중국산 중생대 후기 거미화석(거미목 : 꼬마거미과) 고찰

김주필(Joo Pil Kim),지승환(Seung Hwan Ji),최원문(Won moon Choe) 한국거미연구소 2017 한국거미 Vol.33 No.2

중국 지린성(吉林省) 남부 지역인 랴오위안(Liaoyuan) 탄광 도시인 중생대 후기 셰일(Shales) 지층인 Yixian 층에서 발굴된 꼬마거미과 일종인 Theridiidae sp를 보고한다. This paper report one species, Theridiidae sp. Type Specimen Araneidae sp. was excavated from Lyaoyuan, Jilin China. Inside a stratum the Mesozoic eva (creataceous period). Type Specimen of Lycosidae sp. is deposite at the Joo-pil spider museum. Namyangjoo-si, Gyeongi-do.

역행성 심정지 도관 삽입을 위한 술 중 경식도심초음파의 유용성

유미숙;최원주;김정원;박장수;김경태;김지연;어상일 인제대학교 2011 仁濟醫學 Vol.32 No.-

Background: Retrograde cardioplegia catheter (RCC) insertion is one of methods for administration of cardioplegics during cardiopulmonary bypass (CPB). However its success rate depends on only surgeon's experience. We thought the transesophageal echocardiography (TEE) can guide the R CC insertion, because TEE is commonly used for monitoring status of heart during cardiac surgery. This study was designed to evaluate the RC C insertion time by TEE guidance versus conventional method without T EE guidance. Methods: Sixty patients who were scheduled to undergo elective coronary artery bypass graft (CABG) surgery under general anesthesia were divided into groups as follows: group T [RCC insertion into coronary sinus (CS) by TEE guidance, n=30] and group C [RCC insertion into CS by conventional method, n=30]. We recorded the time of insertion of RCC in to CS in two groups. RCC insertion was done by TEE guidance in case that time was over two minutes by conventional methods in group C. Results: The overall time of RCC insertion into CS was 63.8 ± 23.6 seconds in the Group T and 102.3 ±55.7 seconds in the Group C, respectively (p=0.001). There were no complications during RCC into CS by T EE guidance. Conclusions: TEE guidance for RCC insertion into CS is shorten the time of insertion.

Prevalence of Anti-PF4 Antibodies After First and Second ChAdOx1 nCoV-19 Vaccinations in Women With Adverse Events: A Brief Report and Literature Review

Choe Kye Won,Lim Yong Kwan,Kweon Oh Joo,Lee Mi-Kyung,Chung Jin-Won,Kim Hye Ryoun 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.3

관해유도 항암요법을 받는 백혈병 환자에서 진균 감염증의 예방 : 무작위 배정법과 이중 눈가림법에 의한 Fluconazole과 Nystain의 효과에 관한 다기관 공동연구 A Randomized, Double-blind, Multicenter Trial to Compare Fluconazole with Nystatin

최강원,오명돈,배현주,백경란,박선양,김병국,신완식,강문원,진종률,박종원,김춘추,김동집,한지숙,민유홍,이선주,고윤웅 대한화학요법학회 1993 대한화학요법학회지 Vol.11 No.2

Fluconazole의 진균 감염증 예방 효과와 안전성에 관하여 3개 대학병원에서 관해유도화학요법을 받는 급성 백혈병환자를 대상으로 무작위 배정법과 너도나도 누가림법에 의하여 연구하였다. 모두 62명의 환자에게 fluconazole(100㎎ bid) 또는 nystatin(1,000,000IU/day)을 무작위로 투여하였다. 투약은 관해유도화학요법과 같은 날짜에 시작하여 호중구수가 1,000㎣이상으로 회복되거나 진균 감염증이 확인되거나 의심되어 Amphotericin-B를 시작하거나, 약과 관련된 부작용이 나타날 때까지 계속하였다. 진균 colonization은 fluconazole군에서 감소하였으나 nystqatin군에서는 증가하였다, 표재성 진균감염증으로 nystatin군에서 C. albicans 진균혈증 1례와 C.parasilosis 진균혈중 1례가 발생하였다. 경험적 항진균요법으로 Amphotericin-B를 투여한 경우는 fluconazolerns 34명중 7례(21%), nystatinrns 28명중 10례(36%)였다(p<0.05). Fluconazole군과 nystatin군 사이에 부작용이나 사망률에 차이는 없었다. 결론적으로, fluconazole은 관해유도화학요법을 받는 급성 백혈병환자에서 진균의 colonization을 줄이는데 효과적이고 안전한 항진균제이다. We made a randomized, double-blind, multicenter trial to compare the efficacy and safety of fluconazole with nystatin for prevention of fungal infections in patients with acute leukemia. Sixty-two adult undergoing remission induction chemotherapy for cute leukemia were enrolled. Patients were randomly assigned to receive either fluconazole (100㎎ bid) or nystatin(1,000,000IU×6/day) with corresponding placebo. The study drug was started in initiation of chemotherapy and continued until recovery of neutrophil counts(>1,000/㎣), development of proven or suspected invasive fungal infection, or the occurrence of drug-related toxicity. Fungal colonization decreased in fluconazole(F) group, however increased in nystain(n) group. Superficial fungal infection occurred in 1 of 34 F group, whereas invasive fungal infection developed in 3 of 28 N group. Empirical amphotericin-B therapy was given in 7 of 34(21%) F group and 10 of 28(36%) N group(p>0.05). The incidence of drug-related side effects and overall moratlity were similar in both study groups.

급성백혈병의 관해수도시 trimethoprim sulfamethoxazole 의 간염예방효과에 관한 연구

최강원(Kang Won Choe),우준희(Jun Hee Woo),방영주(Yung Jue Bang),배현주(Hyun Joo Bae),서철원(Cheol Won Suh),김시영(Si Young Kim),박선양(Seon Yang Park),김병국(Byoung Kook Kim),김노경(Noe Kyeong Kim),김승택(Seung Taik Kim) 대한내과학회 1988 대한내과학회지 Vol.35 No.1

N/A Fifty patients with acute leukemia were studied during remission induction treatment in a prospectively radnomized trial to assess the effect of prophylactic trimethoprim/sulfamethoxazole on infection and fever rate. Twenty-three patients randomly received two single-strength trimethoprim/sulfamethoxazole tablets twice daily and twenty-seven patients did not receive any drugs. There were no significant differences in the duration of granulocytopenia, number of febrile days, or use of parenteral antibiotics. But trimethorpim/sulfamefhoxazole prophylaxis resulted in a reduced incidence of microbiologically documented infections (8 versus eighteen; p<0.05). This was mainly the result of a reduction in the episodes of bacteremia in the treatment group as compared with the contirol group. The number of patients without fever in the treatment group was eight compared to only 2 in the control group (p<0.05). Thus, trimethoprim/sulfamethoxazole prophylaxis during granulocytopenia reduced the incidence of microbiologically docummented infection and had more patients afebrile.

A case of malignant melanoma with atypical feature previously treated by laser therapy

( Joo Ran Hong ),( Ji Su Lee ),( Sung Min Kim ),( Ji Youn Hong ),( Jin Hee Kim ),( Hye In Cheon ),( Min Seok Hur ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Laser therapy of pigmented lesions is a commonly performed procedure. However, it should be performed prudently as it can complicate the diagnosis and lead to the diagnosis delay. If there is any doubt whether the pigmented lesion is benign, then a biopsy for histologic evaluation is obligatory. A 44- year-old woman visited our clinic with a coin sized, dark bluish-red, and protruding tumor on her thigh. The patient reported that a pigmented lesion had been treated with laser at a local clinic a year ago without prior histological assessment. A skin biopsy was performed at our clinic, and the biopsy confirmed the diagnosis of malignant melanoma. 18F-FDG PET/CT showed no evidence of distant metastases. Herein, we report a case of malignant melanoma presenting after laser therapy of a pigmented lesion. This case emphasizes the importance of careful examination before the laser therapy, and the value of histopathologic review for accurate diagnosis and treatment.

A case of acral persistent papular mucinosis treated with carbon dioxide laser

( Joo Ran Hong ),( Ji Su Lee ),( Sung Min Kim ),( Ji Youn Hong ),( Jin Hee Kim ),( Hye In Cheon ),( Min Seok Hur ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Acral persistent papular mucinosis (APPM) is a rare subtype of localized lichen myxedematosus. The lesions of APPM are limited to the skin and usually do not require treatment, except for the cosmetic concern. There is no specific treatment of APPM. Topical and intralesional corticosteroids, topical tacrolimus, and laser therapy have been used with variable success. A 63-year-old woman presented with a 10-year history of 2-5mm sized, multiple, discrete, and skin-colored papules on the extensor aspects of her distal forearms. The lesions were asymptomatic and had increased slowly in number. Her medical history was significant only for diabetes and dyslipidemia. Mucin deposition in the upper and mid dermis without epidermal involvement was shown on histopathologic examination. On the diagnosis of APPM, we treated the patient with carbon dioxide laser for some of the lesions which responded well but left behind mild scars. Herein, we report a rare case of APPM treated by carbon dioxide laser. This report would be helpful to suggest a potential treatment option for APPM patients who desire therapy.

Type 2 단순 포진 바이러스에 의한 수막염 1예

최강원,김남중,박영주,신형식,최희정,김홍빈,박상원,김의종,이은봉 대한감염학회 1996 감염 Vol.28 No.3

두통과 발열을 주소로 내원한 26세의 여자 환자에서, 뇌척수액과 수포액에 대한 중합효소 연쇄반응, 수포병변의 바이러스 배양검사에 의해 Type 2 단순 포진 바이러스에 의한 수막염을 국내에서 처음으로 진단하였기에, 문헌 고찰과 함께 이를 보고하는 바이다. Herpes simplex virus(HSV) meningitis is generally due to Type 2 HSV(HSV-2) and occurs especially in young, sexually active adults. HSV meningitis, usually seen in association with primary genital HSV infection, is an self-limited disease manifested by headache, fever, and mild photophobia, which last from two to seven days. A lymphocytic pleocytosis in the cerebrospinal fluid is characteristic. Viral culture of the cerebrospinal fluid is sometimes negative, especially in cases of recurrent disease. The failure of culture technique has led to the use of new diagnostic technique such as polymerase chain reaction(PCR). We report a case of HSV-w meningitis in young woman who presented with headache and fever. With the use of the PCR, HSV-w DNA was detected in cerebrospinal fluid and vesicular fluid from the patient. Symptoms of meningeal irritation subsided spontaneously with supportive care.

Clinical impacts of hazardous alcohol use and obesity on the outcome of entecavir therapy in treatment-naïve patients with chronic hepatitis B infection

Won Gil Chung,Hong Joo Kim,Young Gil Choe,Hyo Sun Seok,Chang Wook Chon,Yong Kyun Cho,Byung Ik Kim,Young Yool Koh 대한간학회 2012 Clinical and Molecular Hepatology(대한간학회지) Vol.18 No.2

Background/Aims: The aim of this study was to analyze the clinical impacts of obesity and hazardous alcohol use on the outcome of entecavir (ETV) therapy in chronic hepatitis B (CHB) patients. Methods: The medical records of 88 treatment-naïve patients who were diagnosed with CHB and received ETV between March 2007 and September 2009 were analyzed retrospectively. Body mass index (BMI) values and Alcohol Use Disorders Identifi cation Test (AUDIT) scores were obtained at 6 months after the initiation of ETV (0.5 mg daily) treatment. Results: A BMI of 25 kg/m2 or more was recognized as an indicator of obesity, and a total AUDIT score of 8 or more was recognized as an indicator of hazardous alcohol use. Of the cohort, 24 patients (27.3%) were obese and 17 (19.3%) were hazardous alcohol users. The rate of seroconversion, alanine aminotransferase (ALT) normalization, and hepatitis B virus (HBV)-DNA negativity (<300 copies/mL) at 3, 6, and 12 months of treatment did not differ significantly between the normal-BMI and high-BMI groups. Moreover, the rate of seroconversion and HBV-DNA negativity at 3, 6, and 12 months of treatment did not diff er signifi cantly between the nonhazardous and hazardous alcohol users. However, the frequency of ALT normalization at 12 months was signifi cantly lower among hazardous alcohol users (91.5% vs. 70.6%; P =0.033). Conclusions: Obesity and hazardous alcohol drinking have no significant impact on the outcome of ETV treatment. However, the ALT normalization rate at 12 months after initiation of ETV treatment was signifi cantly lower among the hazardous alcohol users. (Clin Mol Hepatol 2012;18:195-202) Background/Aims: The aim of this study was to analyze the clinical impacts of obesity and hazardous alcohol use on the outcome of entecavir (ETV) therapy in chronic hepatitis B (CHB) patients. Methods: The medical records of 88 treatment-naïve patients who were diagnosed with CHB and received ETV between March 2007 and September 2009 were analyzed retrospectively. Body mass index (BMI) values and Alcohol Use Disorders Identifi cation Test (AUDIT) scores were obtained at 6 months after the initiation of ETV (0.5 mg daily) treatment. Results: A BMI of 25 kg/m2 or more was recognized as an indicator of obesity, and a total AUDIT score of 8 or more was recognized as an indicator of hazardous alcohol use. Of the cohort, 24 patients (27.3%) were obese and 17 (19.3%) were hazardous alcohol users. The rate of seroconversion, alanine aminotransferase (ALT) normalization, and hepatitis B virus (HBV)-DNA negativity (<300 copies/mL) at 3, 6, and 12 months of treatment did not differ significantly between the normal-BMI and high-BMI groups. Moreover, the rate of seroconversion and HBV-DNA negativity at 3, 6, and 12 months of treatment did not diff er signifi cantly between the nonhazardous and hazardous alcohol users. However, the frequency of ALT normalization at 12 months was signifi cantly lower among hazardous alcohol users (91.5% vs. 70.6%; P =0.033). Conclusions: Obesity and hazardous alcohol drinking have no significant impact on the outcome of ETV treatment. However, the ALT normalization rate at 12 months after initiation of ETV treatment was signifi cantly lower among the hazardous alcohol users. (Clin Mol Hepatol 2012;18:195-202)

Clinical and immunological characteristics of psoriasis patients with latent tuberculosis infection

( Joo Ran Hong ),( Ji Youn Hong ),( Jin Hee Kim ),( Hye In Cheon ),( Min Seok Hur ),( Byung Gon Choi ),( Song Hee Han ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Latent tuberculosis infection (LTBI) is a growing concern for the treatment of psoriasis, as the use of biologics has recently increased. LTBI may also be associated with chronic inflammatory status that results in a change in immune status. Objectives: To investigate the association between the clinical comorbidities of psoriasis and the expressions of inflammatory cytokines induced by LTBI. Methods: We conducted a retrospective analysis for 300 patients with psoriasis using clinical information, including the comorbidities and presence of LTBI. Serum cytokine levels were measured for immunological analysis. Results: The prevalence rates of psoriatic arthritis (p = 0.001) and nail psoriasis (p = 0.014) were significantly higher in patients with LTBI than in those without LTBI. The serum levels of interleukin (IL) 6, IL-8, and IL-23A were greater in the LTBI-positive group than in the LTBI-negative group (p = 0.014 for IL-6, p = 0.025 for IL-8, and p = 0.004 for IL-23A). Conclusion: LTBI may be a risk factor for the development of clinical comorbidities in psoriatic patients through an increase in the levels of inflammatory cytokines, including IL-6, IL-8, and IL-23A.