複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

Isolation and Characterization of Antimicrobial Substance Macrolactin A Produced from Bacillus amyloliquefaciens CHO104 Isolated from Soil

( Seung Je Lee ),( Jeong Yong Cho ),( Jung Il Cho ),( Jae Hak Moon ),( Ki Deok Park ),( Young Ju Lee ),( Keun Hyung Park ) 한국미생물생명공학회 2004 Journal of microbiology and biotechnology Vol.14 No.3

당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

음향방출 파형 파라미터 필터링 기법을 이용한 실시간 음원 분류

조승현(Seung Hyun Cho),박재하(Jae Ha Park),안봉영(Bongyoung Ahn) 한국비파괴검사학회 2011 한국비파괴검사학회지 Vol.31 No.2

음향방출기법은 대형 구조물의 구조건전성감시(SHM)를 위한 매우 효율적인 방법이지만, 롤러코스터 지지구조물처럼 승용물의 운행으로 인한 매우 큰 잡음이 일상적으로 존재하는 경우에는 균열 진전 신호만을 분류하여 실시간 감시를 수행하기가 쉽지 않다. 이와 같은 문제의 해결을 위해 본 연구에서는 실시간으로 음원의 분류가 가능한 파형 파라미터 필터링 기법을 제안하였다. 파형 파라미터 필터링 기법은 음향방출 신호의 파형 파라미터를 이용하여 음향방출 히트를 사전에 필터링함으로써 실시간으로 감시하고자 하는 대상 음원만을 분류해내는데 매우 유리한 점이 있다. 다양한 음원에 대해 음향방출 파형 파라미터를 측정 및 분석하여 제안한 기법의 타당성을 살펴보았다. 또한, 파형 파라미터 필터가 내장된 음향 방출 시스템을 구축하고 이를 실제 롤러코스터 지지구조물에 적용하여 실시간 균열진전 감시를 위한 가능성을 타진하였다. The acoustic emission(AE) technique is a well established method to carry out structural health monitoring(SHM) of large structures. However, the real-time monitoring of the crack growth in the roller coaster support structures is not easy since the vehicle operation produces very large noise as well as crack growth. In this investigation, we present the waveform parameter filtering method to classify acoustic sources in real-time. This method filtrates only the AE hits by the target acoustic source as passing hits in a specific parameter band. According to various acoustic sources, the waveform parameters were measured and analyzed to verify the present filtering method. Also, the AE system employing the waveform parameter filter was manufactured and applied to the roller coaster support structure in an actual amusement park.

Distribution of the Fairy Pitta (Pitta nympha) in the South Korea: A focus on protected areas

Gil-Pyo Hong(홍길표),Jae-Hoon Kim(김재훈),Seul-Gi Seo(서슬기),So-Yeon Cho(조소연),Bo-Yeon Hwang(황보연),Jong-Hyun Park(박종현),Seung-Yeon Lee(이승연),Ga-Young Kim(김가영),Wan-Hee Nam(남완희),Ha-Cheol Sung(성하철) 한국조류학회 2021 한국조류학회지 Vol.28 No.2

국내 팔색조(Pitta nympha) 분포 현황을 알아보고자 전국 국립공원 등 보호지역 중심으로 총 19개 지역을 조사하였고, 전문가 네트워크를 통해 자료를 보강하였다. 전국 19개 지역을 조사한 결과 북한산, 지리산 등 내륙지역 7개 국립공원에서는 팔색조가 확인되지 않았고, 경남 거제, 남해, 해남, 장흥 고흥 등 남해안과 인접한 12개 지역에서 팔색조 서식이 확인되었다. 또한 전문가 네트워크를 통해 수집한 팔색조 출현 위치 정보 82건을 분석한 결과, 전국 8개 광역지자체 모두 팔색조 서식이 확인되었고, 내륙지역(26.8%)보다 해안지역(73.2%)에서 더 많이 출현하였다. 연구 결과를 종합해보면, 우리나라의 팔색조는 주로 제주도와 남해안 지역을 중심으로 많이 분포하며, 그 보다 적은 개체수가 내륙 지역에 넓게 분포하고 있는 것으로 나타났다. The present study investigated the current distribution of Fairy Pitta (Pitta nympha) in South Korea. A total of 19 study areas, including protected areas such as national and provincial parks in South Korea were surveyed, and additional data obtained from an expert network. According to the results, Fairy Pitta was absent in seven inland national parks, including Mt. Bukhan and Chiri parks. Fairy Pitta inhabited 12 areas near the southern coast of South Korea, including Geoje, Namhae, Haenam, Jangheung, Goheung, and Gyeongnam Province. The analysis results of 82 datasets obtained from experts with regard to the locations where Fairy Pitta have been spotted showed that the bird inhabits all the eight metropolitan regions in South Korea, and is more frequently spotted in coastal areas (73.2%) than in inland areas (26.8%). The findings demonstrate that Fairy Pitta is mainly distributed in Jeju Island and the southern coast of South Korea, and is distributed in inland areas at relatively lower numbers.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

서울 시내 4년제 남자 대학생의 우울과 흡연량, 흡연기간, 니코틴 의존도와의 관계

박지영,박소영,이미숙,백수진,신의경,예혜련,오승진,장윤정,조혜진,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

Background: With reports on the relation between smoking and depression appearing since 1980, it has become clear that depression is one of the psychodynamics of smoking, though there has been little or no progress made in the study of whether or not there is indeed a relation between depression and nicotine dependence. Purpose: The purpose of the study was to investigate the effects of depression on the amount and period of smoking and nicotine dependence among university man student smokers. Method: In periodical examination between 14 and 21, May, 2003, using 170 university male. The CES-D(Center for Epidemiologic Studies Depression) Scale and the FTQ(Fagerstrom Tolerance Qustionnaire) were utilized to measure the level of depression and nicotine dependency. The amount of smoking was calculated based on the number of cigarette used. Result: Results indicated that depression had something to do with amount of smoking. Nicotine dependence also was related to depression but total value was relatively low. finally the period of smoking had nothing to do with depression. Conclusion: The results of this study revealed that the amount of smoking of university man student smokers was very high. Both the amount of smoking and nicotine dependence were affected by levels of depression. Accordingly psychiatric nursing access such as emotional support is needed to manage depression and decrease smoking.

레이저가공기를 이용한 SAPH400의 절단특성에 관한 연구

조규재,박종남,이승철 朝鮮大學校 機械技術硏究所 2004 機械技術硏究 Vol.7 No.1

본 연구의 목적은 자동차 구조용 열간 압연강(SAPH400)의 몇 가지에 대한 최적의 절단 가공 조건을 구하기 위한 실험이다. 현재 대부분의 절단가공은 기계적인 방법이 활용되고 있으며,절단속도와 정밀도,금형제작,공구수명 등의 문제점이 많아 CO₂레이저 가공기를 이용하여 이를 해결하고자 하였다. 실험은 유입가스의 압력,절단속도 및 출력의 변화를 주었을 경우 절단면의 조도와 폭에 어떤 영향을 주는가를 연구 · 분석하였다. 실험결과 출력,절단속도 및 절단가스압력을 변화시켰을 때 출력은 1500W,절단속도는 1100mm/min. 절단 가스압력은 0.5kgf/㎠마 일 때 가장 양호한 표면 거칠기 값 18.06㎛을 나타냈다. This study aims at making experiments to fine the optimum cutting processing conditions of some sheets in common use of Steel Automobile Press Hot 400(SAPH400). Current mechanical methods for cutting processing of most have several problems in relation to cutting speed, precision, manufacture of metal mold and life of tools, which we tried to solve by using the CO₂ Laser Machining. We studied and analyzed what effects on the roughness and width of a section changes in the pressure of blowing gas, cutting speed and power according to the quality and thickness of the material might exert. The results from this experimental study are summarized as follows, when power, cutting speed and gas pressure were changed, the finest value of surface roughness, 18.06㎛ was attained at power of 1500W, cutting speed of 1100mm/min and gas pressure of 0.5kgf/㎠.

中溫 嫌氣性 消化에 의한 屠殺場 廢水處理

박정호,임찬섭,최장승,박승조 동아대학교 환경문제연구소 1996 硏究報告 Vol.19 No.1

Slaughterhouse wastewater containing high ammonium ion concentration and organic matter was treated by upflow anaerobic sludge blanket(UASB) reactor. As organic loading rate(OLR) was increased from 0.25㎏COD/㎥·day to 8.0㎏COD/㎥·day, COD removal efficiency was about 80 percent. But in case of OLR increased up to 8.0 ㎏COD/㎥·day, organic removal efficiency was decreased. In case of OLR was increased from 0.25㎏COD/㎥·day to 8.0㎏COD/ ㎥·day and ammonium loading rate was increased from 0.02 ㎏ NH₄^(+)-N/㎥·day to 0.62 ㎏ NH₄^(+)-N/㎥·day, effluent ammonium ion concentration was decreased from 1800㎎/l to 720㎎/l. Biogas production was increased form 0.248 ㎥/㎏COD_(rem) to 0.280 ㎥/㎏COD_(rem) in case of OLR was increased from 0.25 ㎏COD/㎥·day to 6.0 ㎏COD/㎥·day. Methane, carbon dioxide and ammonia gas content were 49%, 49% and 2.0% respectively in initial OLR was 0.25 ㎏COD/㎥·day but ammonia gas does not produced in case of OLR was increased up to 4.0 ㎏COD/㎥·day. In proportion to decrease hydraulic retention time, MLSS concentration in upflow anaerobic sludge blanket reactor was increased.