경주지역 여고생의 초경과 체성장간의 관계

김준섭,권오구,박진석,오종수,박정현,박제식,안세한,이용환,서정호,신태섭,최영배,김덕수,이관,박수경 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

본 연구는 경주지역 1개 고등학교 3학년 여고생을 대상으로 초경 시작 전인 초등학교 4학년부터 고등학교 2학년까지의 키, 몸무게, 가슴둘레 수치와 초경 연령을 파악하여 여성의 초경이 빠를수록 체성장 속도의 변화가 있을 것이라는 가설을 기초로 두 요인간의 관련성을 파악하고자 시행되었다. 경주시 1개 여자고등학교 3학년생 총 317명에 대해 ㅊ경 나이, 초경시 심리 상태, 초경이 시작되었을 때의 상담 여부와 상담하였던 사람, 부모 신장과 초경전후의 식사 규칙성, 다이어트 경험, 수면시간, 스트레스, 음주/흡연 여부, 질병력 등에 대한 설문 조사를 시행하였고, 초등학교 4학년부터 고등학교 2학년까지의 키, 몸무게, 가슴둘레에 대한 정보는 건강기록부에서 확보하였다. 상기 대상자 중 건강기록부가 분실된 39명, 초경나이에 대해 응답하지 않았던 29명 및 결석 등으로 조사를 하지 못하였던 42명을 제외한 조사 대상자는 206명으로 선정하였다. 대상자들의 초경연령 평균값(Mean±SD)은 13.0±1.11이었고, 초등학교 4학년부터 고등학교 2학년까지의 초경 이후 신장 성장률은 감소하였으며, 초경연령이 빠른 군이 초등학교 때는 신장에 있어서 우위를 차지하나 고등학교에 오면서 신장은 비슷한 수준이 되었다. 초경후 1-2년 사이에 체중과 흉위의 증가율은 감소하였고, 초경연령이 빠른 군이 초등학교와 고등학교 사이에 체중과 흉위에서 모두 우위를 차지하였다. 본 연구의 결과는, 흔히 이차 성징의 시작 시점 혹은 사춘기의 시작 시점으로 보고있는 초경 연령이 청소년기의 성장과 밀접한 관련성이 있고, 특히 체중과 흉위의 성장 속도와 밀접한 관련성이 있음을 시사한다. To understand the onset of menarche in relation to changes in physical growth that take place during female adolescence, especially the changes in height and weight velocity. The 207 senior in one women high school of Kyongju were investigated in April 3 to 8, 2001. We collected the information, relation in the age at menarche, height & weight of parents, regularity of eating, and obesity diet, duration of sleeping, sickness & stress near age at menarche, by self-recording. The status of height, weight & chest circumference between the 4th grade of primary school and the junior of high school was collected by individual Health Record. The results were followed; The average age at menarche was 12.95±1.11 years old and the most frequent age of menarche is 13 years. After menarche, the velocity of height, weight and chest circumference were decreased. The most rapid group of menarche hold dominant position in height during elementary school. As time passed, they dont hold dominant position in height. The most rapid group of menarche get an advantage in the weight and the girth of chest after elementary school. The height of subjects is directly proportional to the height of their parents. These results suggest that the starting age at menestuation can be closely associated with physical growth and development.

비개흉 심근 경색 동물모델을 이용한 심근 경색의 자기공명영상에 관한 연구

임명관,박재형,이활,정진욱,이동수,정준기,최영희 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.11

급성 췌장염의 합병이 추정되는 한국형 출혈열 1예

박영수,김창오,김영근,홍성관,장경희,허애정,염준섭,송영구,김준명 대한감염학회 2001 감염 Vol.33 No.5

The Korean hemorrhagic fever (KHF) is an acute febrile disease with characteristic of fever, bleeding tendency, and renal failure. There are many complications of Korean hemorrhagic fever such as infection, anemia, internal bleeding, hypopituitarism, respiratory, and neurologic complication. A few cases were reported on acute pancreatitis with hemorrhagic fever abroad, but there was no case about Korean hemorrhagic fever with acute pancreatitis in this country. We experienced a case of Korean hemorrhagic fever associated with suspected acute pancreatits. With review of articles, we report a case of 51 year-old woman with KHF, where acute pancreatitis developed during management, (Korean J Infect Dis 33:376∼379, 2001)

서울·경기지역 병원직원의 혈액매개 감염노출에 대한 다기관 조사연구

박미라,김정은,박은숙,최정실,정선영,송영구,홍성관,김준명,허애정,양동규,조영주 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

중환자실 병원감염에 대한 다기관 공동 조사연구

박은숙,박미라,진혜영,김정은,최정실,송영구,최영화,이위교,홍성관,허애정,양동규,김준명 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

Takayasu 동맥염이 동반된 임신의 양상과 예후

임준희(June Hee Lim),김성민(Sung Min Kim),김미하(Mi Ha Kim),오수영(Soo Young Oh),문정빈(Jeong Bin Moon),박중신(Joong Shin Park),전종관(Jong Kwan Jun),윤보현(Bo Hyun Yoon),신희철(Hee Chul Syn) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.9

목적 : Takayasu 동맥염을 동반한 임신의 임상적 양상과 본 질환이 산모 및 태아에 미치는 영향에 대해서 알아보고자 하였다. 연구방법 : 본 연구는 후향적 연구로서 1989년 6월부터 1999년 12월까지 서울대학교병원 산부인과에서 분만한 환자들중에 Takayasu 동맥염을 동반한 산모의 14례 임신에 대한 의무기록을 검토하여, 환자의 임신 전 상태와 주산기 예후에 대해 기술하였다. 결과 : 연구 기간 동안 본원에서 분만건수는 총 19,885례가 있었는데 이 중 Takayasu 동맥염이 동반된 여성에서의 분만은 12명의 환자에서 14례였다. 산모와 신생아 사망의 예는 없었으며, 진단 당시 평균 연령은 24.6세 (범위 18세-31세)였고, 임상양상 중에 맥관계 잡음(58.3%), 말초 혈관의 박동감소(50%), 고혈압(50%)순으로 빈도가 높았다. 고혈압 환자 6명중에 5명이(83.3%)이 신혈관성 고혈압이었고, 이중에 2명이 임신중 전자간증을 보였다. 진통중 현저한 혈압상승이 동반된 경우가 3례(25%)있었고, 이중 2례는 임신전 고혈압의 증거가 없었으며, 임신중에 전자간증도 동반되지 않았다. 제왕절개를 통한 분만은 5례(35.7%)에서 이루어졌고, 조기분만은 2례(14.3%)에서, 발육지연 상태의 신생아가 4례(28.6%)에서 있었다. 단지 1명의 신생아가 신생아중환자실에 입원하여 집중치료를 받았는데, 1분 아프가 점수가 5점으로 경도의 쳐짐을 나타내었다. 14례의 임신 중 3례에서 분만 후 산모의 합병증이 초래되었는데 이는 호흡곤란, 흉막삼출, 일시적 혈압감소 등의 심혈관계 합병증에서 기인한 것이었다.결론 : Takayasu 동맥염은 가임기 여성에서 빈발하여 임신 중 처음으로 발견되기도 한다. 주산기에 일어날 수 있는 다양한 심혈관계의 합병증의 가능성에도 불구하고 대부분 본 질환은 임신에 의해 영향을 받지 않고 산과적으로 커다란 문제없이 건강한 아이를 분만할 수 있다. Objective : To evaluate the clinical characteristics, course, and the outcomes of pregnancies with Takayasu's arteritis. Methods : The retrospective study was done by the review of medical records of 14 pregnancies with Takayasu's arteritis found between June, 1989 and December, 1999. Pre-pregnant status and pregnancy outcome were described.Results : Takayasu's arteritis was found in 14 cases among 19,885 women who had delivered at our unit during the study period. There were no maternal or neonatal death. The median age at diagnosis was 24.6 years. Common clinical findings were vascular bruit(58.3%), pulse deficit(50%), and hypertension(50%) at diagnosis. Among the 6 patients who had hypertension, 5(83.3%) showed renovascular hypertension and superimposed preeclampsia developed in 2(33.3%) cases. Marked elevation of systolic blood pressure during labor was associated with 3 pregnancies(25%), including 2 patients who were prepregnant normotensive and without preeclampsia. Cesarean section was performed in 35.7%(5/14) of cases. There were 2 preterm birth(14.3%), 4 growth-restricted newborns(28.6%). Only one was admitted into NICU with 5 Apgar score at 1 minute. Three fourteenths had various postpartum problems, most of which were related to cardiovascular events ; dyspnea, pleural effusion, and transient depressed blood pressure. Conclusion : Because the disorder affects women in childbearing age mainly, it may be recognized the first time during pregnancy. Despite various cardiovascular events which may occur in the perinatal period, the basic disease is usually unaffected by pregnancy and both maternal and fetal clinical outcome may be fair.

유두상 갑상선암에서 종양의 크기에 따른 중앙 경부림프절 전이 및 이와 관련된 인자에 대한 비교분석

이관주(Kwan Ju Lee),김형래(Hyung Rae Kim),김세준(Say June Kim),이상철(Sang Chul Lee),김정구(Jeong Goo Kim),성기영(Gi Young Sung),박우찬(Woo Chan Park),오세정(Se Jeong Oh),안창준(Chang Joon Ahn),이동호(Dong Ho Lee) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.3

Purpose: The aim of this study was to analyze the relationship between central lymph node metastasis and the associated factors in patients with papillary thyroid carcinoma (PTC) according to the tumor size, and we wanted to determine an appropriate treatment for PTC. Methods: From June 2005 to May 2007, 218 patients with PTC underwent total thyroidectomy or lobectomy, and they also received central lymph node dissection at our institution. The patients were divided into three groups: group 1 (tumor ≤5 ㎜), group 2 (5 ㎜<tumor≤10 ㎜), and group 3 (tumor>10 ㎜). We retrospectively reviewed these patients to analyze the relationship between tumor size and the clinicopathological characteristics, including age, gender, lymph node metastasis, extrathyroidal extension, capsular invasion and lymphovascular invasion. Results: There were 47 (21.6%) patients in group 1, 101 (46.3%) patients in group 2 and 70 (32.1%) patients in group 3. The tumor size was closely correlated with the presence of extrathyroidal extension, capsular invasion and lymph node metastasis (P<0.001). Lymph node metastasis was not only closely correlated with tumor size, but it was also significantly associated with extrathyroidal extension, capsular invasion and lymphovascular invasion (P<0.05). Conclusion: Our study confirmed that some factors, including central lymph node metastasis, capsular invasion and extrathyroidal extension, were frequently observed in patients with papillary thyroid microcarcinoma (PTMC), and central lymph node metastasis was related to tumor size, extrathyroidal extension, capsular invasion and lymphovascular invasion. Therefore, routine central lymph node dissection is reco㎜ended during the initial surgery for patients with PTMC.

Process Analysis on the Decontamination of Internal Surface of UF6 Cylinder

Kwan Sik Chun,Sung Hyun Yoo,Young June Cho,Jang Pyo Hong,Wook Jin Han,Beong Soon Choi,Pil Sang Kang,Suk Ju Cho 한국방사성폐기물학회 2009 방사성폐기물학회지 Vol.7 No.3

핵연료 운반용 실린더의 재사용을 위한 용기세척공장의 제염공정에 대한 성능을 평가하기 위하여 Na2CO3 + H2O2 혼합용액의 조합을 약간 달리한 2회의 시험을 실행하였다. 각 시험은 모두 일련의 5 단계에 걸쳐 실시되었다. 우라늄 제염의 주 화학종은 Na4UO2(CO3)3 로 식별되었다. 그리고 첫 단계에서의 세척액은 물이었으며, 이 단계에서 50% 이상의 우라늄이 제염되었다. 그 이후로는 단계가 더해 갈수록 우라늄의 제염양은 지수함수적으로 감소하는 경향을 나타내었으며, 화학양론적으로 제거된 우라늄에 비하여 투여된 Na2CO3 의 양은 과다함을 나타내었다. 이러한 결과들에 의하면, 공정최적화를 통하여 Na2CO3 의 투여량 감축, 세척폐액의 감량, 제염단계 축소 등을 꾀할 수 있을 것으로 판단된다.

Effects of repeated education of inhaler device handling by advanced practice nurse in teaching Korean chronic obstructive pulmonary disease patients

( June Hong Ahn ),( Kwan Ho Lee ),( Jin Hong Chung ),( Kyeong-cheol Shin ),( Eun Young Choi ),( Hyun Jung Jin ),( Jong Geol Jang ),( Kyung Soo Hong ),( Young Seok Lee ),( Euna Lee ),( Mi Jeong Nam ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.0

Objectives: The effects of inhaler education in chronic obstructive pulmonary disease (COPD) patients remain unclear. The objective of this study was to evaluate techniques and adherence in using inhaler devices and to investigate the effects of repeated education using inhaler device handling in COPD patients. Methods: We prospectively enrolled COPD patients who used their particular inhaler device for more than 1 month and evaluated the efficacy of repeated education for COPD. The educational intervention was 6-month education program of three visits, during which subjects were tested their inhaler technique and adherence, taught about inhaler technique face-to-face by advanced practice nurse. Inhaler technique, adherence, mMRC, COPD assessment tests (CAT), EuroQol-5D (EQ-5D), patient health questionnaire (PHQ-9), and feeling of satisfaction with inhaler questionnaire (FSI-10) were compared before and after education. Results: A total of 261 COPD patients performing a total of 308 inhaler devices were included in the study. 244 (93.5%) were men and the mean age was 69.8 ± 7.7. At least one errors were observed in 267 (86.7%) and at least one critical inhaler errors were observed in 43.2% (133/308). Education significantly decreased in percentage of incorrect techniques, incorrect critical techniques and poor adherence (86.7% vs 39.3%, p<0.001; 43.2% vs 8.8%, p<0.001; 2.3% vs 0.4%, p=0.009, respectively). FSI-10 for inhaler was significantly improved after education (44.4 ± 4.7 vs 47.7 ± 4.1, p<0.001). mMRC, CAT, EQ-5D and PHQ-9 were not significantly improved after education. Conclusions: Repeated face-to-face inhaler device handling education by advanced practice nurse significantly improved the inhaler technique, adherence and feeling of satisfaction with inhaler.

Bioinspired DNase-I-coated Melanin-like Nanospheres for Modulation of Infection-associated NETosis Dysregulation

( June Hong Ahn ),( Kwan Ho Lee ),( Jin Hong Chung ),( Kyeong-cheol Shin ),( Eun Young Choi ),( Hyun Jung Jin ),( Jong Geol Jang ),( Kyung Soo Hong ),( Wonhwa Lee ),( Chun Gwon Park ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Background Infection by SARS-CoV-2 causes both uncontrolled inflammatory innate immune responses and impaired adaptive immune responses, leading to local and systemic tissue damage. The factor or process that initiates and propagates the cytokine storm that drives severe COVID-19 is unknown; however, a recent study has proposed that excessive neutrophil extracellular traps (NETs), a special type of neutrophil-specific programmed cell death, could be associated with poor outcomes in severe patients and may play a pivotal role in COVID-19 pathogenesis. We suggest that the dissolution of a basic constituent of NET structure―DNA ―using DNase-I may be appropriate for preventing NET-related pathogenesis in SARS-CoV-2 patients. Methods Whole blood samples were collected from patients after they were diagnosed with the SARS-CoV-2 infection at Yeungnam University Medical Center. Recombinant DNase-I was purchased from Roche (Basel, Switzerland). To demonstrate the effects of DNase-I on DNA degradation, we treated the plasma of severe COVID-19 patients with either free DNase-I or DNase-I-coated melanin-like nanospheres (DNase-I pMNSs). Results The Results (Figure 1) showed that both forms of DNase-I significantly reduced the eDNA levels, and that exposure of DNase-I to the plasma of severe COVID-19 patients increased the activity of DNase-I. We also observed markedly reduced NET levels, MPO activity, and NE levels in neutrophils of severe COVID-19 patients upon treatment with DNase-I pMNSs. The activity of NF-kB and secretion of cytokines IL-1b, IL-6, IFN-g, and TNF-a were slightly reduced upon treatment with free DNase-I, and were further drastically reduced upon treatment with DNase-I pMNSs. Conclusions We demonstrated that eDNA, a NETosis factor, is a potential target for the treatment of SARS-CoV-2-induced sepsis. DNase-I pMNSs are able to modulate COVID-19-associated NETosis dysregulation and prevent further progression of the disease. The DNase-I pMNSs have potential applications in the treatment of SARS-CoV-2-related illnesses and other beta-CoV-related diseases.