VP-16으로 성공적으로 치료된 위 Kaposi 육종 1예

양웅석,송근암,조몽,이재승,송철수,김형욱,김영민,이수봉,김태오,이성훈 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.4

The skin is an uncommon site of distant metastasis from any internal malignancy, and the incidence of metastatic skin lesions as the first symptom of disease is only 0.8% in patients with all systemic malignancies. Furthermore, cutaneous metastasis from adenocarcinoma of the stomach has been found to be extremely rare. A 35-year-old female patient was admitted due to multiple cutaneous nodules in her chest, abdomen, and back. A gastroendoscopic examination and biopsy was made according to the results of skin pathologic findings. Stomach and skin biopsy results revealed a signet ring cell type of adenocarcinoma. A case of gastric adenocarcinoma in which metastatic skin nodules appeared as the first sign of disease, is here in reported with a review of related literature.

A comparison of survival outcome of open, total laparoscopic and laparoscopy-assisted vaginal radical hysterectomy in patients with early cervical cancer of stage IB2

( Sul Lee ),( Hyung Joon Yoon ),( Eun Hye Jeon ),( Juseok Yang ),( Yong Jung Song ),( Hyun Jin Roh ),( Sang Hun Lee ),( Byung Su Kwon ),( Ki Hyung Kim ),( Dong Soo Suh ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: The aim of this study is to evaluate oncologic outcomes of total abdominal radical hysterectomy (TARH), total laparoscopic radical hysterectomy (TLRH) and laparoscopic-assisted radical vaginal hysterectomy (LARVH) in early cervical cancer patients (stage IB2-3, tumor size≥2cm), analyzing the risk factors that may affect the clinical results. Methods: A total of 756 patients underwent radical hysterectomy between 2000 and 2019 from three university hospitals (Pusan National University Hospital, Yang-san Pusan National University Hospital, Ulsan University Hospital) were enrolled. Among them, 172 patients with stage IB2-3 were analyzed retrospectively. Results: Seventy-seven patients were treated with TARH, and 95 were managed via minimally invasive surgery (MIS), consisting of 35 with TLRH and 60 with LARVH. TARH group had better disease five-year disease free survival (DFS) and overall survival (OS) compared with MIS group (86.4% vs. 73.4 for DFS and 91.7 vs. 82.2 for OS), but not statistically significant in both (p=0.058 for DFS and p=0.119 for OS). When TARH and the LARVH group were compared, both five-year DFS and OS were not significant different (86.4 vs 82.2%; p=0.288 for DFS and 91.7 vs 84.4%; p=0.206 for OS). However, when TARH and the TLRH group were compared, TLRH group had significantly worse five-year DFS than TARH (86.4 vs 54.5%; p=0.008), but five-year OS was not significant different (91.7 vs 77.5%; p=0.127). Multivariate analysis showed that LN metastasis and TLRH surgical approaches were an independent prognostic factor for DFS in IB2-3 cervical cancers. Conclusion: Our findings provided the evidence that TLRH surgical approach was associated with worse DFS in IB2-3 cervical cancers but that of LARVH was not. Such results may have important implications of colpotomy method for MIS in cervical cancer.

Bortezomib과 Dexamthasone으로 치료한 골수외 형질세포종 4예

백종현,이은영,장리라,손창배,신은경,서정아,이지숙,이호섭,이상민,신성훈,김양수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Despite the use of aggressive local and systemic treatment including autologous stem cell transplantation in multiple myeloma, extramedullary recurrences are common and the prognosis of these patients is poor. Many novel drugs such as thalidomide, lenalidomide and bortezomib improve the response of treatment of multiple myeloma, but some reports failed to describe thalidomide has effect in extramedullary plasmacytoma. Recent data report on the successful treatment plasmacytomas with bortezomib in patients with advanced multiple myeloma. We treated 4 relapsed or refractory extramedullary plasmacytomas with bortezomib at our institution. We recognized all these extramedullary plasmacytomas decreased and showed more than partial response. This report lends support to the efficacy of bortezomib in the treatment of plasmacytoma and describes the safe use of bortezomib. Responses may, however, be of short duration. Therefore, despite our limited experience, we propose that bortezomib may be considered a therapeutic option for such patients who have risk of radiation therapy

우묵사스레피(Eurya emarginata)의 플라보노이드 화합물의 분리 및 동정

양홍철,박수영,강희경,이남호 제주대학교 생명과학연구소 2001 제주생명과학연구 Vol.4 No.-

The extracts of Eurya emarginata showed inhibitory effect on the growth of HL-60 leukemia cells. So, 80% methanol(MeOH) extract of its leaves was partitioned to hexane, ethyl acetate, n-butanol and residual water fractions. The ethyl acetate fraction, which showed desirable activities, was further purified using SiO2 column chromatography(CC) followed by reverse phase silica gel CC, then another normal CC to give fraction 4-1-8 as a pure compound. The compound 4-1-8 was analyzed by NMR spectrometry using 1H, 13C, DEPT, HMQC and HMBC spectra, and finally proved to be well-known flavono glycoside, Quercitrin.

지역별 납세요인 인지도에 관한 연구

李良玄,崔林洙 중앙대학교 산업경영연구소 2001 산업경영연구 Vol.10 No.1

To analyze taxpayers’perceptions regarding tax payment factors among regions, this study examines factors influencing taxpayers’tax evasion. such as, tax ethical, tax institutional, tax psychological, knowledge, and socio-cultural factors. Then, the following hypotheses are tested: (1) the characteristics of provinces(COP), (2) the characteristics of rural and urban communities(CRU), and (3) the correlation between COP and CRU have relations to taxpayers’perceptions regarding tax payment factors. A simple factorial analysis of variance(ANOVA) shows that there is no difference among regions regarding tax ethical factor. But there are significant differences in tax institutional factor among COP, in tax psychological factor among the correlation between COP and CRU, in knowledge factor among CRU, and in socio-cultural factor among COP at the level of 0.01, 0.05, 0.01, and 0.01, respectively. And the analysis shows that the taxpayers of Kyeongsang-Do in tax institutional factor, urban community in knowledge factor, and Kyeongsang-Do in socio-cultural factor, respectively, have more negative attitudes than any other related region(s). The result, however, shows that there is no great difference among regions regarding tax payment factors. Further, this result is more obvious in CRU than in COP. Accordingly, we can conclude that regionalism has existed though, taxpayers have the homogeneous perceptions regardless of regions.

일부농촌지역의 농약사용실태 및 농약중독 요인 조사

이경민,송주희,장재혁,심수정,강양화,안재경,이숭호,박미영,정문호 대한보건협회 2002 대한보건연구 Vol.28 No.4

Object The usage of agricultural chemical is on the increasing. Use of pesticides has increased agricultural production. However, negative externalities from such use have increased too. Pesticide poisoning is a major public problem. The purpose if this study is to find out the relationship between keeping the safety rules or protective equipments or attending safety education or dose of pesticides use , and poisoning experience. Methods For Gu, H.M. and Pack, S.G. study , we obtained questionnaire data concerning pesticides poisoming. A person interviews on 203 were conducted in two villages in Sinmeari and woulbonri Chunchun , Kangwon province, July 2002. Result 1. 144 people(70.9%) have sprayed pesticides and the rata of experiences of pesticide poisoning was 26% among 144. Spraying time of pesticides was 1-2 hours in 63.9% of farmers. Rate of using the protective equipment was 25.7% (protective clothes), 49.3% (Mask), 48.6 (Gloves), 7.0 (Protective glasses), 64.6% (boots) respectively. 2. Chi-square and multiple logistic regression analysis showed that Duration of spraying per day (<2hr) and using of mask(protective equipment)are significantly association with poisoning experience.(x^2=5.2684 p=0.0217, CI=0.140-0.5853 OR=0.346 p=0.0211 respectively). But no association between poisoning experience and keeping safety rule, attending of safety education. 3. Spraying pesticides. Duration of spraying pesticides, reading manuals and no spraying at fatigue (keeping safety rule) are significantly association with symptom experience(x^2=14.0621 p=0.0002, x^2=7.0639 p=0.0079, CI01.395-10.950 OR=3.908 p=0.0095, CI=0.101-0.726 OR=0.271 0.0094 respectively). But no association between symptom experience and protective equipments, attending of safety education.

An Exprimental Study of Postoperative Intraabdominal Adhesions

이봉우,최봉락,양동휘,김인호,손수상,강중신 啓明大學校 醫科大學 1986 계명의대학술지 Vol.5 No.2

수술후 나타나는 장유착은 적지 않은 빈도를 나타내며 보편화된 개복 수술후 증가된 유착성 장폐색증은 외과영역에서 중요한 문제의 하나로 많은 연구보고가 되고 있으며 유착의 형성은 기계적, 세균학적 및 화학적 외상 즉 복강내 외상이나 손상후의 치유과정의 한단계로 유착이 나타난다고 한다. 장유착의 원인과 이차적인 병태생리학적인 변화에 대한 충분한 이해를 갖고 조기에 적절한 치료를 하면 이병율과 사망율을 감소시킬 수 있는 질환이다. 저자들은 한국산 성숙된 가토를 이용하여 실시한 실험적 연구로써 도끼 60마리를 각 20마리씩 3군으로 나누어 관찰하였다. 즉 모든 토끼는 ether로 open drip마취를 하고 정중선 복별절개로 개복한 후 5.0+ 5.0cm정도의 전벽복막을 점상 출혈이 나타날 때 까지 찰과상을 형성시켜 그 결과를 관찰하였다. 제1군의 20마리는 단지 scratching method만 시행한 control group으로 하고 제2군의 20마리에서는 scratchiing method 후 복강내 polyethylene feeding tube를 넣고 매일 50ㅊㅊ의 생리식염수를 중비하였으며 제3군 20마리에서는 복강투석액인 peritosol solution으로 생리식염수 대신에 매일 50cc씩 복강내에 주입하여 관찰 비교하였다. 모든 토끼들은 개복술 10일후 재 개복하여 복막의 유착과 소장간의 유착정도를 관찰비교하여 다음과 같은 결과를 얻었기에 문헌고찰과 함께 보고하는 바이다. Control group에서는 20예중 유착정도가 15예에서 나타나 75%를 나타내었고 생리식염수 투여군에서는 20예중 13예에서 나타나 65%의 유착을 나타내었으며 peritosol군에서는 20예중 9예로서 45%로 감소된 유착양상을 나타내었다. 본 실험에서는 peritosol투여군이 control group이나 생리식염수 투여군보다 실험적 유착상태가 적은 것에 유의를 하였으며 아직 인체에 peritosol세척 시도는 못해 보았지만, 본실험과 같은 효과가 있다면 술후 장유착 예방에 의의가 있을 것으로 사료되어 보고 드리는 바이다.

여성의 性회복을 위한 연구 방안

이양자,이영수 동의대학교 2004 인간과 문화 연구 Vol.- No.9

農業高等學校 農場實習 및 現場實習 指導方案에 關한 硏究

李良洙,金在基 순천대학 학생생활연구소 1985 學生生活硏究 Vol.4 No.-

市乳의 貯藏期間에 따른 耐冷性 微生物 및 化學的 特性의 變化에 關한 硏究

이수원,강일수,양희진,백승천 성균관대학교 생명과학자원연구소 1997 生命資源科學硏究 Vol.4 No.1

The present study was conducted to predict shelf life of pasteurized milk with analysis of volatile compounds and sensory evaluation of milk to growth of psychrotrophic bacteria. Pseudomonas fluorescens KFRI 00194 inoculated concentration of 10^4 cfu/㎖ to observe of changes on sensory evaluation and volatile compounds of pasteurized milk. The results obtained in these experiments were summarized as follows; The psychrotrophic bacteria number at 4℃ were increased 6.39×10 exp(4)cfu/㎖ until first day and 2.20×10 exp(6)cfu/㎖, 1.17×10 exp(7)cfu/㎖ after 5 and 10days, respectively. The volatile compounds were shown the decreasing tendancies in acetaldehyde, ethanol depending on storage days, especially ethanol contents were significantly decreased between 5 and 10days storage(P<0.05). Diacetyl, 2-heptanone, 2-butanone and 3-methyl-1-butanol were shown the increasing tendencies of contents. Diacetyl, 2-heptanone and 2-butanone were significantly increased between 5 and 10days, 1 and 5days, 5 and 10days and 1 and 5days, respectively(P<0.05). However, 3-methyl-1-butanol was shown a increasing tendancy depending on storage days but the significantly different was not recognized. The changes of sensory evaluation were rapidly decrease from 6.8point first day to 4.2point after 10days and the decrease of organoleptic acceptability was significantly different recognized(P<0.05), excepted of 1 and 2days. The organoleptic acceptability according to increasing of psychrotrophic bacteria numbers were decreased. The organoleptic acceptability depending on changes of volatile compounds were shown to a conversed correlation coefficient with the exception of acetaldehyde and acetone. Especially, 2-heptanone, 2butanone and 3-methyl-1-butanol were gradually decreased of acceptability by the contents.