늑막조직생검으로 진단한 Pleural Paragonimiasis 1 예

김기영,이승환,박진현,이재갑,용석중,신계철,홍욱균,김향인,진춘조 대한내과학회 1991 대한내과학회지 Vol.40 No.5

We report a 28-year old female patient with pleural paragonimiasis who did not have the usual diagnostic triad for this parasitic disease. She did not have chronic hemoptysis, there were no pulmonary infiltrations, and stool, sputum and pleural fluid examinations did not yield paragonimus ova. The diagnosis was made on the basis of ova found in the pleural biopsy. Paragonimus pleural effusion was resolved with frequent thoracentesis and oral praziquantel therapy.

기관지내 전이암

김현수,이상수,오미희,이재갑,원구태,홍희승,용석중,신계철 대한내과학회 1991 대한내과학회지 Vol.40 No.4

The lung is the most common site of metastasis of extrapulmonary malignant tumor. According to past reports, metastatic cancer of the lung has been found in about 2% of all patients at autopsy. But these days, a diagnosis of endobronchial metastatic cancer utilizing bronchoscopy only is not easy. Thus we need other means of gathering more informaction, such as past history, discovery of other metastatic sites, and pathologic findings with special staining and electronmicroscope, especially in cases of poorly differentiated adenocarcinoma and epidermoid cancer, which are common types of primary lung cancer. We present 5 cases of endobronchial metastatic cancer. We found endobronchial metastatic cancer 2 cases of cervix cancer (epidermoid, adenocarcinoma), 1 case of colon cancer (adenocarcinoma), hypernephroma (renal cell carcinoma), and bladder cancer (transitional cell carcinoma). Since it was impossiole to diagnose the metastatic adenocarcinoma from the cervix only with lightmicroscopic findings, we could use past history and unusual radiologic and bronchoscopic findings which was thought to be the specific endoscopic finding of metastic endobronchial cancer. The interval between the diagnosis of the primary cancer and endobronchial metastatic cancer was 25.7 months. In the future, development of immunohistochemistry, monoclonal antibody, and molecular biologic techniques will give us diagnostic clue for differential diagnosis of metastatic endobronchial cancer from primary bronchogenic lung cancer.

배양된 혈관내피세포에서 uncoupling protein 2 유전자 과발현이 세포내 산화스트레스 및 endothelin - 1 mRNA 발현에 미치는 영향

강효경,한정희,홍성관,김하영,남궁일성,박기영,박혜선,이재담,박중열,이인규,이기업 한국지질학회 2001 韓國脂質學會誌 Vol.11 No.2

HWE 방법에 의한 CdSe 박막 성장과 광전기적 특성

신영진,홍광준,이상열,유상하,서상석,문종대,김택성,정태수,신용진,이관교,김혜숙,정준우,정경아 한국센서학회 1997 센서학회지 Vol.6 No.4

The CdSe thin films were grown on the Si(100) wafers by a hot wall epitaxy method (HWE). The source and substrate temperature are 600� and 430 respectively. The crystalline structure of epilayers was investigated by double crystal X-ray diffraction(DCXD). Hall effect on the sample was measured by the van der Pauw method and studied on the carrier density and mobility dependence on temperature. From Hall data, the mobility was increased in the temperature range 30K to 150K by impurity scattering and decreased in the temperature range 150K to 293K by the lattice scattering. In order to explore the applicability as a photoconductive cell, we measured the sensitivity(γ), the ratio of photocurrent to darkcurrent(pc/dc), maximum allowable power dissipation(MAPD), spectral response and response time. The results indicated that the photoconductive characteristic were the best for the samples annealed in Cu vapor compare with in Cd, Se, air and vacuum vapour. Then we obtained the sensitivity of 0.99, the value of pc/dc of 1.39 X 10^7, the MAPD of 335mW, and the rise and decay time of l0ms and 9.5ms, respectively

CBD 방법에 의한 CdS1-xSex 박마의 열처리에 따른 광전기적 특성

문종대,정태수,신현길,김택성,신영진,홍광준,유상하,서상석,최승평,이상열,신용진,이관교,김혜숙,윤은희,김승욱,전승룡 한국센서학회 1995 센서학회지 Vol.4 No.1

Polycrystalline CdS_(1-x)Se_x, thin films were grown on ceramic substrate using a chemical bath deposition method. They ere annealed at various temperature and X-ray diffraction patterns were measured by X-ray diffractometer in order to study CdS_(1-x)Se_x, polycrystal structure using extrapolation method of X-ray diffraction patterns for the CdS. CdSe samples annealed in gas at a 0 it was found hexagonal structure which had the lattice constant a_0=-4.1364Å, c_0=6.7129Å in CdS and a_0=4.3021Å, c_0=7.3021Å in CdSe. respectively. Hall effect on these samples was measured by Van der Pauw method and then studied on carrier density and mobility depending on temperature. We measured also spectral response, sensitivity(γ), maximum allowable power dissipation and response time on these samples.

마이크로 공진 구조체 제작을 위한 다층 폴리실리콘의 스트레스 특성

손병기,장원익,최창억,이창승,홍윤식,이종현 한국센서학회 1999 센서학회지 Vol.8 No.1

Micro polysilicon actuators, which are widely used in the field of MEMS (Microelectromechanical System) technology, were fabricated using polysilicon thin layers. Polysilicon deposition were carried out to have symmetrical layer structures with a LPCVD (Low Pressure Chemical Vapor Deposition) system, and we have measured physical characteristics by micro test patterns, such as bridges and cantilevers to verify minimal mechanical stress and stress gradient in the polysilicon layers according to the methods of mutilayer deposition, doping, and thermal treatment, also, analyzed the properties of each specimen, which have a different process condition, by XRD, and SIMS etc.. Finally, the fabricated planar polysilicon resonator, symmetrically stacked to 6.5㎛ thickness, showed Q of 1270 and oscillation ampitude of 5㎛ under DC 15V, AC 0.05V, and 1000 mtorr pressure. The developed micro polysilicon resonator can be utilized to micro gyroscope and accelerometor sensor.

제 2 형 당뇨병에서 미세혈관 합병증과 대혈관 합병증의 대비

강문호,이기영,정연실,김홍규,서찬종,송광식,박혜영,이원기 대한당뇨병학회 2001 Diabetes and Metabolism Journal Vol.25 No.2

Background: Type 2 diabetes is a heterogeneous disease. As to its complications, microangiopathy predominantly develop in some patients while macroangiopathy is more predominant in others. Therefore, this study was performed to identify the factors associated with such dissociation. Methods: Type 2 diabetic patients were classified into the macro and microangiopathy groups by carotid intima-medial thickness (IMT) and the presence of severe diabetic retinopathy. Patients with IMT ≤ 0.83 mm and severe NPDR or PDR were assigned to microangiopathy group; those with IMT 0.84 mm and no diabetic retinopathy were assigned to macroangiopathy group. Of 95 patients studied, 14 were classified as microangiopathy group and 20 as macroangiopathy group. Results: When the microangiopathy and macroangiopathy groups were compared, the microangiopathy group were significantly younger at the time of examination and at the onset of diabetes, and had longer duration of diabetes. Percentage of patients receiving insulin treatment was significantly higher and plasma C-peptide significantly lower in the microangiopathy group. However, HDL-cholesterol levels were significantly lower in the macroangiopathy group. Furthermore, the multiple logistic regression analyses revealed that younger onset of type 2 diabetes was an independent factor that was associated with the acceleration of microangiopathy. Conclusion: This study suggests that the age at onset of diabetes is an important independent risk factor that is associated with predominant development of microangiopathy in type 2 diabetic patients.

Chemical Bath Deposition 방법으로 제작한 CdSe 박마의 특성

신영진,홍광준,이상열,유상하,서상석,문종대,신현길,김택성,송정훈,유기수,정태수 한국센서학회 1993 센서학회지 Vol.2 No.1

Polycrystalline CdSe thin films were grown on ceramic substrate using a chemical bath deposition (CBD) method. They were annealed at various temperature and X-ray diffraction patterns were measured by X-ray diffractometer in order to study CdSe polycrystal structure. Using extrapolation method of X-ray diffraction patterns for the CdSe samples annealed in N₂ gas at 450℃ it was found hexagonal structure whose lattice parameters a_o and c_o were 4.302 A and 7.014 A, respectively. Its grain size was about 0.3 ㎛. Hall effect on this sample was measured by Van der Pauw method and studied on carrier density and mobility depending on temperature. From Hall data, the mobility was likely to be decreased by piezo electric scattering at temperature range of 33 K and 200 K, and by polar optical scattering at temperature range of 200 K and 293 K. We measured also spectral response, sensitivity (γ), maximum allowable power dissipation and response time on these samples.

반추위 미생물의 질산염 환원 조절물질에 관한 연구

손용석,홍성호,이성호 한국영양사료학회 1999 韓國營養飼料學會誌 Vol.23 No.5

반추위내 미생물들의 질산염(NO₃^-) 환원능력에 관여할 수 있는 물질로 잠재성이 있다고 판단되는 Yeast culture(YC), L-cysteine(CSH) 및 Sodium tungstate(W)의 첨가효과를 관찰하고자, in vivo 및 in vitro 실험을 실시하였다. In vitro 실험에서는 미생물 공여축으로 반추위 누관이 장착된 55㎏ 숫면양에 체중 ㎏당 400 ㎎의 NaNO₃를 2주간 급여 적응시킨 후, 반추위액을 채취하여 첨가물질(YC, CSH. W)들과 함께 배양하면서 pH, 질산염, 아질산염 및 암모니아의 농도변화를 시간별로 관찰하였다. 배양액 내 NO₃^-농도는 대조구에 비해 CSH구와 W구에서는 높게, 그리고 YC구에서는 낮게 나타났다(P<0.05). 배양액 내 NO₂^- 농도는 대조구에 비해 YC, CSH, W구에서 유의적으로 감소하였고(P<0.05), 암모니아 농도는 CSH구에서 가장 낮게 나타났다(P<0.05). In vivo 시험에서는 질산염 중독반응에 대한 Yeast culture의 첨가효과를 관찰하기 위하여, 1차 시험에서는 숫면양 4두를 Switch-over design으로 배치하여 2%의 YC를 2주간 첨가급여하였다. 2차 시험에서는 L-cysteine (CSH)의 첨가효과를 관찰하고자 3두의 숫면양을 3×3 Latin Square 방법으로 배치하여 2주간 NaNO₃(0.5g NO₃^-/BW ㎏^(0.75))와 L-cysteine(0.115g S/W ㎏^(0.75))을 누관을 통해 주입한 후 혈중 NO₂^-와 MHb의 농도 변화를 시간별로 관찰하였다. 혈액 내 NO₂^- 농도는 NaNO₃ 투여 후 2시간때에 대조구에 비해 YC 첨가구에서 유의적으로 낮게 나타났으며, 혈액 내 MHb 농도는 NaNO₃ 투여 후 3시간과 4시간때에 YC 첨가구에서 유의적으로(P<0.05) 감소하였다. 또한, L-Cysteine의 경우에도 NaNO₃에서 유래한 혈중 NO₂^- 농도를 유의적으로(P<0.05) 감소시켰으며, NaNO₃ 투여 후 6시간 때에 혈중 MHb 형성을 유의적으로(P<0.05) 억제시켰다. 따라서, 본 시험에 공시한 3가지 물질들은 모두가 반추위 내 질산염 대사 속도를 조절함으로써 대사산물에서 유래하는 독성을 예방 또는 억제하는데 기여할 수 있음이 확인되었다. This study was conducted to examine the activities of some materials which could affect nitrate and nitrite reduction in the rumen and eventually their toxicity in ruminant animals. Rumen fluid (RF) taken from a fistulated ram was used as inoculum for an in vitro study, where 400 ㎎ NO₃^- ㎏^(-1) BW was added to RF donor rams for 14 days for adaptation. RF was incubated with 20 mM NaNO₃ in the presence of 0.25% Yeast culture (YC), 10 mM L-cysteine (CSH) or 1 mM sodium tungstate (W) for 24 hrs, and time changes of NO₃^-, NO₂^- and NH₃ concentrations in the medium were observed. NO₃^- concentration showed higher values in the medium with CSH and W group than that without addition (P<0.05). As compared with control, significantly lower NO₂^- concentrations were observed in the medium incubated with YC, CSH and W (P<0.05). The addition of CSH caused lower NH₃ concentration than control (P<0.05). Prophylactic effects of yeast culture and L-cysteine on the intensity of nitrate poisoning were also observed in vivo. Four rams were assigned to two group (Control, 2% YC) in a Switch-over design, and three rams were allotted to three treatments (CSH, NO₃^-, CSH + NO₃^- supplement) in a 3 × 3 Latin square design. The sheep fed Yeast culture had lower NO₂^- and MHb concentrations of blood than those fed without Yeast culture (P<0.05). A supplementation of L-cysteine to the diet decreased the level of blood NO₂^- as well as concentration of MHb (P<0.05) caused by NaNO₃ feeding. Consequently, continuous feeding either Yeast culture or L-cysteine could help prevent nitrate toxicity.

무수 불화수소와 메탄올의 기상식각에 의한 실리콘 표면 미세 가공

장원익,최창억,이창승,홍윤식,이종현,백종태,김보우 한국센서학회 1998 센서학회지 Vol.7 No.1

In silicon surface micro-machining, the newly developed GPE(gas-phase etching) process was verified as a very effective method for the release of highly compliant micro-structures. The developed GPE system with anhydrous HF gas and CH₃OH vapor was characterized and the selective etching properties of sacrificial layers to release silicon micro-structures were discussed. P-doped polysilicon and SOI(silicon on insulator) substrate were used as a structural layer and TEOS(tetraethyorthosilicate) oxide, thermal oxide and LTO(low temperature oxide) as a sacrificial layer. Compared with conventional wet-release, we successfully fabricated micro-structures with virtually no process-induced suction and residual product.