Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-kB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1

( Jae Ho Choi ),( Sun Woo Jin ),( Eun Hee Han ),( Bong Hwan Park ),( Hyung Gyun Kim ),( Tilak Khanal ),( Yong Pil Hwang ),( Minh Truong Do ),( Hyun Sun Lee ),( Young Chul Chung ),( Hee Suk Kim ),( Tae 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0

Purpose: The consequences of precipitously rising allergic skin inflammation rates worldwide have accelerated the risk of atopic dermatitis (AD). Natural product-based agents with good efficacy and low risk of side effects offer promising prevention and treatment strategies for inflammation-related diseases. We have already reported that Platycodon grandiflorum root-derived saponins (Changkil saponins, CKS) have many pharmacological effects, including anti-inflammatory and anti-allergic effects, but its influence on AD remains unclear. Therefore, we evaluated the inhibitory effect of CKS, mainly platycodin D, on AD-like skin symptoms in mice and the possible mechanisms in cells. Methods: Mice were sensitized and challenged with 2,4-dinitrochlorobenzene (DNCB). Four weeks after challenge, mice were treated with oral administration of CKS for 4 weeks. In addition, cells were used to evaluate the effect of CKS, mainly platycodin D, on the TARC expression regulated mechanism. Results: CKS attenuated DNCB-induced dermatitis severity, serum levels of IgE and TARC, and mRNA expression of TARC, TNF-α, IFN-γ, IL-4, IL-5, and IL-13 in mice. Histopathological examination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells and mast cells in the ears. Moreover, CKS and platycodin D inhibited TNF-α/IFN-γ-induced TARC expression through the suppression of NF-κB and STAT1 and induction of Nrf2/ARE-mediated hemeoxygenase-1 (HO-1) expression in cells. Conclusion: We suggest that CKS and platycodin D inhibited the development of AD-like skin symptoms by regulating cytokine mediators and may be an effective alternative therapy for AD-like skin symptoms.ⓒ2014 Elsevler Gmbh. All rights reserved.

수중기지국 기반 수중통신망 구축 및 성능 시험

김도훈(Kim Do Hoon),채광영(Chae Kwang Young),고만재(Go Man Jae),정해지(Jeong Hae Ji),유호동(Liu Hao Dong),조용호(Cho Young Ho) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.2

본 논문에서는 수중음향통신을 활용하여 CTD센서와 DO센서를 통해 수중환경데이터를 측정하고, 측정된 값을 육상에서 확인할 수 있도록 하는 실험을 진행하였다. 본 실험은 남해 실해역에서 20년 12월 12일부터 20일까지 진행되었으며, 구조물은 해수면에 해상부이 1대, 해저면에 수중기지국 2대, 센서노드 10대를 설치하였다. 모든 구조물에는 송신을 위한 트랜스듀서와 수신을 위한 하이드로폰이 장착된다. 해상부이는 해저면에 설치된 수중기지국과 센서노드에서 수중환경데이터를 수신한 후 육상 서버와 통신하여 패킷을 전송한다. 데이터는 1시간 단위로 전송되도록 설정하였으며 실험결과, 패킷 성공률은 약91.20%인 것을 확인하였다.

활막육종

김재도,윤영민,손정환,홍영기,손영찬,박정호,Kim, Jae-Do,Yoon, Young-Min,Son, Jeong-Whan,Hong, Young-Gi,Son, Young-Chan,Park, Jeong-Ho 대한근골격종양학회 1996 대한골관절종양학회지 Vol.2 No.1

Synovial sarcoma is an uncommon malignant soft tissue tumor which usually occurs in young-aged person, and frequently involves the lower extremities. Many authors recommended wide excision, adjuvant chemotherapy and radiation therapy. The proposed factors that affect the prognosis are age, size of tumor, site of tumor in the body, depth of tumor, histologic grade and method of treatment. The purpose of the study is to analyze the factors that affect the 5-year survival rate. We retrospectively evaluated 19 cases of synovial sarcoma treated in the Kosin University Medical Center from Jan. 1982 to Dec. 1994. The overall 5-year survival rate was 47.6% and the 5-year survival rates were significantly higher(P<0.05) in the group with smaller size of mass. The significantly lower 5-year survival rates were observed in the patient with deeply located lesion and with higher histologic grade. The 5-year survival rates were higher in the patients treated with wide excision than in the patients treated with amputation. But there was no significant difference between these groups. The adjuvant chemotherapy and radiotherapy were performed. In conclusion, we suggest that the better prognosis will be observed in the patients with smaller size of tumor mass, superficially located and lower histologic grade.

응급센터 입원환자의 통증처치에 대한 응급의학적 고찰

도병수,김현정,정준영,도호석,이창현,이삼범 대한응급의학회 1996 대한응급의학회지 Vol.7 No.2

Study objective: To recognize importance of pain management in ED and properly manage the ED patients complaining pain by analyzing the intervals between arrival time in ED and pain medicine starting time, the types and the administered routes of pain medicine. Design: Retrospective review of ED charts Setting: University teaching hospital Participants: The patients had admitted in ED of Yeungnam University Hospital with a chief complaint of acute abdominal pain or pain due to bone fracture between June 1, 1995 and December 31, 1995. Results: The study group consisted 256 patients, 161 of them female. ED administrations of analgesics were 103 cases, 17 of them administered more than two times. The average time interval between arrival time and medication time was 169.02±120.25 minutes. Each types of perceived analgesics were antispasmodics 55 cases(53.40%), NSAID 26 cases(25.24%) and opioid 19 cases(18.45%). Every analgesics were administered through intramuscular routes, except only 3 cases. Violences of patients or relatives due to delayed pain control were occured 32 cases, 5 cases of them self-discharged and looked for other hospitals. Conclusion: Emergency physicians including interns and residents delayed management so long and ordered inappropriate administration routes and types of analgesics. So we thought proper protocols about pain management in ED were established.

뇌졸중 환자에서 연하장애와 신체기능장애의 연관성

김도성,심영주,김기찬,정호중 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Backgrounds : In almost stroke patients, dysphagia is improved with rehabilitation therapy. But, it is not identified the relationship between dysphagia and physical function recovery in stroke patients. Methods : A total of 21 patients with stroke-caused swallowing disorders based on a videofluoroscopic swallowing study (VFSS) were examined swallowing function and physical function at admission and after treatment for 4 weeks (including Vitalstim). Swallowing function was evaluated by the functional dysphagia scale (FDS) using VFSS before treatment and after treatment. Physical function was evaluated by the motricity index (MI) and modified barthel index (MBI) at admission and after 4 weeks. And the relationship between dysphagia and physical function recovery was evaluated. Results : After treatment for 4 weeks, total score, residue in oral cavity, oral transit time, laryngeal elevation and epiglottic closure, residue in valleculae, residue in piriform sinus, coating of pharyngeal wall after swallow were significantly decreased in FDS (p<0.05). There were a significant improvement in MBI (p<0.05) and the correlation between FDS and MBI. But, MI was not showed correlation with FDS. Conclusions : There was relationships between swallowing function improvement and recovery of physical function in almost FDS factors.

슬관절 골관절염 환자에서 근육내 자극요법의 치료 효과

박영규,우종웅,안승렬,김정아,윤도경,박승회,조경환,홍명호 대한노인병학회 2001 대한노인병학회지 Vol.5 No.4

피부 스포로트리쿰증에서 Itraconazole 경구 투여의 효과에 대한 관찰

원영호,전선도,김성진,이승철 대한의진균학회 1998 대한의진균학회지 Vol.3 No.2

Background: The effectiveness of some therapeutic modalities for cutaneous sporotrichosis may be changed depending on the individual and geographic characteristics, and the clinical type. Itraconazole has been known to be effective for it, however, there have been no standard and ideal guideline on the oral dosage and duration yet. Objective 8: Methods: In this study, we evaluated the effectiveness of oral itraconazole in patients with cutaneous sporotrichosis in relation to dosage and clinical status. The observation of 17 patients with sporotrichosis were made retrospectively, Oral itraconazole was administered at the dose of 200 mg daily in 15 adults over 18 years old and 100 mg in the other 2 children. Results: The duration for healing was within 30 days in 4 cases, within 60 days in 4 cases, within 90 days in 2 cases, within 120 days in 3 cases, and within 150 days of therapy in 2 cases. The average duration in all cases was 12.1 ± 8.6 weeks. Comparison our results to the previous reported one revealed that more shorter treatment time was needed in cases treated with 200 mg daily than that with 100 mg. There was no treatment failure by drug intolerance or resistance. The duration for healing was significantly shorter in the patient groups with prevalence duration more than 5 months, however there was not any significant difference in sex of patients, and the clinical types. The cases with the lesion on the face and cases with fixed type tended to be healed more rapidly than the others, Conclusion: Oral itraconazole may be a safe and effective antifungal agent for the treatment of cutaneous sporotrichosis in a daily dose of 200 mg for 3 months on the average. However, duration for healing could be influenced by the clinical status.

회전자 구조에 따른 SRM의 토오크 특성해석

정도영,이상호,서진우,오홍석,최경호 三陟大學校 1997 論文集 Vol.30 No.1

The switched reluctance motor(SRM) has a simple rotor construction with no windings. It also has simple concentrated windings on the stator. Thus, it is expected to be a lower cost machine to manufacture than the squirrel cage induction motor. This paper presents an advanced rotor structure type, well-round rotor type in SRM. To design the improved SRM we have used FEM and studied and compared with each other. The static torque, instantaneous torque and average torque are more improved than that of typical rotor type which has been a lot of used for SRM.

사료제조공정에서 발생된 악취처리에 관한 연구

박영구,김승호,최선도,고재철 三陟大學校 2000 論文集 Vol.33 No.2

Methods for the treatment of foul odor was physical, chemical and biological. In this study, we utilized biofilter for the treatment of foul odor. Importance factors of a microbe is nutrients, temperature, moistrure and pH. As the results, it was found that matter of the odor was trimethylamine, removal rate(η(%)) fo (CH₃)N₃ appeared 19.7%∼96.5%(site-1), 20%∼95.5%(site-2) after treated to the biofilter, and tended to decrease from 7 months later by a biofilter compaction. Also size of the tree chip was 2cm, degree of the foul odor was degree of 3∼4, propriety temperature was 20∼40℃, the rate of contained moisture was 60∼70%, acidity was pH=8.

급성 하지 동맥폐색증의 치료

고영관,박호철,고석환,김도균,주홍재 대한혈관외과학회 1999 Vascular Specialist International Vol.15 No.1

Background: Arterial emboli remain an important cause of acute arterial ischemia. Despite simplification of operative techniques, the substantial morbidity and mortality still associated with an acute embolus remain a challenge to the vascular surgeon. We wanted to know the adequate evaluation and treatment modality for this limb threatened condition, and to evaluate the results according to etiology, location, time interval before starting treatment, clinical conditions, and limb survival rate. Material and Methods: A retrospective review was conducted on 91 patients who treated for acute lower leg thromboembolism between Jan. 1992 and Dec. 1997. Results: There were 73 men and 18 women and most prevalent age group was in the 5th and 6th decades (53.8%). Over all amputation rate was 25.3% and mortality rate was 5.5%. Cardiac problem was the most common etiologic factor. Associated diseases were cardiac problem (37.4%), hypertension (35.2%), cerebrovascular accident (17.6%), and diabetes (15.4%). Interval from attack to definite therapy, within 24 hours in 14 cases (15.4%), 1 ∼3 days in 23 (25.3%), after 4 days in 54 (59.3%) were noted. The locations were aorta and iliac in 25.3%, femoral in 38.5%, popliteal in 19.8%, tibial in 4.4%, and 15.4% in graft site in other of frequency. Clinical categories were grade I in 9.9%, IIa in 40.7%, IIb in 30.8%, and III in 18.7%. According to Eagle' s criteria, low risk group were 34 cases (37.4%), moderate risk group were 39 cases (42.9%), and high risk group were 18 cases (19.8%). Of the 91 patients, conservative treatment in 2 (2.2%), thrombolytic therapy in 33 (36.3%), thromboembolectomy in 56 (61.5%), bypass in 16 (17.6%), endarterectomy and vessel ligation were performed. The 1-month and 1-year limb salvage rates were 73.4% and 71.1%, respectively. Especially, salvage rates in the Department of Vascular Surgery were 84.9% and 83.7%, whereas that of Thoracic and Orthopedic Surgery were 44.4% and 33.0% (p=0.0001). Conclusions: Cardiac problem especially atrial fibrillation was the most common etiologic factor. Prompt balloon catheter embolectomy performed under local anesthesia is a safe, simple, and effective method of treatment and the preferred mode of management in the great majority of patients. Nonoperative management with thrombolytic agents or high-dose heparin therapy alone is occasionally indicated in highly selected patients. The prognosis of acute arterial thromboembolism of lower extremity can be improved by early detection, early adequate treatment, and the involvement of a qualified vascular surgeon.