각종 암종질환에서 혈청구리 및 아연농도의 변화에 관한 연구

김만우,오금탁,장경식,채종구,홍순표,조건국 朝鮮大學校 附設 醫學硏究所 1987 The Medical Journal of Chosun University Vol.12 No.1

The copper and zinc concentrations were measured in sera of 27 cases of hepatoma, 20 cases of stomach ca., 7 cases of esophageal ca., 12 cases of colorectal ca., 9 cases of lung ca., 18 cases of ovarian ca. and 48 cases of normal control in Chosun University Hospital from Jan. 1986 to July 1986. The results are as follows; 1. The mean concentration of copper in serum of normal control group was 96.0±5.02㎍/㎗ (Mean±2SE), in hepatoma, stomach ca., esophageal ca., colorectal ca., lung ca. and ovarian ca. concentrations were significantly increased each 126.4+12.77, 125.6±11.29, 140.5±14.23, 117.3±11.91, 181.4±30.56 and 130.5±13.80㎍/㎗ (P < 0. 001) in comparison with the mean value of normal control group. 2. The mean concentration of zinc in serum of normal control group was 104.8±3.40㎍/㎗ (Mean±2SE), in hepatoma and lung ca. concentrations were significantly decreased each 65.1±7.27 and 72.7±12.86 ㎍/㎗ (P < 0. 00l). 3. The ratio of serum copper level to zinc level (Cu/Zn ratio) in serum of normal control group was 0.94±0.057 in hepatoma, stomach ca., esophageal ca., lung ca. and ovarian ca. concentration ratios were significantly increased each 2.09±0.324, 1.86±0.122, 1.50±0.114, 2.55±0.513 and 1.51±0. 243 (P < 0.001).

디지털 및 일반 측방두부규격방사선사진에서 측정 방법에 따른 계측치의 비교

김미자,허경회,이원진,허민석,이삼선,이진구,안병근,최순철 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.1

Purpose : To compare cephalometric measurement between measuring methods in digital and conventional lateral cephalometric radiograph. Materials and Methods : Twenty digital and conventional lateral cephalometric radiographs were selected. In digital group, cephalometric measurements were performed manually using hardcopies and automatically using VCeph^(TM) program on the monitor. In conventional group, the same measurements were performed manually on conventional films, and for automatic measurement conventional films were digitized by scanner. All measurements were performed twice by 4 observers, and 24 cephalometric variables were calculated and the time spent for each measurement was recorded. The differences in measurements data and the time spent for each measurement were compared within each group. Intra-observer and inter-observer comparisons were performed. Results : In both groups, no statistically significant difference between manual and automatic measurements was observed and most of the variables didn’t show statistically significant differences between methods. The observer with less experience tended to show statistically significant differences of measurements between methods, and differences from other observers. The differences of measurements between methods in digital group were lesser than those of conventional group with statistical significance in 8 variables out of 24. With automatic method and in digital group, the spent time was shorter. Conclusion : With direct digital radiograph, automatic method using manually idenitified landmarks can be preferable in cephalometric analysis.

마약성 진통제 사용에 관한 지식 및 태도의 비교

김경희,최경숙,이순실,이병구 한국병원약사회 2000 병원약사회지 Vol.17 No.4

Narcotic analgesics has been known as representitive drugs for pain control n terminally ill patient with palliative care, narcotic analgesics use is most effective and best, way to reduce pain in that patients However many patients are poorly complient with narcotic analgesics for lack of knowledgement of narcotics effect, perception of addictive drug, tolerence and adverse reaction. In addition to many doctors do not choose the adequate narcotics according to pain severity. It has been reported that effective pain management has not been achieved by doctors and nurses because of shortness of knowledgement of narcotic use on administration. This study was performed to identify pharmacist knowledgement of narcotic analgesics in respect that the pharmacist are responsible for patient education of narcotic medication, to identify the barrjers of narcotic dispensing and administration and then to compare the knowledgement between doctors, nurses and pharmacist. At first we surveyed the pharmacist's knowledgement and attitude by written questionnaire in SNUH in Sep. 2000, and then we compared this result and doctors and nurses' result has been taken already in SNUH in May 1999. The questionnaires are composed of narcotics classification 11, narcotic pharmacology 8, narcotic administration 5, more detail question 15 cited in Elliot study. The result is analysed by average, S.D., frequency, percentile, comparison of knowledgement of doctors, nurses and pharmacist is analysed by paire t-test, ANOVA. As a result, the pharmacist group has higher average in knowledgement of narcotic analgesics, however it was not different from doctor and nurse's significantly. According to result of attitude analysis, 48% of pharmacist has been hesitated in dispensing and administration of narcotics, that was because of the difficulty in management of narcotic prescription (25%). The role of pharmacist in pain management of patients who take narcotic analgesics is very important and great. We ought to obtain a certain of accurate knowledgement of narcotic analgesic use and perform a effective and responsible medication education and counseling.

골반부 방사선 치료 환자에서 in vivo 선량측정시스템의 임상적용

김보경,지의규,허순녕,이형구,하성환 대한방사선 방어학회 2002 방사선방어학회지 Vol.27 No.1

방사선치료 시 종양에 정확한 양의 방사선을 조사하는 것은 국소 재발을 방지하고 합병증의 빈도를 낮춰 효과적인 치료를 가능하게 하는 중요한 요소이다. 종양에 조사되는 방사선량의 측정을 통해 치료의 정확성을 확인하기 위한 여러 방법들이 시도되고 있으며, 투과선량을 이용한 측정법도 그 중 한 예로 비침습적이며 매 치료 시 측정이 가능한 장점을 가지고 있다. 본 교실에서는 투과선량을 이용한 in vivo 선량측정시스템과 임의의 치료 조건에서 투과선량을 계산하기 위한 알고리즘을 개발하였다. 본 교실에서 개발한 in vivo 선량측정시스템의 단기간 및 장기간의 재현성을 확인하고, 환자의 방사선치료에서의 이용 시 발생할 수 있는 문제점을 파악하고 알고리즘의 정확성을 확인하기 위하여 본 연구를 시행하였다. 2000년 7월 25일부터 8월 14일 사이에 방사선치료를 시행 받은 환자 66명을 대상으로 투과선량의 측정을 시행하였으며, 이 중 골반부위의 방사선 치료를 3회 이상 시행 받은 11명의 환자를 대상으로 측정선량과 예측선량의 비교 분석을 시행하였다. 측정시스템의 재현성의 확인을 위하여 환자의 치료 전 및 치료 중 매시간 기준 조사조건에서 측정치를 확인하였다. 일별 몇 일 중 변동은 ±2% 이내로 재현성을 확인할 수 있었다. 본 시스템의 사용 시 별다른 문제점은 없었으나, 2명의 흉부 치료환자에서 투과선이 치료용테이블의 측면 금속을 관통하는 문제가 발생하였다. 골반부위 환자에서는 골반부위의 불균질조직에 의한 영향의 확인을 위하여, CT 및 simulation film을 이용하여 골 조직의 두께를 확인하여 보정 전 및 후의 값을 비교하였다. 전후방 및 후방조사야의 경우 골 조직의 보정을 시행하지 않은 경우 평균 오차가 -5.20%내지 +2.20%이었으며, 보정을 시행한 경우 -0.62%내지 +3.32%로 환자에 따라 정도의 차이는 있으나 골 보정이 필요함을 확인할 수 있었다. 측정치와 예측치 간 오차의 표준편차는 1.19%내지 2.46%로서 재현성이 높음을 확인할 수 있었다. 좌우 측방조사야에서 골 보정을 시행하지 않은 경우 평균오차는 -10.80%내지 +3.46%로서 골 조직의 보정이 필요하지 않은 1인의 환자를 제외하면 모두 음수 값을 지녔고, 보정을 시행한 경우 -0.55%내지 +3.50%의 평균오차를 지녀 골 보정의 필요성을 확인할 수 있었다. 측정치와 예측치 간 오차의 표준편차는 1.09%내지 6.98%로 전후방조사야의 경우보다 재현성이 낮음을 알 수 있었다. 복와위로 방사선치료를 시행 받은 환자의 경우를 제외하면, 표준편차는 1.09%내지 3.12%로 1례 외에는 2.57% 이내로 재현성이 높음을 확인할 수 있었다. 본 실험을 통하여 in vivo 선량측정시스템의 안전성과 재현성을 확인할 수 있었다. 정확한 예측치를 얻기 위하여 불균질 조직이 조사야에 포함되는 경우 보정이 요구되며, 골반의 경우 골 조직의 보정이 중요한 요인임을 알 수 있었다. 이를 위하여 불균질 조직에 대한 정확한 정보가 요구되며, 이는 CT 영상을 이용하는 것이 크게 도움이 되리라 생각된다. The accuracy of radiation dose delivery to target volume is one of the most important factors for good local control and less treatment complication. In vivo dosimetry is an essential QA procedure to confirm the radiation dose delivered to the patients. Transmission dose measurement is a useful method of in vivo dosimetry and it's advantages are non-invasiveness, simplicity and no additional efforts needed for dosimetry. In our department, in vivo dosimetry system using measurement of transmission dose was manufactured and algorithms for estimation of transmission dose were developed and tested with phantom in various conditions successfully. This system was applied in clinic to test stability, reproducibility and applicability to daily treatment and the accuracy of the algorithm. Transmission dose measurement was performed over three weeks. To test the reproducibility of this system, X-ray output was measured before daily treatment and then every hour during treatment time in reference condition (field size; 10 cm x 10 cm, 100 MU). Data of 11 patients whose pelvis were treated more than three times were analyzed. The reproducibility of the dosimetry system was acceptable with variations of measurement during each day and over 3 week period within ±2.0%. On anterior- posterior and posterior fields, mean errors were between -5.20% and +2.20% without bone correction and between -0.62% and +3.32% with bone correction. On right and left lateral fields, mean errors were between -10.80% and +3.46% without bone correction and between -0.55% and +3.50% with bone correction. As the results, we could confirm the reproducibility and stability of our dosimetry system and its applicability in daily radiation treatment. We could also find that inhomogeneity correction for bone is essential and the estimated transmission doses are relatively accurate.

骨盤腔內 巨大 橫紋筋肉腫 1 例

金瑩洙,河泰原,朴滿洙,姜瞬求,李重禾,尹栗老,薛鍾求 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

Rhabdomyosarcoma, which is a very rare and highly malignant disease in urologic field, has three categories-pleomorphic, alveolar, embryonal, and may arise from any part of the body that contains embryonal mesenchyme, whether striated muscle tissue is present or not. The common site in the genitourinary tract are prostate, bladder, and vagina. Herein we experienced a rhabdomyosarcoma of the pelvic cavity and reviewed literature briefly.

성장에 따른 백서 절치유두의 신경 분포 변화

김영진,남순현,김현정,이재문,구대학 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.1

출생후 성장에 따른 절치 유두의 신경분포 및 변화를 관찰하기 위하여 생후 1, 5, 10, 15, 20, 25, 35일 된 백서와 완전히 성장한 백서를 대상으로 calcitonin gene related peptide (CGRP)를 이용한 면역조직 화학적 방법으로 관찰하여 다음과 같은 결과를 얻었다. 생후 1일군에서는 염주알 모양의 굵은 신경섬유가 성긴 결합조직에 나타났다. 5일군에서는 이러한 신경섬유의 밀도와 분지가 증가하여 상피하층으로 더욱 가까이 연장되었고 여러개의 varicosities도 관찰되었다. 10일군부터 신경섬유의 분지 및 밀도가 증가하였고 상피하층에서 신경총을 관찰할 수 있었으며 상피내 신경섬유의 진입을 관찰할 수 있었다. 20일군에서는 증가된 상피층내 신경섬유를 관찰할 수 있었으나 25일군에서부터 전반적인 신경섬유의 분포 및 밀도가 많이 감소되었으며 성장이 완료된 군에서는 chemosensory corpuscle 지역을 제외하고는 신경섬유를 거의 관찰할 수 없었다. The purpose of this study was to investigate the distribution of nerves in the incisive papilla of rat by each developing stage. The distribution on nerves in the incisive papilla was investigated by means of immunohistochemistry using an antibody against calcitonin gene related peptide (CGRP). The results were as follows : At 1 day after birth, CGRP-immunoreactive(IR) nerve fibers first appeared in loose connective tissue without forming an apparent terminal structure. At 5 days, the CGRP-IR nerve fibers increased in density and extended more to subepithelium. CGRP-IR nerve fiber began to penetrate into the epithelium at 10 days and reached maximum at 20 days. At 25 days, intraepithelial nerve fibers were not found, and the distribution and density of nerve fiber began to decrease. In adult rat, the nerve fiber almost could not be found in dome region except in chemosensory corpuscle region.

酢漿草가 황달렛드의 혈청비리루빈에 미치는 영향

金順愛,李範九,趙台淳 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.1

Oxalis corniculata Linne is a perennial plant which exists all over the country. Although Oxalis has been used to treat the jaundice, the action mechanism is not clear. Thus, this study was performed to determine whether Oxalis altered the bile flow and the levels of serum bilirubin in α-naphthylylisothiocyanate (ANIT)-induced jaundiced rats. The results are summarised as follows. 1) The bile flow and cholate concentration were not changed in ANIT(100mg/kg)-treated rats compared with that of normal control rats. 2) Total serum bilirubin levels were significantly decreased by Oxalis treatment in ANIT (20mg/kg + 100mg/kg consecutive p.o.)treated rats. 3) The levels of total serum bilirubin and conjugated bilirubin were markedly reduced in Oxalis fed rats for 4 days after ANIT(100mg/kg) administration

일부 농촌지역 청소년층의 성장발육과 영양상태에 관한 연구

김종진,윤태영,최중명,박순영,구도서,박양원 慶熙大學校 1987 論文集 Vol.16 No.-

In order to assess the physical growth and development, and nutritional status of primary, middle and high school students in the town of Samchoek, Kangwon province as rural area, physiques of 3,793 persons(Male; 1,884. Female; 1,909)were measured from May 1 to May 31 in 1986 and various physical and nutritional indices related to them were calculated.

선천성 일측성 폐정맥 폐쇄증 1 예

김철호,이계영,심영수,김건열,한용철,한성구,정희순,임정기,박재형 대한내과학회 1988 대한내과학회지 Vol.35 No.3

Unilateral pulmonary vein atresia is a rare congenital disease and is frequently associated with intracardiac anomalies. It is usually diagnosed in childhood and is very rarely diagnosed in adulthood. A case of unilateral pulmonary vein atresia in a 20-year old female is de- scribed. The relevant findings were symptoms of exertional dyspnea, roentgenographic evidence of decreased lung volume, increased interstitial infiltration with septal lines in the involved side (right), and aoscence of blood flow in a radionuclide perfusion scan. Pulmonary angiography showed an extremely small right pulmonary artery and thining of the peripheral branches, and nonvisualization of the draining pulmonary veins. Bronchial arteriography showed rommunication between the bronchial artery and the right pulmonary artery and it was drained to the left pulmonary artery. Cardiac catheterization showed no intracardiac anomaly. The right bronchography was normal; pulmonary function studies showed a pure restrictive pattern and markedly in creased physiologic dead space. MRI showed no visible right pulmonary vein.

원발성 복막수염의 방사선학적 소견 : 초음파와 CT 소견

구자홍,송순영,이재균,김홍자,원영준 關東大學校 醫科大學 醫科學硏究所 1999 關東醫大學術誌 Vol.3 No.1

Purpose : To describe ultrasound(US) and CT findings of primary epiploic appendicitis Materials and Methods : From March, 1999 though Novemer 1999, clinical, US, and CT findings were reviewed in nine patients with primary epiploic appendicitis (eight women and one men, aged 27-54 year[mean, 36 years]). All patients performed US and four patients performed abdominal CT. The main symptoms were rapid onset, localized abdominal pain and tenderness(left lower quagrant pain[n=8], right abdominal pain[n= 1]) Results: US revealed small, ovoid, and mass are echogenic(n=7) or isoechoic(n=2) mass, located anterolateral to the colon. The echopattern of the mass are echogenic(n=7), or isoechoic(n=2). CT performed in four patients shown small oval fatty mass with a thin peripheral rim and central high attenuation area at anterolaeral side of the colon. Some streaky infiltration are associated around the fatty mass. Conclusion: Primary epiploic appendicitis has fairy. characteristic US and CT findings that enable a rapid diagnosis and valuable far differential diagnosit of other condition of acute abdomen.