소아에서 Fogarty 카테터를 이용한 일측폐 환기 마취 경험

유수봉,강효석,임지훈,김두식,류시정 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Thoracic surgery may be greatly facilitated by causing selective atelectasis of the lung being operated on (one-lung ventilation anesthesia). But the tube used for one-lung ventilation is greater outer diameter than conventional endotracheal tube when compare to each other with same inner diameter, so in some young children it is impossible to one-lung ventilation using double lumen tube or bronchial blocker tube because of narrow vocal cord. We performed one lung ventilation anesthesia using conventional endotracheal tube and Fogarty catheter as a bronchial blocker in 11-year old women who received lung biopsy surgery and left lower lobectomy.

한국판 섬망 평가 척도-98(K-DRS-98)의 표준화 연구

임경옥,김수영,이양현,이선우,김정란 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6

Objective : This study was conducted to develop and to validate the Korean version of Delirium Rating Scale-Revised-98(K-DRS-98), which is a scale for diagnosing delirium and evaluating its severity. Method : After developing the K-DRS-98, 102 patients were rated by it among 4 diagnostic groups, such as delirium (N=25), dementia (N=27), schizophrenia (N=25) and others (N=25). To test for reliability, K-DRS-98 was independently administered by two psychiatrist. To test for validity, Korean version of Mini-Mental State Examination (MMSE-K) and Clinical Global Impression (CGI) were administered simultaneously. Statistical analysis was done with SPSS window version 12 package and statistical significance was p<0.05. Result : Intemal consistencies (Cronbach α) of two raters were 0.867 and 0.858, respectively. Inter-rater reliability (κ) was 0.893 for severity items of K-DRS-98 and κ value of diagnosis items was 0.969. In Delirium group, Pearson correlation Coefficients (r) of K-DRS-98 were -0.682 for MMSE-K and 0.667 for CGI. In comparison Delirium group with Others, ANOVA post hoc multiple comparison LSD was statistically significant (p<0.001). The cutoff score to diagnosis of delirium can be recommended 16 for seventy items and 21.5 for total score, respectively. Conclusion : The K-DRS-98 was showed good reliability and validity for the assessment of delirium. The K-DRS-98 is an easy and useful tool for diagnosing delirium and assessing its severity.

철근 콘크리트 구조물의 내진 구조 해석에 관한 연구 : 비탄성 지진응답을 고려한 동적해석을 중심으로 Of Dynamic Analysis for Considering Inelastic Seismic Response

임희철,장정수 朝鮮大學校 建設技術硏究所 1999 建設技術硏究 Vol.19 No.2

The objective of this publication is to present the state-of-art in inelastic dynamic and static approaches to the analysis and design of structures subjected to earthquakes. This emphasizes that the response of building structures in actual intense earthquakes in inelastic, and that such response can be realistically estimated only though inelastic dynamic analysis. Much of the discussion is focused on the controlled utilization of inelastic response in earthquake-resistant design of concrete structures.

후두부 발작성 간질파와 동반된 양성 소아기 간질의 임상적 연구

유영수,이상도,김지언,임정근,박영춘 대한신경과학회 1996 대한신경과학회지 Vol.14 No.4

운동신경원성 질환에 대한 임상적 고찰

임정근,이동국,김광수,이상도,박영춘 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3

Clinical features, electromyographic findings and the prognosis were observed in 51 patients (33 men and 18 women) who were diagnosed as acquired motor neuron disease at Keimyung University Dongsan Hospital between Jan. 1985 and Aug. 1992. The mean age at onset in our study was similar to that in several other domestic studies but was younger than that in western studies. The therapeutic effect of L-threonine couldn't be evaluated correctly, but L-threonine may have no effect on the course of MND.

사람 대장조직 DNA Topoisomerase I 에 관한 연구

오수정,권기량,임규,황병두 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

DNA topoisomerase I was prepared from normal mucosa and cancer tissue of human colon and the properties were compared. Specific activity of the enzyme from normal mucosa was 257.2 unit/mg protein/ min and that from cancer tissue was 403 unit/mg protein/min. Both enzymes showed a broad pH optimum from pH 5.8 to pH 7.4 and arc heat-labile, being completely inactivated by heat treatment at 55℃ for 5 minutes. The enzyme from normal mucosa was activated 0.2 M K^+ and 0.15 M Na^+ approximately 20 and 4 folds and that from cancer tissue was activated approximately 40 and 10 folds, respectively. Mg^2+ was the most potent activator, the enzyme from normal mucosa being 5, 20, and 60 folds activated at 2 mM, 10 mM, and 20 mM, respectively and the enzyme from cancer tissue being 2.5, 13, 26 folds activated, respectively. Both enzymes were inhibited by 2 mM ATP and 5 mM GTP in the presence of Mg^2+ and K^+ , respectively. ddATP and ddGTP were the potent inhibitors of these enzymes. The enzvate front nurmal mucosa was activated by spermine, spermidine, and histone H3 and that from cancer tissue was activated by histone H1. The enzyme from normal mucosa yeas completely inactivated by alkaline phosphatase treatment whereas the enzyme activity from cancer tissue was indifferent. The molecular weight of both enzymes were 150 KD. Camptothecin and 10-OH-camptothecin variably inhibited DNA relaxation according to tile enzyme preparation and there was no DNA fragmentation in the cleavage assay. From the above results, the possible role of phosphorylation for regulation of this enzyme and the application of camptothecin to colon cancer were discussed.

식도를 포함한 전위장관을 침범한 전이성 악성 흑색종 1예

최정영,김준기,신성하,고영춘,조상욱,서강석,강명원,임연근,여향순,김경수 全南大醫大 2001 전남의대학술지 Vol.37 No.1

豌豆의 실용형질의 유전력, 상관 및 경로 분석

金翰林,文楨洙 濟州大學校 亞熱帶農業硏究所 1992 亞熱帶農業硏究 Vol.9 No.-

豌豆 育種에 있어서 播種期에 따른 品種의 生態反應과 實用形質에 對한 選拔指標의 變化를 究明하기 위하여 Sparkle外 16品種을 春播에서 10月 15日, 11月 4日, 春播에서2月20日, 3月 11日 4回 播種하고, 이들에 對한 實用形質을 調査하여 播種期移動에 따른 名 形質의 生態反應 遺傳力, 遺傳相關, 表異型相關, 環境相關 및 經路係數를 分析한 結果는 다음과 같다. 1. 開花까지 日數 및 生育日數는 早播할수록 길어지고 晩播 할수록 짧아지는 傾向으로 開花 및 生育日數가 긴 早期播種에서 生育狀兄이 좋은 편으로 濟州道에서 豌豆栽培는 10月中旬에 播種하는 것이 收量構成要素의 形質發現이 良好하여 種實收量이 많았다. 2. 秋播 및 春播에서 共히 成熟期가 빠른 早生品種은 Sparkle, Jeonbug, Jeonkwang30, Sojeong 等이었고, 成熟期가 늦은 晩生 品種은 Frescory, Chejujerae Ⅰ, Ⅱ, Alderman, Namuradaehyup, Laseui 等이었다. 3. 莖長은 春播에 比하여 平均 50cm程度 秋播에서 길었는데 秋播와 春播에서 平均 莖長이 70~100cm인 短莖品種은 Sparkle. Profinos R.S. Thomas Laxton, Jeonbug, Alderman 等이었고, 中程度(110~140cm)인 品種은 Frescory, Chejujerae Ⅱ, Laseui, Namuradaehyup, Rondo 等이었으며, 140cm~200cm인 長莖品種도 있었다. 4. 株當分枝數는 早播할수록 많은 傾向이었으나 多分枝形品種은 Frescory, Chejujerae Ⅰ, Ⅱ, Kwangdojeokhyup, Alpine, Namuradaehyup 等이었고, 그 外 品種은 小分枝型이었다. 5. 莢長 및 莢幅은 播種期間에 큰 差가 없었으나, 品種間에 莢長이 긴 것은 8~9cm, 짧은 것은 6~7cm 內外였다 6. 株當莢數는 播種期가 늦어질수록 현저히 減少하였고, 모든 播種期에서 共히 莢數가 많았던 品種은 Chejujerae Ⅰ, Targ, Frescory, Alpine, Thomas Laxton, Alderman 等이었다. 7. 莢當莢數는 播種期間에 大差 없었고 粒數가 많은 品種은 6~7粒, 적은 品種은 4~5粒 程度였다. 8. 100粒種은 播種期가 늦어짐에 따라 減少되었고, 大粒種은 Laseui(26.03g), Kwangdojeodhyup(24.0g), Chejujerae Ⅱ(22.43g), Sparkle(20.43g) 等이었으며, 小粒種은 Thomas Laxton(14.63g), Frescory(14.70g), Daejung 11(14.95g) Jeonbug(14.95g) 等이었다. 9. 株當莢塘重도 早播할수록 많아 秋播의 平均莢當重(8.76g/株)에 比하여 春播의 平均莢當重(3.72g)은 겨우 42% 程度였다. 10. 株當 種實重은 早播할수록 많고, 早播할수록 많고, 晩播할수록 減少程度가 甚하여 秋播의 平均種實重(23.23g/株)에 比하여 春播의 平均(10.14g)은 44% 程度였으며 品種別로는 秋播時 多收性 品種이 春播에서도 共히 多收性은 아니었으며, 秋播에서 多收性品種은 Laseui, Targ, ChejujeraeⅡ, Thomas Laxton 等이었고, 春播에서는 Chejujerae I, Namuradaehyup, Kwangdojeokhyup, Alderman 等이었으며, 秋播와 春播에서 共히 多數性 品種은 Chejujerae I, Kwangdojeokhyup, Namuradaehyup 等이었다. 11. 遺傳力은 100粒重, 開花까지 日數, 生育日數 및 開花로부터 成熟까지 日數, 莢長 및 莢幅等은 比較的 높았고, 株當莢數, 株當分地數는 中種度였으며 株當 種實重, 莢當粒數, 株當莢當重에서는 낮은 傾向이었다. 12. 形質間의 相關은 播種期에 따라 다르며 一定한 傾向이 없었다. 種實重은 株當莢當重 및 株當莢數와 귀傳相關이 높았고, 100粒重과는 秋播에서 높게 나타났다. 13. 表現型相關은 遺傳相關이 큰 경우 큰값을 보였고, 大部分의 形質間의 表現型相關은 遺傳相關보다 多少 낮고 遺傳相關과 表現型相關과의 正負의 方向은 같은 경우가 많았다. 14. 株當 種實重에 對한 經路係數는 全播種期에서 直接效果가 모두 큰 形質은 없으나 大體로 높은 것은 開花까지 日數, 株當莢當重, 100粒重, 株當 莢數 順이었다. 15 株當莢當重, 100粒重 및 株當莢數는 株當種實重과 遺傳相關은 勿論 直接效果도 높아 多收性 品種의 選拔指標로 活用할 수 있다고 思料된다. These studies were carried out to clarify the ecological response and the changes of selection criteria in accordance with the difference of seeding dates in pea (Pisum sativum L.) The studies were conducted to estimate genotypic, phenotypic and environmental correlations, heritability, and path coefficient for the major agronomic characters using 17 cultivars including Sparkle which were seeded on October 15, November 4, February 20 and March 11 in Cheju Island, Korea. The result obtained were summarized as follows: 1. The days from seeding to flowering and days from seeding to maturity were prolonged in early seeding and shorted in late seeding, the middle of October was the optimum seeding time to get the highest yield and the agronomic characters of the yield components in Cheju Island. 2. Early maturing cultivars were Sparkle, Jeonbug, Jeonkwang 30 and Sojeong, and late muturing cultivars were Frescory, Chejujerae Ⅰ, Ⅱ, Alderman, Namuradaehyup and Laseui. 3. Stem length was longer (50cm) in winter seeding than in spring. The short stem cultivars (70-100cm) were Sparkle, Profinos R. S. Thomas Laxton, Jeonbug and Alderman, and the middle stem cultivars (110-140cm) were Frescory, Chejujerae Ⅱ, Laseui, Namuradaehyup and Rondo, the other cultivars were 140-200cm in stem lenght. 4. As pea were seeded early, the number of branches per plant increased. The numerous branch cultivars were Frescory, Chejujerae Ⅰ, Ⅱ, Kwangdojeokhyup, Alpine and Namuradaehyup, and the others were small branch cultivars. 5. Pod length and pod width had no change with the difference of seeding dates, but long pods were 8cm to 9cm and short pods were 6cm to 7cm. 6. As the pea were seeded late, the number of pods plant decreased greatly, but cultivars with the numerous pod were Chejujerae I. Targ, Frescory, Alpine, Thomas Laxton and Alderman. 7. The number of seeds per pod had no change with the difference of seeding dates, the large number of seeds were 6 to 7 and the small mumber were 4~5. 8. Weight per 100seeds of pea was decreased in late seeding, cultivars with heavy seed were Laseui (26.03g), Kwangdojeokhyup (24.0g) Chejujerae Ⅱ(22.43g) and Sparkle (20.43g), and cultivars with light seed were Thomas Laxton (14.63%), Frescory (14.7g), Daejung 11 (14.95) and Jeonbug (14.95g). 9. The shell weight of pea in early seeding was increased, the average shell weight in spring seeding was lighter than in winter seeding. 10. The weight of seed per plant in early seeding was increased, but that was decreased greatly in late seeding, average seed weight was 56% lower in spring seeding than in winter seeding. High yielding cultivars in winter seeding were not always high in spring seeding High yielding cultivars in winter seeding were Laseui. Targ, Chejujerae Ⅱ and Thomas Laxton, and high yielding cultivars in spring seeding were chejujerae Ⅰ, Namuradashyup, Kwangdojeokhyup and Alderman, and high yielding cultvars for both spring and winter were Chejujerae Ⅰ, Kwangdojeokhyup and Namuradaehyup. 11. The Heritabilities estimated for the days from seeding to flowering, from flowering to maturity, from seeding to maturity, 100 seed weight, pod length and pod width were high, while the number of pods and the number of branches per plant showed medium values, the seed weight and shell weight per plant and the number of seeds per pod were small values. 12. Relationships between the characters differed with seeding dates and the changes in correlation coefficient had no definite tendency. As for the genotypic correlation, the seed weight was highly correlated with the shell weight and the number of pods per plant in the both seasons and with 100 seed weight in winter. 13. The phenotypic correlations were showed high positive values when genotypic correlation were high, The most phenotypic correlation values were lower than genotypic correlation. The genotypic correlations and phenothpic correlations were generally showed the same directions in positive and negative. 14. Direct effect estmates of the characters versus seed weight were not high at all the seeding dates, but the days from seeding flowering, the shell weight per plant, 100 seed weight and the number of pods per plant had a large influence. 15. The genotypic correlation coefficient and direct effects of the shell weight per plant, 100 seed weight and the number of pods per plant versus the seed weight showed high positive values, as a result, it was thought that these characters were useful selection criteria for the seed yield.

예·체능 전공 대학생들의 여가실태와 개선방향에 관한 연구

박장근,정수현,임란희 명지대학교 예체능연구소 2003 藝體能論集 Vol.14 No.-

The objective of this research which investigates the leisure activity form and a satisfactory degree of physical training and art university students and there is a place where it presents the improvement plan for this field In order to attain the objective of the research We executed self-admistration method question of the collection from 2001 May 21st until 2001 August 31st to 370 people physical traning subject 100 person, fine arts subject 100 person music 100 person baduk subject 70 person university students who are located in the H, K university in seoul and M, Y university in Kyonggi-Do It reveals from the research the following conclusion. 1. the leisure activity participation which it follows in personal quality and form quality analysis(1) views from result of the participation form the appreciation 27.3%, sports 26.8%, playing and amusement 26.8% it appeared the fact that it is the difference which considers form the sex the subject, the religion and the family economic leave. (2) According to the results of participation for one month, from the fourth to the sixth of attendance was 27.1 percent and from the third to the fourth of attendance was 24.1 percent. However, there were some differences in two items as major add religion. (3) From the result of the participation form due to the dwelling duration, from two hours to three hours was 35.7% percent. But there were some differences in gender as well. (4) From the result of the participation form due to the duration, over three years was 49.2 percent and there was no difference in this part. (5) From the result of the participation form due to the companion, a friend was 65.9%, other sex friend was 15.4% However, There were some differences in two items as major and grade. (6) From the result of the participation for due to the pocket money in one month, from 200,000 to 300,000 was 35.1 percent , from 100,000 to 200,000 was 23.0 percent, there were also some differences in two items as grade and the family economic level. (7) The result of the participation form which it follows in activity consuming expense is appeared that 10-30 thousand won below 48.1% and 10 thousand won 24.1%. It appeared the fact that there is the difference un the grad the family economic level. (8) The result of the participation form which it follows in hindrance activity, there are 39.7% economic power 30.8% It appeared the fact that there is the difference insufficient time in the subject the family economic level. 2. The evaluation scale regarding a leisure activity satisfactory analysis satisfactory degree is like that very at 5 scales of the Likert, (5 pieces), it is like that, (4 pieces), it is an usual, (3 pieces), it is not like that, (2 pieces), it is not like that very, (1 piece) with it evaluated, When it sees a leisure activity satisfactory moral investigation result, it appers Order broad way that stress solution average 3,87 (sd=.96) with to appear most highly ,friendship planning average 3.55 (sd=1.07) using of knowledge 3,29 (sd=.99) study ability improvement 3,09 (sd=1.10) physical strength increase 3.05(sd=1.23).

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.