Aspergillus sp. ISR 균주를 통한 콜레스테롤 합성저해제 lovastain의 생산

박상은,조미현,신동화,황승환,박천석 경희대학교식량자원개발연구소 2005 硏究論文集 Vol.24 No.-

본 연구에서 한국 토양에서 분리된 lovastatin 생산 균주인 Aspergillus sp. ISR 균주를 이용하여 여러 배지 조성 성분이 lovastatin의 생산에 미치는 영향을 관찰하였다. 탄소원으로는 lactose보다 glycerol 5%가 가장 효과적이었으며 질소원과 인산염의 경우는 기본 RPM배지 조성과 농도에서 보다 효과적인 것을 발견하지 못하였다. 복합영양원으로 rapeseed meal 보다는 대두박이 보다 효과적이어서 저렴한 배지원으로 사용이 가능할 것으로 사료된다. 최종적으로 최적화된 배지를 사용하여 52 mg·L^(-1)의 lovastatin을 생산할 수 있었고 이는 기존의 RPM 배지보다 수율이 4.5배 증가한 것이다. 좀 더 효과적인 lovastatin의 생산을 위하여 회분식 발효에 대한 연구와 분자유전학적인 연구를 통한 고생산 균주의 제조에 대한 연구가 진행중이다. Effects of various nutritional components on the production of lovastatin were investigated in the Aspergillus sp. ISR. Among various carbon (C) sources, glycerol was determined to be the most effective C source at the concentration of 5% (v/v). In case of nitrogen sources, 0.2% (w/v) KNO_(3) efficiently induced the lovastatin production in Aspergillus sp. ISR. Interestingly, the addition of soybean meal into the production medium enhanced the lovastatin production compared to the rapeseed meal. Conclusively, Aspergillus sp. ISR produced 52 mg·L^(-1) of lovastatin in the optimized medium containing 5% (v/v) glycerol, 0.2% (w/v) KNO_(3), 0.3% (w/v) KH_(2)PO_(4), and 0.3% (w/v) soybean meal, which was 4.5 times higher than the amount produced using the standard RPM (rapeseedmeal production medium).

두개내 동맥 병변을 보인 혈관형 베체트씨병 2예

박은미,성정준,이정주,강동화,노재규 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

대동맥-장골동맥 폐색증에 대한 경피경관 혈관성형술 및 스텐트삽입술의 누적개존율

최동현,이상목,고석환,홍성화,오수명,윤충,박호철,오주형 대한혈관외과학회 2004 Vascular Specialist International Vol.20 No.1

중등도 심부전증 환자에서 Carvedilol의 치료 효과

차동훈,차영수,국진환,황경화,김형태,임상욱,김태용,조윤경,박필원 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.4

말초동맥질환에 있어서 혈장 호모시스테인 농도의 의미

최동현,이상목,고석환,홍성화,오수명,윤충,박호철 대한혈관외과학회 2004 Vascular Specialist International Vol.20 No.1

骨髓樣化生으로 移行된 本態性血小板過多症 1例

박희숙,김무원,이동화 大韓血液學會 1986 大韓血液學會誌 Vol.21 No.2

한국 여성운동과 걸스카우트운동 : 과거·현재·미래 Yesterday, Present and Tomorrow

정세화,이동원,김미숙,박진숙,장화경,홍승아 이화여대 한국여성연구소 1988 여성학논집 Vol.5 No.-

One of the major implications of women's movements seems to lie in the fact that it tends to promote women's consciousness-raising and, thus, heighten social status of women in general. It would be very much the case when discussion centers around the emergence of Korean women's movements in modern sense. Due to the socio-political atmospheres of the lathe 19th century Korean society, its basic characteristics owe to strong tones of patriotic nationalism under the slogan of "learning is might enough to deal with the imperialistic foreign powers of the time." As such, ever since the introduction of women's enlightenment movements of the time, Korean women's movements have provided for the advancement of egalitarian society. However, assessing the effectiveness of programs that are practiced by the existing women's organizations in Korea, it deserves mention in that most programs are for the adult female members, assuming it would only be applicable to those adults. In this regard, it can be said that the Korean Girl Scout organization has worked a unique role to make up such voids in women's movements - most programs developed and exercised by the Girl Scout are reserved for those young girls. For instance, special activities like social services, field campaigns, and international gatherings would definitely work a profound impact in the formation of gender-role stereotypes of the youth. The present study tries to examine the Korean Girl Scout movement being the case of women's movement organization. Discussion will cover such topics as; historical reviews of Korean Girl Scout movement, principal organizational goals and its practice in real life, and internal dynamics of members between "staffs" and the ordinary members themselves-on perceptions of the movement, evaluation of leaderships, and the future orientations of the Girl Scout, etc. Various research methods are employed. Book reviews, in-depth interviews, questionnaires, and participant observations are utilized, when the respective measurement is required. Major findings of the study can be summarized as follows: (1) Numbers of Girl Scout membership have declined since 1980, while revealing its utmost pick upto mid-70s. In terms of regional distributions of the members, both Seoul and Kyung-Nam Branches are the most prosperous. Whereas commemoration ceremonies and camping works are considered most impressive programs, membership trainings and field works are the lowest. About 70 percent of the members show their length of activities in Girl Scout less than one year. Most members are involved in the activities based on self-decision in order to have social services, club memberships, or self actualizations. They are satisfied with most of the programs, especially when participating in the social service programs. (2) As for the staff members, about half of the leaders in the headquarters are newly appointed. Whereas majority of the 'field' staffs are young (in their 20s, or 30s), other leaders are considered old (most of them are in their 40s, 50s, or 60s). Half of the leaders are involved in the activities for less than 5 years. They are recruited by either colleagues' or office seniors' recommendations. Reasons to participate in the movement are to have self-actualized or to have opportunity for social services. All in all, leaders are satisfied with the Girl Scout activities mainly because they can see their youth members progressing and developing. (3) Several issues for the better organizational managements seem to be related. prevalence of aspirational differences between leaders and members tends to cause psychological burdens. Other problematics such as lack of free communication networks, tensions due to cohort differences, authoritarian leadership styles, and financial difficulties would hinder Girl Scout movement more promising and popular to all. Based on the research findings, two major suggestions might be in order. First, underlying rationales of the Girl Scout movement should be reoriented. A special emphasis on the creation of self-supportive 'androgynous individuals' would be the case (in this regard, an intensive program targeted for those pre-school-aged members would be the most effective). As a way to achieve the strategic reformulation, reliance on the interdisciplinary program (for example, coordination with the university) will be one possibility. Secondly, an organizational management should be sufficiently considered. provisions (tangible and intangible) for the 'field leaders' being the key leader group in the Girl Scout movement should be afforded enough to keep their participations voluntary and continuous.

디이젤기관의 흡입선회유동에 관한 연구

정동화,최은순,박상규 麗水水産大學校産業技術硏究所 1992 産業基術硏究所 論文集 Vol.1 No.-

Enhancement of performance of engine depends upon how perfectly combustion is effected, and air swirl is a factor contributing to this aim. In this paper, the variation of induction air swirl according to intake port shapes is studied by steady flow test. As a result of the steady flow test, using various shapes of intake port the following points are clarified. 1. Air swirl in actual engine cylinder can be fully estimated by steady flow test. 2. A valve position can have a substantial effect upon swirl. 3. The change of port inlet area has an effect on the variation of air swirl.

가네트를 활용한 고강도콘크리트의 고온수열 후 잔존압축강도특성

김동익,윤요현,박정민,김화중 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The study which it describes the high concrete which industrial by-product used garnet powder was quality of residual strength after heating. The test unit water content 160kg/m', water reunion ratio did with 30%, 35% and the aggregate ratio is 40%, 42%, 44%, displacement ratio admixture is 0%, 10%, 20%. Admixture garnet powder, fly ash, blast-furnace slag and it was compared with the residual strength of concrete after was heated to normal temperature, 50℃,100℃, 150℃, 200℃, 350℃, 500℃, 600℃, 800℃.With this test was got the next conclusion. To previously 350℃, the weight reduction was not big, it was visible the weight reduction which was sudden from 350℃, and it showed the aspect which also the compressive strength reduction is identical. It compared with admixture nothing replacement concrete, garnet replacement concrete relatively weight reduction and compressive reduction appeared small. Like this tendency recording where the replacement ratio will be increased the tendency which appeared relative small.

황산산성 용액에서 기체 발생 속도에 의한 히드라진과 요오드의 반응속도에 관한 연구

이송주,박동화 광주보건대학 1989 論文集 Vol.14 No.-

We have studied the kinetics of the N₂H₄=l₂ reaction in sulfuric acid media by gas evolution Choi?? has explained that the reaction of N₂H₄-Br₂processes through the Competitive Consecutive Second order reaction mechanism, and we have assumed N₂H₄-l₂ reaction processes through the same mechanism. The rate constant(k'₁) was found to be 0.87~0.98X 10^(-1) M^(-1) sec^(-1) with change in [N₂H₄]_(0), [l₂]_(0), 2a(=2[N₂H₄3_(0)-(l₂]) and inversely proportional to hydrogen concentration. we have also found th at, as k₃ is constant, a comparatively stable intermediate is present .