정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

DC 링크의 분명한 수식화에 의한 AC-DC 조류계산

정형환,안병철,허동렬 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.2

This report has been suggested a calculation method include the DC-Link equations into process of power flow repetition of AC system, on to use the fast decoupled method. The DC link model which consisted of thirteen non-linear equations could be expressed using nine non-linear equations in accordance with the consideration of system configuration and functional characteristic. In recognition of the advantage for DC transmission on a side of elevation upon an economical transmission through a lower loss and a stability enhancement, the estabishment of real system and this study are doing to activate in the world. Also in our land, the DC transmission between the shore and Jae-Ju Province is going to expedite in actual fact. Such as fact in today, it has been done to think that is meaningful to exhibit the effective power flow for advactage fo a memory capacity, a calculatot's speed, and can be known the electric power distributions of integrated AC-DC system.

말기신부전 환자에서 심혈관계 합병증 예측인자로서의 호모시스테인의 의의

정종훈,신병철,김현리 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Backgroud: Thromboembolic phenomena are major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). In the last years, the accumulation of evidence coming from studies in patients with chronic renal failure have demonstrated an increased relative risk of coronary artery disease (CAD) in association with hyperhomocysteinemia. We elucidate the effects of homocysteine on diagnostic marker of cardiovascular risk factor of patients with ESRD. Methods: One hundred thirty-three patients were enrolled in the study performed at a Chosun university hospital. Ninety patients were on dialysis (58 hemodialyzed patients and 32 peritoneal dialyzed patients). Hyperhomocysteinemia was defined as a fasting plasma homocysteine level more than 15 μmol/L. Results: A total 71 patients (53.4%) had hyperhomocysteinemia. The prevalence of hyperhomocysteinemia was 60.3%, 46.9%, 48.8% among hemodialysis, peritoneal dialysis and kidney transplantation, respectively. CAD was present in 40.6% of patients (54 patients). The mean homocysteine concentration was 22.35 ± 5.94 μmol/L and 15.07 ± 5.45 μmol/L in patient with (n=54) and without (n=79) CAD, respectively (p<0.01). There was significant difference including age, serum creatinine, cardiac troponin-T (cTn-T), homocysteine level, total cholesterol, CRP in the two group (p<0.05). Plasma homocysteine concentration showed significant positive correlations with age (r= 0.261, p<0.05), cTn-T (r= 0.244, p<0.05), CRP (r= 0.422, p<0.01) in overall and negative correlations with hemoglobin (r= -0.240, p<0.05) in dialysis patients. Conclusion: Hyperhomocysteinemia, elevation of cTn-T, and elevation of CRP were diagnostic markers of ischemic heart disease of ESRD patients undergoing hemodialysis and peritoneal dialysis. The homocysteine is more potential diagnostic marker than cTn-T and CK-MB in ischemic heart disease with ESRD patients.

골인이 Morphine 중독 마우스의 금단 증상에 미치는 효과

정태호,김정철,채성철,강병조,이인자 최신의학사 1991 最新醫學 Vol.34 No.2

돌와(Gynostemma pentaphyllum)엑기스가 白鼠의 肝臟障碍에 미치는 影響

丁明鉉,文永熙,姜壽鐵,李炳柱 조선대학교 약학연구소 1989 藥學硏究誌 Vol.11 No.1

This study was attempted to invesigate the effects of extract and crude saponins of Gynostemma pentaphyllum Makino on the activities of S-GPT, S-GOT, Al.P, LDH and the levels of total-bilirubin, total-cholesterol in the serum of nomal rats and experimentally CCl_4-intoxicated rats, and on the effect of body, liver and spleen weight in CCl_4-intoxicated rats. The results were shown as follows; The extract (GE.) and crude saponins were showed a significantly decrease in the activities of S-GPT, S-GOT, Al.P and the level of total bilirubin in the serum elevated by CCl_4, but crude saponins was more decreased than GE. The activities of LDH were significantly decreased of the 4th and the 6th days after administration of GE., and crude saponins was decreased in proportion to the number of days. The level of total cholesterol were significantly decreased in all sample groups. when compared with control group, but remarkably decreased in GE. 500㎎/㎏ and crude saponins 100㎎/㎏. The liver and spleen weight were decreased on the administration of GE. and crude saponins. According to the above results, it is thought that GE. and crude saponins exhibited significant antihepatotoxic activity in the CCl_4-intoxicated rats.

Enterococcus faecium 19-46-4에 의한 Cholic Acid의 생산

정은영,김명수,이철훈,김병홍 한국산업미생물학회 1996 한국미생물·생명공학회지 Vol.24 No.5

항균활성을 갖는 혐기성 미생물에 대한 탐색연구에서 항균활성이 강한 Enterococcus faecium 19-46-4를 선발하여 혐기적 배양으로 이 균주가 생산하는 항생물질의 분리, 정제 및 이화학적 특성 및 구조분석을 행하였다. 40ℓ 균배양액으로부터 iso-butanol extraction, C-18 liguid column chromatography, HPLC등을 통해 약 100mg의 항균물질을 분리정제하여 KIST 194로 명명하였고, KIST 194를 UV, IR, ^1H-NMR, ^13C-NMR, EI-MS와 LC-MS 등의 기기분석을 한 결과 cholic acid (3α, 7α, 12α-trihydroxy-5β-cholan 24-oic acid)로 동정하였다. A facultative anaerobe Enterococcus faecium 19-46-4 was used to study the production of an antimicrobial substance in anaerobic conditions. Major part of the antibiotic activity was found in the culture filtrate of the bacterium. The active compound was extracted by an equal volume of iso-butanol and concentrated in vacuo (at 50℃) before purification by C-18 liguid column chromatography and HPLC. A chromatographically pure compound was obtained by two passages of HPLC columns, The compound appeared as a pale-yellow powder. The yield was about 2.5 mg l^-1 culture filtrate. The compound was named as KIST 194. KIST 194 were identified as cholic acid (3α, 7α, 12α-trihydroxy-5β-cholan 24-oic acid) based on its physico-chemical properties determined by UV, IR, ^1H-NMR, ^13C-NMR, EI-MS and LC-MS.

May-Thurner Syndrome 환자의 좌측 하지 심부정맥혈전증 : Pigtail 카테터 회전을 이용한 치료의 효용성과 안전성 Lower Extremity Deep Vein Thrombosis of May-Thurner Syndrome

정구용,염차경,이주호,강병철 대한혈관외과학회 2004 Vascular Specialist International Vol.20 No.1

다중 출력 MLP신경망을 이용한 한국어 음성인식에 관한 연구

鄭光宇,朴炳哲 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.1

In this paper, to improve the performance of the speaker-independent speech recognition system, a new reural network model and learning algorithm were proposed. Recognition algorithm for performance improvement of the recognition system had two kinds. Several experimental results were given to prove the performance of proposed algotithm on the isolated digit recognition of the speaker- independent. First, the algorithm for extraction of the feature vector was proposed. it imported, to stabilize the sequence of the feature vector to input speech, the 'Inertia Term' between neighbor frames. If, caused the reducing fluctuation components produced on the sequence of the feature vector of speech signal and tine suppressing superposition of probability distribution between feature vectors. As a result, the ability of phoneme discrimination was improved on the speaker independent speech recognition system or 3.9%. Second, the Multi-Output MLP(MO-MLP) neural network structure was proposed. It had, for reflecting the variation of the feature of the phoneme which was produced on the variable phonological environment, the structure which was assigned several output nodes to the same phoneme. So, the convergence characteristic of the neural network could be improved by the proposed structure for complex learning data and this structure could improve the ability of recognition system by generating the multi-template pattern on a neural network for 8.4%.

중학교 과학교육 행사에 관한 과학교사의 인식연구(Ⅱ)

최병철,정호용 여수대학교 2002 論文集 Vol.17 No.-

The various science fair have the objection and the role in cultivating diverse experiences and dreams for science to students in the scientific education of the middle school. As the results in his study, it is discovered through this investigation there to be estrangements between the contents of programs for various items executed on the spot and the science teacher's recognitions. According to the analysis I will find the previewing points of the solving-methods for revealed problems to make narrow between the poles of estrangements.

JPEG에서 필터를 이용한 압축률 개선에 관한 연구

申仁澈,金成鍾,鄭炳善 단국대학교 1995 論文集 Vol.29 No.-

Recently the application of the digital image processing has been increased with technical advances in digital computers. It is necessary to compress the digital image data in order to store and transmit it with real time. It is possible to redisplay the relatively exact image and decrease bandwidth of transmission path with the reduced information by compression. JPEG in ISO and CCITT defines the standard compression and restoration algorithm for grayscale and color still image. In this paper, we propose a method of decreasing higher frequency component and increasing spatial redundancy in image, and the compression ratio. In order to decrease higher frequency components of the images, various filters were used in the preprocessing. Compression ratio and processing time were compared. Results shows the enhanced compression ratio without damage of image quality by using filter in JPEG.