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          • Dimethyl-esculetin이 Carbon tetrachloride 負荷家兎의 serum total cholesterol에 미치는 影響

            李敦日,金成鎬 조선대학교 약학연구소 1978 藥學硏究誌 Vol.1 No.1

            In order to confirm the effect of dimethyl-esculetin on the change of serum total cholesterol, this study was performed. The ten rabbits were equally divided into two groups : A and B. The A group was injected carbon tetrachloride, 0.1㎖ per Kg. was used to study for control group. The B group has been treated with dimethyl-esculetin for 7 days before carbon tetrachloride injected 30㎎ per day. The resulto f the serum total cholesterol of each group is following ; The group pretreated with dimethyl-esculetin showed available protective effect on the liver damage of rabbit injected carbon tetrachloride.

          • 좌제기제가 Propranolol의 생체이용율에 미친영향

            조삼상,이진환 조선대학교 약학연구소 1994 藥學硏究誌 Vol.16 No.1

            This paper was designed to investigate the influence of suppository bases contained dextran 40000 on the rectal absorption and the dissolution rate of propranolol witepsol suppository. Suppositories were prepared by the fusion method. Propranolol(16㎎) was added to the witepsol base which containing 2.5, 5, 10% of dextran. The release rate of propranolol from witepsol suppository were decreased with increasing dextran content. The maximum blood concentration (C_max) were decreased and time to reach C_max(T_max) were delayed with increasing dextran content and the relative bioavailabilities were increased. After all, Dextran could be applied in sustained release suppository of propranolol.

          • 何首烏 및 白首烏엑스가 흰쥐의 實驗的 高脂血症에 미치는 影響

            丁明鉉,文永熙,李炳柱,鄭銀津 조선대학교 약학연구소 1994 藥學硏究誌 Vol.16 No.1

            This study was attempted to investigate the effect of Polygoni multiflori Radix and Cynanchi wilfordii Radix extract on the activities of S-GOT, S-GPT and level of total lipid, triglyceride. β-lipoprotein, phospholipid and total cholesterol in the serum of experimentally induced hyperlipermic rats, and on the effect of body, liver and spleen weight in rats. The results were shown as fouow; a) Polygoni multiflori Radix The activity of S-GOT was remarkably decreased, and activity of S-GPT was significantly decreased in all sample group, when compared with the control group(high lipid diet). The level of triglyceride and total cholesterol were remarkably decreased in all sample group, when compared with the control group. The level of total lipid and phospholipid were remarkably decreased on the 7 days after admistration of all sample group. The body weight of the rats decreased and the liver weight increased in control group were shown reduced as normal group on the administration of sample extract. b) Cynanchci wilfordii Radix The activities of S-GOT, S-GPT were remakably decreased in sample 100, 300㎎/㎏, when compared with the control group. The level of triglyceride and total cholesterol were remarkably decreased in sample 100, 300㎎/㎏. The level of phospholipid was significantly decreased in sample 100㎎/㎏. In sample treated group the death rate on the rats were 50 percentage in sample 500㎎/㎏. therefore in administration of sample 300, 500㎎/㎏ were very toxics. The body weight of the rats were remarkably decreased in all sample group, when compared with the normal and control group.

          • 봉선화 뿌리의 成分硏究

            文永熙,高在鍾 조선대학교 약학연구소 1994 藥學硏究誌 Vol.16 No.1

            Impatiens balsamina Linne(Balsaminaceae)known as "BONG SUN HWA" in Korea and used for treatment of Scrofulosis, Carbunculus and Dysenteria, etc.. From the roots of Impatiens balsamina, α-spinasterol and scopoletin were isolated and characterized by UV, IR, NMR, MS and chemical tests.

          • C_3 및 C_7위치에 치환된 새로운 세파로스포린 化合物의 合成과 抗菌活性(Ⅰ)

            황화영,하재천,김영수,고옥현,강형룡 조선대학교 약학연구소 1994 藥學硏究誌 Vol.16 No.1

            The synthesis and antimicrobial activity of cephalosporin having (Z)-2-(2-aminothiazol-4-yl)-2-trityloxyiminoacetamido group and 5-(2-chlorophenyl)-4-phenyl-4H-1, 2, 4-triazol-3-thiomethyl group on the C_3 and C_7 position of the cephem ring, respectively are descrived. This compound was tested for antimicrobial activity in vitro against Candida albicans ATCC 10231, Bacillus subtilis ATCC 6633, Micrococcus luteus ATCC 9341, Staphylococcus aureus ATCC 6538P, Mycobacterium phlei IIP-IPH, Escherichia coli KCTC 1039, Escherichia coli ESS, Klebisiella pneumoniae KCTC 1560, Salmonella typhymurium TV-119, Pseudomonas aeruginosa IFO 13130. The antimicrobial activity of synthetic compound was better as compare with cefotaxime and cefazoline against Micrococcus luteus ATCC 9341 & Escherichia coli KCTC ESS.

          • C-3 및 C-7(치환) 세파로스포린계 항생제의 합성과 항균활성에 관한 연구(2)

            河在天,高玉鉉,姜馨龍 조선대학교 약학연구소 1995 藥學硏究誌 Vol.17 No.1

            In order to development new cephalosporin antibiotics 7β[(z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[5-(1,5-dimethyl-2-pyrroletetrazol-2-yl]methyl-3-cephem-4-carboxylic acid(9) and 7β-[(z)-2-(2-aminothiazol-4-yl)-2-(methoxyimi no) acetamido]-3-[5-naphthyltetrazol-2-yl]methyl-3-cephem-4-carboxylic acid(10) were synthesized. These compounds were tested for antimicrobial activities in vitro against Bacillus subtilis ATCC 6633, Micrococcus luteus ATCC 9341, Mycobacterium phlei IFO 3158, Alcaligenes faecalis KCTC 1004, Escherichia coli 8S, Salmonella typimurium KCTC 1925, Pseudomonas aeruginosa IFO 13130, Klebsiella pneumoniae KCTC 1560 and Candida albicans ATCC 10231, respectively. Compound(10) showed good antimicrobial activities against Bacillus subtilis ATCC 6633, Micrococcus luteus ATCC 9341 and Mycobacterium phlei IFO 3158 but compound(9) showed lower antimicrobial activities as compare with cefotaxime and cefazolin.

          • 고속액체 크로마트 그라피에 의한 혈장 중 Fenoprofen의 분석

            魯虎昌,白采善 조선대학교 약학연구소 1995 藥學硏究誌 Vol.17 No.1

            A high performance liquid chromatographic method is described for the quantitation of fenoprofen, α-methyl-3-phenoxy benzene acetic acid, in human plasma. Fenoprofen and internal standard in plasma was extracted by simple method using acetonitrile without acidifying. Fenoprofen was analyzed isocratically on a reverse phase column MicroPak MCH-10 with a mobile phase consisting of 55% acetonitrile + 0.5%phosphoric acid. At a flow rate of 1ml/min, the retention times of fenoprofen and internal standard were 7.5 and 10min, respectively. The absorbance was detected at 205nm, and quantities estimated from peak height ratios. The limits of sensitivity of the assay for fenoprofen was 0.202㎍/ml. Overall average recovery for a sample was 103.4%.

          • 개의 신장기능에 미치는 Bromocriptine의 영향

            高錫太,黃明性 조선대학교 약학연구소 1995 藥學硏究誌 Vol.17 No.1

            Bromocriptine(BRC), which is a relatively specific agonist of D_2-receptor and antagonist of D_1-receptor in central dopamine receptor, when given intravenously in dog, elicited diuretic action. At the same time, glomerular filtration rates(GFR) and filtration fractions(FF) were increased, and then amounts of sodium and potassium excreted in urine, osmolar clearance (Cosm) and free water clearance(??) were augmented, but reabsorption rates of sodium and potassium in renal tubules were not changed at all. BRC, when infused into a renal artery, did not affect on renal function of both infused and control kidney. BRC infused into a renal artery did not influence on the renal action of intravenous dopamine. Above results suggest that intravenous BRC produces diuretic action caused by indirect changes of renal hemodynamic states and BRC is not antagonist of D_1-receptor in kidney of dog.

          • 商陸 Extract가 개의 腎臟機能에 미치는 影響

            高錫太,李熙淑,李相鉉 조선대학교 약학연구소 1986 藥學硏究誌 Vol.8 No.1

            Effect of Phytolaccae Radix on renal function was investigated in dog using it's water and methanol extracts. Phytolaccae Radix water extract (PWE), when injected intravenously, produced significant diuresis accompanied with the increased glomerular filtration rate and renal plasma flow and also exhibited the increased urinary sodium and potassium excretion and the decreased reabsorption rate of sodium and potassium in tubles, as well as osmolar clearance was increased, but free water clearance was increased only in a small dose and decreased in a large dose of PWE. Phytolaccae Radix methanol extract (PME) given intravenously produced antidiuresis associated with the decrease of all renal function. PWE, when administered into a renal artery, produced diuresis with the increase of amounts of sodium and potassium excreted in urine and with the increase of osmolar and free water clearances, with no significant changes of glomerular filtration rate and renal plasma flow, these with no confined only infused kidney. PME given into a renal artery elicited antidiuresis along with the decreased all renal function only in experimental kidney. Above results suggest that PWE produces diuresis through indirect improvement of hemodynamics and direct inhibition of elecrolyte reabsorption in tubules, and that PME, elicite antidiuresis by direct suppression of renal hemodynamics.

          • Quaternary Ammonium Salt Cephalosporin계 抗生劑 合成

            高捧奭,高玉鉉,姜馨龍 조선대학교 약학연구소 1995 藥學硏究誌 Vol.17 No.1

            For the development of quaternary ammonium salt cephalosporin antibiotics with improved antimicrobial activities, a series of 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-(methox yimi no) acetamido]-3-[4-alkyl (or aryl)-3- thiosemicarbazid-1- nicotinonium] methyl -3- cephem -4- carboxylate were synthesized. Antimicrobial activities of these new compounds were examined against Gram(+) and Gram(-)bacteria. It was found that the moiety synthesized cephalosporin derivatives were good antibacterial activities against Escherichia coli. Almost these compounds were more antibacterial activities than cefazoline. These new compounds showed lower activity than cefotaxime against Pseudomonas aeruginosa.

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