정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

3차원 자유곡면의 정밀연마기술에 관한 연구

조종래,정윤교 한국공작기계학회 2006 한국공작기계학회 추계학술대회논문집 Vol.2006 No.-

In the current environment, the mold industry should response to the human's need more quickly. However, in the manufacturing of molds, the most time consuming process is on the final stage-the polishing process. The polishing process of the mold not only affects the final appearance and the quality of the mold, it also occupies the total production time and cost up to 30 ∼ 50%. Almost all the polishing process in the mold industry are conducted manually. The dust and noise producted by the polishing process are not good for human health. the monotonic nature of polishing process even lends itself to bo rejected by workers. Beside, the polishing process needs exceptional skill that can only be taught by experienced master. For mass production of molds, automatic polishing of the mold is a necessary. For the automation of the polishing process, that is classified the sculptured surface as 3 parts according to the surface characteristic. it classified the case which the structure inside is the sculptured surface, the case which a structure outside is the sculptured surface, the case which the one sided of the structure consists of complex surface. According to each picture characteristic, it is applied MAGIC polishing technique, Hydrostatic polishing technique and Magnetic fluid polishing technique and is polished precisely. And it is evaluated each about the sculptured surface polishing characteristic.

이중 산화구 시스템에서 HRT에 따른 유기물 및 영양염류의 처리성 평가

윤조희,김승현,이상훈,정기홍 경남대학교 환경문제연구소 1999 환경연구 Vol.22 No.-

This study was conducted to estimate treatability of organics and nutrients at new developed double oxidation ditch system when the ratio of anoxic/oxic basin volume was 1. An internal recycle pump did not need because of using with port and baffle in this system. The results obtained from this study were as follows. The removal efficiency for TOC was over 93%, and the removal rate was 1215.3 g/㎥/day when the HRT was over 8hr. The removal efficiency for TIN was over 85%, and the maximum removal rate was 110.6 g/㎥/day when the HRT was over 16hr. The removal efficiency for PO₄^(3-)-P was 83%, and the maximum removal rate was 25.4 g/㎥/day when the HRT was 16hr.

Tetracyclic Isoquinoline유도체의 합성

조수동,정윤성,김정주,안철진,신동수 Institute of Genetic Engineering Changwon National 1998 Gene and Protein Vol.2 No.1

To develop new pharmacological charactization of isoquinoline derivatives, we have synthesized 3-benzyl-9,10-dimethoxy-6,7,11b,12-tetrahydropyridazino [4',5': 5,6] [1,4] -oxazino [3,4-а]isoqinolin-4(3H) -one. We have developed a convenient cyclization of novel isoquinoline derivatives starting from 3,4-dimethoxy phenethylamine using boron trifluoride diethyl etherate.

절삭조건과 AE 신호들과의 관계에 관한 실험적 연구

조종래,정윤교,원종식 창원대학교 공작기계기술연구센터 1999 연구업적집 Vol.1 No.1

This paper investigates the relationship between cutting conditions and Acoustic Emission(AE) signals; AEavg, AErms, AEmode, as the base working to monitor the tool wear with in-process. For this purpose. cutting tests were conducted on a CNC lathe with comprehensive cutting conditions. It is known that AEavg and AErms are increased as the increasing of cutting velocity and depth of cut respectively. The new parameters, derived from AEavg and AErms, which may be used for the in-process detection of tool wear is discussed. It is also known that AEmode may also be applied for in-process monitoring to make the self diagnosis system because of its stability to the variation of cutting conditions.

퍼지 이론을 이용한 해저면 분류 기법

조진석,윤관섭,박순식,나정열,석등우 한양대학교 이학기술연구소 2003 이학기술연구지 Vol.6 No.-

음파를 이용한 해저면 분류를 위하여 2003년 5월 19-25일까지 남해해역에서 음향 실험을 실시하였다. 실험 해역은 해저 구성물질이 각기 다른 6개의정점을 선정하였으며 5개의 주파수(30,50,80,100,12 kHz)를 이용하여 해저면 반사 신호를 측정하였다. 또한 피스톤 코어를 이용하여 해저 퇴적물의 입도분석을 실시하였다. 해저면의 분류를 위해서는 펴지 이론(fuzzy logic)을 사용하였으먀, 이때의 입력 소속함수(input membership function)는 주파수 종속성을 갖는 해저면 반사손실 모텔(HYBRL, Hanyang University Bottom Reflection Loss)이 이용되었으며 출력 소속함수(out membership function)는 해저면의 평균입도 값으로 출력되도록 구성하였다. 퍼지이론을 통해 역산된 평균입도(mean grain size)와 코어 분석 자료를 비교하여 퍼지이론을 이용한 해저면 분류 방법의 가능성을 확인하였다. Acoustic experiments are performed for seafloor classificaton from 19 May to 25 May 2003. The six differnet sites of bottom composition are settled and the bottom reflecton losses with frequencies(30, 50, 80,100,120 kHZ) are measured. The fuzzy logic is used to classify the seabed. In the fuzzy olgic, HYBRL(HanYang Univ. Bottom Refleciton Loss) of frequency dependence is used as a input Membership functions and the output membership functions are composed of the values of the mean grain size of the bottom. The possibility of the seafloor classsification is verified comparing the inversed mean grain size using fuzzy logic with the results of the coring.

선양치성종양으로 오진하여 수 차례 재발한 상악동의 선방세포암종

윤정훈,조세인,김수관 大韓顎顔面成形再建外科學會 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.6

A 46-year-old male appealed severe palatal and buccal swelling in the Lt. maxilla in 1990. In 1986, the patient was already carried out the clinical and radiological examination in our hospital. Multiple radiolucency was seen from #21 to #25 periapical area and Lt. maxillary sinus in the panoramic view at this time. But, the patient came home without special examination or inspection for itself. January 1990, the mass took an impression to grow bigger and the patient had visited again. Partial maxillectomy was carried out at this time and pathologic diagnosis was an adenomatoid odontogenic tumor. After 3 years, lesion was recurred and carried out hemimaxillectomy with Weber-Furgusson incision. September 2001, facial swelling was recurred again and patient was suffered from nasal breathing, lacrimal obstruction and exopthalmus. In this case, the tumor cells composed of nodular and papaillary cystic pattern with microcyst formation, highly suggestive of an adenomatoid odontogenic tumor. Histopathologically, the recurrent tumor was proved to be the same pattern of the primary tumor, which is compatible with acinic cell carcinoma. However, adenomatoid odontogenic tumor did not appear destructive multilocular radiolucency. In addition, this tumor had frequently observed amyloid-like or calcified materials in biopsy specimen. Therefore, oral pathologists had kept in mind into the correlative analysis of histopathologic and oral radiographic features, which is essential for definitive diagnosis.

육상 양식장 인접해역의 해양학적 환경특성

조규대,이충일,김동선,양윤정 한국환경과학회 2002 한국환경과학회지 Vol.11 No.4

Field observations for research of oceanographic characteristics in waters adjacent to fish farm on land and water quality at area where water is supplied to fish farm and area where water is discharged from fish farm are carried out in coastal waters of Pyoson located in the southeastern region of Jeju Island in March, May, August and November of 2000. Semidiurnal tides to the northeast and southwest dominate. The mean velocities of current around neap tides and spring tides are 8.52㎝·s^-1, 28.36㎝·s^-1, respectively. The difference of temperature between area where water is supplied to fish farm and area where water is discharged from fish farm is about 0.6℃. Seasonal variation range for temperature and salinity is 13.5℃ and 3.5psu, individually. Concentrations of nitrate(NO_3), phosphate(PO_4^3-), silicate(SiO_2) and COD(chemical oxygen demand) are high in autumn. Particularly, concentrations of nitrate and COD in winter and spring at station where water is supplied to fish farm are higher than these at station where water is dischared from fish farm. However, concentration of phosphate and silicate at station where is supplied to fish farm in spring, summer and autumn is higher than that at station where water is dischared from fish farm. Water quality in the study area is grade 1 and this level is kept up in the whole year.

Clostridium difficile 장염에 의한 속발성 유전분증에서 발현된 독성 장염

조형원,정혜경,강현주,이윤표,강혜원,심기남,정성애 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1

Amyloidosis is characterized by extracellular deposition of protein fibrils in one or multiple organs. AA amyloidosis is secondarily occurred to be related with chronic infections or inflammatory diseases. We report a 67-year-old man suffered from secondary AA amyloidosis related with chronic Clostridium difficile colitis after repeated total hip replacement surgery. Infection control is the most important treatment of AA amyloidosis secondary to chronic infection. However, the patient’s C. difficile colitis was not controlled well, eventually toxic megacolon with sepsis was developed. Consequently, he had to take total colectomy, but he expired with multi-organ failures. We suggested that early surgical procedure might be one option for intractable C. difficile colitis complicated with secondary amyloidosis.

혀에 발생한 낭 선종 : A CASE REPORT

윤정훈,조세인,김운규,김수관 大韓顎顔面成形再建外科學會 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.5

Cystadenoma of the minor salivary glands is a rare benign neoplasm. Characteristic histological features of varying sized cystic spaces with intraluminal papillary projections are diagnostic. However, salivary gland tumor is particularly difficult to interpret. Primarily, as further clinical and histological differential diagnoses have to take into account the mucoepidermoid carcinoma and the papillary cystadenocarcinoma. And also, biologic behavior of this peculiar lesion i uncertain. We report on a 71 year old female with a mucosal lesion at the tongue with its histologic features and differential diagnosis. Post-operative course was uneventful and there was no recurrence sign at this time. However, close follow-up is necessary, because the recurrent cases had been reported in literatures.