불완전 척수손상 후의 자동보행훈련

정재훈 한국전문물리치료학회 2003 한국전문물리치료학회지 Vol.10 No.3

제2형 당뇨병 환자에서 Voglibose와 Acarbose의 비교임상연구

정인경,정재훈,민용기,이명식,이문규,김광원,정윤이,박중열,홍성관,이기업 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.26 No.2

연구배경:아카보스와 보글리보스는 ­glucosidase inhibitors로써 비록 약리학적 작용이나 부작용에 있어서 두 약물간에 차이가 있다는 것은 잘 알려져 있으나 당뇨병 환자를 대상으로 아직 이에 대한 두 약물간에 직접적인 비교에 대해 연구된 바는 없었다. 이에 저자등은 국내 2형 당뇨병 환자에 대해 유효성과 부작용 발현에 대해 두 약제를 비교하고자 무작위법에 의한 위약 대조군의 이중 맹검법 연구를 시행하였다. 방법:시험 약제 투여 4주간의 관찰기를 설정하여 공복혈당의 변화가 30㎎/dL 이하이고, 식후 혈당이 200㎎/dL 이상인 환자로 기타 제외 기준에 해당하지 않은 환자 53명을 대상으로 하여 보글리보스 군(24명)과 아카보스 군(29명)으로 무작위로 나누었다. 치료기간은 총 8주로 하였으며, 4주간 간격으로 혈청학적 검사와 부작용을 분석하여 치료 효과가 부작용을 평가하였다. 결과:1)혈당 변화:보글리보스군은 식후 1시간 혈당이 치료 후 4주, 8주째 의미 있게 감소하였도, 아카보스군은 식후 1시간과 2시간 혈당이 치료 후 4주, 8주째 의미있게 감소하였다. 또한 관찰기 혈당에 대한 치료 4주째 감소량은 아카보스군에서 더 큰 경향을 보였으나, 치료 8주째에는 두 군 간의 강하정도에 의미있는 차이가 없었다(p=0.569). 2)인슐린 치의 변화:보글리스 군은 식후 1시간 인슐린 치가 치료 전에 비해 치료 4주, 8주째 감소하는 경향을 보였고, 공복 인슐린이나 식후 2시간 인슐린치는 치료전 후에 의미 있는 차이가 없었다. 아카보스군에서는 치료 전후로 공복 인슐린, 식후 1시간과 2시간 인슐린치에 의미 있는 차이를 보이지 않았다. 두약제 간에 치료 전과 치료 8주사이의 식후 2시간 인슐린의 감소량이 보글리보스 군에서 의미있게 높았다(p=0.040). 3)당화혈색소:보글리보스 군은 치료 전에 비해 치료후 당화혈색소가 감소하는 경향을 보였고, 아카보스군은 치료 전에 비해 의미있게 감소하였다. 당화혈색소 변화량은 두 군간에 의미 있는 차이는 없었다(p=0.412). 4)지질대사의 변화:중성지방, 콜레스테롤, 고밀도 진단백 콜레스테롤에 대해 두 군간에 의미 있는 차이는 없었다. 5)부작용:소화기계 부작용의 빈도는 치료 4주째 보글리보스 군에서 의미 있게 낮았으나(p=0.028), 치료 8주째 부작용의 빈도는 두 군간에 의미 있는 차이가 없었다(p=0.215). 결론:2형 당뇨병 환자에서 보글리보스와 아카보스의 두 약제의 임상적 유효성과 부작용발현에 대해 비교한 결과 치료 후 8 주 후 혈당강화효과는 두 약제간에 유사한 효과를 보였으나 보글리보스군에서 4주째의 초기 위장관 부작용이 적었다. Background : Acarbose and voglibose are alpha-glucosidase inhibitors. Although different pharmacological effects and adverse abdominal events associated with the two drugs have been reported, no study directly compared acarbose and voglibose in diabetes has been undertaken. To compare the pharmacological effects and gastrointestinal adverse events between two drugs, a randomized, placebo-controlled, double-bind study was performed in type 2 diabetes patients. Methods : The period of study was 12 weeks(observation period: 4 weeks; treatment period: 8 weeks). Fifty-three patients were randomized into two groups(the acarbose group: 24 patients; the voglibose group: 29 patients). The serum glucose, insulin, fructosamine, HbA_1c, cholesterol, triglyceride and the incidence of adverse events were measured. Results : 1) The reduction of glucose from before treatment to 4 weeks after treatment was significantly higher in the acarbose group, but the change before treatment and 8 weeks after treatment in the two groups was similar(p=0.569). 2) The insulin significantly decreased after voglibose treatment(p=0.040). 3) HbAa_1c level tended to decrease in voglibose group, and there was a significant decrease after acarbose treatment. However, the change in HbA_1c level before and after treatment was similar between the two groups(p=0.412). 4) The two drugs did not cause any other changes in the total, HDL-cholesterol and triglyceride. 5) The number of patients with gastrointestinal adverse events was significantly low 4 weeks after voglibose treatment (p=0.049), but the incidence in the two groups was similar after 8 weeks(p=0.215). Conclusions : Acarbose and voglibose significantly improved postprandial hyperglycemia in diabetes. The incidence of gastrointestinal adverse events was low 4 weeks after voglibose treatment(J Kor Diabetes 26:134~145, 2002).

양측 하악과두 골절에 대한 관혈적 정보술후 나타난 근약화와 시력장애 : 증례보고

정기훈,신용길,김태열,신재명,윤규호,전인성 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.6

The condylar fracture show high occurrence rate in the following of symphysis and angle, because it is easy to have concentration of outer pressure due to its long and narrow anatomical shape and mouth opened state when trauma is attacked. For the clinical findings, there are trismus, opening deviation, mal-occlusion and open bite The classification of condylar fracture is varied due to the location of condylar bone fragment, fracture site. There are conservative and surgical methods for treatment modalities. Because of many advantages, conservative method is widely used it has no particular limits of treatment adjustment but the cases of absolutely surgical correction indication are easily found in clinical experience. Although many methods are suggested for treatments of condylar fracture, there are no particular surgical methods for precise reduction due to difficult accessibility in high condylar neck fracture. For precise reduction of condyle, we used Nam's method. However, in Nam's method, because condyle is fixed when once it is kept off externally reduced in avascular state, so complication such as condyle resorption is pointed out as a problem. In our clinic, we obtained some knowledge by treating a patient who had muscle weakness and vision disorder after temporary airway obstruction follownig the both condylar fracure operated using Nam's method, so here we reported the case with a study of documents.

Rotary type과 linear type 자동흡연 장치에 따른 담배연기 중 타르, 니코틴 및 일산화탄소의 함량 비교

정재훈,김영신,임흥빈,석영선,신주식,이학수 충북대학교 연초연구소 2004 煙草硏究 Vol.19 No.-

본 실험은 type별 흡연 장치의 담배 주류연 포집에 대한 차이를 비교하고자 주류연 중 일반적인 다량의 성분을 측정하였다. 1. 니코틴 함량은 대체로 linear-type 흡연 장치에서 높은 경향 이였으나 유의한 차이는 없었다. 2. 수분 함량은 두 가지 type 간에 유의한 차이는 없었다. 3. tar 함량은 저 농도에서 linear-type 보다 otary-type 흡연 장치가 높은 경향 이였으나 유의한 차이는 없었다. 4. 일산화탄소는 rotary-type과 linear-type 모두 유의한 차이는 없었다. 본 실험결과 ISO 표준 흡연 조건에서 담배 주류연의 tar, 니코틴, 일산화탄소 함량의 측정은 흡연 장치의 type별 통계적으로 유의한 차이는 없는 것으로 판단된다. This study was conducted to compare rotary-type with linear-type automatic smoking machine referred to ISO 3308 in the determination of tar, nicotine and CO in cigarette smoke. Sample were used with 4 kinds of domestic branded cigarettes(tar ; 1, 3, 6, 10 mg/cig) and CORESTA Monitor 4 cigarettes(tar ; 14 mg/cig). Tar and nicotine contents were analysed by gas-chromatograph methods in accordance with ISO 4387 and 10315-1. Determination of carbon monoxide in the vapour phase of cigarette smoke was meaured by NDIR method in ISO 8454. Sample preparation were performed in conditioning room at 22℃, 60 % for 48 hours according to ISO 3402. There was no significant difference between two smoking machine from 1 mg/cig to 14 mg/cig tar cigarettes, but, the contents of three components measured by rotary type showed higher tendency than those by linear type in the case of hight tar cigarettes. The results were the opposite in low tar cigarettes.

T-SCAN을 이용한 교정치료후의 교합접촉 변화에 관한 연구

정기훈,김재덕,김광원 대한치과교정학회 1995 대한치과교정학회지 Vol.25 No.3

본 연구는 교정치료가 끝난 26명의 환자에서 T-Scan을 이용하여 교정치료직후와 3개월후에 교합접촉의 변화를 구하여 시간의 경과에 따른 총접촉수의 변화와 전치부접촉수의 변화, 구치부 접촉수의 변화 및 총접촉되는 치아수와 전치부와 구치부의 접촉되는 치아수의 변화를 비교분석한 바 다음의 결론을 얻었다. 1. 평균적인 총접촉수의 변화는 교정치료 종료시 11.27개에서 3개월후 13.15개로 증가하였는데, 통계학적으로 유의한 차이를 보였다(p<0.05). 2. 전치부 접촉수에 있어서는 변화가 없었다. 3. 구치부 접촉수의 변화는 통계학적 유의성이 있었다(p<0.01). 총접촉수의 변화는 구치부 접촉수의 변화에 기인하였다. 4. 총접촉치아수에 있어 변화는 통계학적 유의성이 있었다(p<0.05). 5. 전치부의 접촉치아수는 약간 증가하기는 하였으나, 유의한 차이를 보이지 않았다(p>0.05). 6. 구치부 접촉치아수의 변화는 통계학적으로 유의성을 보였다(p<0.05). 7. 초기 치아접촉수와 시간의 경과에 따른 접촉수의 변화량은 약한 역상관관계를 보였는데, 이는 초기 접촉수가 적을수록 보다 많은 접촉수의 증가가 있었다는 것을 보인다(r=-0.38, p<0.05). This study was undertaken to investigate the changes of tooth contacts following orthodontic treatment, using T-Scan system. Occlusal contacts in maximum intercuspation were examined in 26 patients at the end of the active phase of orthodontic treatment and again 3 months into the retention phase to assess the initial posttreatment occlusal changes. The obtained results of this study were as follows : 1. The mean total number of contacts increased from 11.27 at the end of orthodontic to 13.15 at the follow up visit, which was found to be statistically significant (p<0.05). 2. The change of number of contacts on anterior teeth was unchanged. 3. The change of number of contacts on posterior teeth was found to be statistically significnat (p<0.01). 4. The change of total number of teeth in contact was significant (p<0.05). 5. The number of ant. teeth in contact was slightly increased, but Which was not found to be statistically significant(p>0.05). 6. The number of post. teeth in contact significantly increased, which was statistically significant (p<0.05). 7. A statistically significant relationship was found between the total number of contacts at the end of treatment and the change in the contacts over time. The fewer the number of tooth contact was at the end of orthodontic treatment, the greater number of tooth contact increased over time(r=-0.38, p<0.05).

박물관의 물리적 환경과 관람피로와의 관계에 관한 연구 : 관람자의 만족도를 중심으로

정재훈,이경훈 대한건축학회 2004 대한건축학회논문집 Vol.20 No.2

The purpose of the study is to analyze the causal relationship of physical environment and museum fatigue concerning how museum fatigue would take place and, in turn, what effects it could give visitors in the aspect of their satisfaction. The data gathered from 760 visitors in 30 museums were analyzed by the regression analysis and path analysis. The results of analysis indicated that, 1) museum fatigue was more likely to be affected by mental fatigue rather than physical one. mental fatigue had the direct influence on visitors' satisfaction, while physical fatigue only had the indirect effect. 2) the factors which affect on visitors' mental fatigue were contents of exhibition, thermal comfort, and rest area, those on visitor's physical fatigue were exhibition area, staying time, contents of exhibition, and thermal comfort. 3) visual and locomotor accessibility affected directly to visitors' satisfaction. and 4) individual characteristics did not show any influence on visitors' satisfaction and fatigue.

반음절기반의 한국어 연속숫자음인식과 그 후처리에 대한 연구

정재부,정훈,정익주 한국음성과학회 2001 음성과학 Vol.8 No.4

This paper describes the effect of new recognition unit, a unit based on semi-syllable, and its post processing method. A recognition unit based on semi-syllable expresses Korean connected digit's coarticulation effect. An existing method using semi-syllable limits next models, derived from current recognized models, to make complete connected digit sequence. However, this paper uses a new method to make complete connected digit sequence. The new post-processing method recognizes isolated digit words which include digits sequence from the digit combinations being able to occur from current recognized semi-syllable sequence. This method gives an improved accuracy rate than that of existing method. This new post processing provides two advantages. 1) It corrects current rnis-recognized semi-syllable unit. 2) When people say each digit, they say it without regard to saying duration.

결핵균 약제감수성 검사의 비용효율성에 관한 다기관 연구

정석훈,이대동,최재철,김선주,신정환,정윤성,이은엽,오승환,배길한,장철훈 대한감염학회 2005 감염과 화학요법 Vol.37 No.1

목적 : 우리나라에서의 결핵균 감수성 검사는 검출 균주의 일부에서만 시행되고 있다. 본 연구에서는 모든 검출 균주들에 대해서 감수성검사를 실시하면서, 진료에 필요한 결과를 충분히 제공하고 경제적이면서 현실적인 감수성검사 방안을 제시하고자 한다. 재료 및 방법 : 5개 대학병원에서 일정기간 연속적으로 의뢰된 502균주의 감수성 결과를 분석하였다. 검사결과의 해석 및 2차 약제 감수성검사의 필요성은 NCCLS approved standard M24-A의 권고 기준에 따라 판단하였다. 결과 : 최소한 1가지 이상의 약제에 내성을 보인 경우는 초치료 환자의 10% (38/363), 재치료 환자의 61%(85/139)였으며, 다약제 내성을 보인 경우는 초치료 환자의 3% (11/363), 재치료 환자의 44% (61/139)였다. NCCLS 권고에 따라 2차 약제에 대한 감수성 검사를 시행하지 않아도 되는 경우는 초치료 환자의 96%, 재치료환자의 47%였다. 결론 : 초치료 환자는 95%에서 1차 약제에 대한 검사만으로 충분하므로 필요한 경우에만 2차 약제를 추가로 검사하고 재치료 환자에서는 1, 2차 약제를 동시에 검사할 필요가 있을 것으로 생각한다. Background : The anti-mycobacterial susceptibility test is performed on only a small percentage of clinical isolates in Korea. The aim of this study is to propose an anti-mycobacterial susceptibility testing scheme, which is not only economic and practical but also fully informative to physicians. Materials and Methods : The anti-mycobacterial susceptibility test results of 502 strains, isolated from five university-affiliated hospitals, were analysed. The interpretation of the results and the need for second-line drug susceptibility test were judged according to the recommendation of NCCLS M24-A guidelines. Results : The isolates from 10% (38/363) of treatment-navie patients and 61% (85/139) of retreatment patients showed resistance to at least one of the anti-mycobactial agents; 3% (11/363) and 44% (61/139) of isolates from each group were multi-drug resistant. According to the recommendation by NCCLS, the percentage of patients not needing the susceptibility test results for second-line drugs were 96% for treatment-naive and 47% for re-treatment patients. Conclusion : Since the susceptibility test against first-line drug is sufficient for 95% of treatment-navie patients with tuberculosis patients, susceptibility test against second-line drugs may be performed only when it is necessary. As for the re-treatment patients with tuberculosis, susceptibility test for both first-line and second-line drugs should be performed simultaneously.

단일부위 경부 창상에 의한 다발성 뇌신경 손상 -증례 보고

박정미,김성훈,심재호 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.3

박물관 관람자의 만족도에 영향을 미치는 요인에 관한 연구

정재훈,이경훈 대한건축학회 2004 대한건축학회논문집 Vol.20 No.6

The objective of this study is to investigate how physical environment and individual traits affect visitors' satisfaction. In doing so, the physical environment factors and individual traits were set up as the independent variables, and visitors' overall satisfaction was considered to be the dependent variable. Also, learning, aesthetic arousal, enjoyment and fatigue were set up as the mediating variables to explain the relationship between physical environment and visitor's satisfaction. The results of analysis were as follows; 1) Among physical environment characteristics of museum, visitors' enjoyment was mainly influenced by the content of exhibition, visitors' learning by both the content of exhibition and thermal comfort, and aesthetic arousal by the content of exhibition. 2) Individual traits were found to have no significant influence to visitors' satisfaction except a gender. 3) Satisfaction was more directly affected by visitors' enjoyment and learning while indirectly affected by visitors' aesthetic arousal and museum fatigue. 4) Among physical environment factors, the content of exhibition and visual and locomotor access were found to directly affect visitors' satisfaction.