Poster Session : PS 0831 ; Upper GI Tract : Clinical Factors to Predict Angiographically Detectable Non-Variceal Upper Gastrointestinal Bleeding in Patients Refractory to Endoscopic Treatment

( Tae Hwan Ha ),( Tae Hoon Oh ),( Sung In Yu ),( Min Kim ),( Jong Wook Kim ),( Won Ki Bae ),( Jae Hyung Kim ),( Seung Suk Baek ),( Mi Jin Ryu ),( Ye Na Choi ),( Ji Young Park ),( Eileen L Yoon ),( Tae 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Non-variceal upper GI bleeding (NVUGIB) is a common medical problem that has signifi cant association with morbidity and mortality. Angiographic detection and subsequent transarterial embolization (TAE) is a primary treatment option when medical and endoscopic treatments fail. We investigated clinical factors that could affect the success of the angiographic detection and prognosis after TAE in patients with NVUGIB refractory to endoscopic therapy. Methods: A retrospective analysis of the clinical data was done in patients with failed endoscopic treatment who underwent angiography for the treatment of acute NVUGIB between May 2002 and May 2013. Patients were divided into detection or non-detection groups according to the presence of bleeding stigmata in angiographic fi nding. Rebleeding defi ned as subsequent bleeding event within 7 days and mortality within 30days were analyzed as outcome parameters after TAE following detection in angiography. Results: A total 45 patients 37 (male, mean age, 65.9±14.9 years) were analyzed and classifi ed as a detection group (n=25, 55.5%) and non-detection group (n=20, 44.6%). Peptic ulcers were the most common cause of refractory NVUGIB. Larger transfusion amount (5.7±3.9 unit vs. 3.5±2.8 unit; P=0.03), prolonged aPTT level (34.2±17.3 sec vs. 21.8±13.8 sec; P=0.01) and short time interval between last endoscopy and angiography (17.5±25.9 hours vs. 34.3±59.5 hours; P=0.04) were found to be signifi cant factors for predicting angiographic detection. TAE was performed in all patients detected in angiography. Rebleeding (44%) was significantly associated with higher Rockall score (8.3±1.5 vs. 6.6±2.4; P=0.046) and mortality (12%) was signifi cantly associated with higher Rockall score (9.3±0.6 vs. 7.1±2.2; P=0.002) and higher level of BUN (55.3±47.4 vs. 27.6±17.4; P=0.01). Conclusions: Clinical characteristics associated with angiographic detection in patients with NVUGIB refractory to endoscopic therapy were severe bleeding, bleeding tendency and early angiographic intervention. The Rockall score is useful parameter for predicting rebleeding and mortality after TAE.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

서부 경남지역에서의 백반증 환자에 대한 임상연구

尹太進 慶尙大學校 1996 論文集 Vol.35 No.1

Background: Vitiligo is an acquired, often disfiguring skin disease characterized by the loss of melanin, which results in depigmented areas of the skin. Other studies on clinical manifestations of vitiligo have not performed in western gyeongnam province. We investigated clinical aspects of vitiligo in Korea. Objective: This study was basde on the avalysis of 333 cases of vitiligo patients between July, 1987 and August, 1995 at the Department of Dermatology, Gyeonsang National University Hospital. Results: The results are summarized as follows: 1. There were 159 males and 174 females. The mean age at the first visit was 27.4 years, and the mean age of onset was 25.7 yeras. The duration of the disease was less than 3 years in 238 patients(71.5%) 2. The most common type of vitiligo was the localized focal type(54.1%). The most common site of initial involvement was the face(30.6%), and the distribution of lesions was most common tn the face(24.3%). The most common degree of depigmented lesion was less than 5% of the body surface area(34.5%) 3. The most common precipitating factor was trauma(9.6%). Associated diseases were alopecia areata(11 cases), halo nevus(7 cases), psoriasis (2 cases), diabetes melitus(2cases), and thyroid disease(2 cases). Family history was present in 19 patients(5.7%) 4. The most common previous treatment was sun exposure after oxsoralen application (27.2%) Conclusions: We investigated the clinical aspects of 333 vitiligo patients in our clinics and made a comparative study. These data will be available for the study of vitiligo patients in our clinics and made a comparative study. These data will be available for the study of vitiligo in the future.

Cyclosporine 제제의 피부과적 이용

윤태진 대한화학요법학회 1998 대한화학요법학회지 Vol.16 No.1

Cgclosporine has been in clinical use for 2 decades, primarily for the prevention and treatment of organ transplant rejection. In more recent years, It has been recognized as beneficial in the treatment of many dermatologic diseases such as psoriasis, lichen planus, Beh et s disease, atopic dermatitis, pyoderma gangrenosum, and epidermolysis bullosa acquisita. The principal effect of cyclosporine is in suppressing a CD4 T cell-mediated response and, although its exact mechanism of action is unclear, new evidence provides strong support that cyclosporine inhibits calcineurin phosphatase and subsequent T cell activation. The selective action of cyclosporine on helper T cells and its rapid therapeutic action and weak myelotoxicity are the key advantages in the treatment of many dermatologic diseases. The main limitation includes drug toxicity, especially nephrotoxicity, frequent relapse after treatment cessation, and high cost. This presentation will deal with the therapeutic spectrum of cyclosporine in dermatology, its mechanism of action, metabolism, and side effects. Cyclosporine can be safely administered when potential toxicities, dosing, and monitoring guidelines are known.

장기간의 트레이닝이 체격 및 체력에 미치는 영향

윤규태,이승준,이승준 순천향대학교 기초과학연구소 2000 순천향자연과학연구 논문집 Vol.6 No.1

The purpose of this study is to investigate how a long-term training affect a physique and a physical strength on two groups of being trained and untrained. There are 11 items divided under as a factor of the physique and 12 items as a factor of the physical strength to be measured and compared the relationship between two factors. The results of this study are as follows: 1.The most significant differences statistically among factors of the physique in this study appears in chest, lower limb length and upper arm girth. 2.In case of the physical strength, there are significant differences in vertical jump, side step, sit-up, chinning bar, toe touching and mobility tests Like above the results showing, it causes that trainees have been more grown up than untrainees in the development of Staying power, muscular power and promptitude. In addition, there are a lot of benefit to keep the continuant exercises for the development of the body and the physical strength

퍼지 전문가 시스템을 이용한 BLDC 전동기의 자동조정 PID 속도제어에 관한 연구

진광식,윤태성,권세현 國立 昌原大學校 産業技術硏究所 1998 産技硏論文集 Vol.12 No.-

This paper proposes the rule-based expert system with auto-turning of PID controller gain and shows the efficiency of fuzzy expert system for the speed control of BLDC motor. The PID controller gain tuned using RZN(refined ZN) formula to initial tuning and fuzzy expert system to subsequent tuning. The fuzzy expert PID control method proposed in this paper results in the reduction of overshoot, the rapid response and the robustness for disturbances and noise.

폐지의 효소 탈묵

윤경동,박성배,박용현,엄태진 慶北大學校 農業科學技術硏究所 2004 慶北大農學誌 Vol.22 No.-

Cellulolytic enzymes were prepared from alkaline resistant microorganisms which were newly screened from calcic soil. Characteristics of enzymes and enzymatic deinking efficiency of wastepaper were investigated. The results were summarized as fellows: 1. The recovery rate of crude enzyme was 93.7% in Bio-B and 57.4% in Bio-F. 2. The protein content in crude enzymes was lowest and the thermal stability of crude enzymes was highest in Bio-F. 3. The brightness gain of Bio-F deinked pulp was best in ONP and Bio-B deinked pulp was best in MOW. 4. The reject yield was increased with enzymatic deinking flotation process. 5. The residual ink area of paper was increased with enzymatic deinking and large size of ink particles were remained in paper.

BLDC 모터의 속도 제어를 위한 퍼지 가변 구조제어에 관한 연구

진광식,윤태성,박종락 國立 昌原大學校 産業技術硏究所 1998 産技硏論文集 Vol.12 No.-

This paper shows the efficiency of fuzzy integral variable structure controller(FIVSC) with sliding mode which outperforms a traditional variable structure controller(VSC). This approach of the FIVSC solves the chattering problem which has been occurred in VSC and is applied to brushless D.C. motor. The simulation results verify the efficiency of the FIVSC.

인터넷 포르노그라피 연구 : 그 내용과 사회적 담론 It's Contents and Social Discourses

윤태진 연세대학교 언론연구소 2000 언론 사회 문화 Vol.- No.8