플러그셀 크기 및 용토가 거어베라의 묘생장에 미치는 영향

조문수,예병쾌,박윤영,전하준 한국환경농학회 2003 한국환경농학회지 Vol.22 No.1

양액재배용 거어베라 우량묘를 생산하기 위한 기초연구로 플러그셀 크기 및 용토가 묘생장에 미치는 영향을 조사하였다. 용토의 물리성을 측정한 결과 가비중, 진비중 및 공극율은 퍼얼라이트에서 가장 높게 나타났으며 수분보유량은 코코피트에서 가장 높게 측정되었다. 162, 129, 72, 50구 플러그셀 트레리별로 퍼얼라이트 코코피트 그리고 퍼얼라이트+코코제트(1:1)을 채우고 60일간 육묘하여 묘의 생육을 조사하였다. 묘의 엽수는 125구 코코피트 처리에서 가장 많았으며 엽면적은 50구 코코피트 처리에서 높게 나타났다. 신초와 뿌리의 생체중 및 건물중 그리고 엽록소 함량은 퍼얼라이트+코코피트 처리에서 높게 측정되었다. 플러그셀 크기가 클수록 유모 생장에 효과적이었으며 퍼얼라이트 단용 보다는 코코피트와의 혼용 용토에서 유묘 생육이 가장 양호하였다. This study was conducted to examine the effects of plug tray cell size and growth media on good seedling production of Gerbera hybrida Hort. Seedlings were worm for 60 days in 50, 72, 128, 162 cell trays continuing perlite, cocopeat and perlite+cocopeat(1:1, v/v). Perlite showed higher bulk density than cocopeat and perUte+cocepeat. Total porosity was greater in perlite, cocopeat and perlite+cacopeat in order. Cocopeat showed the highest water balding capacity. Number of leaves were greatest in 128 cell tray containing cocopeat. Leaf area was greatest in 50 cell tray containing cocopeat. Seedling growth was also better in plug tray of bigger cell size. Seedling growth of fresh and dry weight of shoot and root was much better in the growth media of perlite+cocopeat.

HPGe 검출기에 의한 지각방사선의 핵분광학적 연구

전재식,채하석,진응국,이철영,조혁,하정우 충남대학교 기초과학연구소 1992 연구논문집 Vol.12 No.-

고순도 Ge(HPGe) 검출장치를 사용한 현장측정을 통하여 지각방사선에 대한 핵분광학적 연구를 수행하였는바 지각방사선장의 핵분광학적 특성차이를 규명하기 위하여 지면의 자연방사성 핵종분포가 대표적 전형인 충남대학교 캠퍼스내 미경작 개활지 잔디밭과, 우라늄 함량이 높은 곳으로 알려진 괴산군 덕평리 지역 등 특이한 두 지역을 측정지점으로 선택하였다. 환산선량의 비교확인을 위하여 HPGe 분광측정은 3″ø×3″원통형 NaI(T1) 섬광검출기에 의한 분광측정과 동시에 수행하였으며 본 연구에 사용된 HPGe 검출기에 대한 스펙트럼-선량율 환산인자 G(E)는 감마선속이 검출기 축에 수직 입사하는 것으로 가정하고 Monte Carlo 방법으로 씨뮬레이션한 감응스펙트럼들을 사용하여 산출하였다. 이 G(E)를 사용하여 산출된 선량율(D˙_Ge)은, 이미 기준기급 전리함과의 비교 교정을 통하여 스펙트럼-선량 환산체계가 확립된 바 있는 NaI(T1) 검출기로 구한 선량율(D˙_NaI)과 만족스러운 일치를 보였으며 D˙_Ge와 D˙_NaI 사이의 상관계수는 +0.9988, 회귀 방정식의 기울기는 1.001을 나타내었다. 측정한 스펙트럼에서는 미미한 크기의 ^137Cs 감마선 피크가 확인되었으나 1960년대에 수행되었던 대기권 핵실험의 영향이나 Chernobyl 원전사고의 영향은 관측되지 않았다. Study of terrestrial gamma-rays was carried out by means of in-situ spectrometry using high purity germanium (HPGe) detector system. Two distinguishable fields of measurements, namely, uncultivated flat lawns in CNU campus where the distribution of natural radionuclides in the ground in known to be quite typical and well-known uranium rich area of Dukpyung-ri in Gwoesan-kun were selected in order to specify the difference in spectrometric characteristics of the fields. In-situ HPGe spectromety was accompanied by scintillation spectrometry with 3″ø×3″cylindrical NaI(T1) detector for comparative confirmation of derived dose rates from the spectra measured. Spectrum-dose rate conversion operator, G(E), of our particular HPGe detector was calculated using response spectra simulated by Monte Carlo method with an assumption of gamma-ray beams incident vertically to the detector axis. Resultant dose rates (D˙_Ge) showed satisfactory agreement with those obtained by NaI(T1) spectrometry and corresponding G(E) operation (D˙_NaI) of which system has been well-established through intercalibration with a reference ion chamber. Correlation coefficient and the slope of regression equation between D˙_Ge and D˙_NaI came out to be +0.9988 and 1.001, respectively. Though traceable height of ^137Cs gamma-ray peak was identified on the field spectrum, ground contamination of fission products released from atmospheric nuclear test performed in 1960s and possibly from Chernobyl accident was not observed as of today.

정신재활 치료가 정신분열병 환자의 재발율, 입원횟수, 입원일수 그리고 치료 경비에 미치는 효과 : 2년 추적조사 연구

조진석,공지현,김진원,심경순,하준선,김철권,강동호,장정희,변원탄 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

목 적 : 사회기술훈련, 환자교육, 가족교육, 집단치료, 예술치료, 작업치료와 같은 포괄적인 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 정신분열병 환자의 재발율, 입원횟수, 입원일수, 직접 치료경비 등에 어떤 효과가 있는 지를 알아보기 위함이다. 연구방법 : 1993년 9월부터 1995년 2월까지 양산 신경정신병원의 폐쇄병동에서 퇴원한 20∼35세 사이의 정신분열병 환자 173명을 대상으로 46명에게는 6개월동안 정신재활 치료를 시행하였고 127명에게는 통상적인 외래치료만 시행한 후 연구시작 시점을 포함하여 2년동안 양군에 속한 환자들을 대상으로 재발율, 입원횟수, 입원일수, 직접 치료경비 등을 1년 단위로 추적 조사하였으며, 연구시작 시점을 기준으로 전과 후의 매년 평균 입원횟수, 입원일수, 직접 치료경비도 서로 비교하였다. 결 과 : 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 재발율, 입원횟수, 입원일수, 직접 치료비용이 현저히 감소되었다. 그리고 정신재활 치료를 받은 군에서는 치료 전에 비해 치료 후에 재발율, 입원횟수, 입원일수, 직접 치료비용이 유의하게 감소하였지만 통상적인 외래치료만 받은 군에서는 치료 전과 후간에 유의한 변화를 보이지 않았다. 결 론 : 정신분열병 환자들에게 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 환자의 임상적 경과를 호전시킬 뿐 아니라 가족의 경제적 부담도 줄일 수 있다. Objective : We evaluated the clinical efficacy of a comprehensive psychiatric rehabilitation of schizophrenia, including family psychoeducation, patient education, social skills training, group psychotherapy, art therapy, and occupational therapy. Method : From September 1993 to February 1995, 173 chronic schizophrenics who met DSM-IV criteria and were discharged from a locked ward were assigned into the psychiatric rehabilitation service group(psychiatric rehabilitation group, n=46) or the customary out-patient service group(out-patient group, n=127) prospectively, but not randomly. Assignment was based on preferences of patients and their relatives, Each subject included in the psychiatric rehabilitation group received twice weekly patient education, social skills training, family psychoeducation, group psychotherapy, art therapy, occupational therapy and maintenance chemotherapy during a 6-month period. Those in the out-patient group received individual supportive psychotherapy and maintenance chemotherapy according to their clinical needs for 10-20 minutes once per week. After entry into the study, all subjects were assessed for the number of readmission, days of hospitalization, and the direct treatment costs through the first and second year of follow-ups. These outcome variables were also compared pre-and post-2 years at the time point of entry into the study. Aftercare chemotherapy on a weekly to monthly basis continued for the remainder of the two year follow-up period. Results : With regard to the mean number of hospital admissions per year, the mean days of hospitalization per year, and the direct treatment costs per year, the psychiatric rehabilitation group had significantly decreased all clinical outcomes 2 years after compared with before receiving psychiatric rehabilitation. But there were no significant differences in the all clinical outcomes between before and after study intake in the out-patient group. For the number of relapse regardless of drug compliance, 4 patients(9%) during first year and 14 patients(30%) during second year were relapsed in the 46 subjects of the psychiatric rehabilitation group. In contrast, 75 patients(59%) during first year and 90 patients (71%) during second year relapsed in the out-patient group. When considering the effect of drug noncompliance to relapse, 4(9%) and 14 patients(30%) were relapsed while on medication respectively during the first and second year in the 46 of the psychiatric rehabilitation group, vs. 27(34%) of 79 patients on medication during the first year and 31(46%) of 68 patients on medication during the second year were relapsed in the out-patient group. Conclusions : These results indicate that the comprehensive psychiatric rehabilitation can be useful therapeutic intervention both to improve the clinical outcomes of schizophrenic patients and to reduce the economical burden of their relatives.

Investigation on Delamination Characteristics of 2-Ply Clad Metals and Adhesive Joints for Aluminum/Stainless Steel via the Peel Test

Jun‑Hyung Sim,Yungeun Ha,Min‑Kyun Kim,Min‑Joong Kim,Young‑Rae Cho 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.2

Bonding properties are important for metallic multilayer composites (MMCs) comprising different materials or materialswith different mechanical properties. In this study, we fabricated 2-ply Al/stainless steel (STS) clad metals and Al/adhesive(adh)/STS joints. To manufacture samples with various mechanical properties, T6 heat treatment was performed on cladmetals, and adhesive joints of several thicknesses were prepared. For each sample, the bonding strength was characterizedvia a T-peel test and the results were analyzed using the peeling angle. For 2-ply Al/STS clad metals, the T6 heat treatmentresulted in opposite trends in the mechanical properties. The bonding strength of 2-ply Al/STS clad metals was affectedby the peeling angle, i.e., a small peeling angle provided a small bonding strength at the interface. However, for the 2-plyAl/adh/STS joints, the bonding strength of adhesives on metals depended on each adherend of the stress state. As the differencein mechanical properties between the two adherends increased, the difference in each peeling angle of Al and STSalso increased. The peeling angle of adherends reached a limiting value when the sample contacted the clamping jig head;therefore, a new term, apparent bonding strength (ABS), is necessary to differentiate this new strength from the bondingstrength obtained under non-contact conditions. We believe that the concept of peeling angle and ABS proposed herein willplay a crucial role in describing the delamination behavior and bonding strength of MMCs via the peel test.

특발성 경련질환으로 오인된 원발성 부갑상선기능저하증 1례

신성하,최정영,김준기,고영춘,조상욱,김순호,임중규 全南大醫大 2001 전남의대학술지 Vol.37 No.1

소아에서 출혈을 동반한 단일 연소성 용종의 내시경적 절제술

김준기,조상욱,신성하,고영춘,최정영,서강석,강명원,임연근,여향순,김경수 全南大醫大 2001 전남의대학술지 Vol.37 No.3

주의력결핍/과잉행동장애와 양극성장애 공존 환아군과 주의력결핍/과잉행동장애 환아군의 비교연구

정동선,하규섭,정희연,구훈정,황준원,김붕년,신민섭,조수철,홍강의 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6

Objective : Attention deficit hyperactivity disorder (ADHD) is frequently comorbid with a variety of psychiatric disorders. Among them, bipolar disorder (BPD) has especially attracted growing interest. This is partly due to the fact that early onset BPD has been frequently misdiagnosed as ADHD because of symptomatic overlap. The aim of the present study is to find the differences in demographic data and clinical features of ADHD+BPD and ADHD in children and adolescents. Method : Children and adolescents patients participating in the present study have been enrolled at the child psychiatric clinic since 2004. 14 patients meeting the DSM-IV chteria for ADHD+BPD and 19 patients meeting the criteria for ADHD and 15 healthy comparison subjects were recruited. All groups were evaluated through the Schedule for Affective disorders and Schizophrenia for School-Age Children-Present and Life Time version-Korean version (K-SADS-PL-K). Demographic data and clinical charactehstics of the subjects were also collected. Parents were asked to complete the Child Behavior Check List(CBCL) and the Toddler Temperamental Scale (TTS) clinical ratings were obtained using the Young Mania Rating Scale(YMRS), the Children's Depression Iventory (CDI) and the Dupaul ADHD scale. Clinical variables between ADHD+BPD and ADHD were analyzed using the Mann-Whitney U test. YMRS, CDI, Dupaul ADHD scale (inattention and hyperactivity), CBCL, and TTS among the three groups were analyzed using the Kruskal-Wallis test with post-hoc Mann-Whitney U test. Results : 1) ADHD+BPD group had an earlier onset age of ADHD than ADHD group 2) ADHD+BPD group had more co-morbid psychiathc disorders than ADHD group. 3) Compared to ADHD group, ADHD+BPD had more psychiathc family history, especially mood disorders. 4) ADHD+BPD group had prodromal symptoms such as irritability, anger dyscontrol and academic dysfunction, compared to ADHD group who rarely showed prodromal symptoms. 5) ADHD+BPD group had higher ADHD scores than the ADHD group in the Dupaul ADHD inattentive scale. 6) In global functions of CBCL, ADHD+BPD group showed more impaired functions at home and school than ADHD group. 7) In Attention diagnostic system (ADS), ADHD+BPD group had more omission and commission errors than ADHD group, especially in the visual system. 8) In the subtests of the IQ profile, ADHD+BPD group had lower arithmetic and block design scores than ADHD group. Conclusion : Clinicians have to rule out underlying bipolarity in children and adolescents with ADHD who show earlier age of onset and severe clinical features. Bipolarity should be explored intensively in ADHD children and adolescents who have early onset of symptoms and severe functional impairment.

Suppression of lung inflammation by the methanol extract of <i>Spilanthes acmella</i> Murray is related to differential regulation of NF-κB and Nrf2

Kim, Kyun Ha,Kim, Eun Jung,Kwun, Min Jung,Lee, Ji Yeon,Bach, Tran The,Eum, Sang Mi,Choi, Jun Yong,Cho, Sayeon,Kim, Sang-Jun,Jeong, Seung-Il,Joo, Myungsoo Elsevier 2018 Journal of Ethnopharmacology Vol.217 No.-

<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P>Although <I>Spilanthes acmella</I> has been used to relieve inflammation, fever, pain, or infection in traditional Asian medicine, experimental evidence supporting these functions is scarce. Here, we examined an anti-inflammatory function and a possible underlying mechanism of <I>S. acmella</I> Murray (SAM).</P> <P><B>Materials and method</B></P> <P>The methanol extract of SAM was fingerprinted by HPLC. C57BL/6 mice were administered with a single intratracheal (i.t.) LPS and 2 h later with a single i.t. SAM. The effect of SAM on lung inflammation was assessed by histology, semi-quantitative RT-PCR, and MPO assay of lung tissue. The effects of SAM on a pro-inflammatory factor NF-κB and an anti-inflammatory factor Nrf2 were analyzed by immunoblotting of nuclear proteins and by semi-quantitative RT-PCR analysis of mRNA of the genes governed by these transcription factors. V5-Nrf2 was precipitated by an anti-V5 antibody and the ubiquitinated V5-Nrf2 was revealed by immunoblotting of HA-tagged ubiquitin.</P> <P><B>Results</B></P> <P>The i.t. SAM robustly diminished a neutrophilic lung inflammation induced by i.t. LPS treatment of mice. In RAW 264.7 cells, SAM suppressed the nuclear localization of NF-κB and the expression of NF-κB-dependent cytokine genes. SAM increased the level of Nrf2 in the nucleus and the expression of Nrf2-dependent genes while suppressing ubiquitination of Nrf2.</P> <P><B>Conclusion</B></P> <P>Our results suggest that SAM can suppress a neutrophilic inflammation in mouse lungs, which is associated with suppressed NF-κB and activated Nrf2. Our results provide experimental evidence supporting the anti-inflammatory function of <I>S. acmella</I>.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

생쥐 대장 평활근 세포에서 내향 정류성 칼륨 전류의 특성 연구

이은주,김명,정명섭,조향훈,김기훈,하현철,김준수,최석,전제열 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Objectives: K^(+) channels play an important role in regulating cellular excitability. The aim of this study was to know whether or not inward rectifier K^(+) channel exists in colonic smooth muscle cells. Methods: Mouse colonic smooth muscle cells were isolated using collagenase, and then we recorded their membrane currents using a whole-cell patch clamp technique. Results: With 90 mM K^(+) in bath, hyperpolarization-induced inward currents from -120 mV to 20 mV with 400 ms duration at a holding potential of -10 mV showed rapid activation, inactivation and inward rectification. The inactivation showed single exponential time course. Reduction of external K^(+) to 60 mM decreased the amplitudes of the currents in whole test voltage range and shifted the reversal potential to more negative potential. The inactivation process and peak currents of hyperpolarization-induced inward currents were not affected by removing external Na^(+). External Ba^(+) blocked hyperpolarization-induced inward currents by dose-dependent manner and pure Ba^(+)-sensitive currents showed strong inward rectification. Cs^(+) also suppressed hyper- polarization-induced inward currents. Ba^(+) and Cs^(+)-induced inhibitiOn of hyperpolarization-induced inward currents was voltage-dependent, and the extent of inhibition increasing with membrane hyperpolarization. Conclusions: These results suggest that inward rectifier KU channels may exist in proximal colonic smooth muscle and may play an important role in regulating membrane potential.

정신분열병 환자에서의 한국어판 사회적응 척도의 개발 : 신뢰도 및 타당도 연구

김철권,서지민,김상수,조진석,하준선,김정옥,변원탄 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 정신분열병 환자의 사회적응 정도를 측정하는데 사용되는 사회적응 척도의 한국어판을 개발하기 위함이다. 방 법: 사회적응 척도를 번역한 후 정신분열병 환자 67명과 정상인 78명을 대상으로 신뢰도와 타당도를 검증하였다. 결 과: 자료분석 결과 검사-재검사 신뢰도는 0.85, 검사자간 신뢰도는 0.89, 내적 일치도는 0.87로 높은 수치였다. 변별 타당도를 검증하기 위하여 정신분열병 환자군과 정상 대조군을 비교한 결과 정신분열병 환자군에서 사회적응 정도가 유의하게 낮았다. 구성 타당도를 알아보기 위하여 10개 영역간의 상관관계를 측정한 결과 성적적응 영역을 제외한 모든 영역들에서 유의한 상관관계를 보였다. 본 척도의 전반적 평가 영역 결과와 GAF 결과간의 상관성을 통해 간접적으로 검증한 공존 타당도 역시 유의하였다. 결 론: 한국판 사회적응 척도는 우수한 신뢰도와 타당도가 입증되었고 나아가 정신분열병 환자의 사회적응 정도를 평가하는데 유용하게 사용되어질 수 있을 것이다. Objectives: The purpose of this study was to develop the Korean version of the Social Adjustment Scale Ⅱ-Revised Version(KSAS Ⅱ-RV) in the schizophrenics. Methods: KSAS Ⅱ-RV was administered to 67 schizophrenic patients and 78 matched normal controls for examining the reliability and validity. Results: Data analysis showed statistically significant reliabilities and validities of KSAS Ⅱ-RV. The test-retest reliability, inter-rater reliability, and internal consistency for total scores of KSAS Ⅱ-RV were 0.85, 0.89. and 0.87, respectively. Evidence for discriminant validity of KSAS Ⅱ-RV comes from the results that the mean scores of schizophrenic patients were significantly high than those of normal controls. Construct validity was assessed by calculating the 10 inter-subareas correlations of the KSAS Ⅱ-RV, and all except the sexual adjustment area were statistically significant. Significant correlations between the global area scores of KSAS Ⅱ-RV and those of Global Assessment of Functioning Scale lend support for the concurrent validity of this instrument indirectly. Conclusions: KSAS Ⅱ-RV was found to be a valid and reliable instrument which can be used to evaluate the degree of social adjustment in the schizophrenic patients.