2009년 인플루엔자 대유행 중 인플루엔자 진료소 방문자의 연령 분포 변화

김백남,곽이경,문치숙,김연숙,김의석,배인규,염준섭,이창섭,허지안 대한감염학회 2010 감염과 화학요법 Vol.42 No.2

The pandemic influenza (H1N1 2009) virus, after being introduced in Korea in April, 2009, spread rapidly nationwide in mid-2009. This study was conducted to characterize trend in age distribution of visitors to Flu-clinics during the pandemic. Demographic, clinical and laboratory data of visitors to flu clinic from Week 36 to 52 (August 30 to December 26) of 2009 were retrieved and collected from electronic databases at 9 hospitals. Visitors 0-6, 7-12, 13-18, 19-29, 30-64, and 65 years or more of age were classified into group I to VI, respectively. A total of 107,467 visitors were seen at Flu-clinics for a 17-week study period. Of those, 32,485 were laboratory-confirmed. Antivirals were prescribed for 62,533 visitors. Numbers of visits, prescriptions of antivirals, and laboratory-confirmed cases of the pandemic influenza (H1N1 2009) peaked at Week 44. A large number of visits by group II and III were followed by those of group I and V, especially around the peak. Numbers of visits by group VI were lowest in all hospitals. In some hospitals, higher number of visits lasted longer in children than in adults while vice versa in other hospitals depending on the location. In summary, the pandemic influenza (H1N1 2009) was presumed to peak in late October and involved majorly children and students in Korea. Unique age distribution of visitors to flu clinic was observed in some hospitals.

Nuclear factor I-C가 치근발생 과정에서 Hertwig's 상피초 형성에 미치는 영향

신인철,박주철,정문진,오현주,박선화,이창섭,김흥중,Shin, In-Cheol,Park, Joo-Cheol,Jeong, Moon-Jin,Oh, Hyun-Ju,Park, Sun-Hwa,Lee, Chang-Seop,Kim, Heung-Joong 대한소아치과학회 2005 大韓小兒齒科學會誌 Vol.32 No.3

치아의 형성은 상피-간엽간의 상호작용을 통해 조절되어지는 복잡한 발생과정이다. 지금까지 치관의 발생에 관여하는 유전자 및 그들의 신호전달경로에 관한 연구는 다수 진행되어 왔지만 치근의 발생을 조절하는 기전에 대해서는 별로 알려진 것이 없다. 최근에 NFI-C knock out 생쥐에서 정상치관에 비정상적인 치근을 가지는 치아가 보고되었다. 본 연구의 목적은 NFI-C가 어떻게 치근의 형태와 상아모세포의 분화에 관여하는지를 규명하는 것이다. NFI-C knock out 생쥐의 치근 발생동안에 HERS의 역할을 연구하고자 cytokeratin 면역조직화학적방법과 치근상아질의 특성을 규명하기 위해 DSPP mRNA in-situ hybrydization법을 수행하였다. 1. NFI-C knock out 생쥐의 치근형성시 HERS의 역할 Wild type과 knock out type 모두에서 cytokeratin은 모든 HERS 세포들과 반응하였고, HERS와 법랑상피 사이의 양성반응세포들의 연속성은 치경부 부위에서 소실되었다. Knock out type에서 치근상아질이 침착된 후, cytokeratin 양성-HERS 세포들은 치경부에서 불규칙한 배열과 극성의 상실을 보였다. 2. NFI-C knock out 생쥐의 치근상아질의 특성 DSPP mRNA의 발현은 wild type에서 치관과 치근상아질의 상아모세포 모두에서 강한 발현을 보인 반면, knock out type에서는 치관부위 상아질의 상아모세포에서만 강한 발현을 보였다. 3. NFI-C knock out 생쥐의 치근 발생과정에서 HERS는 치관으로부터 정상적인 확장을 보인 반면, 치근부위에서의 상아 모세포 분화는 실패하였다. 위의 결과들로 보아 NFI-C는 치근형성 과정에서 상아모세포 분화에 중요한 역할을 하는 것으로 사료된다. Tooth formation is a complex developmental process that is mediated through a series of reciprocal epithelial-mesenchymal interactions. Several signal pathways and transcription factors have been implicated in regulating molar crown development, but relatively little is known about the regulation of root development. It was reported that NFI-C knockout mice showed abnormal root formation with normal crown. The aims of this study are to elucidate how the NFI-C regulate the determine of root shape and odontoblasts differentiation. We carried out immunohistochemistry using cytokeratin to investigate the role of Hertwig's epithelial root sheath and DSPP mRNA in-situ hybridization to conform the nature of root dentin during root development in NFI-C knockout mice. Cytokeratin reacted with all the HERS cells and the continuity of cytokeratin positive cells between the HERS cells and enamel epithelium was lost in the cervical region both wild and K/O types. After root dentin deposition cytokeratin positive-HERS cells showed irregularity and loss of polarity in the cervical region in K/O type. DSPP mRNA was strongly expressed in odontoblasts of crown and root dentin in wild type mice, whereas expression of DSPP mRNA was restricted in odontoblast of crown dentin in the K/O type. During root formation in NFI-C knockout mice, HERS normally grow out of the crown but fail to induce odontoblast differentiation in root portion. These results suggest that NFI-C may play important roles in odontoblast differentiation during root dentin formation.

LED 광중합기의 조사 mode가 복합레진의 미세경도 및 수축응력에 미치는 영향

박인호,오유향,이난영,이창섭,이상호 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.2

이 연구의 목적은 LED 광중합기(Elipar Freelight 2?, 3M-ESPE, USA)의 조사 mode에 따른 복합레진(Supreme?, Filtek Flow?, 3M-ESPE USA)의 수축응력과 미세경도를 평가하는 것이다. 수축응력을 측정하기 위해 스트레인 게이지가 사용되었다. 표본은 조사 mode와 충전방법에 따라 6개의 군으로 나누어졌다. A군: Filtek Flow?이장, Supreme? 충전, 10초 광중합, B군: Filtek Flow?이장, Supreme? 충전, 15초 광중합, C군: Filtek Flow?이장, Supreme?충전, 15초 soft start 광중합, D군 Supreme? 충전, 10초 광중합, E군: Supreme?충전, 15초 광중합, F군: Supreme?충전, 15초 soft start광중합. 스트레인 게이지를 아크릴릭 링에 부착하고 strain meter에 연결한 후 광중합하고 10분 동안 1초 간격으로 측정하고 기록하였다. 24시간 후에 각각 표본의 미세경도를 측정하였다. 결과는 ANOVA와 Tukey test를 이용해 통계학적으로 분석하였다. 결과는 다음과 같았다. 1. Soft start curing 했을 때 수축응력 이 낮았다(p<0.05). Flow able resin을 이장한 군에서는 효과가 없었다. 2. 10초간 조사한 군은 15초간 조사한 군에 비해 수축응력이 적었다(p<0.05) 3. 미세경도 측정결과 상면과 하면에서 각 군 간에 차이는 없었다(p>0.05). 하지만, 하면의 미세경도가 상면에 비해 80%에 이르지 못했다. The purpose of this study was to evaluate the polymerization contraction and the micro hardness of composite resin(Supreme?, Filtek Flow?, 3M-ESPE, USA) according to irradiation modes of LED curing unit(Elipar Freelight?, 3M-ESPE, USA). The strain guage method was used for determination of polymerization contraction. Sample were divided by 6 groups according to curing modes and filling method. Group A: Supreme?, Filtek Flow? lining, 10seconds curing, Group B: Supreme?, Filtek Flow? lining, 15seconds curing, Group C: Supreme?, Filtek Flow? lining, 15seconds soft start curing, Group D: Supreme? only, 10seconds curing, Group E: Supreme? only, 15seconds curing, Group F: Supreme? only, 15seconds soft start curing Preparations of acrylic molds were followed by filling and curing. Strain guage attached to each sample were connected to a strain meter. Measurements were recorded at each second for the total of 10 minutes including the periods of light application. And micro hardness of each group after 24hours from light irradiation were measured. Obtained data were analyzed statistically using Repeated measures ANOVA and Tukey test. The results of the present study are as follows: 1. In flow able resin liner group, soft start curing group was not found decrease of polymerization contraction. But, In Supreme only filling group, the lowest polymerization contraction was found in soft start curing group. 2. 10 seconds curing group showed statistically significant reduction of polymerization contraction compared with 15 seconds curing group(p<0.05). 3. The micro hardness values of each group not revealed significant difference(p>0.05). But, lower surface micro hardness was not reached 80% of upper surface micro hardness.

소규모 농업용 저수지의 저류량-용수공급능력 결정에 관한 연구

안승섭,정순돌,이증석,윤경덕,장인수 한국환경과학회 2002 한국환경과학회지 Vol.11 No.12

This study aims at the effective estimation of water supply capacity of small scale reservoir and the proposal of the data which is necessary to establish the water resources management plan of down stream area of the reservoir in the future by comparison and examination about reservoir operation technique for the security of agricultural water in small scale reservoir. The result of flow calculation by Tank model is used for the input data as the inflow data which is needed for the analysis of water supply capacity. Stochastic method, simulation method, and optimization method are used to examine the water supply capacity, and water security amount is compared with each method. From the analyses of water supply capacities by each method, slightly different results are shown in spite of the effort to compare them equally using input data such as inflow data under equal conditions, and the comparison of water supply capacities by each method are follows; linear planning method, and transition probability matrix method in the order of amount from the largest. It is thought that the simulation method in which comparatively reasonable application of the inflow data is possible and is simulated in successive time series dam operation of the three methods used in this study thus, simulation model is proper to estimate the water supply capacity of agricultural small scale reservoir. And it is judged that the heightening of efficiency of water resources utilization according to the development of downstream area of dam may be possible using the upward readjusted water supply amount of 55.18×10^6ton at 95% and 90% supply reliability respectively which are above the planning water supply amount of 50.0×10^6ton when the simulation method is introduced as the standard.

복싱선수의 운동수행능력 수준에 따른 정신력요인 분석

오인석,채성배,이창섭 忠南大學校體育科學硏究所 1995 體育科學硏究誌 Vol.13 No.1

The purpose of this study was to identify the relationship between mental toughness and the level of performance and playing experience in boxing players. Subjects were 138 boxing players of high schools and colleges in Korea. Mental Toughness Test was used which was developed by Loehr(1982). The analysis of data was conducted by using One-Way ANOVA and Scheffe's test. The results were as follows; 1. With regard to the performance level, the mental toughness showed a significant difference in the factors of Arousal Control, Attention Control, Visualization and Imagery Control, and Attitude Control. 2. With regard to the years of playing experience, the mental toughness showed a significant difference in the factors of Arousal Control and Attention Control.

A 4-Gbps/pin transceiver with a multi-level simultaneous bi-directional scheme for serial link applications

Woo-Seop Kim,in-Hyun Kim,Chang-Hyun Kim,김석기 한국물리학회 2004 Current Applied Physics Vol.4 No.1

This paper presents a simultaneous 4-level bi-directional transceiver, which performs data rate of eight times of the clock ratewithout the need of a high-speed clock generator. The proposed transceiver was fabricated using a 0.11l m CMOS process in900· 300 l m2 and performs data rate of 4 Gbps/pin with the use of a 500 MHz clock. The main features of the I/O interfacecircuit are 4-level pushpull linear output drivers, multi-level auto-impedance control, hierarchical multi-reference selected sam-pling, a self-biased wide common-mode range dierential amplier and an impedance-controlled reference voltage generator. Thetransceiver performs data rate of 4 Gbps/pin with 180 mV· 690 ps passing eye-windows on the channel over 1.8 V supply voltages.

통합적 지적정보를 이용한 지가정보시스템 구축

황창섭,임인섭,최석근 충북대학교 건설기술연구소 2002 建設技術論文集 Vol.21 No.2

This study focused on construction of the land price information system which can efficiently, scientifically, and accurately manage the individual announced land price. The system is adapted to the test area(Kakyung-dong, Chongju city), whose master plan is being made. As a result, it is concluded that can improve the efficiency and accuracy of land price management. Also, users can easily use it without professional knowledge since if offer convenient user environment. Furthermore, it can rapidly search character and classification of land sue-zoning, the present condition of land price and so on. And it can cause the improvement of good quality service for people by issuing accurately and rapidly documents related to a city plan.

소아에서의 shell teeth의 치험례 : A CASE REPORT

박인호,윤정훈,이난영,이창섭,이상호 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.1

Shell teeth는 매우 드문 상아질 이상으로 상아질 이형성증의 한 형태로서 특징적으로 정상적인 법랑질, 매우 얇은 상아질, 비정상적으로 큰 치수강, 짧아진 치근 등을 보인다. Shell teeth는 1954년 Rushton이 21세 남자 환자에서 나타난 증상을 설명하여 처음 명명하였으며, 1984년 Kinirons이 8세 남아의 shell teeth에 대해 보고하였다. 1992년 Harrison과 Kennedy는 7세 6개월 된 남아에서 보인 shell teeth를 14년간 관찰하여 보고하였는데 이 환아는 유치열과 영구치열 모두 shell teeth가 관찰되었고, 일반적인 shell teeth와 달리 치관에서는 shell teeth의 특징이 나타나지 않았으며, 치근에서만 나타났다. 매우 얇은 상아질과 큰 치수강은 국소적 이형성증에도 관찰되는 특징인데, shell teeth는 전치열에서 보이는데 반해 국소적 이형성증은 한정된 몇 개의 치아에서만 관찰되어 감별진단 할 수 있다. 본 증례는 3세 남아에 관한 것으로 구강내 소견은 모든 유치 치관이 파괴되어 상아질이 노출되어 있었고, 방사선 소견은 얇은 상아질로 둘러싸인 매우 큰 치수강과 확장된 치근관을 보였으며 다수의 소구치가 결손되어 있었다. 환아는 행동조절의 문제 때문에 전신마취하에 치료를 받았다. 현재 환아는 공간유지장치를 장착하고 있으며, 정기적인 관찰이 필요하리라 사료된다. Shell teeth, a rare dysplastic condition of dentin, was first described by Rushton in 1954. It is characterized by normal enamel, extremely thin dentin, correspondingly large pulp chambers, and shortened roots. This case report is of a male 3 years old. He is refered to the Chosun University dental hospital Pediatric Dentistry because of dental caries and dentin hypoplasia. Intra-oral examination showed attrition of all primary teeth. Radiographic examination showed that the pulps were extremely large with only a shell of surrounding hard tissue. The permanent premolars were missed congenitally. The diagnosis was shell teeth. Because of behavior problem, all dental treatment was undertaken with general anaesthesia. Extration, endodontic treatment and SS crown were performed. The patient has now been wearing the space maintainer and manages it well. The patient is seen intervals for supervision and follow-up care.

Erupted complex odontoma에 의한 하악 제 1대구치 맹출지연

박인호,오유향,이상호,이창섭 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.4

치아의 맹출지연을 일으키는 여러 원인 중 치아종은 법랑질, 상아질, 치수와 같은 치아를 구성하는 조직을 갖춘 harmartoma로 complex odontoma(복합 치아종)와 compound odontoma(복합 치아종)로 구분된다. 치아종의 원인에는 외상, 감염, 치아발육상의 장애, 유전적 요인등을 들 수 있으며, 호발 부위는 상악 전치부와 하악 구치부이다. 이 중 compond odontoma는 악골의 전방부에, complex odontoma는 악골의 후방부에 잘 발생하는 경향이 있는데 대부분 악골내에서 발생하지만 드물게 점막을 뚫고 치조골의 상방으로 석회화 된 종괴가 맹출한 형태의 치아종을 erupted odontoma라 한다. erupted odontoma는 매우 드문 질환으로 일반적으로 맹출지연을 일으키지는 않는다. 본 증례는 맹출이 지연된 하악 제 1대구치 치관 상방에 나타난 erupted complex odontoma를 제거 후 치아를 맹출 시키는데 양호한 결과를 얻었기에 보고하는 바이다. Odontoma, hamartomas of odontogenic orgin, are composed of all the structures that make up teeth, which may lead to interference with the eruption of its associated tooth. On the basis of gross, radiographic, and microscopic features, two types of odontoma are recognized: compound and complex. The etilogy of odontomas is unknown, although local trauma, infection, and gentic factors have been suggested. Odontomas occur central in bone between the roots of teeth and the mauority are asymptomatic. Although these tumors occur frequently and constitute 22% of all odontogenic tumors, are very rare. Erupted odontoma are defined as tumors that it occurs a calcifed mass may be defected on the ridge. The treatment of chice is the surgical removal of the lesion followed by a biopsy. This report presents a case of 8-year-old girl with the delayed eruption of the mandibular first molar by the calcified mass within the operculum covered the central fossa. And it was diagnosed as erupted complex odontoma by excisional biopsy.

침 시술로 발생한 Non-O1, Non-O139 Vibrio cholerae에 의한 패혈증

임태섭,지아영,이중희,장수연,김인수,김영주,김범경,김승업,박준용,안상훈,한광협,김도영 Ewha Womans University School of Medicine 2013 EMJ (Ewha medical journal) Vol.36 No.S

Vibrio cholerae is mainly known to cause gastrointestinal infection after seawater exposure or raw seafood intake. It is rarely reported to cause cellulitis or sepsis, but threre has been no known case after acupuncture. Herein, We report a 56-year-old cirrhotic patient of non-O1, non-O139 Vibrio cholerae septicemia caused by cellulitis of both lower extremities after acupuncture.