Antioxidant and hepatoprotective effects of Korean ginseng extract GS-KG9 in a D-galactosamine-induced liver damage animal model

Yun Ho Jo,Hwan Lee,Myeong Hwan Oh,Gyeong Hee Lee,You Jin Lee,Ji Sun Lee,Min Jung Kim,Won Yong Kim,Jin Seong Kim,Dae Seok Yoo,Sang Won Cho,Seon Woo Cha,Mi Kyung Pyo 한국영양학회 2020 Nutrition Research and Practice Vol.14 No.4

BACKGROUND/OBJECTIVES: This study was designed to investigate the improvement effect of white ginseng extract (GS-KG9) on D-galactosamine (Ga1N)-induced oxidative stress and liver injury. SUBJECTS/METHODS: Sixty Sprague-Dawley rats were divided into 6 groups. Rats were orally administrated with GS-KG9 (300, 500, or 700 mg/kg) or silymarin (25 mg/kg) for 2 weeks. The rats of the GS-KG9- and silymarin-treated groups and a control group were then intraperitoneally injected Ga1N at a concentration of 650 mg/kg for 4 days. To investigate the protective effect of GS-KG9 against GalN-induced liver injury, blood liver function indicators, anti-oxidative stress indicators, and histopathological features were analyzed. RESULTS: Serum biochemical analysis indicated that GS-KG9 ameliorated the elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in GalN-treated rats. The hepatoprotective effects of GS-KG9 involved enhancing components of the hepatic antioxidant defense system, including glutathione, glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT). In addition, GS-KG9 treatment inhibited reactive oxygen species (ROS) production induced by GalN treatment in hepatocytes and significantly increased the expression levels of nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) proteins, which are antioxidant proteins. In particular, by histological analyses bases on hematoxylin and eosin, Masson"s trichrome, α-smooth muscle actin, and transforming growth factor-β1 staining, we determined that the administration of 500 mg/kg GS-KG9 inhibited hepatic inflammation and fibrosis due to the excessive accumulation of collagen. CONCLUSIONS: These findings demonstrate that GS-KG9 improves GalN-induced liver inflammation, necrosis, and fibrosis by attenuating oxidative stress. Therefore, GS-KG9 may be considered a useful candidate in the development of a natural preventive agent against liver injury.

GIS와 항공정사사진을 이용한 산림정보 관리시스템 구축

김준범,조명희,권태호,김인호,조윤원,신동호 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.2

우리나라 산림행정 업무의 대부분은 서류 및 대장에 의존하고 있는 실정으로 신속, 정확하고 다양한 업무 처리를 위해서는 첨단의 공잔정보기술을 이용한 과학적인 산림정보 관리시스템의 개발이 시급하다. 특히 지리정보시스템(GIS)과 항공사진 활용기술의 도입은 산림이용기본계획이나 산지개발, 산림자원 관리 및 산림보호 정책 등의 의사결정지원에 효율적으로 기여할 수 있을 것이다. 본 연구에서는 GIS와 항공사진(1998년도 촬영)을 기반으로 주요 산림정보인 수치지도, 수치임상도, 임야도 및 관련 속성데이터 둥을 가공하여 DBMS(data base management system) 내에 저장하였으며, 이를 기반으로 세부 응용시스템인 지번별 임야정보 검색, 산지이용개발 정보관리, 법정제한림 정보관리, 산림자원 정보검색 등의 인터페이스를 개발함으로써 산림 관련 실무자가 산림정보의 종합적인 공간분석 및 질의 검색이 가능한 산림정보 관리시스템을 구축하였다. 본 시스템의 구축으로 산림의 효율적 관리는 물론, 경제적인 산림자원 및 임산업 육성과 쾌적한 산림환경을 조성할 수 있을 뿐만 아니라 관련 부서들 간의 표준화된 공간 자료 공유와 과학적인 정보체계의 연동으로 산림자원 관리를 위한 집약된 공간 및 전자 정보화 인프라 구축의 기반을 마련할 것으로 사료된다. Recently in order to more effectively and scientifically process forest official tasks, which have been focused on documents and inventories, they should be applied with the up-to-date spatial information technologies. Especially, the forest resource information management based on GIS (geographic information system) and aerial orthophoto is expected not only to play an important role as DSS (decision support system) for domestic forest conservation policy and forestry development industry but also to service forest resource information toward people such as the owners of a mountain rapidly. In this study, the important forest information such as digital topography map, digital forest type map, digital forest cadastral map, digital aerial photographs and attribute data were first reprocessed and constructed in DBMS (data base management system). In addition, forest officials could analyze and retrieve forest information by using detail sub-application systems such as forest cadastral retrieval, forest land development information management, reserved forest information management and forest resource information retrieval. For this, the user interface is developed by using Visual Basic 6.0 and MapObjects 2. 1 of ESRI based on CBD (component based development) technology. The result of developing this system will not only perform constructing economical forest and better environment but also be the foundation of domestic spatial technology for forest resource management.

J-R 곡선에 대한 시편크기의 영향에 관한 연구

조연제,석창성,김영진,양원호,최용식 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.1

The objective of this paper is to investigate the constraint effect on fracture resistance curves. A series of fracture toughness tests with different specimen sizes taken from nuclear piping materials(SA312 TP347 SA516 Gr. 70) were performed. Test results show that fracture toughness is increased with increase in specimen size, probably due to the relaxation crack tip constraint. Elastic-plastic finite element analyses were also performed to investigate the constraint effect. Numerical results show that the stress triaxiality at the crack tip is the governing factor for fracture toughness.

전격성 경과를 취한 만성 호산구성 폐렴 환자 1예

윤호상,진춘조,유광하,이상엽,이수인,정상만,김선두,이순제,이길도,전혜정 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Chronic eosinophilic pneumonia(CEP) is a rare disease of unknown etiology characterized by chronic infiltration of the lung with eosinophils. It presents with profound systemic symptoms comprising fever, night sweats, weight loss, dyspnea and blood eosinophilia with nonsegmental air-space consolidation confined to the outer third of the lung, the "photographic negative of pulmonary edema". Histopathologic features of chronic eosinophilic pneumonia are intraalveolar and interstitial infiltrations with eosinophils, histiocytes, giant cells, scattered lymphocytes and plasma cells. Glucocorticoid therapy cause prompt resolution of symptoms as well as disappearans of blood eosinophils, elevated serum Ig E levels and the roentgenographic lesions. Infrequent radiographic findings include nodular infiltrates, consolidations, cavitations, atelectasis and pleural effusions. Deaths from CEP although rare, have been reported, but the majorities of CEP have benign courses and do not need a therapy with ventilator. We report a case of chronic eosinophilic pneumonia, which had a sudden course associated with diffuse pneumonic consolidations on the both lung and bilateral pleural effusion.

코칭 관리의 과정 모델 분석

육조영,김희수,윤찬호 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

The purpose of this study is to examine the process of 'coaching(administration)' .For that purpose, this study brought in the concept of the management process (VanderZwaag, H.J.) and the administrative process(Hodgkinson, C.) and examined the process model of 'coaching(administration)' . As the result of this study, the process of coaching (administration)' was characterized as follows. 1. The process model of 'coaching(administration)' consists of philosophy, planning, organizing, managing and valuating. 2. At the stage of philosophy and planning, the policy of 'coaching(administration)' is made. 3. At the stage of organizing and managing, the policy of 'coaching(administration)' is implemented and the process of 'coaching(administration)' goes on toward the purpose effectively. 4. The last stage of process (valuating) feeds back to the stage of philosophy. 5. The stage of philosophy has the possibility for changing the direction of process through the consideration of value.

국제스포츠 정보 시스템의 현황 분석

육조영,윤찬호,김범수,노덕선,이무연,배진희,이승훈 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

Information has become a strategic tool with progress of sports science and sports technology. Demand on sports information is spreading to leisure, recreation, sociology, science of nutrition, psychology, sports medicine, sports therapy, prophylactic medicine, alternative medicine, sports industry and sports nature etc. if on line data base can be manipulated freely then acceleration and quality improvement of the study in this field can be effected and it is possible to gain new insight for receiving latest information But next problem is cost for use. For this reason this author summarized quick and effective on lline search points as follows: 1. Data base should be chosen with clear purpose for its use. Conduct prior investigation on contents and fee system of data base. With the same data base fee system may be differed depending on distributor therefore it is necessary to try different distributors at first as much as possible. 2. Prior to starting on line search prepare search method. If on line is started and then search method is checked than quickly telephone charge will go up. Search method should be prepared in advance by thinking sufficiently of what theme is to be searched. 3. Look for good advisor: lf there is no advisor nearby then the best thing is counselling with the person in charge for the distributor. If the result of search is stored at floppy disk by "downloading" then even after communication line is cut off it will be possible to print out anytime. 4. In this study the author explained about on-line search of lterature data line but recently it is possible to search overseas sports news or information on rate of victory or defeat of prfessional footbali etc. in real time. In Japan it is possible to search feature articles of Nihon Kesai or Asahi (except culture and sports column) by on-line. However in our country there are not many data bases in the field of sports and physical education which can be on-line searched. Our country belongs to up per level in the world in terms of study of sports science and technology and we are attracting attention from countries in Asia and from different parts of the world and the task facing us now is developing independent and unique data base for our country.

크론병에 대한 CoPPLX의 방어효과에 대한 연구

이호학,김유림,문창기,이재일,양병윤,김종수,이정민,정재혁,안석진,박상준,김윤권,김소연,김영중,조민구,최영자,장성조 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

국제 스포츠 정보 시스템의 동향 분석

육조영,임정일,윤찬호,이무연,노덕선,배진희,이승훈 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

As Follow suggested : The purpose of this study was to consider tendency of modern sports information. today Modernst information system had four areas such as collection, clearance, communication and application So, most literuture of America and Europe was collected, cleared, communicated and apilcated in international sports data base. If we utillited communication circuit properly, we could use sports information beneficently at the laboratory and office. In the future and now, one was that special sports institution needed to obtain Education about sports imformation such as information of specialization, and information of knowledge on both soft phase and hard phase of new media. Although korea used date base of foriegn country efficiently, korea had to make effort to create its own information system and wish to avoid friction of economy and fiction of information.

延伸 및 熱處理한 Nylon6 纖維의 二重 熔融現象에 對한 實驗的 考察

朴然欽,洪喆載,曺元鎬 成均館大學校 科學技術硏究所 1983 論文集 Vol.34 No.2

The thermal analysis of nylon 6 drawn and heat-treated at different draw ratios and temperatures has been carried out using a differential thermal calorimeter(DSC). The origin of double melting peaks in DSC thermogram has been controversial. If double melting peaks were due to the same species, i.e. the recrystallization process, it is expected that the heat of fusion of lower melting peak increases with the drawing temperature. The opposite, in fact, is observed, i.e., higher drawing temperature results in more of the higher melting peak. A single melting peak of the remelting thermograms shows that double melting peaks in drawn nylon 6 are not caused by the original crystal melting and its recrystallization in DSC. It is concluded that the material which shows the higher melting peak of double melting peaks may be morphologically different from that of the lower melting peak.

학국에서 심방세동의 임상양상에 관한 연구

이선미,조정휘,홍순조,최윤식,안신기,김성순,김영훈,김윤년,조정관,차태준,김유호,최기준,김준수,이상민,신동구 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.5