Predicting postoperative total calcium requirements after parathyroidectomy in secondary hyperparathyroidism

( Byung Heon Kang ),( Soon Young Hwang ),( Jeong Yeop Kim ),( Yu Ah Hong ),( Mi Yeon Jung ),( Eun Ah Lee ),( Ji Eun Lee3 ),( Jae Bok Lee ),( Gang Jee Ko ),( Heui Jung Pyo ),( Young Joo Kwon ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.6

Background/Aims: To prevent hypocalcemia after parathyroidectomy (PTX), parenteral calcium is required in addition to oral calcitriol and calcium. After switching to oral calcium, patients can be discharged from the hospital. The aim of this study was to analyze the clinical characteristics and outcomes of PTX performed at a single Korean center and to investigate the associated laboratory factors used to analyze the total amount of postoperative calcium required. Methods: We enrolled 91 hemodialysis patients undergoing PTX from November 2003 to December 2011. We collected clinical and laboratory data preoperatively, 12 and 48 hours postoperatively, at discharge, and 3 and 6 months postoperatively. Results: In total, 59 patients underwent PTX with autotransplantation (AT), 6 underwent total PTX without AT, 11 underwent subtotal PTX, and 15 underwent limited PTX. Total PTX without AT showed the lowest recurrence rate. At all postoperative time points, the mean levels of serum calcium, phosphorus, and intact parathyroid hormone (iPTH) decreased significantly, compared with preoperative levels; however, alkaline phosphatase (ALP) increased significantly from 48 hours postoperatively to discharge (p < 0.001). On multiple linear regression analysis, the total amount of injected calcium during hospitalization showed a significant correlation with preoperative ALP (p < 0.001), preoperative iPTH (p = 0.037), and Δphosphorus at 48 hours (p < 0.001). We developed an equation for estimating the total calcium requirement after PTX. Conclusions: Preoperative ALP, preoperative iPTH, and Δphosphorus at 48 hours may be significant factors in estimating the postoperative calcium requirement. The formula for postoperative calcium requirement after PTX may help to predict the duration of postoperative hospitalization.

Impedance를 이용한 전도성고분자 센서의 가스감응특성

이경문,유준부,이병수,전희권,이상태,이덕동,허증수 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

Special Issue of Professor Kiehwa Lee`s Retirement: Geophysical Environments of the Korean Peninsula : Articles ; Geoelectrical Structure of the Kyongsang Basin from Magnetotelluric Sounding

( Choon Ki Lee ),( Heui Soon Lee ),( Byung Doo Kwon ),( In Ky Cho ),( Seok Hoon Oh ),( Yoon Ho Song ),( Tae Jong Lee ) 대한지구물리학회 2006 지구물리 Vol.9 No.3

위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

전통누룩 진균류를 이용한 입국의 제조 및 입국곰팡이의 동정

김재호 ( Jae Ho Kim ),권영희 ( Young Hee Kwon ),이애란 ( Ae Ran Lee ),김혜련 ( Hye Ryun Kim ),안병학 ( Byung Hak Ahn ) 한국균학회 2012 韓國菌學會誌 Vol.40 No.4

다양한 향미를 가진 막걸리의 개발을 위해 전통누룩으로부터 분리한 곰팡이로 입국을 제조한 후 품질특성을 분석하여 입국의 규격에 적합하며 이취가 없고 관능이 우수한 9균주를 입국 제조용 우수균주로 최종 선발하였다. 선발된 균주는 Aspergillus oryzae(C1-5-2-2, C20-7-3, CN1.3.1-4, CN16.19.1-1, N152-1, N220-1), Mycocladus corymbiferus (N162-2), Rhizopus oryzae(N20), Lichtheimia corymbifera (N21)로 동정되었으며, 제조한 입국의 산도는 5.0~6.8, 당화력은 128~241sp이었다. Various koji were prepared by fungi isolated from traditional nuruk and their quality characteristics were investigated. Acidity and saccharification power of their koji were ranged in 5.0~6.8 and 128sp~241sp. Nine fungi which were showed good quality and sensory evaluation were identified by analysis of their nucleotide sequences with PCR-amplified 18S rDNA internal transcribed spacer-1(ITS-1) and ITS-4 genes. Among them, six strains were identified as Aspergillus oryzae and the other strains were identified as Mycocladus corymbiferus, Rhizopus oryzae, Lichtheimia corymbifera.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

복강경 대장절제술의 초기 경험

이승현,안병권,백승언 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.1

Background : Laparoscopic colon resection has many benefits, such as decreased incidence of pulmonary complication, faster return of the bowel function, decreased narcotic requirements, shorter hospital stay, and faster recovery time. However it has long learning curve because of complex mesenteric blood supply, multiple quadrant location and bowel anastomosis. The aim of this study was to identify the clinical outcome for laparoscopic colorectal surgery as initial experience. Methods : From Jan. 2002 to Dec. 2006, we reviewed 16 patients who had underwent laparoscopic colon resection at Kosin University Gospel Hospital. We studied the clinical outcome, such as operative time, passage of flatus, retrieved lymph node, complications, hospital stay. Results : Of the 16 patients, 6 cases were male, 10 cases were female. The median age was 50.1 years(26-69). The primary diseases were cancer in 15 cases (93.7%), and benign in 1 case. The operative procedure were right hemicolectomy in 3 cases (18.8%), left hemicolectmy in 1 cases (6.3%), anterior resection in 6 cases (37.5%), low anterior resection in 4 cases (25.0%) and total colectomy in 1 case (6.3%). The mean operative time was 227.8 minutes (150-370). The flatus passage was 2.6 days (1-6). The mean number of retrieved lymph node was 12.2 (3-27). The postoperative complication was wound infection in 2 cases. The mean hospital stay was 11.1 days. Conclusions : The laparoscopic colorectal surgery seems to be safe. To evaluate the benefit compare to open colorectal surgery, we need further study.

芥子 收量檢定試驗區의 크기와 모양에 따른 變異係數(C.V.) 推定

權炳善,李洪宰 順天大學校 1985 論文集 Vol.4 No.1

芥子의 圃場實驗을 遂行함에 있어 適正試驗區의 面積 및 모양을 定하기 위해 實驗한 結果는 다음과 같다. 1. 實驗經費를 고려하지 않은 경우의 適正面積은 10-12㎡의 범위로 推定된다. 2. 分散(S²), 標準偏差(S.D) 및 變異係數(C.V.)는 實驗區 面積이 클수록 낮았고 實驗區모양은 列數를 많게 配置한 正方型에서 變異係數(C.V.)가 낮았다. This study was carried out to determine the optimum plot size and plot shape in Yield trials of mustardseed. Based on the obsservations of 360 basic units, plot size of 10-12㎡ was found to be appropriate for mustardseed yield trials. Lower coefficients of variation indicated the preference of square plot to rectangular plot.

Cycloheximide가 옥수수(Zea mays L.) 잎의 노화과정에 미치는 영향

權炳奎,李承姸 경북대학교 과학교육연구소 1989 科學敎育硏究誌 Vol.13 No.-

The present study was investigated to clarify the changes of chlorophyll (a,b) and soluble protein content, absorption spectrum, PSⅡ activity and CP-complex in senescence of corn (Zea mays L.) leaves induced by cycloheximide at different concentrations and times. The leaf disks were placed in darkness at 25℃ ± 2℃. After leaf disks were treated with cycloheximide at various concentrations, the chlorophyll content was measured on the 4th. day. Cycloheximide clearly showed strong preservation of chlorophyll at the concentration of 0.01-1mM. Cycloheximide at 0.001mM did not prevent the chlorophyll degradation. Cycloheximide(0.1mM) prevented the loss of chlorophyll. About 70% of initial content of Chl. a and 71% initial content of Chl. b remained on the 6th. day. The absorption spectra of DMSO extracts from corn leaf disks that had been incubated for 4 days in distilled water or 0.1mM cycloheximide were measured. When leaf disks were incubated with cycloheximide, both the peaks for the red band of chlorophyll and the carotenoid band remained fairly extent. Cycloheximide(0.1mM) prevented the loss of soluble protein, and about 70% of initial content of soluble protein remained on the 6th. day. Cycloheximide(0.1mM) treatment inhibited the rate of DCIP photoreduction by 60%. When CP-complexes and thylakoid polypeptide were separated by SDS-PAGE, CP Ⅰ, CPⅡa, LHCP bands were disappeared, FP band was quantitatively increased, and thylakoid polypeptide bands were partly disappeared, with cycloheximide(0.1mM) treatment. Therefore, cycloheximide prevented the loss of chlorophyll and soluble protein, destroyed thylakoid membrane of chloloplast, and inhibited PSⅡ activity.