과학교육 개선을 위한 실험모델 제작에 관한 연구(Ⅰ)

이기종,이광호,이종철,김자홍 全北大學校 基礎科學硏究所 1991 基礎科學 Vol.14 No.1

A curriculum for teaching materials in Science Education was studied as a model for modified xperiment on fundamental courses. Coscious effort can be made to desingn experiments that require minimum apparatus, that require low-cost equipment that can be made to from cheap locally available materials. Computer-aided instruction programs at high school, freshman course level have been developed. The software package was consist of five programs: The program contains explanation and problems for the calculation of resonance energy, molecular structure, mole concept, Rutherford's experiment, thermodynamic processes. Special course equipment package explanation mole concept, Rutheford's experiment, thermo dynamic processes. Special course were designed in Science Education with the understanding that to a certain extent science values would be covered in all of the modified experiments and program models.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Adamkiewicz 동맥의 폐색에 의한 척수경색 1례

이광훈,이종걸,이태연,신동익,이성현,이상수,한설희,차상훈 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

Southern Blot Hybridization법을 이용한 악성 림프종의 면역유전형에 관한 연구

전호종,기근홍,김윤신,이미숙,이미자,장원재,장숙진,박영진,정춘해,정종훈,양성훈,이광민 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Immunogenotyping using gene rearrangement analysis has emerged as a precise laboratory aid in the diagnosis and classification of malignant Iymphoid neoplasms. The lineage and clonality of the malignant Iymphoid neoplasms can be identified by the demonstration of rearrangements of antigen receptor genes of the immunoglobulin and T-cell receptor genes. The analysis of the gene rearrangements on the malignant Iymphoid neoplasms are also useful as a sensitive unique clonal markers to detect early recurrence in patients with malignant Iymphoid neoplasms after treatment. To analyze the sensitivity and specificity of gene rearrangements in the diagnosis of malignant Iymphoid neoplasms. 24 cases of malignat Iymphoma were examined by Southern blot hybridization using CTβ-T cell receptor β chain gene-DNA probe and JH-immunoglobulin heavy chain gene-DNA probe. The results of the immunogenotypings using Southern blot hybridization disclosed high correlation between the immunophenotyping using immunohistochemical stain with monoclonal antibodies (B-cell Iymphoma 84.2%. T-cell Iymphoma 75% ). The analysis of the gene rearrangement of the angioimmunoblastic lymphadenopathy(AILD) and unclassifiable Iymphoma using immunohistochemical stain could resolve the monoclonality and lineage . Rearranged bands to the CTβDNA probe were observed in one case out of 2 cases of AILD. One case of unclassifiable Iymphoma showed rearranged bands to the CTβ DNA probe. There were no rearrangements in reactive follicular Iymphoid hyperplasia and paracortical Iymphoid hyperplasia. In conclusion, DNA gene rearrangement study should be applied to differentiate the clonality and cell lineage in the malignant Iymphoma with indistinctive immunophenotype.

煉炭工場 勤勞者의 塵肺症 發生과 肺換氣能에 關한 硏究

李忠揆,金光鍾,車喆煥 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.1

A briquet is a source of major energy for heating and cocking in the common households in Korea. For its production, a total of 2,000 workers are employed in 17 briquet factories in Seoul Korea, where they are heavily exposed to the coal dust while working. In this study ail attempt was made to analyze and evaluate the prevalence of pneumoconiosis among 152 coal workers and the ventilatory function in two briquet factories. Also, concentrations of total and respirable dust in The working environment were investigated. To obtain the amount of respirable dust, the total amount of dust in the air of each working place was measured and analyzed based on the size of particles. To determine the prevalence and type of pneumoconiosis, radiographic examinations and pulmonary function test were performed on each workers. The results are as follows: 1. The average concentrations of total and respirable dust in working places of two factories were 16.1mg/㎥ and 10. 2mg/㎥ respectively, both of which are greater than the threshold limit value. The concentrations of the total dust in each section of the factory also were beyond the TLV. The distribution of particles less than 7μ was about 60% of the total amount of dust. 2. The career history of the examines revealed the 5~9 service year group as the largest, with 51 out of 152 workers (33.6%). By the age group, 40~49 year was the largest, 82 out of 152 workers (53.9%). 3. The results of the radiographic examinations showed that 24 workers with pneumoconicsis were advanced to category 1, 2 and 3 with a prevalence rate of 15.8%. The prevalence rate showed a tendency ta increase remarkably in accordance with the age and the number of working years. 4. In case of pneumoconiosis in category 1 , 2 and 3, a high correlation between the age and the number of working years was seen (r=0.547, p<0.01). 5. In the distribution of pneumoconiosis by grade, category 2 was 54.1% of all the cases, category 1, 41.7% and category 3, 4.2%. 6. The %FEV_(1.0) and MMEF of cases were less than that of the normal group. 7. Among the workers exhibiting pneumoconiosis as determined by ventilatory function test, 25% were of obstructive type, 4.2% restrictive type, and 70.8% normal.

확장된 Huckel 이론에 의한 이원자 분자의 고찰

李廣純,洪宗基 聖心女子大學校 1987 論文集 Vol.19 No.-

원자간의 반발력을 고려하여 이원자 분자의 에너지와 전화분포등을 확장된 Huckel이론으로 구하였다. 이들 반발에너지는 Hellmann-Feynnlnn 이론으로 계산하였으며 전자의 비편재에너지는 일-전자 문제로 처리하여 구하였다. 이들 결과를 근거로 이 이론으로 고체표면에 흡착된 분자상태를 고찰하고 있다. Molecular energies of N₂ and CO isoelectron molecule are calculated by using the ASED -MD theory which is take into account of repulsion energy resulting from a molecule followed by the superposition of the rigid atom. The repulsion energies are calculated by Hellmann-Feyman electrostatic theorem. The electron delocalization energy ?? give rise by the Extended Huckel theory using one-electron Hamiltionian. We are now testing an applying this theory to the solid surface systems.

菜蔬類의 原形質體融合에 관한 硏究

李炳基,殷鍾旋,高正愛,韓光洙 전북대학교 유전공학연구소 1988 遺傳工學硏究所報 Vol.1 No.1

This study was carried out to investigate the optimal conditions for producing somatic cell hybrids of vegetables. The conditions investigated are enzyme concentrations and duration of treatment for isolation of protoplast, concentration of PEG 4000 for fusion of isolated protoplasts, and viability of isolated protoplasts and fused protoplasts. The results obtained are as follows: 1. The size of onion protoplasts which are isolated from white mesophyll tissue is 52.6μm. The size of welsh onion and nanking shallot protoplasts is almost uniform (about 45μm) but the size of tomato and potato protoplasts isolated from callus tissue is various(21 to 86μm). 2. The optimal conc. of enzyme for isolation of protoplasts in the mesophyll tissue of radish, chinese cabbage, welsh onionm, and nanking ahallot are 0.5% macerozyme and 1.0% cellulase. While the onion is 0.5% macerozyme and 1.5% cellulase. 3. The optimal duration of enzyme treatment for produced intact protoplasts were 4hr in chinese cabbage, 5hr in radish, 3hr in welsh onion, and 2hr in nanking shallot and onion respectively. 4. Isolated protoplasts from mesophyll tissus were fused easily and produced the hetero-karyon with 25-35% PEG 4000 in inter-or intraspecies, while protoplasts of tomato and potato derived from cell were not fused easily. 5. The isolated protoplasts were viable until 1-2 days duration of culture, after 3-4 days they were died. The fused protoplasts regenerate cell wall in 1-2 days, while cell division and morphological changes were not observed.

자기공명영상을 이용한 정신분열증 환자의 뇌량크기 측정

이종훈,이재광,나철 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4

In order to evaluate the morphological change of corpus callosum which may play a major role in abnormal neural transfer of information between two cerebral hemisphres in schizophrenics, the authors measured the size of corpus callosum of the 25 schizophrenic patients who were diagnosed by DSM-Ⅲ-R(1987), visited at department of neuropsychiatry, Chun-Ang university hospital(Young San, Phildong) from October 1993 to March 1994, by using the midline saggital slice of MRI. These results were compared with the size of corpus callosum of 25 neurotic patients who had visited at Chung-Ang university hospital. The results were as follows : 1) Schizophrenic patients had larger total callosal area, genu area, splenium area than control group. 2) Female schizophrenic patients had significantly larger splenium area and higher ratio of splenium to total callosal area than the female control group. Male schizophrenic patients had significantly larger total callosal and genu area than the male control group. 3) Although male schizophrenic patients had simillar size of corpus callosum with female schizophrenics, the male control group had larger splenium, thicker anterior callosal width and higher ratio of splenium to total callosal area than the female control group.

模型(Model)理論

李光鍾 청주대학교 행정문제연구소 1978 행정학논집 Vol.1 No.-

行政改革의 主要變數와 戰略

李光鍾 청주대학교 사회과학연구소 1983 한국사회과학연구 Vol.1 No.-

In this paper, the writer has discussed the following dimensions on administrative reform. (1) The definition and some processes of administrative reform. (2) Environment and administrative system. (3) The objectives and main variables of administrative reform. (4) Strategy for administrative reform. Administrative reform is a continuous activity that takes place in such varied circumstance and, therefore, meaningful generalization is difficult. The demand for reform of public administration arises from the malfunctioning of the natural processes of administrative change. Generally speaking, movements of reform begin with the intention of removing obstacles to change or of improving on the results of change where it is being accommodated. Administrative reform is the artificial inducement of administrative transformation, against resistance. Administrative reform is articifial, strategic for the betterment of efficient performance because it is man-made, deliberate, planned; it is not natural, accidental or automatic. Administrative reform is deliberately abstracted from its surroundings to concentrate on the specific stages that reformers experience in their esseneially political struggle to change existing behavior patterns and functional tasks in administrative system.