정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

개질 아스팔트 혼합물의 변형강도 측정 연구

김광우,도영수,이기호,조문진,최선주 강원대학교 부설 석재복합신소재 제품연구센터 2004 석재연 논문집 Vol.9 No.-

본 논문은 아스팔트 혼합물의 소성변형 저항성과 상관성이 높은 특성치를 찾고자 Kim test를 개발하여 현재 적용성 연구결과를 다루고 있다. 이 논문은 새로운 강도특성치인 변형강도(S_(D))를 개발하는 Kim, test 연구의 4단계 연구 결과이다. 13 mm 골재(편마암, 화강암)와 입도(밀입도, 갭입도) 5가지 폴리머로 제조한 8가지 바인더로 두 가지 입도에서 소성변형 저항성이 다른 32가지 혼합물을 만들었다. 슬래브(305㎜×305㎜×62㎜)공시체를 제조하여 한쪽은 Kim, test를 수행하기 위하여 18 cm정도로 잘라서 코어를 3개 채취하고 다른 한쪽은 12cm크기로 하여 반복주행시험을 실시하였다. Kim, test는 하중봉 3(0.75), 4(1.0)을 사용하였다. W/T시험으로부터 최종 침하 깊이와 동적안정도의 두 가지 소성변형 계수를 각 혼합물별로 구했다. 각 하중봉과 골재별, 입도별로 S_(D)와 소성변형 계수간의 통계적 상관관계 분석을 수행한 결과 S_(D)와 소성변형 계수와의 결정계수가 매우 높게 (R²>0.95) 나타났다. 하중봉 4(1.0)이 3(0.75)보다 다소 높은 상관성을 보였다. 향후 Kim test실험에서 하중봉 4(1.0)을 사용하고 4단계 방법을 이용한다면 소성변형 특성치인 침하깊이(DR)와 동적안정도(DS)와의 상관성이 매우 큰 시험법이 될 것이다. 또한 변형강도의 파괴 메커니즘은 콘크리트의 펀칭파괴와 유사하여 콘크리트의 전단강도 추정식을 근거로 아스팔트 콘크리트의 재료 특성에 적합한 추정식 계수 ◁ 원문 수식 참조 ▷ 를 얻었다. 이 식을 이용한다면 아스팔트 콘크리트가 견딜 수 있는 임계하중을 변형강도에 근거하여 추정할 수 있을 것이다. This study shows predictability of rut parameters of modified and unmodified asphalt concretes based on the deformation strength (S_(D)) which is calculated from the maximum load, deformation and size variables of loading head under simple static loading. This paper is the result of latest studies, phase 4 which is a part of Kim, Test studies for developing a new strength property for asphalt concrete. Two aggregates, gneiss and granite, two gradations, dense-graded, gap-graded, with maximum, size of 13mm and eight binders using different contents of five polymers (RLDPE, RHDPE, LDPE, SBS, SBR) were used to produce 32 different mixtures. A slab (305㎜×305㎜×62㎜) was cut into two pieces(18cm and 12cm width) and three 10cm cores were taken for S_(D) test from the larger piece and wheel tracking test was performed on the smaller piece. Kim test was performed using loading head 4(1.0), 3(0.75). Two rut parameters, depth of rut and dynamic stability, from the rut depth-cycle curve from a WT test were obtained for each mixture. Statistical analysis were performed for each loading head, aggregate, and gradation to find out correlation between S_(D) values and each rut parameter. The analysis results showed that S_(D) had high R² (over 0.95) on the average with rut parameters. The loading head 4(1.0) showed R² better than 3(0.75). It is concluded that S_(D) is the property that has excellent predictability for rut parameter of asphalt concretes. An equation, ◁ 원문 수식 참조 ▷ was obtained based on the equation of concrete shear load creating punching failure and current test data, because the failure mechanism of S_(D) is similar to punching failure of concrete. In the equation, P is shearing force creating punching effect, b is length of perimeter of punching area and d is depth of specimen. If this formula is used, a critical load for deformation failure will be predicted based on the S_(D).

영산강 상류일부의 水質汚染에 관한 調査硏究 : 산동교를 중심해서

류일광,이치영,강영식,김관천 광주보건대학 1990 論文集 Vol.15 No.-

Water quality of Young San river was examined for 3 months from April 12, 1989. to Jun 12, 1989. For checking the water quality 4 sampling position were selected. The results we obtained are as follows. 1. The average for Young San river was 6.6∼7.4 of pH, 3.6∼8.7mg/ℓof Dissolved dxygen (DO), 18.67∼33.47mg/ℓof chemical oxygen demand (COD), 47.66∼250mg/ℓ of suspended solid (SS), 37.83∼114.66mg/ℓ of N-hexane abstraction maters, 5.16∼6.63mg/ℓ of BOD. 2. The monthly average for Young San river was 6.5∼7.5 pH,3.5∼10.4mg/ℓ of DO. 15.07∼48.90mg/ℓ COD, 6.2∼10.2 mg/ℓ of BOC, 2∼250mg/ℓ of SS. 2∼124mg/ℓ of N-hexane abstraction mater, in April, 6.2∼7.5 of pH, 3.5∼8.2mg/ℓ of DO, 2.4∼5.7mg/ℓ BOD, 18.21∼32mg/ℓ of COD, 16∼123mg/ℓ of SS, 9.5∼95mg/ℓ of N-hexane abstraction matter, in May 6.9∼7.5 of pH, 3.8∼7.50mg/ℓ of pH, 3.8∼7.50mg/ℓ of DO, 4.0∼5.8mg/ℓ of BOD, 18.23∼of COD, 123∼163mg/ℓ of SS, 102∼125mg/ℓ of N-hexane abstraction matter in Jun. 3. The sampling positions averag for Young San San river was 6.9∼7.5 of pH, 7.5∼10.4mg/ℓ of DO, 15.07∼22.8mg/ℓ of COD, 3.5∼6.2mg/ℓ of BOD, 2∼125mg/ℓ of ss, 2∼102mg/ℓ of N-hexane abstraction matter in posiction 1.7.3∼7.5 of pH, 6.0∼7.5mg/ℓ of DO, 46.25∼52.05mg/ℓ of COD, 2.4∼8.5mg/ℓ of BOD, 58∼123mg/ℓ of SS, 62∼120mg/ℓ of N-hexane abstration matter in position 2. 6.2∼7.3 of pH, of pH, 4.23∼6.7mg/ℓ of DO, 4.9∼7,9mg/ℓ of BOD, 18.23∼36.75mg/ℓ of COD, 89∼152mg/ℓ of SS, 75∼123mg/ℓ of N-hexane abstraction matter, in position 3, 6.5∼7.2 of pH, 4.0∼10.2mg/ℓ of BOD, 3.5∼3.82mg/ℓ of DO, 23.6∼52.32mg/ℓ of COD, 123∼250mg/ℓ of SS, 95∼125mg/ℓ of N-hexane abstraction matter in position 4.

침 시술로 발생한 Non-O1, Non-O139 Vibrio cholerae에 의한 패혈증

임태섭,지아영,이중희,장수연,김인수,김영주,김범경,김승업,박준용,안상훈,한광협,김도영 Ewha Womans University School of Medicine 2013 EMJ (Ewha medical journal) Vol.36 No.S

Vibrio cholerae is mainly known to cause gastrointestinal infection after seawater exposure or raw seafood intake. It is rarely reported to cause cellulitis or sepsis, but threre has been no known case after acupuncture. Herein, We report a 56-year-old cirrhotic patient of non-O1, non-O139 Vibrio cholerae septicemia caused by cellulitis of both lower extremities after acupuncture.

Aspergillus candidus F1484 균주가 생산하는 항진균 화합물의 분리 및 특성

김성옥,이소영,김성규,손광희,김영국,문석식,복성해 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.5

Candida albicans의 효모형태에 대해 활성을 나타내는 항진균 물질의 탐색 중에 Aspergillus candidus F1484 균주의 발효액으로부터 항진균 화합물 F1484를 단리하고 ethyl acetate 추출, silica gel column chromatography, ODS column chromatography 및 preparative HPLC를 행하여 분리정제하였다. F1484 화합물은 EI-MS, ^13C-, ^1H-NMR, DEPT, HMQC 및 HMBC에 의한 구조분석을 행한 결과 이 화합물은 항진균 물질인 chloroflavonin과 동일한 구조를 나타내었으며 효모형태의 Candida albicans에 대한 항진균 활성뿐만 아니라 여러 종류의 인체 종양 세포주에 대해서도 세포독성을 나타내었다. In the course of screening for the antifungal compounds against Candida albicans, an antifungal compound (F1480) was isolated from the culture broth of Aspergillus candidus F1484. Isolation and purification of compound F1484 were performed using ethyl acetate extraction, silica gel column chromatography, ODS column chromatography, and preparative HPLC. The structure of compound F1484 was determined by the spectroscopic analyses of EI-MS, ^13C-, ^1H-NMR, DEPT, HMQC, and HMBC. This compound appeared to have a structure of antifungal agent, chloroflavonin. In addition to antifungal activities against the yeast phase of Candida species, compound F1484 showed cytotoxic effect against various human tumor cell lines.

"Dice와 fill" 방식을 이용한 1-3 압전복합재의 제조와 횡방향 단위 크기에 따른 압전특성 평가

김영덕,김광일,정우철,김흥락,김동수 한국비파괴검사학회 2002 한국비파괴검사학회지 Vol.22 No.4

NDT나 의료용 영상장치에 응용되는 압전복합체는 일반적인 세라믹이나 고분자 압전재료에 비하여 많은 장점을 가진다. 이들 응용분야에서는 전기기계결합게수가 높아야 하고, 음향임피던스가 낮아야 한다. 그러나, 압전복합제의 횡방향 단위 크기가 조밀하지 못한 경우 횡방향으로 전행하는 판파에 의한 불필요한 진동이 표면에 발생하게 된다. 횡방향 단위 크기와 세라믹 체적비에 따른 압전 특성을 조사하기 위하여 PMN-PZT 세라믹과 Epofix 에폭시로 에폭시의 폭을 달리하면서 1-3 형 압전복합체를 제작하였다. 제작된 1-3형 압전복합체의 두께방향 진동모드의 전기기계결합계수, 음향임피던스는 각각 0.36~0.64, 9.8~22.7 MRayl로 나타났으며, 횡방향 단위크기가 줄어들수록 횡방향 모드 공진 주파수가 증가하였다. The piezoelectric composites had many adventages in comparison qith conventional piezoelectric ceramics and piezopolymers for ultrasonic transducers used in NDT and in medical ultrasonic imaging. The electromechanical coupling coeffucient should be high and the acoustic impedance should be low in these applications. However, the cross-coupling with spurious oscillations caused lateral spatial scale. The thickness mode electomechanical coupling coefficient of 1-3 type of piezoelectric composites were 0.36 to 0.64, and the acoustic impedance of them were 9.8 to 22.7 MRayl. The lateral resonance frequency of 1-3 type piezoelectric composites shifted to high frequency region with decreasing lateral spatial scale.

比較憲法에 관한 硏究 : 民主主義國家의 憲法과 共産主義國家의 憲法을 中心으로

金水暎,黃革周,權光植,吳再煥,崔聖俊,金益鉉,金永休,王任東 朝鮮大學校 法政大學 1977 法政大論文集 Vol.4 No.-

This paper aims to make clear the fundamental differences between the constitutions of two political systems, constitutional democracy and communism. (1) Fundamental Human Rights The recognition and the protection of fundamental liberties are the essences of the political system of constitutional democacy. The reality of individual liberties is the only reliable criterion that differentiates the two political systems, since the institutional apparatus of both government, assemblies, elections, parties, bureaucracies have become stereotyped to the point of identity. Recognition or nonrecognition of fundemental guaranties are closely related to the ideological telos of either system. In the constitutional democracy they crystallize the supreme values of human self-realization and dignity. In the communist states they are denied legitimacy not only because they may function as foci of opposition against monolithic power but also because they could obstruct the ideology of economic planning under collectivism. The idelolgical foundation and functional purpose of classical fundamentalism underwent a fa -reaching transformation in the Marxian society. The Russian Revolution preaches and practices the primacy of the collectivity over the individual. Instesd of being "inalienable" interpreted as obligations of the state toward the laboring masses. The attitude of Marxism in the U.S.S.R. and the so-called "People's Democracies" toward fundamental liberties is altogether different. All constitutions in the Soviet orbit contain elaborate statements on fundamental rights of the citizens, characteristically coupled with provisions concerning their duties toword the state and the community. Civil liberties in the classical sense, which the constitution of communist states merely summarizes, are overshadowed by the new social and economic rights. The guaranty of the civil rights proper is hedged in by the rubber clause that they are guaranteed " in conformity with the interests of the working class" and "in order to strenghthen the socialist system". Especially political rights of the suffrage are converted into compulsory mass participation in the political process directed by the party hierarchy. And its single party (communist party)was the straight negation of all political liberty. (2) Patterns of Governament In the modern democratic-constitutional state the essence of the power process consists in the attempt to establish an equilibrium between the various competitive plural forces within in state society, with due regard to the free unfolding of the human personality. In communist state, social control and political power are monopolized by a single power holder, subordinating the individual to the ideological requirements of the group domination the state. The basic difference between the two political systema conists in whether, in the various stages of the governmental process, political power, is distributed among and shared by several independent power holders or whether political power is concentrated in and monoploized by a single power holder, be it an individual person, and assembly, or a party. Assembly government system revived in the Stalin constitution of 1936 in the U.S.S.R. from where it spread, after the Second World War, to all satellite states, as well as East Germany, Red China, North Korea. No communist state fails to conform to this standard pattern. Assembly government, by its own biological laws. easily transforms itself into a regime in which a single power holder exercises the monopoly of political power. This may well be the intrinsic reason for the communist preference. By necessity the communist state is a plice state. Another indispensable instrument of social control is the single party. The governmental techniques of a communist regime are necessarily authoritarian. But the regime does much more than exclude the power addressees from their legitimate share in the formation of the will of the state. It attempts to mold the private life, the soul, the spirit and the mores of the citizens to a dominant ideology that the various instrumentalities of the power process force on the non-conformists.

탄소나노튜브 캐소드의 전계방출 및 열화특성에 미치는 페이스트의 조성과 분위기 가스의 영향

김동희,김태식,정원섭,김광호,손영국,조영래 대한금속ᆞ재료학회 2006 대한금속·재료학회지 Vol.44 No.3

정상과 갑상선 종양조직에서 사람 IGF-I 유전자의 발현

김성운,장현하,박상미,김덕윤,우정택,양인명,김진우,김영설,김광원,고석환,홍성화,최영길 경희대학교 유전공학연구소 1993 遺傳工學論文集 Vol.5 No.-

Many of the growth-promoting properties of growth hormone(GH) are mediated by insulin-like growth factor-I(IGF-I), a highly conserved circulating 70-amino acid peptide. Recent studies have shown that multiple mechanisms influence IGF-I gene expression, including transcription from two promoters, alternative RNA splicing, and variable polyadenylation. In thyroid tissue, thyroid stimulating hormone(TSH) and IGF-I are the most possible candidates for follicular cell proliferation and hypertrophy. Actually IGF-I had autocrine and paracrine effect for tissue growing. We prepared thyroid tumor tissue mRNAs using single step method for detecting IGF-I levels according to different tissues, i.e., thyroid adenoma or papillary thyroid carcinoma. We used Northern blot analysis for IGF-I mRNA and RNase protection assay (RPA) for IGF-I transcription start sites. For Northern blot, we used whole human IGF-I cDNA as a DNA probe and for RPA, we used IGF-I exon 1 containing noncoding promoter 1 as a riboprobe. We got good RNA bands from Northern blot analysis around 1 kb (IGF-IA) and 7.5 kb (IGF-IB) region. To clarify the amount of both IGF-IA and IB mRNAs, we measured autoradiographied signal of IGF-I mRNAs bands using densitometer. In IGF-IA signals, there's no change among liver and thyroid tissues, but in case of IGF-IB mRNA bands, the signal was markedly increased in thyroid carcinoma tissues than that of normal thyroid tissue (85% vs 14%). In the study of RPA, all thyroid tissues used the same transcription start sites as those of liver's. We concluded that that this different regulation of IGF-I mRNA was originated from tissue specificity. That meant some tissue specific transcription factor/s were related to tissue IGF-I expression.

트레드밀 걷기 운동 시 무게부하의 차이가 호흡순환기능 및 대사기능에 미치는 영향

김용규,이채산,김자영,박미숙,김광중,이광호 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

The purpose of this study was to compare on cadiopulmonary and metabolism function of 10㎏ weight loading group(10 females) and W university students with non weight loading group(10 females. Each group did treadmill walking exercise for twenty minutes by the modified balke protocol. Heart rate(HR), systolic(SBP), MVO₂, and VO₂max were analyzed using 2×2(groups×during) repeated measures analysis of variance (MANOVA). And peak blood velocity(PBV) and MBV were analyzed by using 2×2(groups×during) repeated measures analysis of variance (MANOVA). Lactate and glucose were amalyed by separate 2×2 (groupxduring) analysis of variance(ANOVA). Results of this study suggest that: The change of HR, SBP and MVO₂ in experience and control group showed the significant(p<.05) increase during walking exercise. Variables between experience and control group showed not significant level. But VO₂ in each group showed the significant(p<.001) increase during walking exercise. Differenc among each group showed significant(p<.001) level. Lactate and glucose level in each group showed significant(p<.001, p<.05) increase during walking exercise. Differences among each group showed not significant level. PBV and MBV in each group significant(p<.001) increase during walking exercise. Difference among each group showed significant(p<.05) level. According to these results, weight loading walking exercise considering safety promotes to cardiovascular function and it is expected to be an effective exercise methods able to improve the physical inefficiency of long time walking type.