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이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
( Seung Hwan Paik ),( Sihyeok Jang ),( Ohsang Kwon ),( Seong Jin Jo ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: Previous studies have revealed that premature hair graying (PHG) is associated with systemic diseases such as coronary artery disease and osteopenia. However, investigating socioclinical, anthropometric, and biochemical association factors with PHG in both sexes with a large number of participants is scarce. Objectives: We planned to identify factors associated with PHG in Korean young adults. Methods: A cross-sectional study was conducted in 2,308 participants between March 2015 and February 2016. The gray hair status and various scioclinical, anthropometric, and biochemical data were collected. Statistical analysis was conducted in participants younger than 30 years. Results: After exclusion of participants who had insufficient data or met the exclusion criteria, the final number of subjects were 2,163 (1,191 men and 972 women). The age of participants was 23.2±2.7 years (mean±SD). Of the 2,163 participants, 264 (12.2 %) were categorized as PHG group. In univariate logistic regression analysis, age, sex, family history, systolic blood pressure, diastolic blood pressure, body mass index (BMI) were selected as candidate factors because they showed associations with PHG (P<0.1). In multivariate logistic regression analysis, family history of PHG (odds ratio [OR], 8.146), male sex (OR, 1.941), age (OR, 1.141), BMI (OR, 1.074) were significantly associated with PHG (P<0.05). Conclusion: Family history of PHG, male sex, age, and BMI are major associated factors with PHG.
Gene mapping study for constitutive skin color in an isolated Mongolian population
Seung Hwan Paik,김현진,손호영,Seungbok Lee,임선화,주영석,Je Ho Yeon,Seong Jin Jo,은희철,서정선,권오상,김종일 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.3
To elucidate the genes responsible for constitutive human skin color, we measured the extent of skin pigmentation in the buttock, representative of lifelong non-sun-exposed skin, and conducted a gene mapping study on skin color in an isolated Mongolian population composed of 344 individuals from 59 families who lived in Dashbalbar, Mongolia. The heritability of constitutive skin color was 0.82, indicating significant genetic association on this trait. Through the linkage analysis using 1,039 short tandem repeat (STR) microsatellite markers, we identified a novel genomic region regulating constitutive skin color on 11q24.2 with an logarithm of odds (LOD) score of 3.39. In addition, we also found other candidate regions on 17q23.2, 6q25.1,and 13q33.2 (LOD ≥ 2). Family-based association tests on these regions with suggestive linkage peaks revealed ten and two significant single nucleotide polymorphisms (SNPs) on the linkage regions of chromosome 11 and 17, respectively. We were able to discover four possible candidate genes that would be implicated to regulate human skin color: ETS1,UBASH3B, ASAM, and CLTC.
Linkage and association scan for tanning ability in an isolated Mongolian population
( Seung Hwan Paik ),( Hyun Jin Kim ),( Seung Bok Lee ),( Sun Wha Im ),( Young Seok Ju ),( Je Ho Yeon ),( Seong Jin Jo ),( Hee Chul Eun ),( Jeong Sun Seo ),( Jong Il Kim ),( Oh Sang Kwon ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.11
Tanning ability is important, because it represents the ability of the skin to protect itself against ultraviolet (UV) radiation. Here, we sought to determine genetic regions associated with tanning ability. Skin pigmentation was measured at the outer forearm and buttock areas to represent facultative and constitutive skin color, respectively. In our study population consisting of isolated Mongolian subjects, with common histories of environmental UV exposure during their nomadic life, facultative skin color adjusted by constitutive skin color was used to indicate tanning ability. Through linkage analysis and family-based association tests of 345 Mongolian subjects, we identified 2 potential linkage regions regulating tanning ability on 5q35.3 and 12q13.2, having 6 and 7 significant single nucleotide polymorphisms (SNPs), respectively. Those significant SNPs were located in or adjacent to potential candidate genes related to tanning ability: GRM6, ATF1, WNT1, and SILV/Pmel17. [BMB reports 2011; 44(11): 741-746]
우리나라 간암 환자에서의 Cytochrome p450 2E1유전자의 다형성에 관한 연구
백승운,이효석,김정룡,윤정환,장유현,황유진 대한소화기학회 1998 대한소화기학회지 Vol.30 No.4
Background/Airns: Cytochrome P450 2E1(CYP2EI) is the only enzyme that rnetabolizes very low doses of N-nitrosodimethylamine(NDMA) and is characterized by its ethanol inducibility. Recently, it has been shown in an animal-experimental study that NDMAinduced hepatocarcinogenes was facilitated by chronic alcohol ingestion. CYP2E1 expression in human beings was reported to be about 10 times higher in genotype c2/c2 than in genotype c1/c1. Bacause CYP2El gene expression is the highest in the liver, we hypothesized that the polymorphism of CYP2E1 may affect the risk of hepatocellular carcinoma(HCC), especially in patients with chronic alcohol consumption. Methods: We enrolled 46 HCC patients and 32 age-sex-matcied healthy controls without liver disease or cancer in any other organ. The genotypes in the 5-flanking region of CYP2E1 gene were determined by restriction fragment length polymorphisms using two endonucleases: PstI and RsaI. Results: The frequencies of genotype A(c1/c1), B(c1/c2) and C(c2/c2) were 56.5%, 39.1%, 4.4% in HCC patients, and 62.5%, 28.1%, 4.4% in controls, regiectively. The frequency of allele c2 was 23.9% in HCC patients and 23.4% in control, re.;pectively. The difference in the frequencies of both CYP2E1 genotyps and alleles was not statistically significant between the HCC patients and controls. The HCC patients with a history of ckonic alcohol ingestion were more like]y to carry genotype B and C than in patients without such history, even though the differences are not statistically significant(p=0.077). Conclusions: Although polymorphisms of CYP2E1 gene is not a major genetic risk factor for the development of HCC, it might increase the risk of HCC in patients with chronic HBV or HCV infection and chronic alcohol consumption. Further study to test this bypothesis on a large number of patients and on patients of different ethnic groups is warranted.