위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

T 세포활성항원 CTLA-4의 기능에 관한 연구 : T 세포에서 표적세포 살해능과 CTLA-4 발현과의 연관성 Target Cytotoxicity of T Cell Correlates with CTLA-4 Production

노만택,조양자,김용식,최용,조보현,최장원,정용훈 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.4

CTLA-4, a T cell activation antigen and a homologue of CD28, was originally identified as a gene by a series of reverse genetic approaches. While CD28 molecule has been characterized well as a stimulator of T-cell function via enhanced lymphokines production and stablilization of those mRNA, most of the functions of CTLA-4 remain unknown. It has been widely accepted that CTLA-4 functions as an immune suppressor which is down-regualting the function of CD28. We previously showed that 34 KD form of this antigen mainly expressed CD8+ subset, a cytotoxic or suppressor, of activated peripheral blood lymphocyte. Based on our previous finding this study was conducted to further characterize immunological function of CTLA-4 especially in terms of involvement of this molecule in T-cell effector function mediating target cell cytotoxicity. 4 human T cell clones with different target cytotoxicities were employed in this study. NBL46 (CD4+) and NBL77 (CD8+) were cytotoxic and NBL32 (CD4+) and NBL58 (CD 8+) were non-cytotoxic to target LBF cell in target cell chromium release assay. And in Western blot assay 34 kD antigen was detected in NBL46 (CD4+) and NBL77 (CD8+) clones but not in NBL32 (CD4+) and NBL58 (CD8+) clones. It was summarized that expression of the CTLA-4 antigen was associated with cytotoxicity but not with subset phenotypes of T cells. In conclusion CD8+ T subset of PHA-stimulated PBL was major and only CTLA-4 producer and this molecule was induced during mid to late stage of T cell activation. The cytotoxicity of T cell clones to its target cell was directly correlated with its CTLA-4 production and vice versa. And it was highly suggested that primary function of CTLA-4 may involved in T cell effector function which mediates target cell killing.

Hybrid Light‐Emitting Diodes: Electrically Driven Quantum Dot/Wire/Well Hybrid Light‐Emitting Diodes (Adv. Mater. 45/2011)

Ko, Young‐,Ho,Kim, Je‐,Hyung,Jin, Li‐,Hua,Ko, Suk‐,Min,Kwon, Bong‐,Joon,Kim, Joosung,Kim, Taek,Cho, Yong‐,Hoon WILEY‐VCH Verlag 2011 ADVANCED MATERIALS Vol.23 No.45

<P>Electrically driven hybrid light‐emitting diodes (LEDs) consisting of quantum dots, wires, and wells based on the nanometer‐sized pyramid GaN structure are reported by Taek Kim, Yong‐Hoon Cho, and co‐workers on page 5364. The LEDs exhibit mixed emissions from InGaN quantum dots, wires, and wells formed at the tops, edges, and sidewalls of the pyramids, respectively. The hybrid LEDs containing low‐dimensional quantum structures provide a broad‐band, highly efficient visible lighting source. </P>

그림책의 패러디 전략과 구성원리 : ｢아기 돼지 삼형제｣를 중심으로

조용훈 한국초등국어교육학회 2009 한국초등국어교육 Vol.41 No.-

이 연구는 그림책 ｢아기 돼지 3형제｣의 패러디 전략을, 그림과 글과의 미적 관계를 고찰하여 구명한 논문이다. ｢아기 돼지 3형제｣는 도덕적·윤리적 가치를 교육하거나, 새로운 텍스트의 생산, 이밖에도 읽기와 쓰기의 통합교육을 위해 연구돼 왔다. 그런데 패러디 대상으로서의 원전에 대한 논의 없이 연구가 진행돼 왔고 더구나 그림책임에도 불구하고 글과 그림의 미적 관계를 동시에 고려하지 않았다. 이에 주목하여 이 글은 모본으로 알려진 제이콥스의 텍스트와 최근 국내외에서 출간되는 텍스트들을 우선 비교 검토했다. 그리고 3편을 선정해서 글과 그림의 관계가 패러디 전략에 어떻게 작용하고 있는지 상세하게 고찰했다. 3편은 글과 그림이 설명과 보완의 관계가 아니라 괴리와 이화, 즉 아이러니관계에 있는 텍스트이다. 글과 그림의 충돌을 통해 주제를 참신하게 전달하는데 주력한다. 그 결과 ｢늑대가 들려주는 아기돼지 삼형제 이야기｣는 글의 내용만으로는 기존의 통념을 깨는 텍스트처럼 읽히나 실은 그것이 왜곡됐다는 것을 글과 그림의 아이러니칼한 관계로 제시한다. 이 텍스트는 패러디를 재차 패러디한 중층 구조로 구성됐다. ｢아기늑대 세 마리와 못된 돼지｣는 두 동물의 역할을 전도시켜 관습적 생각을 새삼 재고하게 만든다. 요컨대 이웃이나 타자에 대한 배타적 태도는 실은 타자의 실제적 위협에서가 아니라 자기 안위라는 이기적 태도에서 기인한다고 주장한다. 공동체는 서로를 이해하고 함께 할 때 공존가능하다는 것을 새삼 일깨운다. 끝으로 ｢아기돼지 세 마리｣는 계승돼 온 텍스트를 새로운 방식으로 재생산한다는 것은 어떤 시의성을 갖고 있으며 그것은 어떻게 가능한가 등의 질문을 통해 글쓰기의 본질을 새삼 고민케 한다. 특히 텍스트의 교차와 공존을 다양한 그래픽과 연계시켜 그림책이 갖는 그림과 글의 중요성을 끊임없이 환기시켜 주목된다. 패러디는 전통적 유산을 새롭고 비판적으로 통찰하되 예술성을 잃지 않아야 하며 항상 새로운 해석의 가능성을 제공해야 한다. 이런 점에서 그림책은 글과 그림의 미학적 관계가 패러디 전략에 어떻게 기능하는지 검토하는 것은 당연하다 할 것이다. This study has considered the parody technique of the illustrated book [Three Little Pig Brothers] by examining the aesthetic relation of writing and painting. This book has been studied in light of the education of its moral or ethical value, or production of a new text, or integral education of writing and reading. However, there has been no study on the original text as the object for parody;moreover, despite the fact that it is an illustrated book, the previous studies have not concerned themselves with the aesthetic relation of writing and painting. Shedding light upon these aspects, this study has compared and examined the text by Jacobs known as the original text, and other texts recently published inside and outside the nation. After that, it has examined in detail the impact of the relation of writing and painting on the parody technique by selecting three particular texts. The three texts are the texts in which writing and painting are in ironical relation, namely the relation of alienation and differentiation not the relation of explanation and supplementation. They focus on conveying the theme in a fresh way by making writing being in conflict with painting. As a result, while the content of ｢The true story of the 3 little pigs by a wolf｣ reads like a text that subverts the normal conception, the text shows that in fact it is distorted by with the ironical relation of writing and painting. This text consists of multiple structures in which a parody is parodied. The text ｢The three little wolves and the big bad pig｣ makes the reader to rethink the conventional thought by reversing the role of two animals. In short, it argues that the unfriendly attitude on neighbours and others in fact stems from the egoistic attitude with concern for self-safety rather than real antagonism towards them. This reawakens the truth that a community can exist when the members of the community understand each other cooperating with each other. Lastly, the text ｢The 3 little pigs｣ allows the reader to reconsider the nature of writing by presenting such questions as what kind of implications does it have to re-produce a text inherited in a new way, and how it is possible. In particular, it is worth attention as it continuously reminds the reader of the importance of the mixture of writing and painting in an illustrated book by combining variety of graphics with the texts. The parody work should not lose its value as an artwork always providing the reader with the possibility to be newly interpreted while it should reconsider the tradition from a new and critical perspective. In this regard, it would be worthwhile to examine how the aesthetic relation of writing and painting has an effect upon the parody technique in the illustrated book.

기-액병류상향 충전탑에서 액체체류량과 축방향혼합특성

조지훈,손민일,박용성,함병호,김태옥 明知大學校 産業技術硏究所 1993 産業技術硏究所論文集 Vol.12 No.-

For upward cocurrent gas-liquid flow in a packed column, holdup and axial mixing characteristics of liquid were investigated. In an air-water-glass bead system. liquid holdup and residence time distribution(RTD) were measured and Peclet number based on axial dispersion model was evaluated from experimental RTD. We found that liquid holdup was increased with increasing liquid velocity and size of packing material, and it was decreased with increasing gas velocity. Also, liquid holdup for the cocurrent up flow system was larger than that for the downflow system at the same experimental conditions. As increasing gas velocity, the in fluence of packing size and operation method on liquid holdup was reduced. The calculated Peclet number was not affected by gas velocity, and it was increased with increasing liquid velocity and with decreasing packing size. Furthermore, the effect of liquid velocity on Petlet number for higher liquid Reynolds number(Re1>70) was larger than that for lower Re1. In these conditions, correlations of the dynamic liquid holdup and the Bodenstein number were obtained.

상호텍스트성 중심의 동시 교육 방법 연구

조용훈,고지운 淸州敎育大學校 初等敎育硏究所 2002 初等敎育硏究 Vol.12 No.-

上界解法에 의한 엎셑鍛造中의 形狀變化와 荷重의 豫測

趙鏞柱,李丙薰 부산대학교 공과대학 1983 硏究報告 Vol.26 No.-

The change of geometry during upset forging of a cylindrical rod was predicted and was described as a function of reduction in height, height-radius ratio, and shear fiction factor. It was assumed that the change of geometry occured in the path of lower upper bound load. The upper bound load considering the changed shaped due to bulging was lower than that not considering the changed shape.

대학교 신입생의 특성에 관한 실태조사(Ⅱ) : 1995학년도 조선대학교 신입생을 대상으로 1995 chosun University Entrants

조용래,박상학,김상훈,표경식,김학렬,김양옥,김기순,박종 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.2

1980年度 痢疾樣 大便을 가진 患兒들에 對한 臨床的 細菌學的 觀察

趙龍勳,南聖枝,具滋薰,安斗洪,薛盛用 慶北大學校 醫科大學 1980 慶北醫大誌 Vol.21 No.2

1980年 1月부터 1980年 8月까지 滿 8個月間 痢疾樣 大便을 主訴로 本 小兒科에서 入院및 來院한 患兒 75名을 對象으로 臨床的, 細菌學的 觀察을 하여 다음과 같은 咸績을 얻었다. 年齡別 分布는 1歲에서 5歲 사이가 35例(47%)로 가장 높았으며 이들中 Shigella는 23例(30%), Entameba histolytica는 13例(17%)였고 Vibrio parahaemolyticus는 한 例도 檢出되지 않았다. 檢出된 Shigella 23菌株는 모두 Shigella flexneri 였다. 月別分布는 6月 16例(20%), 7月 30例(40%)로서 最多數를 占하였으나 細菌性 痢疾의 경우 月別에 관계없이 均等하게 分布하고 있었다. 臨床症狀및 理學的 所見으로는 細菌性痢疾의 경우 38℃ 以上의 發熱 19例(83%), 嘔吐 6例(26%), 腹痛 8例(35%), 痙攣 5例(22%)였으며, 아메바性 痢疾에서는 發熱 4例(31%), 痙攣 1例(8%)로서 細菌性 痢疾에서 아메바性 痢疾보다 發熱과 痙攣이 빈번히 나타났다. 泄瀉의 性狀에서는 細菌性 痢疾 23例中 血粘液性이 19例(83%)였는데 비해 아메바性 痢疾 13例에서는 粘液性이 8例(62%)였다. 泄瀉의 回數에서도 細菌性 痢疾에서는 대부분이 11回以上이었는데 比해 아메바性 痢疾에서는 대부분이 10回未滿이었다. 末梢血液에서의 白血球數는 全例의 35%에서 白血球 增多症을 보였다. 分離된 Shigella 23菌株에 對한 抗生劑 感受性 檢査를 平板混合포稀釋法에 依해 調査해 본 結果 kanamycin, gentamicin, amikacin, cephaloridine, rifampin이 100%의 感受性을 나타내어 가장 높았고, nalidixic acid에서도 87%의 感愛性을 나타냈으며, sulfonamide, chloramphenicol, streptomycin, tetracycline, ampicillin, bactrim 에서는 한 菌株를 제외한 모든 菌株에서 耐性을 나타냈다. 그리고 이들 Shigella 23菌株中 1菌株를 제외한 나머지 모든 菌株에서 6種 以上의 抗生物質에 對해 多抗生物質耐性을 보여 주었다. A clinical and laboratory study was conducted on 75 children with dysentery-like stool, who were admitted or visited to our pediatric department during 8 months period from January to August 1980. The following results were obtained: One to five years of age group was affected most frequently (47%). Shigella flexneri was identified by stool culture in 23 cases (30%) and Entameba hitolytica in 13 cases (17%). In bacillary dysentery group, fever was the most common symptom occuring in 83%, followed by abdominal pain in 35%, vomiting in 26% and convulsion in 22%. In amoebic dysentery group, fever was noted in 31% and convulsion in 8%, showing some contrast to the frequency of fever and CNS manifestation. About the character of diarrheal stools, 83% of bacillary dysentery group showed bloody, mucoid stool and 62% of amoebic dysentery group mucoid ones. Frequency of diarrhea was 11 times per day or more in 73% of bacillary dysentery patients, and 10 times per day or less in 92% of amoebic dysentery patients. The result of sensitivity test of isolated Shigella to various antibiotics were as follow: 100% sensitive to kanamicin, gentamicin, amikacin, cephaloridine and rifampin. 87% to nalidixic acid, and 4.3% to sulfonamide, chloramphenicol, streptomycin, tetracyclin, ampicillin and bactrim. And 22 out of 23 isolated Shigella strains revealed multiplydrug-resistance patterns to 6 or more antibiotics.

운율, 미적 구조의 원리

조용훈 청주교육대학교 2001 論文集 Vol.38 No.-