Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

젊은 성인에서 흡연에 의한 상완동맥 내피기능의 부전에 관한 연구

이상철,권영주,방덕원,이선해,이보영,김지욱,김영훈,온영근,현민수,김성구 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1

Background and Objectives : Cigarette smoking is a major factor and the most modifiable risk factor for atherosclerosis. Endothelial dysfunction is an early event in atherosclerosis, before the structural change of the systemic arteries. We hypothesized that endothelial dysfunction might be present in the systemic arteries of young adult smokers and that this might be dose-dependent phenomenon. Therefore, we try to certify that smoking is associated with endothelial dysfunction in healthy young adults without other risk factor of atherosclerosis. Subjects and Methods : we studied noninvasively 29 subjects aged 3 to 4 decades without other risk factor of atherosclerosis, they were composed of the two groups, current smokers(n=15) and nonsmokers(n=14). Smoking history varied from 3 to 20 pack years. Using high-resolution ultrasound, vessel diameter and mean flow rate were measured at rest, during reactive hyperemia(with flow-mediated endothelium-dependent dilation), and after sublingual nitroglycerin(NG-induced endothelium-independent vasodilation). Result : Flow mediated endothelium dependent dilation was observed in the control subjects (9.4±3.44%) but was impaired in the smokers(5.8±2.51%)(p=0.004). NG-induced endothelium independent dilation is no difference in all subjects. Conclusion : Cigarette smoking is associated with endothelial dysfunction in healthy young adults.

강인한 퍼지 디지털 PI+D 제어 시스템의 설계 및 구현

권태익,이재홍,김승철,설재훈,임영도 동아대학교 정보기술연구소 2001 情報通信硏究所論文誌 Vol.9 No.1

In this paper, Fuzzy Digital PI+D Controller plans for load, noise, plant change, Fuzzy Controller makes use of simple four rule and membership function, and plant used three phase Induction Motor. Characteristic of system compared from experimentation respectively the proposed Control System, Digital PID Control and Digital PI+D Control System.

협채용 강낭콩의 채종기술 확립 : Phaseolus vulgaris L.

권철상,황영현 慶北大學校 農業科學技術硏究所 2004 慶北大農學誌 Vol.22 No.-

Pod-edible bean or snap bean is a fairly new crop to domestic farmers but the national demand is steadily increasing in recent years along with the development of westem food business and change in dietary patterns. At the same time, much efforts are being made to export it to foreign country, mainly to Japan. The amount of seeds introduced from outside is also continuously increasing along with the enlargement of area planted for the crop. Hybridization breeding for the crop has already been started to supply the cheaper and better seeds which will reduce the seed costs and forster the higher income to the farmers. In this experiment, several technologies related with the production of quality seeds are preliminary investigated. Some of the results obtained are summarized as follows; 1. Highly significant interaction was recognized between planting dates and no. of pods per plant and no. of branches but no interaction between planting dates and plant height and no. of nodes on main stem. Days to maturity was proportionally reduced to later planting dates. 2. Rate of viviparous pods and seeds was gradually increased in later planting dates but rate of germination was increased in earlier planting dates with lower germination rate in white seed coat grains than in colored seed ones. 3. Seed yield was highter in the earlier planting dates with a great deal of varietal difference. Early to mid April was considered to be the optimum planting dates for snap bean in Kyungbuk area. High correlation was recognized between seed yield and no. of pods per plant, no. of seeds per plant, and 100 seed weight. 4. Days to flowering was three and seven days longer in Cheongsong, high mountainous area than in Kunwi, somewhat prairie lowland. One hundred seed weight was also higher in Cheongsong than in Kunwi. Rate of viviparous grains, pods, and decayed seeds was higher in Cheongsong but, at the same time, the rate of germination and seed yield was also higher in Cheongsong. 5. One hundred seed weight of KLG5007 increased continuously up to 35days after flowering and decreased thereafter but that of KLG50027 increased to 40days after flowering and slowly reduced thereafter. The content of crude oil reached to maximum at 40 days after flowering and reduced thereafter. The rate of germination in Gangnangkong 1 was the highest, 89.3%, at 35 days after flowering and reduced thereafter while that in KLG50027 reached to maximum, 70.7%. at 40days after flowering and reduced thereafter. Thus, the optimum harvesting time for snap bean was considered to be 35~40days after flowering. 6. The snap bean pods at yellow bean stage easily became viviparous ones under saturated moistured conditions for 24 hours at 25~30℃. Therefore, it is recommended to harvest pods somewhat earlier than yellow-bean stage and let them do post maturing, especially when it is to be rained.

산청군 산림지가 형성요인에 관한 연구

권철현,이상태,신현철,최재채,정영관 경상대학교 농업생명과학연구원 2003 농업생명과학연구 Vol.37 No.1

본 연구는 산청군 남부와 북부지역 361개소의 공시지가와 일반시가에 대하여 분석하였다. 지가 형성요인에 대하여 단계별 회귀분석을 실시하였으며, 그 결과는 다음과 같다. 남부지역에 대한 공시지가와 관련된 5변수 모형에 의한 추정식은 Y = 332.1973 +0.0099X_26 - 0.3577 X_8+ 0.0291X_24 - 2.6768X_2 - 26.1452X_3 이며, 회귀식에 대한 설명력은 90%로 높게 나타났으며, 일반시가에 대한 추정식은 Y = 1035.7976 -185.8280X_21 -3.3937X_1 + 405.6658X_19 -0.4703X_8 이며, 추정식에 대한 설명력은 92%롤 비교적 높게 나타났다. 북부지역에 대한 지가 형성요인에 의한 공시지가 추정모형은 Y = 176.7875 + 0.0205X_25 -0.1168X_8 + 0.0015X_26 -46.3447X_21 로 추정되었으며, 회귀식에 대한 설명력은 96%, 일반시가의 추정 모형은 Y = 203.0697 + 0.0430X_25 + 0.0027X_26 -28.8276X_4 -46.7856X_21 -0.0007X_23 으로 추정되었으며, 회귀식에 대한 설명력은 90%로 나타났다. 이상과 같이 접근요인은 부의 영향을, 그 외 다른 요인들은 지가에 양의 영향을 미치는 것으로 나타났다. This study was carried out to analyze the publicly announced land price and actual land price compared to the northern and southern region of 361 forest land place in Sanchung county. To decipher factors for making forest land price it used the stepwise regression analysis. And the result of analysis are followings; Y = 332.1973 +0.0099X_26 - 0.3577 X_8+ 0.0291X_24 - 2.6768X_2 - 26.1452X_3 (R^2=90%) and the estimation equation of actual price analyze the publicly announced and actual price compared to the northern and southern regions of Sanchung county of price was obtained as Y = 1035.7976 -185.8280X_21 -3.3937X_1 + 405.6658X_19 -0.4703X_8(R^2=92%). In the northern region, the estimation equation of publicly announced land price by the factors for making forest land price was obtained Y = 176.7875 + 0.0205X_25 -0.1168X_8 + 0.0015X_26 -46.3447X_21(R^2=96%) and the estimation equation of actual price was obtained as Y = 203.0697 + 0.0430X_25 + 0.0027X_26 -28.8276X_4 -46.7856X_21 -0.0007X_23(R^2=90%). In the result of the stepwise regression analysis, it was a showed negative effect of the proximity factor and the positive effect between others factor and land price.

한국의 재활의료 전달체계

권혁철,정영일,남은우 高神大學校 保健科學硏究所 1993 보건과학연구소보 Vol.3 No.-

This study was carried out for reorientation of Rehabilitation Service Delivery System (RSDS) through reviewing reference and observing field practice. The most important results are as follows: 1. The current rehabilitation facility for handicapped persons can be classified into four categories : (a) those for physically disabled persons, (b) those for mentally disturbed persons, (c) those for visually disturbed persons, and (d) those for acoustic and speech disturbed persons. The nationwide number of rehabilitation facilities is 101 of those, 43.5% is for physically disabled persons and 32.9% is for mentally disturbed persons. 2. A small number of circulating rehabilitation centers for physically disability are being run by comprehensive rehabilitation centers since 1992. 3. The hospitals are self-supporting only 20% of their operational costs, and the rest of the operational costs comes from federal tax(40%) and local tax(40%). 4. The number of handicapped persons in Taegu and Kyungpook province is estimated to be about 50,000, but only 20 percent out of them ws registered. The rehabilitation facilities located in this area receives 69% of their operational costs from central government. This figure is higher than the national average of 64.6%. 5. Although RSDS is different from other medical delivery system, nonetheless, it should be developed as a sub-system of national health care delivery system. Its development should also be in accordance with the need of local community. Therefore we suggest the development policy for the development of RMDS must consider the following points.; First, all rehabilitation-related medical systems should be integrated unde ra single comprehensive system so that handicapped persons may easily obtain better service available. Second, rehabilitation programs based on local community should be rejuvenated. In addition to in-patient service, development of intermediate facilities and programs connecting home and society should be encouraged. Third, rehabilitation medical services should be more specialized. Also, more emphasis should be given to team approach to rehabilitation medical services. Fourth, a comprehensive rehabilitation information system should be developed so that handicapped persons may have easy access to public welfare facilities, and the central government should formulate a comprehensive long-term plan for the rehabilitation system.

호밀 (Secale cereale L.)유식물의 질산환원효소의 활량과 단백질함량에 관한 Cycloheximide의 영향

권오용,이영하,오희목,박흥순,이진철 충남대학교 자연과학연구소 1988 忠南科學硏究誌 Vol.15 No.2

This work was accomplished with 6 day-old rye (Secale cereale L.) seedlings to determine the effect of the antibiotics by cycloheximide on in vivo nitrate reductase activity, protein and RNA content. The nitrate reductase activity by treating 0.1μM and 0.1 mM cycloheximide was lower than that of the control group. The optimum pH for the nitrate reductase of the control group was 7.6 in the range of pH 5.6-8.0, but, in the case of 0.1mM cycloheximide treatment group, the optimum pH was decreased to 6.8 within the weak the acid region. The protein content of shoot and root in the 0.1μM and 0.1 mM cycloheximide treatment groups were respectively found at the 96%, 82% level of that in the control group. In the higher cycloheximide treatment (0.1 mM CH), not only nitrate reductase activity and protein content but also RNA content was greatly decreased. In this fact, it was suggested that the 0.1 mM cycloheximide had affected on the RNA polymerase. On the basis of there results, it was concluded that the decreased nitrate reductase activity by treating cycloheximide occurred primarily according to the decreased nitrate uptake, and the decreased protein and RNA content depended upon the results of the direct and indirect effect of cycloheximide on the protein synthesis.

생쥐 안구에서 산화적 손상에 의한 superoxide dismutases와 metallothionein의 나이에 따른 유도의 차이

이홍영,이태범,안춘산,변익건,최석민,권대승,최철희 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2

The basal levels and inducibility of superoxide dismutases (SODs; Mn-SOD and Cu/Zn-SOD) and metallothionein (MT) was investigated in the eyes of mice with age. Oxidative stress was induced by paraquat, an intracellular superoxide generator, in 1, 4, 8, and 12 months of age and then mRl\As of SODs and MT in the eyes were determined by RT-PCR assay. The basal level of Mn-SOD mRNA increased from 1 month to 8 months but decreased thereafter. Mn-SOD mRNA was induced by paraquat until 4 month but not after 8 months. On the other hand, the basal level of Cu/Zn-SOD mRNA decreased with age. Cu/Zn-SOD mRNA was not induced by paraquat until 4 months. The basal level of MT mRNA declined with age whereas its inducibility by paraquat was intact at all ages. Taken together, the results indicate that SODs and MT are differentially expressed and induced according to the age. It could be also implicated that failure in induction of Mn-SOD with age may be one of causative factors in the aging process whereas induction of Cu/Zn-SOD and MT may be one of important factors in defense against oxidative stress in the eyes. 서론: 최근 노화는 반응성 산소종에 의한 산화적 손상의 축적결과라는 설이 각광을 받고 있다. 노화과정에서 노화와 관련된 질병을 비교적 잘 나타내는 안구를 선정하고, 정상생쥐의 안구에서의 superoxide dismutases (SODs) 와 metallothionein (MT) 의 함량 뿐 아니라 산화성 스트레스를 유발하는 paraquat에 의한 SODs와 MT의 유도능과 나이와의 상호관계를 조사하여 이들의 노화과정에서의 역할을 규명하고자 하였다. 재료 및 방법 : 본 연구에서 1, 4, 8, 12개월된 정상생쥐의 안구에서 반응성 산소종 생성의 초기에 중요한 방어기전인 SODs mRNA와 hydroxy radical (OH·)에 의한 산화적 손상의 마지막 방어기전인 MT mRNA의 함량과 산화성 스트레스를 유발하는 paraquat에 의한 유도능을 역전사 중합효소 연쇄반응 (RT-PCR) 으로 조사하였다. 결과: 정상생쥐의 안구의 노화과정에서 Mn-SOD와 Cu/Zn-SOD, 그리고 MT mRNA의 항정상태 함량을 조사한 결과, Mn-SOD mRNA는 8개월까지는 증가하다가 12개월에서 감소하였으나, Cu/Zn-SOD mRNA는 나이와 함께 감소하였다. 그러나 MT mRNA 는 8개월까지는 감소하다가 12개월에서 약간 증가하였다. 산화성 스트레스를 유발하는 parraquat에 의하여 Mn-SOD mRNA는 1개월과 4개월에서만 유도되었고, Cu/Zn-SOD mRNA는 8개월과 12개월에서만 유도되었으며, MT mRNA는 관찰한 전 기간에서 유도되었다. 결론: 이상의 결과를 종합하면 SODs와 MT는 안구에서 나이에 따라 서로 다르게 발현되고 유도되는 것으로 생각되며, 노화과정에서 Mn-SOD유도의 이상이 노화의 원인이 되는 인자로 작용하고, 반면에 Cu/Zn-SOD와 MT의 정상적인 유도능이 산화적 스트레스에 대하여 방어역할을 하는 것으로 생각된다. 이와 같이 연령이 증가함에 따라 Mn-SOD, Cu-Zn-SOD, 및 MT의 발현과 유도능의 차이가 있게 되고, 그 결과 반응성 산소종에 의한 산화적 손상의 정도의 차이로 노화의 속도가 조절되지 않나 생각된다.

원광의대 부속 제 2병원 신경정신과 환자에 대한 통계적 고찰

박민철,김종주,박남진,오상우,권혁일,권영숙,박종호 圓光大學校 醫科學硏究所 1986 圓光醫科學 Vol.2 No.2

We examined 1,856 patients who visited Won Kwang Neuropsychiatric hospital since July 11 of 1984(since the hospital opened) until June 11 of 1986. We researched diagnostic and other distributions of inpatients and outpatients. The study revealed as follows : 1. Of total patients males visited this hospital more than females as 52.7%. Most of them(67.1 %) resided in Iri, Iksan and Kimje. In the point of insurance, insured patients and uninsured patients except medicaids were 73 %. Males(60%) were more insured medically than females (55.4%). While insured patients relatively resided in urban area, but uninsured patients except medicaids did in rural area. 2. Of outpatients neurotic disorder was the most as 35.1%, secondly schizophrenic disorder and thirdly affective disorder, but of inpatients schizophrenic disorder was the most as 41.4%, secondly neurotic disorder thirdly affective disorder. 3. Alcohol abuse (98.2 %), paranoid disorder, convulsive disorder and child mental disorder were mostly found in males, but neurotic disorder (59 .6 %), affective disorder and other psychotic disorder were mostly found in females. 4. In unmarried ones schizophrenic disorder ( 43 .6 %), neurotic disorder, other psychotic disorder were common, but in married ones neurotic disorder (55.1 %), schizophrenic disorder, affective disorder were common. 5. On the distribution of age schizophrenic disorder was found the most in the twenties (28.4 %), next in the thirties and in the forties, but neurotic disorder was found the most in the thirties, next in the twenties and in the forties. 6. On the distribution of age at onset schizophrenic disorder develops mostly during the twenties (45.5 %), secondly during the teens and thirdly during the thirties, but neurotic disorder develops mostly during the thirties and the twenties (53.1 %). 7. On the duration of hospitalization 34.4% of the patients was hospitalized during less than 15 days, 22.0% during 60-90 days and 80.4% during less than 3 months. 8. In the result of treatment 41.2% of the patients was improved and 31.7% a little improved. In total 72.9% of the patients got helped therapeutically.

뇌졸중 환자의 경상운동이 상지기능에 미치는 영향

조영남,김홍근,권혁철 대구대학교 특수교육재활과학연구소 2008 再活科學硏究 Vol.26 No.2

경상운동은 다른 쪽의 신체에서 일어나는 의도된 움직임의 경상 반전으로 발생하는 한 쪽 신체의 무의식적인 운동이다. 본 연구는 뇌졸중으로 인한 편마비 환자에게서 나타나는 경상운동이 상지기능에 미치는 영향에 대해 알아보고자 하였다. 65명의 뇌졸중 환자를 대상으로 연구한 결과, 경상운동이 나타나지 않은 환자군의 상지기능은 경상운동이 나타난 환자군의 상지기능과 통계학적으로 유의한 차이를 보였으며, 경상운동이 나타난 환자군에 비해 상지기능이 좋은 것으로 나타났다. 또한, 경상운동이 나타나지 않은 환자군과 경상운동이 경한 환자군, 경상운동이 중한 환자군의 상지기능을 비교한 결과 경사운동이 적게 나타날수록 상지기능이 좋은 것으로 나타났다. 연구의 결과를 종합하여 볼 때, 뇌졸중으로 인한 편마비 환자에게서 나타나는 경상운동은 상지기능을 감소시키는 요인 될 수 있는 것으로 나타났다. The purpose of this study was to compare upper extremity's motor function according to the mirror movements in hemiparetic patients with stroke. Mirror movements are involuntary movements in one side of the body that occur as mirror reversals of the intended movement on the other side of the body. The subjects of the study were 65 stroke patients who were admitted from May, 2004 to April, 2005 in the Y University medical center. This study used the Manual Function Test(MFT) and the Purdue pegboard test to evaluate upper extremity‘s motor function. The severity of mirror movements were assessed according to the criteria of Woods and Teuber. The results of the study was as follow; First, The upper extremity‘s motor function in hemiparetic patients without mirror movements was significantly different in hemiparetic patients with mirror movements(p< .05). Second, The upper extremity's motor function in hemiparetic patients with mild mirror movements was significantly different in hemiparetic patients with severe mirror movements(p< .05). The result showed that the mirror movements in hemiparetic stroke patients are correlated with upper extremity's motor function and the severity of mirror movements affected upper extremity's motor function. 경상운동은 다른 쪽의 신체에서 일어나는 의도된 움직임의 경상 반전으로 발생하는 한 쪽 신체의 무의식적인 운동이다. 본 연구는 뇌졸중으로 인한 편마비 환자에게서 나타나는 경상운동이 상지기능에 미치는 영향에 대해 알아보고자 하였다. 65명의 뇌졸중 환자를 대상으로 연구한 결과, 경상운동이 나타나지 않은 환자군의 상지기능은 경상운동이 나타난 환자군의 상지기능과 통계학적으로 유의한 차이를 보였으며, 경상운동이 나타난 환자군에 비해 상지기능이 좋은 것으로 나타났다. 또한, 경상운동이 나타나지 않은 환자군과 경상운동이 경한 환자군, 경상운동이 중한 환자군의 상지기능을 비교한 결과 경사운동이 적게 나타날수록 상지기능이 좋은 것으로 나타났다. 연구의 결과를 종합하여 볼 때, 뇌졸중으로 인한 편마비 환자에게서 나타나는 경상운동은 상지기능을 감소시키는 요인 될 수 있는 것으로 나타났다. The purpose of this study was to compare upper extremity's motor function according to the mirror movements in hemiparetic patients with stroke. Mirror movements are involuntary movements in one side of the body that occur as mirror reversals of the intended movement on the other side of the body. The subjects of the study were 65 stroke patients who were admitted from May, 2004 to April, 2005 in the Y University medical center. This study used the Manual Function Test(MFT) and the Purdue pegboard test to evaluate upper extremity‘s motor function. The severity of mirror movements were assessed according to the criteria of Woods and Teuber. The results of the study was as follow; First, The upper extremity‘s motor function in hemiparetic patients without mirror movements was significantly different in hemiparetic patients with mirror movements(p< .05). Second, The upper extremity's motor function in hemiparetic patients with mild mirror movements was significantly different in hemiparetic patients with severe mirror movements(p< .05). The result showed that the mirror movements in hemiparetic stroke patients are correlated with upper extremity's motor function and the severity of mirror movements affected upper extremity's motor function.