DJ-1/park7 modulates vasorelaxation and blood pressure via epigenetic modification of endothelial nitric oxide synthase

Won, Kyung Jong,Jung, Seung Hyo,Jung, Soo Hyun,Lee, Kang Pa,Lee, Hwan Myung,Lee, Dong-Youb,Park, Eun-Seok,Kim, Junghwan,Kim, Bokyung Oxford University Press 2014 Cardiovascular research Vol.101 No.3

<P><B>Aims</B></P><P>DJ-1/park7, a multifunctional protein, may play essential roles in the vascular system. However, the function of DJ-1/park7 in vascular contractility has remained unclear. The present study was designed to investigate whether the DJ-1/park7 is involved in the regulation of vascular contractility and systolic blood pressure (SBP).</P><P><B>Methods and results</B></P><P>Norepinephrine (NE) elevated contraction in endothelium-intact vessels in a dose-dependent manner, to a greater extent in DJ-1/park7 knockout (DJ-1/park7<SUP>−/−</SUP>) mice than in wild-type (DJ-1/park7<SUP>+/+</SUP>) mice. Acetylcholine inhibited NE-evoked contraction in endothelium-intact vessels, and this was markedly impaired in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP>. Nitric oxide (NO) production (82.1 ± 2.8% of control) and endothelial NO synthase (eNOS) expression (61.7 ± 8.9%) were lower, but H<SUB>2</SUB>O<SUB>2</SUB> production (126.4 ± 8.6%) was higher, in endothelial cells from DJ-1/park7<SUP>−/−</SUP> mice than in those from DJ-1/park7<SUP>+/+</SUP> controls; these effects were reversed by DJ-1/park7-overexpressing endothelial cells from DJ-1/park7<SUP>−/−</SUP> mice. Histone deacetylase (HDAC)-1 recruitment and H3 histone acetylation at the eNOS promoter were elevated and diminished, respectively, in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP> controls. Moreover, SBP was significantly elevated in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP> controls, but this elevation was inhibited in mice treated with valproic acid, an inhibitor of Class I HDACs including HDAC-1.</P><P><B>Conclusion</B></P><P>These results demonstrate that DJ-1/park7 protein may be implicated in the regulation of vascular contractility and blood pressure, probably by the impairment of NO production through H<SUB>2</SUB>O<SUB>2</SUB>-mediated epigenetic inhibition of eNOS expression.</P>

Event Mean Concentrations (EMCs) and First Flush Characteristics of Runoff from a Public Park in Korea

Jung, Jae-Woon,Park, Ha-Na,Yoon, Kwang-Sik,Choi, Dong-Ho,Lim, Byung-Jin The Korean Society for Applied Biological Chemistr 2013 Applied Biological Chemistry (Appl Biol Chem) Vol.56 No.6

Characteristics of non-point source (NPS) pollution runoff from a public park in Gwangju, Korea were investigated. Results exhibited the highest pollutant concentrations at the start of the rainfall events due to their build-up and wash off processes. The average event mean concentrations (EMCs) were 27.8, 7.2, 56.3, 7.5, and 0.84 mg/L (range: 4.2-54.8 mg/L) for COD, (0.5-20.8 mg/L) for TOC, (22.3-138.4) for SS, (1.4-18.5 mg/L) for T-N, and (0.17-2.02 mg/L) for T-P, respectively. The study site presented a strong first flush effect for most rainfall events. However, no first flush effect was observed in rainfall events with small rainfall factors (e.g. intensity, amount, and runoff depth). On the other hand, the ratios of total pollution loads discharged by the first 20% of runoff volume were 32% for COD, 34% for TOC, 36% for SS, 42% for T-N, and 50% for T-P. Especially, $MFF_{20}$ (mass first flush) values of T-N and T-P were larger than those of other pollutants (COD, TOC, SS), indicating that T-N and T-P are easily transported by stormwater runoff from the public park. First flush management of T-N and T-P, therefore, is required for efficient water quality management of the public park.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

서울·경기지역 병원직원의 혈액매개 감염노출에 대한 다기관 조사연구

박미라,김정은,박은숙,최정실,정선영,송영구,홍성관,김준명,허애정,양동규,조영주 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

Method for Protection of Single‑Line‑Ground Fault of Distribution System with DG Using Distance Relay and Directional Relay

Jung‑Hun Lee,Min‑Su Park,Hong‑Seon Ahn,Kyung‑Won Park,Jun‑Seok Oh,Seung‑Gyu Jeon,Dong‑Kyu Kim,Jae‑Eon Kim 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.4

When large scales DG are connected to the distribution system of unidirectional power currents, bi-directional power currents are formed, making it impossible to use conventional overcurrent protection methods alone to detect and isolate fault sections for ground and short-circuit faults. To solve these problems, this study proposed the method of protection against single-line-ground fault of common neutral line multi-contact local power distribution system using distance relay and directional relay. The proposed protection method was applied to the common neutral multi-ground distribution system to validate the protection against single-line-ground fault through the PSCAD/EMTDC software package and efectively detect and isolate only the zone of single-line-ground fault without malfunctions.

수입각증후군에 의한 급성 복증 1례

정은욱,지삼룡,이영태,박지훈,김동기,제인수,채두근,박성재,박은택,이연재,이상혁,설상영,정정명 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Afferent loop syndrome is an uncommon complication of a gastrectomy and Billroth Ⅱ reconstruction. It may cause symtoms at any time from the first postoperative day to many years after the gastrectomy. Afferent loop syndrome is characterized by abdominal pain, vomiting and elevation of serum amylase. Thus, it is difficult to differentiate afferent loop syndrome from other cause of acute pancreatitis. However, the history of gastrectomy can be an important clue for diagnosing afferent loop syndrome. We experienced one case of chronic afferent loop syndrome with acute pancreatitis. After appropriate management, the abdominal pain disappeared and serum amylase level decreased. We report this case with a review of relevant literatures.

끝나지 않는 기억전쟁(mnemonic battle)

박동숙(Dong-Sook Park),이재원(Jae-Won Lie),정사강(Sa-Gahng Jung),강혜원(Hye-Won Kang),김해원(Hae-Won Kim) 한국여성커뮤니케이션학회 2014 미디어, 젠더 & 문화 Vol.29 No.4

제주 4?3 사건은 약 7년 동안 남북한 정권, 민간인, 미국 등 서구 열강의 힘 등이 복합적으로 작용해 숱한 사람들이 사망한 사건이다. 4?3 사건을 둘러싼 논의와 갈등들은 한국 근현대사의 문제들과 닿아 있으며 4?3 사건과 그 진상규명과정에서 파생한 갈등들, 한국사회에서 4?3 사건이 기억되는 맥락은 매우 복합적인 결을 지니고 있다. 본 연구는 4?3 사건을 두고 일어나는 기억의 의미투쟁 현장을 신문은 어떻게, 얼마나 보도하고 있는가를 고찰하고자 했으며 이를 위해 1999년부터 2013년까지 14년 동안 경향신문 동아일보 조선일보 한겨레신문(가나다순) 기사 중 4?3 위주로 보도된 654건의 연도별 보도량과 주제, 기사의 의미와 기사 속 행위자 등을 분석하여 미디어 기억이 어떤 이야기를 하고 있는지 살펴봤다. 4?3을 둘러싼 최근 14년간의 뉴스미디어의 기억 지형을 살펴본 바, 사회적으로 드러난 4?3사건을 둘러싼 중요한 이슈 지점들과 4?3사건을 기억하는 미디어의 기억 지형에서 나타나는 중요한 순간들은 일치하지 않았으며 언론은 지엽적이고 파편적이며 정치 ‘싸움’에 집중된 갈등적인 요소들을 두드러지게 부각시키고 있었다. 무엇보다 4?3사건이 지니고 있는 본질적인 갈등양상과 뉴스미디어에서 그려내고 있는 갈등의 내용과 모습은 큰 차이를 보이고 있으며 뉴스미디어를 통해 이뤄지고 있는 기억전쟁은 왜곡된 형태를 지니고 있는 것으로 드러났다. The Jeju April 3(4?3) Incident occurred during seven years, from 1947 to 1954 in the island of Jeju. Two separated Korean governments, Korean civilians, United States of America and the other actors were complexly related to the incident and 25,000 casualties were estimated. The ongoing discussion and conflict regarding the 4?3 incident is still controversial and the context in which the incident is remembered in Korean society is complicated. Considering the complex nature of the Jeju April 3 Incident, this Study examined the mnemonic battle in Korean newsmedia, how Korean newsmedia covered this incident last fourteen years. For this study, four Korean daily newspapers- Kyunhyang, Dong-A, Chosun and Hanguerae were selected and 654 articles directly related to the incident were collected and analysed. Consequently the main issues and important moments of the 4?3 incident exposed in society and in newsmedia were in discord and inconsistent. The newsmedia covering the incident focused on peripheral issues, fragmented memories and minor conflicts instead of the essence of the incident, and therefore distorted the nature of it.

안중근의사기념관 - 한양대학교 + JU건축사사무소

정동구(Jung, Dong-gu),이승일(Lee, Seung-il),박제유(Park, Je-yu) 현대건축사 2007 월간 CONCEPT Vol.- No.98

김정은 시대 북한사회 변화 실태 및 북한주민 의식조사

강동완(Kang Dong Wan),박정란(Park Jung Ran) 북한학회 2014 북한학보 Vol.39 No.2

김정은 정권의 체제안정성 평가는 정치적 권력관계와 함께 북한주민들의 충성도와 사상통제, 사회경제적 변화 요인 등을 통해 살펴볼 수 있다. 최근 북중 접경지역에서 밀수를 통한 상품과 자본 그리고 이른바 한류로 대변되는 외부정보의 유입 등으로 인해 최소한 장마당으로 대변되는 북한 주민들의 행위양식은 많은 변화를 보이고 있다. 김정은 집권 3년은 지배 정당성과 지지를 위해 정치, 경제적 부분보다 단기간에 가시적 성과를 제시할 수 있는 문화와 체육 분야에 집중되었다. 새로운 지도자에 대한 기대감으로 인해 정권안정성과 충성도는 더욱 높아졌을까, 아니면 과거와 다를 바 없는 경제난의 지속으로 인해 현상변경에 대한 요구만 높아졌을까. 본 연구는 북한 당국의 통제범위를 넘어 외부정보에 노출되며 자본주의 행위양식을 축적하고 있는 북한주민의 의식변화와 사회구조가 체제변화에 미칠 영향에 대해 주목한다. 본 연구는 김정은 시대 3년의 사회변화 실태와 현황 그리고 북한주민의 의식변화를 살펴보기 위해 제3국에서 북한 주민 100명을 대상으로 면접조사를 실시하였다. The North Korean regime will claim high stability if the uniform order system flows downwards along its hierarchy with closure maintained through the strict control of outside information. However, it will be no exaggeration that the behavioral patterns of North Korean people at least represented by farmers' markets are already in a transitional period toward capitalism due to the recent influx of external goods, capital and information represented by the so-called Korean Wave through smuggling along the borders between North Korea and China. In its third year, the Kim Jung-eun regime has focused on the areas of culture and sports, which can generate visible results in a short period of time, rather than those of politics and economy for the sake of ruling legitimacy and support. Claiming to advocate North Korea as a powerhouse in the socialist civilization, it has tried to demonstrate the leadership of the new leader and his possibilities for changes through the idea of cultural and sports powerhouse. What would North Korean people think of at the result of those achievements? Would their expectations for the new leader lead to the stability of and loyalty to the regime? Or would they have more demands to change the current state due to the continuance of economic hardship from the past? Keeping the possibility of bottom-up changes, this study focused on the effects of changing perceptions of North Korean people, who were exposed to outside information and accumulating the capitalist behavioral patterns, and the social structure on changes to the regime, which had not detected political resistance force yet. In an effort to examine the patterns of social changes in the third year of Kim Jung-eun regime, the study conducted an interview investigation with North Korean people. The study was based on a direct interview investigation with 100 North Korean people in China from January to May, 2014 in order to examine their consciousness.

Notes on bird species newly recorded in Korea

Kim, Hwa-Jung,Kim, Dong-Won,Hur, Wee-Haeng,Jang, Byoungsoon,Lee, Yun-Kyung,Kwon, In-Ki,Park, Jong-Hyun,Park, Jong-Gil,Kang, Chang-Wan,Kim, Eun-Mi,Choi, Soon-Kyoo,Kim, Han-Kyu The National Institute of Biological Resources 2020 Journal of species research Vol.9 No.4

A total of 527 species of birds have been recorded in Korea. We summarize the records of three genera and six species that have been newly reported in Korea, discovered through the avian monitoring programs carried out by The National Institute of Biological Resources from 2013 to 2016. These six newly recorded species are; Ring-necked Duck (Aythya collaris), Lesser Scaup (Aythya affinis), Bufflehead (Bucephala albeola), Black-winged Kite (Elanus caeruleus), Mongolian Lark (Melanocorypha mongolica) and Crested Myna (Acridotheres cristatellus). One Ring-necked Duck was observed on March 23, 2014 in Jungrangcheon Stream. One male Lesser Scaup was recorded on February 24, 2014 in Gyeongpoho Lagoon. A male bufflehead was first seen in Yeongrangho Lagoon on January 26, 2013. The Black-winged Kite was first observed on January 23, 2013 at the Gangseo Wetland Ecological Park. One Mongolian Lark was also recorded on May 11, 2016 and May 12, 2017 in Marado Island. The Crested Myna was first observed on April 20, 2016 in Seomando, Island.