중증 화상 환자에서 영양지원

박지영,목혜숙,신현선,노순예,김애심,백금선,김도헌,허준,전욱 대한화상학회 2003 대한화상학회지 Vol.6 No.2

급성 신부전증을 초래한 Wegener씨 육아종증 1례

박일,임영국,최성도,임현성,정종훈,문철웅 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.1

호흡기 증상과 급성신부전증이 발생된 환자에서 혈액검사, 혈청학적 검사, 방사선학적 검사, ANCA test 및 신생검을 통하여 Wegener씨 육아종증을 경험하였기에 문헌 고찰과 함께 보고하는 바이다. 본질환이 재발하는 경우는 cyclophosphamide에서 azathioprine으로 치료약을 바꾸었을때나 특히 ANCA 반응이 양성으로 지속시 발생한다. Godman과 Churg는 상기도의 괴사성 육아성 병변, 하기도의 괴사성 혈관염, 국한성 신사구체염을 진단의 지표로 삼았다. 특히 상기도 점막의 생검 소견상 괴사성 육아성 혈관염이 보이면 일단 본 증을 의심하고 폐 생검과 신 생검이 필요로 한다. Wegener's Granulomatosis is an uncommon disease which is characterized by granulomatous vasculitis of both lung and kidney. Although the cause is unknown, it's suggesting that disordered immunity with both antibody and cell-mediated tissue damage occurs. The disease affects patients of any age. Characteristic clinical manifestations are diverse but in clude saddle nose deformity, sinusitis, productive coughing, myalgia, fever etc. Characteristic laboratory abnormalities include elevated ESR, neutrophilic leukocytosis, anemia and positive test for ANCA test. Renal biopsy is important for diagnosis. The treatment of choice is a combination of corticosteroid and cytotoxic agent. A53-year-old woman was admitted to our hospital because of productive coughing, short of breathing, oliguria, nausea, and vomiting. Three months ago, she was suffered from general weakness, poor appetite, tingling sensation on extremity, and loosely stool. Twenty days ago, above symptoms were aggravated, she admitted local clinic. Six days ago, because of CBC showed anemia , she was done transfusion. During transfusion, she was developed urticaha then productive coughing, dyspnea, increased serum BUN and creatinine levels. She was transferred to our hospital under the impression of ARF. On the admission, she was chronic ill-looking appearance with pale conjunctiva, tachypnea, dyspnea, and cold sweating. We have checked the patient by CBC, serum and serologic test, X-ray, ANCA test, renal biopsy. With renal biopsy microscopic examination study revealed necrotizing vasculitis, We treated a combination therapy with methyl-PDS and cyclophosphamide. She had a good response. So we report wegener's granulomatosis with the review of relevant literature.

Banana 栽植樣式이 生育과 收量에 미치는 影響

吳現道,朴才昊,金龍湖 濟州大學校 亞熱帶農業硏究所 1987 亞熱帶農業硏究 Vol.4 No.-

本 試驗은 1985年 3월 부터 1986年 3月에 걸쳐 栽植樣式이 生育과 收量에 미치는 影響을 究明하기 위하여 濟州大學校 亞熱帶農業硏究所 plastic film house에서 遂行되었다. 그 結果를 要約하면 다음과 같다. 바나나의 草長, 葉數, 葉幅, 葉長, 果掌數, 果房重은 栽植樣式에 따라 影響을 받지 않았으나 假莖長, 假莖直徑, 抽穗期, 成熟期는 有意性이 인정되어 正方形, 三角形, 長方形, 栽植樣式 順으로 假莖長과 假莖直徑이 增加하였고 抽穗期와 成熟期도 短縮되었다. 果掌當 果指數와 果掌重은 栽植樣式에 따라 1段에서 差異가 있었고 長方形, 三角形 栽植樣式에서 2段에서는 현저하게 감소하였으나 3段 이후부터는 緩慢하게 감소되는 傾向을 나타내었다. 果掌當 果指長과 果指直徑은 1段에 比해 2段에서 增加하였는데 長方形, 正方形, 栽植樣式에서 1段∼2段 差가 컸으며 果指直徑의 變化는 栽植樣式 및 果掌間에 따라서 差異가 크게 나타났다. 正方形, 三角形 栽植樣式에서 1段에 比해 2段 果指重이 增加하였으나 3段 이후부터는 감소되는 경향을 나타내고 栽植樣式 및 果掌間에 따라 差異가 컸다. This experiment was carried out to elucidate the influence of spatial arrangement at planting on the growth and yield in bananas (Musa cavendish Lambert 'Dwarf Cavendish') from March, 1985 to March, 1986 in the plastic film house at Research Institute for Subtropical Agriculture, Cheju National University, Cheju, Korea. The results obtained are summarized as follows. Plant height, no. of leaves, leaf width, leaf length, no. of hands, and bunch weight, were little affected by planting pattern. However, pseudostem length and diameter were greater and date of emergence and maturity were earlier in the order of regular, triangular, rectangular planting. The number of fingers/hand and hand weight were significantly affected by planting pattern in 1st hands and decreased remarkably in 2nd hand of the rectangular and triangular planting, but tended to be decreased slowly from 3rd hand. Finger length and diameter/hand were greater in 2nd hand than in 1st hand and more significant in the difference of 1-2 hands in rectangular and regular planting than that of triangular planting, finger diameter/hand were afected remarkably by planting pattern or hands. Finger weight/hand were increased in 2nd hand against 1st at regular and triangular planting, but tended to be decreased from 3rd hand and affected by planting pattern or hands.

Benzotriazole계 유도체의 제초활성과 분자 설계

성낙도,박현주,박승희,변종영 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-

Benzotriazole 유도체들의 정량적인 구조와 발아후 벼(Oryzae sativa L) 및 피(Echinochloa crus-galli)에 대한 생장저해 활성값(pI_50)사이의 관계들이 QSAR 방법으로 연구되었다. QSAR 분석에 의하면, 자유 라디칼 파라미터(E_R)가 매우 중요한 요소이었으며 pI_50 값은 파라치환기(X)의 E_R 파라미터에 대하여 포물선형의 관계를 나타내었다. (3)의 생장저해 활성은 (4)보다 우세하였으며 생장저해 활성이 가장 큰 화합물은 (3b)이었고 피의 생장저해 활성에 대한 E_R 파라미터의 적정값은 각각 E_R(3)=0.52와 E_R(4)=0.15이었다. 분자설계 결과, 치환기(X)가 전자 끌게이고 적정값 (0.52)와 E_R 파라미터를 가지는 분자가 가장 활성이 클 것으로 기대되었으며 Benzotriazole 유도체들의 생장저해 활성은 광합성반응(PS-II)에서 전자전달을 효과적으로 차단하는 결과로 믿어진다(1991년 9월 15일 접수, 1991년 9월 31일 수리). The relationships between the quantitative structure of benzotriazoles and their post-emergence growth inhibiting activity(pI_50) against Oryzae sativa L. and Echinochloa crus-galli were investigated using a generalized quantitative structure activity relationships(QSAR). According to the QSAR analysis, the free radical parameter (E_R) is a very important factor and the growth inhibiting activity values showed parabolic relation to E_R parameter of para-substituents(X). The activity of (3) was superior to those of (4) and (3b) is selected as the most highly effective compound. The optimal values of E_R parameter of the growth inhibiting activity aganist E. crus-galli are E_R(3)=0.52 and E_R(4)=0.15, respectively. From the result of molecular design, the substituents(X) of electron withdrawing properties and E_R parameter of optimal value(0.52) were most desirable for high activity of the benzotriazoles. And in view of this, benzotriazoles may also be effective in blocking the photosynthetic electron transfer.

제주 지역의 B형 간염 바이러스 유전자형

조지현,박도심,김태현,염주진,김학철,문주현,양재식 대한간학회 2004 Clinical and Molecular Hepatology(대한간학회지) Vol.10 No.1

목적: HBV 감염이 무증상의 자연 회복부터 간경변 혹은 간세포성 간암까지 다양하게 나타나는 요인들로 숙주의 요인과 바이러스의 요인으로 구분되어 제시되는데, 바이러스 요인으로는 감염된 바이러스이 유형이나 염기 변이들이 논의된다. HBV 유형을 구분하는 데는 혈청형과 유전자형이 이용되는데 근자에는 주로 유전자형이 이용된다. 이러한 HBV의 분포는 지역적으로 다르나 지역에 따라서 다른 유형들이 혼재되어 있다. 동남아시아는 B형이지만 극동아시아는 C형으로 알려져 있으며, 대만과 오키나와에서는 B와 C형이 혼재되어 나타난다. 이러한 결과로 미루어 보아 우리 나라의 남부지역에서는 B과 C형이 혼재되어 있을 가능성이 있다. 이에 본 연구는 제주 지역에서 HBV의 유전자형을 조사하고자 하였다. 대상과 방법: 원적지가 제주도이면사, HBsAg가 양성이었던 107명(평균 연령: 46.5세)을 대상으로 하였다. 이들의 혈청으로부터 HBsAg/antiHBe를 분석하고, DNA를 추출하여 7개의 유전자형에 따라 특이성을 갖는 시발체(genotype specific primer)들을 이용하여 PCR로 증폭한 후 이를 분석하였다. 주된 유전자형의 일부와 다른 유형에서 증폭에 이용되었던 시발체를 다르게 이용하여 hemi nested PCR로 증폭한 후 염기를 분석하여 계통발생학적 분석법을 이용하였다. 결과: 1. PCR에 의한 HBV DNA 양성은 107명 중 59명(55.1%)이 양성이었다. HBeAg/anti HBe의 발현 양태에 따라 음성/음성에서 2명(66.7%), 음성/양성에서 30명(41.1%), 양성/음성에서 24명(85.7%), 양성/양성에서는 3명(100%)에서 증폭되었다. 2. Multiplex PCR에서는 58명의 유전자형이 C형, 1명에서는 B형과 C형이 동반 출현하였다. 3. Genotype specific primer를 이용하여 각각 따로 PCR을 시행한 경우에 A형에 의하여 증폭된 예가 1예, B형에 의하여 증폭된 예가 1예, C형에 의하여 증폭된 예가 59예로 A형과 B형 모두가 C형에서 증폭된 예였다. 4. 한 쌍의 시발체에 의하여 증폭되었던 A형과 B형 및 C형의 일부에서 염기를 분석한 결과 모두 C 유전자형이었다. 결론: HBsAg이 양성인 제주 지역 주민의 HBV의 유전자형은 C형일 것으로 생각된다. Background/Aims: Hepatitis B virus (HBV) was classified into 8 genotypes by a sequence divergence in the entire genome designated from A o H. HBV genotypes have distinct geographic distributions. Recently, HBV genotypes have been partially found as influencing the clinical manifestation of chronic liver disease in hosts. In Korea, the distribution of HBV genotypes remains unclear. The aim of this study was to evaluate the prevalence of the HBV genotype on Jeju Island. Methods: Hepatitis B virus genotypes were evaluated among 107 hepatitis B carriers residing on Jeju Island. We used single PCR and multiplex-PCR assay with genotype-specific primer pairs for HBV genotypes A-F for the genotyping. Results: 1. Fifty nine samples (55%) were positive for HBV DNA. The positivity was different according to the pattern of HBeAg/anti-HBe expression, as -/-; 2/3 (66.7%), -/+; 30/73 (30%), +/-; 24/28 (85.7%) and +/+; 3/3 (100%). 2. In the single primer set of genotype-specific PCR, 59 samples (100%) were detected as genotype C and 2 (3%) were also detected as genotype A and B. 3. In multiplex-PCR, 58 samples (98%) were detected as genotype C and only one (2%) as a mixed pattern of genotype B and C. 4. When the PCR products were amplified with universal sense and genotype specific anti-sense from one genotype A, one B, and 2 C, all were included in genotype C. Conclusions: These results suggest that on Juju Island, almost all HBV genotypes are C.(Korean J Hepatol 2004;10:42-50)

돼지감자에 있어서 系統別 栽植距離와 主莖切斷詩期가 生育 및 收量에 미치는 影響

高永友,吳現道,朴昌奎 濟州大學校 亞熱帶農業硏究所 1987 亞熱帶農業硏究 Vol.4 No.-

돼지감자의 系統別 栽植距離와 主莖切斷時期를 달리하여 生育, 收量 및 糖含量의 變化를 調査하였다. 그 結果를 要約하면 다음과 같다. 白色種보다 赤色種이 株當 塊莖數가 顯著히 많았으며, 塊莖數量도 많았고, 塊莖의 크기도 컸다. 疎植하였을때에 比하여 密植하였을 경우 10a當 地上部와 塊莖收量은 增加하는 傾向이었다. 二系統에 있어서 株當 塊莖種은 草長, 莖直徑, 莖當 節數, 株當 分枝長, 地上部 收量, 株當 塊莖 乾物重과 相關關係가 있었다. 株當 塊莖數는 白色種에서 다른 形質과 有意的인 相關關係는 없었으나 赤色種에서는 다른 形質과 有意的인 相關이 있었다. 主莖切斷時期에 있어서 切斷區에 比해서 無切斷區가 地上部와 塊莖收量이 많았으며, 切斷時期가 이를 수록 약간 增收하는 傾向을 보였다. 白色種이 赤色種보다 糖含量이 높았으며 收穫時期別 糖含量이 變化는 거의 없었다. 貯藏中의 糖含量이 變化는 貯藏期間에 따라 거의 變化 없었으며, 長期間 貯藏이 可能하였다. Field experiment was conducted to determine the effects of spacing in row and main stem cutting date on growth and yield of Jerusalem artichoke. Investigated were also the effects of harvesting date and storage period on sugar content of tuber. The results obtained are as follows; The red line had more tubers per plant and smaller tuber than the white line but the white had more tuber yields than the red line. Top and tuber yield of two lines increased with decreasing spacing in row. Fresh weight of tuber per plant correlated with plant length, diameter of stem, number of nodes per stem, length of branch per plant, fresh and dry weight of top per plant and dry weight of tubers per plant in two lines. Significant correlations between the number of tubers per plant and the other characters were observed in the red lines but were not in the white lines. Top and tuber yield of two lines were decreased by main stem cutting dates and tended to decrease with delaying cutting date of main stems. The white line had a higher sugar content than the red line. Sugar content of two lines was not affected by harvesting date. There was almost no change of sugar content during the storage period indicating that storage of tuber for a long time is possible.

Effect of Body Condition Score (BCS) on In Vivo Embryo Production and Pregnancy Rate Following Superovulation in Hanwoo

Gyu-Tae Yeom,Hae-Geum Park1,Nam-Tae Kim,Sung-Woo Kim,Hyun Kim,Yoon-Jung Do,Young-Sin Kim,Soo-Bong Park,Jae-Hwan Kim,Sang-Rae Cho,Jae-Hyeon Cho,Yeoung-Gyu Ko 韓國受精卵移植學會 2013 한국동물생명공학회지 Vol.28 No.1

Body condition score (BCS) is a useful management tool for distinguishing differences in nutritional needs of cows in the herd. Although it is not always possible to quantify the nutrient content of the feed supplied to the donor cow, the nutritional status can be determined by the BCS. The objective of this study was to evaluate in vivo embryo production, return to estrous of donor and pregnancy rate of recipients following BCS in Hanwoo superovulation. Sixty nine Hanwoo donor cows were flushed on day 7 of estrus cycle with same FSH and artificial insemination by the same technicians. Embryos were recovered on 7 days after the third insemination by flushing the uterus with Embryo Collection Medium. The results obtained were as follows: No differences were observed in the efficiency of superovulation rates regardless of BCS (≤2.0, 2.5 to 3.0, and ≥3.5). The mean number of total embryos was each 5.20±0.86, 11.56±1.04, and 6.23±1.07. The mean number of transferable embryo from ≤2.0, 2.5 to 3.0, and ≥3.5 of BCS was 2.60±0.87, 7.94±0.89, and 4.75±1.32, respectively (p<0.05). Return to estrous regardless of donor BCS was no difference. The pregnancy rates of recipient were BCS ≤2.0 11.76%, 2.5 to 3.0 40.79%, and ≥3.5 11.11%, following transfer of fresh embryos produced in vivo, respectively. These results indicate that if the Hanwoo with BCS 2.5 to 3.3 are used for donor and recipient, the embryo production and the conception rate will be greater.

봉독약침이 류마티스 관절염 환자의 관절 통증, 종창 및 급성 염증 반응에 미치는 영향

이상훈,이현종,백용현,김수영,박재경,홍승재,양형인,김건식,이재동,최도영,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective In order to study the effects of bee venom(BV) on the pain, edema, and acute inflammatory reactant of rheumatoid arthritis(RA) patients. Methods Patients with RA who met the ACR(American College of Rheumatology) 1987 revised criteria for the diagnosis of RA were treated with the BV therapy twice a week for 3 months. Tender Joint counts, swollen joint counts, Visual analog scale(VAS), morning stiffness, ESR. C-reactive protein(CRP) were analyzed before and after BV therapy. Results The results as follows. 1. Tender joint counts in patients after BV therapy were significantly lower than those before BV therapy(9.0±7.9 vs 15± 11.4, p=0.002). 2. Swollen joint counts of the patients after BV therapy were significantly lower than those before BV therapy(50±61 vs 15±23, p=0.001). 3. VAS in patients after BV therapy was significantly lower than those before BV therapy(608± 17.6 vs 380± 159, p=0.000). 4. Duration of morning stiffness in patients after BV therapy was significantly reduced compared with that before BV therapy(119.1± 112.6 min vs 59.0±89.7 min, p=0.009). 5. ESR and CRP were not significantly changed before and after BV therapy, suggesting BV itself could make inflammatory reaction as well as therapeutic effect. Conclusions BV therapy improved tender joint counts, swollen joint counts and duration of morning stiffness in this study, and further study is needed on long-term effect of BV therapy.

退行性關節炎 韓方治療에 對한 最近 硏究 動向 : 臨床硏究 方法論을 中心으로 Herbal Medicines in the Treatment of Osteoarthritis in Pubmed and Chinese Medical Journals

서병관,류성룡,이송실,허정은,백용현,이재동,최도영,조윤제,김남재,박동석 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Objective : The aim of this study was to review systemically clinical trials on the effectiveness and safety of herbal medicines in the treatment of osteoarthritis. Methods : Computerized literature searches were carried out on seven electronic databases, and hand-searching on some chinese medical journals in library of Kyung Hee Medical Center. Trial data were extracted in a standardized, predefined manner and assessed independently. Results : 1. Thirty reports of clinical trials and two reports of meta-analyses concerning herbal medicine were collected and reviewed Among these reports three medical herbs were applied as topical medicine and others as internal medicine. 2. The western studies established NSAIDs or placebo as their control group. Five chinese reports established formulated herb pill(Ruanshnagshenjin pill) as their control group and Six did not establish a control group at all. 3. ACR was the most highly used diagnostic criteria in the western studies while the Chinese used their official criteria established by their government or the criteria of their text books. 4. 20 reports chose the Lequesne functional index, SHAQ, WOMAC OA index, AIMS, and their own unique scoring system as the criteria of analysing the effect. Others chose clinical symptoms, articular functions, and lab finding as their criteria. 5. 7 single herbs and 19 formulated herbs were studied. Among the formulated herbs, Achyranthes japonica was studied in 10 of the studies and Angelica gigantis Radix in 8, making them the most often studied herbs among the studies.

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.