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하성환,Ha Sung Whan,Suit Herman D. The Korean Society for Radiation Oncology 1988 Radiation Oncology Journal Vol.6 No.2
악성종양 치유에 있어서 증식가능한 종양세포의 완전한 세포사 필요성 여부를 확인하기 위하여 C3Hf마우스의 섬유육종을 이용하여 실험을 시행하였다. $10^1$ 내지 $10^5$개의 종양세포를 근육에 이식한 후 3일 경과 후에 방사선조사를 시행하고 120일간 관찰하여 종양치유에 필요한 방사선량을 측정하였다. 평균 $50\%$에서 종양이 치유되는데 필요한 방사선량$(TCD_{50})$은 $10^1,\;10^2,\;10^3,\;10^4\;및\;10^5$개의 종양세포에 대하여 각각 14.8, 27.1, 42.4, 49.9 및 65.5Gy였다. 종양치유에 증식가능 종양세포의 완전한 세포사가 필요한 것으로 가정하여 이론적으로 계산한 수치는 각각 15.65, 28.50, 40.97, 53.41 및 65.85Gy로서 이론적 계산수치는 위의 실험결과와 거의 일치하였다. 따라서 최소한 본 실험에 사용한 종양모델에서는 종양치유를 위하여는 모든 증식 가능한 종양세포의 세포사가 필요함을 확인할 수 있었다. To answer the question whether last clonogenic cell should be eradicated for the tumor to be controlled, radiation tumor control study was performed using microscopic tumors of variable sizes ranging from 101 to 10s tumor cells. $TCD_{50}'s$ estimated from experimental data were 14.8, 27. 1, 42.4, 49.9 and 65.5 Gy for $10^1,\;10^2,\;10^3,\;10^4\;and\;10^4$ tumor cells, respectively. Theoretical calculations, assuming that all the clonogenic cells should be inactivated, were 15.65, 8.50, 40.97, 53.41 and 65.85 Gy. From this well matched data, it can be concluded that all the clonogenic cells should be eradicated for tumor control, at least in this tumor model.
하성환,허승재,박찬일,Ha, Sung-Whan,Huh, Seung-Jae,Park, Charn-Il 대한방사선종양학회 1984 Radiation Oncology Journal Vol.2 No.2
The therapeutic effect of mammary breast cancer of rat (Sprague Dawley) was estimated by single and 5 fractionated irradiation of $Co^{60}-\gamma-ray$. Response rates over 50a were 20, 43, 67, $80\%$ respectively by single dose irradiation of 800, 1,200, 1,600, 2,000 rad, and 20,38, 57, $88\%$ by 5 fractionated irradiation of 1,400, 2,100, 2,800, 3,500 rad. $50\%$ tumor control dose$(TCD_{50})$ were 1,282rad, 2,312rad respectively with single and fractionated irradiation.
하성환 대한영상의학회 1976 대한영상의학회지 Vol.12 No.2
We introduce a simple new technique of peroral transglottic intubation of bronchographic catheter with fluoroscopy. The majority of disadvantages of the transglottic method can be overcome with this technique and, of course, the advantages of transglottic procedure are exaggerated. And one of the most important development is that the neck might not be fully extended as has been mandatory in previous procedures, transglottic or percutaneous. This fact is important because many patients, especially old aged, have pathology of the cervical spine and full extension of neck is impossisible or greatly discomfortable. And stout, short necked patients have given difficulty for the radiologists. These problems can be easily solved with this technique. This technique can be summarized as follw. 1. The oral cavity, pharynx and larynx are anesthetized with spray of 2% lido caine. 2. Then 1 to 2% lidocaine is dripped over the larynx through a curved cannula, with or without fluoroscopy. 3 Under fluoroscopic control, M tras' catheter is introduced over a wire mandarin to the upper larynx and, during inspiration, the catheter is advanced into the trachea through the glottis. This technique is a modification of M tras' methed. With fluoroscopy, the bronchographic catheter can be intubated into the trachea more easily and with less discomfort to the patients. A total of 90 bronchographies were carried out using this technique and average time consumption was 10 minutes. We conclude that, with this new technique brobchography can be performed more conveniently not only to the patients but also to the radiologists.
하성환 대한방사선치료학회 1997 大韓放射線治療技術學會誌 Vol.9 No.1
다량의 방사선에 피폭되는 경우 인체에 해로운 영향을 미치는 것은 틀림이 없으나 미량의 방사선인 경우에는 다량의 방사선인 경우와 다른 효과를 나타내며 심지어 정반대의 영향을 나타내기도 한다고 볼 수 있으며 여러 역학조사에서 이러한 사실이 증명되고 있다. 1991년의 국제방사선방어기구(ICRP) 보고서 및 1994년의 UNSCEAR 보고서는 미량의 방사선에 대한 적응반응을 인정하고 있다. 일부 학자들은 소량의 방사선에 지속적으로 피폭(연간 1 rem)됨으로써 암사망률을 감소시킬 수 있다고 주장하면서 현재의 개념을 수정하여 피폭한계 및 법적 제한 등을 변경하여 환경방사능을 증가시킴으로써 향후 인류의 생활의 질을 향상시켜야 한다고 주장하고 있다.