韓國型 Turnip Mosaic Virus의 純化

김병훈,권오병,마병철,강미란,권무식 성균관대학교 생명과학자원연구소 1996 生命資源科學硏究 Vol.3 No.1

Chinese cabbage(Brassica campestris subsp pekinensis) useful for making a traditional Korean food, Kimchi, has been considered as the most important vegetable in Korea. In order to supply large quantity of chinese cabbage to the consumer, the mass cultivation is demanded. However, the mass production has been faced to serious problem due to fungal, bacterial and/or viral infections. It has been reported that the viral infections are the worst phatogeruc causes in a number of plants. In the chinese cabbage, turnip mosaic virus(TuMV) is the most serious pathogen. Five different strains of TuMV(Cl, C2, C3, C4, and C5) were identified in the world. We are reporting two strains(C4, C5) purified from Brassica nigra. They are all filamentous on electron micrographs. The TuMV C4 is about 1,300nm long, whereas the C5 is about 1,200nm long in average. They are larger than those reported previously(680-900nm). They will be used to produce monoclonal antibodies against the TuMV coat proteins. The antibodies arc required to develop a sensitive and specific screening methods for the TuMV infected plants.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

알레르기 뮤신을 지닌 만성 부비동염의 임상적 특징

동헌종,김성민,장병찬 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.3

청소년비행과 성격양상 및 가족역동간의 관계

김헌수,민병근,김현실 울산대학교 의과대학 1992 울산의대학술지 Vol.1 No.1

The present study was intended to explore the correlation between juvenile delinquent behavior and their character, mood state and family dynamics. Data were collected through questionnaire survey. Subjects served for this study consisted of 1,838 adolescents including 601 juvenile delinquents and 1,237 adolescent students in Korea, sampled from Korean student population and adolescent delinquent population confined in juvenile correctional institutions, using nonprobability samping method. Their age ranged between 12 and 21. The actual number of cases put into the analysis was 1,696 adolescents including 511 delinquents and 1,185 adolescent students. Data were analysed by IBM PC of Behavioral Science Center at the Korea University, using SAS program. Statistical methods employed were χ²test, simple correlation, principal component analysis, principal component regression analysis and LISREL path analysis. The results of this study were follows: 1. Inconsistent by parental child rearing patterns tended to affect delinquent behavior among delinquent adolescents. The more were paternal and maternal attitudes arbitrary, restricted, mistrusing their children and punishment-oriented, the higher occured their children's delinquent behavior. On the other hand, adolescent students were consistently rearing by their parents, their parental attitudes were democratic, flexible, trusting their children and reward-oriented. In comparison of both parents in the degree of influence on their children was revealed that paternal child rearing pattern was more influential on their children's behaviors than maternals's. 2. The psychological instability of family tended to be contributing to deliquent behaviors among deinquent adolescents. Coldness, dissatisfaction, discord, tenseness and disharmony of family paychological climate revealed significant correlation with delinquent behaviors. On the other hand, student's family stability was more comforable than delinquent family. 3. The disharmonious parent-child relationships were presented to influence on delinquent behaviors and aggressive impulsiveness. Parental rejection toward their children's opinions, lack of affection toward their children, non-self-sacrificing for their children, alienated parent-child relationship, children's disregard toward their parental authority and children's rejection of parental opinions were positively correlated to behavioral problems among delinquent adolescents, while harmonious parent-child relationships among student adolescents were maintained. 4. The whole psychological climates of delinquent's family tended to be rigid, while student's psychological climates of family flexible. 5. Delinquents were more anxious, aggressive and impulsive than student adolescents. They exhibited some learning problems such as interpersonal difficulties. their character patterns tended to be immature and weak ego functioning, while student's character patterns more mature and flexible. 6. The relative comparison of the whole psychological climates of family, anxiety trait, character pattern and social learning ability in terms of predictability revealed that character pattern variables function as the most important determinant of both aggressive impulsiveness and delinquent(aggressive) behaviors.

한국 정신 역동학실제의 현황 분석

김헌수,김현실,민병근 울산대학교 의과대학 1993 울산의대학술지 Vol.2 No.1

This study was intended to get the base-line data of psychodynamic formulation for teaching the residents through the analysis of the current status of psychodynamic formulation in Korea. Data were collected through the mailings-questionnaire survey. Subjects served for this study consisted of 1,034 psychiatrists including 259 residents and 775 psychiatric specialists in Korea, using census method. Statistical method employed was percentage rate. 1. 267 respondents(25.8%) among 1,034 psychiatrists replied to our mailings questionnaire. 2. 83.5 percent of respondents perceived psychodynamic formulation to be very important, 46.8 percent of respondents felt formulation to be crucial for second year residents, while 37.8 percent of respondents stated that they referred to textbooks of psychiatry, others(25.1 percent) sent guidelines for the mental status examination and/or descriptions of the intake interview. 5.6 percent of respondents did not provide any materials for psychodynamic formulation. 2 percent of respondents did not answer this question. 55.4 percent of respondents recognized general psychiatry, psychopharmacology and biological psychiatry to be more important than the teaching of formulation. As a result, though the Korean psychiatrists recognized formulation to be very important, they did not sufficiently provide the materials about psychodynamic formulation. 3. the Korean psychiatrists prefered to psychoanalysis models, focal psychodynamic approaches and/or biopsychosocial approaches in case of formulating the psychiatric patients, while the American psychiatrists tended to adapt psychoanalysis and/or ego psychological models to their patients. 4. 72.7 percent of respondents indicated that they distinguished psychodynamic formulation and diagnostic assessment, while 20.9% of respondents emphasized that all patients require a diagnostic assessment. 48.7 percent of respondents viewed that psychodynamic tended to be overlooked and declined due to recent advanced biological psychiatry.

膽痲疹의 原因, 症狀 및 鍼灸治療穴에 對한 文獻的 考察

金柾勳,李賢,李秉烈 대전대학교 한의학연구소 2001 한의학연구소 논문집 Vol.10 No.1

The following results were obtained. 1.The Urticaria is similar to the korean medical name of yeun-jin(연疹), yum-leu(염류), pung-jin-geu(風疹槐), pung-sa(風사), pung-so-yeunjin(風搖연진). 2.The most part of the causes that induce Urticaria are like that, the sup-yeul(濕熱) that caused by the sa-gi(邪氣)'s invasion, food and behavior's fault, is gathering in the gastrointestinal tract. 3.The symptomes are like that, the severe pruritic blisters are spread on the whole body, and the color of the blisters is red or white, and nausea, vomitting, abdominal pain, chest discomfort are induced with the Urticaria. 4.The Su-Chok yangmyong Kyong(手·足陽明經), Chok taeum Kyong(足太陰經) and Chok taeyang Kyong(足太陽經) are used for the acupuncture therapy of Urticaria. 5.The acupuncture points of the Kokch(曲地), Hyolhae(血海), Chok-Samni(足三里), Samumgyo(三陰交), Hapkok(合谷) are used for the acupuncture therapy of Urticaria. 6.the Pye-area(肺區), Shinmun(神門), dammajin-area(??麻疹區), Shinsangsun(腎上腺), Chimbu(枕部) are used for the acupuncture therapy of Uriticaria in the ear-acupuncture therapy of Urticaria.

발기부전증 환자의 MMPI 평가 분석

김헌수,김영돈,이재우,나철,이길홍,민병근,김세철 大韓神經精神醫學會 1988 신경정신의학 Vol.27 No.1

The present study was intended to examine the relationship of the MMPI mean scales in the Korean impotent and Beutler's decision rules to acertain the empirical utility of the MMPI in discriminating between organic and psychogenic erectile dysfunction. Subjects served for this study consisted of 451 patients visited to department of neuropsychiatry and urology, Chung-Ang University Medical Center from May 1, 1985 to July 31, 1987. Their age range was between 22 and 84. The actual number of cases put into the analyses was 97 including 53 psychogenic impotents and 43 organic impotents. Statistical methods employed were χ² and T score. Results of the study were presented as follows: 1) The mean overall 4-3/3-4 MMPI profile(17.7%) revealed somatic complaints, depression, conflict with spouse and emotionally unstable personality trait. However, there were no significant relationship of mean T score between psychogenic and organic impotents. 2) Applying the Beutler's rule decision, we found that our hit rate of rule I or rule Ⅱ were 12.3% and 47.2%, respectively. Applying the two rules to 97 cases, the hit rate was 60.4% with nonsignificant Chi square of 0.017. These results revealed no significant differences between psychogenic and organic subjects. Finally, we failed to examine the validity of Beutler's decision rules adapted to our 97 subjects.

개선된 유전 알고리즘의 최적해 비교에 관한 연구

우병훈,배극윤 한국의사결정학회 2000 경영과학연구 Vol.9 No.-

The Optimization problem is to select the best of many possible design alternatives in a complex design space. Genetic Algorithms, one of numerous techniques to search optimal solution, have been successfully applied to various problem(for example, parameter tuning in expert system, structural systems with a mix of continuous integer and discrete design variables) that could not have been readily solved with more conventional computational techniques, But, Conventional Genetic Algorithms are ill defined for two classes of problems ie, parameter convergence and penalty function. Therefore, this paper developed Revised Algorithms to solve these problems, As a case study, sin function example and design of gear train are demonstrated to show the effectiveness of The two Revised Genetic Algorithms(R. G. A & H. G. A.) and one of the Revised Genetic Algorithms was more effectiveness. That's H. G. A. It has robustness and problem-independent characteristics. In the reproduction step of the H. G. A. the roulette wheel method is replaced the random search and the creeping value method is modified to improve local optimum solutions in the mutation step. The encoding and decoding procedures are replaced with the real number representation method in the H. G. A.

맨손체조의 動作과 用語에 關한 硏究

蘇秉憲 서울 敎育大學校 1975 論文集 Vol.8 No.-

규칙적인 운동과 여성의 정신건강

조병훈,이강헌 昌原大學校 學生生活硏究所 1996 학생생활연구 Vol.9 No.-