method. Each of the platelet aggregation methods has value for evaluating the effects by various mechanisms of the anti-platelet agents. The ideal method for estimating the platelet aggregation as it relates to safety and efficacy in patients treated with anti-platelet agents will need to be determined in clinical trials.

표면도포제에 따른 수복용 글라스아이오노머 세멘트의 표면조도 비교

최병재,황동환 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.4

The purpose of this paper is to investigate the surface roughness of glass ionomer cement during initial setting time followed by applying surface coating agent. No other finishing or polishing procedure is done and each surface coating agents (varnish, adhesive, gloss, sealant) are used after filling of glass ionomer cement. Surface roughness indices(Ra) are measured and surface contours are obtained electronically by Surfcorder SEF-30D(Ko-saka laboratory Ltd. Japan). The results are as follows: 1. During initial setting time, surface roughness increases slightly regardless of surface coating agents. But it is statistically insignificant. (p>0.05). 2. Among surface coating agents used, Ra indices of group using varnish are high significantly compared to other groups regardless of elapsed time.(p<0.05) Among the groups which has used other surface coating agents except for the varnish group, similar Ra index all over the experiment is obtained, when compared to control group (no agent). 3. If no surface treatment is performed, tri-cure glass ionomer cement (Vitremer) has higher Ra Index than light cure glass ionomer cement (Fuji Ⅱ LC) (t<0.05). But there is no difference between two groups in RA index if any kinds of agents are applied except for sealant. (t>0.05)

生命工學 認知度 및 經濟的 價値評價

林裁煥,玄柄煥 충남대학교 농업과학연구소 1997 농업과학연구 Vol.24 No.1

Modern biotechnology, specifically for the use of recombinant DNA(rDNA), has brought about a revolution in our ability to control and use life forms. Most of the world's leading countries view biotechnology as the key scientific and industrial discipline for the 21st century and are making all-out efforts for scientific and technological advance in the related fields. The impact of biotechnology on the nation's economy has been growing explosively as such diverse industries invested increasingly on the fruits of biotechnological research. However, such an impact could only be realized through concerted endeavours from the government to private sectors for guarantee of the successful technological advances in this scientific area. There are risks associated with every technology; the classical application of biotechnology has not been exempt. For example, the introduction of bio-tech to agriculture might be destroied the ecosystems. Therefore, to increase the research budgets by the government and private sectors, we need to identify the public attitudes and preference on the acceptance of bio-technology and on the potential economic value of it. For the study, we surveied 959 persons including students enrolled in college of agriculture, Chungnam National University. And to measure the economic value of biotechnology, we use the Contingent Valuation Method(CVM) which is considered as the new approaching method in the bio-technology field.

난소적출 백서에서 estrogen투여가 실험적 치아이동에 미치는 영향

김오환,박병건,김정기,진근호 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.4

난소를 적출한 백서에서 실험적 치아이동 동안 치주와 치조골 조직의 반응에 대한 에스트로젠의 효과를 알아보기 위하여 체중 250gm 내외의 성숙한 백서 80마리를 난소척출한(ON)군과 난소적출하고 에스트로젠을 투여한 (OE)군, sham operation만 시행한(NN)군, sham operation을 시행하고 에스트로젠을 투여한 (NE)군으로 각각 분류하여 교정력을 가하였다. OE군과 ON군은 교정력을 가하기 3주전에 난소를 적출하여 에스트로젠 결핍성 골다공증을 유발시켰다. OE군과 NE군에서는 2일에 한번씩 에스트로젠을 50㎍/kg BW씩 복강내에 주사하였다. 치근의 압박측과 인장측의 Howship's lacuna와 파골세포수를 비교 분석하였고, 치아 이동량을 계측 분석하였으며 그 결과는 다음과 같다. 1. 교정력을 가하기 전 NN군에서 보다 ON군에서 치조골 부위에 더 많은 Howship's lacuna와 파골세포가 관찰되었다. 2. 교정력을 가한 후 1일에서 15일까지 압박측의 lacuna와 파골세포의 증가양상은 NN군에서 보다 ON군에서 더 컸으며, ON군의 lacuna수는 OE군보다 교정력을 가하는 전기간동안 높은 수치를 나타냈다. 3. 인장측의 파골세포수는 ON군에서 3일까지 급격히 증가하고 이후 감소하였으나, 전기간 동안 NN군에 비해 높은 수치를 나타냈다. 4. 치아이동 속도는 NN군, OE군, NE군에서 비슷하였고, ON군에서 7일에서 11사이에 다른 군에 비해 뚜렷한 증가를 보였다. 5. 교정력 제거 후 7일간 재발을 관찰한 결과 처음 12시간이 가장 큰 재발 이동량을 나타냈으며, 모든 군에서 유사한 양의 재발을 보였다. The purpose of this study was to evaluate the effect of estrogen on the periodontium and alveolar bone tissue response during experimental tooth movement in ovariectomized rats. Eighty female rats, 250gm in body weight, were classified into four groups; sham operated group(NN), ovariectomized before 3 weeks to begin the experiment, which resulted in estrogen-deficient osteoporosis. In OE group & NE group, estrogen was injected 50㎍/kg BW. every other days. The left maxillary 1st molar was moved mesially with 60g force. Each four rats were sacrificed after 1,3,5,15 days from application of orthodontic appliance and after additional 7days from removal of orthodontic appliance. Histological findings on mesial roots of upper 1st molar in pressure and tension side are observed. The results were summarized as follows; 1. In pressure side of alveolar bone, the number of osteoclasts and Howship's lacuna of ON group was significantly more than that of NN group from 1 day to 15 days(p<0.05). Especially the number of Howship's lacuna of ON group was significantly more than that of OE group during all experimental period(p<0.05) 2. In tension side of alveolar bone, the number of osteoclasts of ON group was significantly increased from 1 day to 3 days and decreased after 7 days. But the number of osteoclast of ON group was significantly more than that of NN group during all experimental period(p<0.05). Also the number of Howship's lacuna of all groups was abruptly increased at 1 day, but slowly decreased till experimental 15 days. And the number of Howship's lacuna of ON group was significantly more than that of NN group from O hr to 7 days(p<0.05) 3. The speed of tooth movement of OE group & NE group was similar to that of NN group(p>0.05). The amount of tooth movement of ON group between 7 days and 15 days was significantly greater than those of other groups(p>0.05). 4. The degree of relapse of ON group after 7 days from removal of orthodontic appliance was similar to those of other groups(p>0.05).

任意價値法(CVM)을 이용한 人工씨감자의 經濟價値評價 : 忠淸南道를 중심으로 In the case of Chungnam Province

玄柄煥,林栽煥 충남대학교 농업과학연구소 1996 농업과학연구 Vol.23 No.1

The potato has been used as a part of key staple foods in Korea. Recently, the demand for the potato tends to increase due to its nutritional quality, and the quantity of imports has rapidly been increasing. Contamination of seed potato by pathogens especially could cause a severe reduction of total production. In order to solve the problem, Korea Research Insistute of Bioscience and Biotechnology(KBIBB) developed the new commodity called a "potato microtuber". Before its production and distribution, researches on new commodity should be undertaken in many aspects, especially in terms of economic aspects. The main objectives of this study are to measure the economic value of the potato microtubers and to forecast its spreading effects and to examine the Contingent Valuation Method(CVM) could be accepted in the economic analysis for a new agricultural product, here in potato microtubers. Through the regression results, the consumer behavior analysis had performed for potential users of potato microtubers, and through the demand function derived by the consequence of functional relationship, consumer's surplus was estimated.