상악확장술 치료효과의 메타분석 : 견치간 폭경과 대구치간 폭경 확장의 비교 및 급속과 완속 확장의 비교 comparison of intercanine/intermolar expansion and rapid/slow expansion

고창희,임성훈,윤영주,김광원 대한치과교정학회 2004 대한치과교정학회지 Vol.34 No.1

본 연구의 목적은 다수의 연구들로부터 추출한 각각의 결과를 체계적이고 객관적인 방법으로 병합, 개관하는 통계분석법인 메타분석을 이용하여 상악확장술에서의 견치간 폭경과 대구치간 폭경의 확장 및 급속과 완속 확장에서의 확장량과 재발량을 비교하는 것이었다. 메드라인 검색을 통해 1979년부터 2000년까지의 문헌들 중 사람을 대상으로 상악확장술의 효과에 관해 조사한 문헌 388개를 찾은 후 논문 선택 및 제외 범주에 따라 최종적으로 7개의 문헌을선정하여 메타분석을 시행하여 다음과 같은 결과를 얻었다. 1. 상악확장술에 의한 상악 제 1대구치간 폭경은 평균 6.0mm의 확장되었으며, 보정 후 측정에서 평균4.8mm가 유지되어 평균 20.0%(1.2mm)의 재발경향을 보였다. 2. 상악 견치간 폭경은 제 1대구치간 폭경의 확장보다 2.3mm적은 평균 3.7mm 확장되었으며, 보정 후 측정에서 평균 2.6mm가 유지되어 평균 29.7%(1.1mm)의 재발경향을 보였다. 3. 급속 상악확장술과 완속 상악확장술의 치료효과의 차이는 확장량과 보정 후 재발량 및 유지량에서 6% 미만(0.1-0.3mm)이었다. 그러나 상악 견치간 및 제1대구치간 폭경 변화에 있어서 두 방법 간에 골격성 및 치성 확장량의 비율에서 차이가 있을 수 있다. As a research method that weighs and combines evidence, meta analysis produces evidence that is more powerful than the original studies. The purpose of this study was to compare the intercanine/intermolar expansion and rapid/slow expansion in the maxillary expansion treatment using meta analysis. Medline was searched from 1979 to 2000 for all studies examining the stability of transverse expansion of the human maxilla, and 388 articles were found. Then these articles were reduced to 7 based on the defined inclusion and exclusion criteria, and a cumulative Meta evaluation score was computed for each study. The results were as follows; 1. The mean expansion in intermolar width was 6.0mm. Of the 6.0mm, 4.8mm was retained and 20.0%(1.2mm) was relapsed while wearing retainers. 2. In intercanines width, the mean expansion was 3.7mm. Of the 3.7mm, 2.6mm was retained and 29.7%(1.1mm) was relapsed while wearing retainers. 3. The differences in the amount of expansion and relapse between rapid expansion group and slow expansion group were less than 6%(0.1-0.3mm). But, there might be differences in the skeletal/dental exapnsion ratios according to the expansion method.

Swivel joint를 이용한 비대칭 발치증례의 교정적 공간폐쇄

고창희,임성훈,김광원,정동기,김도영,박선주,양용근 조선대학교 구강생물학연구소 2003 口腔生物學硏究 Vol.27 No.1

Extraction therapy is popular treatment protocol in orthodontics. Generally, symmetric premolar extraction is performed. But, in some cases, asymmetric extraction is required to solve asymmetric dental alignment. But asymmetric extraction treatment has side effects and disadvantages like a) collapse of dental arch form. b) canting of occlusal plane, c) extended treatment duration. For a good treatment result, we applied the orthodontic space closing arch wire with swivel joint to allow rotational movement of arch wire segments during space closure, Now we present a case treated with orthodontic space closing arch wire with swivel joint.

Azithromycin으로 치료한 임신 중 쓰쓰가무시병 1예

김광석,최진욱,서호종,김기훈,박성호,서광섭,고성만,김순혜,김호정 대한감염학회 2001 감염 Vol.33 No.5

We report a case of tsutsugamushi disease in a 26 year-old pregnant woman who was treated with azithromycin. Her gestation period was 27 weeks and she admitted with fever, rash, and eschar on the right shoulder. Currently recommended medications for the treatment of scrub typhus are doxycycline or chloramphenicol. But, these drugs are class D drugs according to the U.S. Food and Drug Administration (FDA) Fetal Risk Summary, so they couldn't be used to treat pregnant women. Recently, a few case reports suggested that azithromycin, a relatively new macrolide antibiotic, was effective and safe for the treatment of scrub typhus in pregnant women. And, there is no evidence that azithromycin causes harmful effects to the developing fetus or to children. On the basis of current in vivo test that confirms the effectiveness of azithromycin, it may be the drug of choice for the treatment of scrub typhus in pregnant women and children. (Korean J Infect Dis 33:380-382, 2001)

모시조개 배지에서의 장내세균 및 비브리오균 증식

김용훈,고광균,이강순 순천향대학교 1992 논문집 Vol.15 No.2

This study was performed to develop a culture medium which fovors the growth of Vibrio vulnificus of the extract with a short-necked clam(Cyclina sinesis). The new plating medium made of the extract of a short-necked clam was tested for the growth of Vibrio vulnificus and a members of Enterobacteriaceae as well as Staphylococcus aureus and their abilities to form colonies in the media were compared with these to form colonies in the medium. The following results were obtained 1. The Vibrio vulnificus grew well and formed large colonies on the Cyclina sinensis agar plate and yeast-extract peptone agar plate. The Cyclina sinensis agar medium was better than the thiosulfate-citrate0bile salt-sucrose(TCBS) agar for the isolation of Vibrio vulnifificus. 2. All the bacteriae of Enterobacteriaceae family grew well on the Cyclina sinensis agar and the Brain Heart Infusion agar plate but the growth was inhibited on the MacConkey agar. 3. The growth of Staphylococcus aureus was much inhibited on the Cyclina sinensis agar media.

일본뇌염 바이러스에 대한 HI 항체 보유율

이종훈,고광균 최신의학사 1979 最新醫學 Vol.22 No.4

膈下逐瘀湯과 膈下逐瘀湯合四君子湯의 抗癌 및 免疫調節作用에 關한 實驗的 硏究

崔昇勳,安圭錫,文濬典,高光錫 대한동의병리학회 1994 동의생리병리학회지 Vol.9 No.1

연구배경 : 암은 사망의 주요 원인이 되는 질환으로 매년 증가하고 있는 추세이다. 이에 mouse에 암을 유발하여, 약물치료를 시행함으로써 높은 치료효과를 거두는 한약제재를 개발하여 암의 치료에 기여하고 아울러 근본적인 예방치료에 대한 새로운 방법을 제시하고자 함. 방법 : 생쥐에 Sacroma 180을 이식하여 복강암을 유발하고 격하축어탕 및 격하축어탕합사군자탕을 투여하여 생명연장률과 B cell 및 T cell, 혈청항체가, 임파구증식반응, IL-2 생산능 및 자연살해페소의 활성도를 측정하였다. 결과 : 격하축어탕과 격하축어탕합사군자탕은 면역조절작용을 통한 항암효과가 있을 것으로 생각되며, 활혈거어제인 격하축어탕과 보기제인 사군자탕을 합방했을때, 그 효과가 증가되었다. In order to investigate the effects of Gyeokhachukeotang and Gyeokhachukeotang plus Sagunjatang on anti-tumor and immunodulatory reaction to the ICR and C57BL/6 mice which have abdominal tumor after Sarcoma-180 cells were transplanted, the extracts of herbal medicines above mentioned were orally administered to the mice for 21 days to observe the extention of survival duration of the mice, quantitation of T cells and B cells, productivitiy of interleukin-2, lymphocytes transformation, hemagglutinin titer and hemolysin titer and activity of splenic natural killer cells. The results are summarized as follows; 1. In the effect of life extention, the Gyeokhachukeotang-medicated mice group inclined to show extended duration of life, which is of no great significant difference and the mice group medicated with mixture of Gyeokhachukeotang plus Sagunjatang appeared to survive longer than the Gyeokhachukeotang-medicated mice group, which is not meaningful. 2. Considering T cell and B cell content, the Gyeokhachukeotang-medicated mice group had a meaningful increase in B cell (P<0.05) content, and the mice group medicated with the mixture of Gyeokhachukeotang plus Sagunjatang remarkably showed a significant increase in both T cell and B cell (P<0.01). 3. Considering serum antibody titer tended to increase in case of the Gyeokhachukeotang-medicated mice group, which is of no significant difference, while decreasing in case of the mice group medicated with mixture of Gyeokhachukeotang plus Sagunjatang. 4. In lymphocyte transformation marked a significant increase the Gyeokhachukeotang-medicated mice group, marked a significant (P<0.01), and remarkably showed a significant increase the mice group medicated with the mixture of Gyeokhachukeotang plus Sagunjatang (P<0.001). 5. As for the productivity of interleukin-2 and the activity of NK cells, the both tested groups inclined to show an increase or a decrese, but there is no significance.

Methylprednisolone 및 Levamisole 투여가 Bovine Gamma-Globulin으로 초래된 생쥐의 IgA 신병증에 미치는 영향

이광도,노은석,고철우,구자훈,송경은,김용진 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.4

목적 : 본 연구는 생쥐를 대상으로 실험적 IgA 신병을 유발시키고 부신피질제재 및 levamisole 등의 면역제재를 투여하여 이들 약제의 IgA 신병증에 미치는 영향을 알아보고자 시행하였다. 대상 및 방법 : 실험동물은 체중 20-30gm 생쥐로서 암수 구별없이 사용하였다. 실험에 사용한 Bovine Gamma-Globulin (BGG, Sigma, U.S.A.)은 0.1% 농도로 식수에 섞어 매일 섭취시켰으며 제Ⅰ군은 BGG만을 섭취시켰고, 제Ⅱ군은 BGG섭취와 같은 시기부터 methylprednisolone을 격일로 존대를 통하여 경구 투여하였으며, 제Ⅲ군은 BGG 섭취와 같은 시기부터 levamisole을 격일로 존대를 통하여 경구 투여하였다. 실험 제 100일째 실험동물을 도살하고 신장을 적출하여 병리조직학적 검사를 시행하였다. 결과 : 실험개시후 100일째에 채취한 혈액검사상 혈청 BUN과 creatinine치는 각군간에 유의한 차이가 없었다. 병리조직학적 변화는 광학현미경 소견상 세군 모두에서 사구체의 미세한 변화만이 관찰되었다. 전자현미경적 소견은 세군 모두에서 기저막의 비후는 없었으며 족돌기도 잘 유지되어 있었다. 기저막쪽으로 향한 메산지움 영역에서 전자밀도가 높은 침착물이 흔히 관찰되었다. 면역형광현미경적 소견은 형광물질의 강약에 따라 약양성 (+), 중등도 양성 (++) 및 강양성(+++) 으로 구분하였다. 제Ⅰ군에서 형광물질은 IgA에서만 실험동물 9마리 모두에서 관찰되었다. 반면 IgM. IgG및 C_3는 모두 음성이었다. 면역형광물질은 모두 메산지움 및 기저막 일부에서 관찰되었으며 과립형이었다. 특히 강양성으로 보인 경우는 5마리였다. 제Ⅱ군에서도 결과는 같았으나 강양성은 20마리중 8마리였다. 역시 IgG, IgM, C_3는 음성이었다. 제 Ⅲ군에서도 결과는 같았으며 강양성은 20마리중 11마리였다. IgG, IgM은 모두 음성이었으며 단지 1마리에서 C_3가 약양성이었다. 결론 : 본 연구결과에 의하면 BGG투여로 초래되는 생쥐에서의 IgA 신병증의 실험모델에서는 methylprednisolone과 levamisole은 신장조직 소견상 IgA 침착정도나 병변의 경중에는 그 차이를 보이지 않았다. The pathogenesis of IgA nephropathy, first described by Berger and Hinglais in 1968. has not been defined clearly and appropriate treatment modality also not established. Present study has been conducted to induce IgA nephropathy in experimental animal and to see the effectiveness of methylprednisolone and levamisole on the experimentally induced IgA nephropathy. Mice weighing 20-30gm were used as experimental animal and Bovine gamma-globulin (BGG) (Sigma U.S.A.) was given as 0.1% drinking solution (Group Ⅰ). Group Ⅱ received methylprednisolone (5㎎/㎏) and Group Ⅲ levamisole (5㎎/㎏) on alternate day in addition to BGG-containing solution. On the 100th day of experiment, animals were sacrificed and blood chemistries and renal histopathologic examinations were done. Histopathologic examination: In all three groups, light microscopic, electron-microscopic and immunofluorescent microscopic findings were similar. Light microscopy showed mild focal mesangial proliferation and electron microscopy showed electron-dense materials deposited in the mesangial area near the basement membrane. Immuriofluorescent stain using fluorescin isothiocyanate goat anti-mouse IgA (Biodesign, U.S.A.) demonstrated prominent IgA staining in the mesangial area in all three group. Staining with IgG, IgM and C_3 were all negative. In conclusion, present experiment did not show any effectiveness of methylprednisolone nor levamisole on the BGG-induced IgA nephropathy in mice. And the effectiveness and its acting mechanism of methylprednisolone on human IgA nephropathy has to be studied further.

1972년 8월 서울시내 침수지역하수에서 대한 장내병원균 분리상태

김성희,김우식,고광균,이연태,이종훈 中央醫學社 1974 中央醫學 Vol.26 No.5

Bacteriological survey was performed with the 81 seweage specimens taken from the flooded areas in Seoul City (Young; dungpo-Ku, Yongsan-Ku, Mapo-Ku, Seongdong-Ku and Seodaemoon-Ku) during August, 1972. Thirteen strains of enteric pathogens were isolated. from their specimens of the 13' strains of isolates, 5 strains of Salmonella species, 6 strains of Shigella and 2 strains of Vibrio parahaemolyticus were confirmed by means of biological, biochemial and serological test, respectively.

Isotope Selective Optical Pumping of Thallium Atoms in a Vapor Cell

Kwang-Hoon Ko,Do-Young Jeong,Gwon Lim,Hyunmin Park,Taek-Soo Kim,Yong-Ho Cha 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.51 No.I

Isotope selective optical pumping has been investigated in a thallium vapor cell. A numerical calculation is performed to establish the isotope selective characteristics. In addition, metastable atoms that are optically pumped by a continuous-wave ultraviolet laser are probed by using a frequency doubled diode laser. The measured values, such as the spectral width, the peak shift, and the isotope selectivity, are compared with the numerical results.

Measurement of the isotope selectivity of the strontium magneto-optical trap by a time-of-flight mass spectrometer

Ko, Kwang-Hoon,Lim, You-Kyoung,Jeong, Do-Young,Park, Hyunmin,Kim, Taek-Soo,Lim, Gwon,Ki Cha, Hyung The Optical Society 2006 Journal of the Optical Society of America B Vol.23 No.12