사람 재식별: 학제간 연구 과제

정동선 한국인터넷방송통신학회 2012 한국인터넷방송통신학회 논문지 Vol.12 No.6

인터넷의 확산과 정보 교환, 배포와 수집 기술에 대한 의존도의 증대로 과거와는 비교할 수 없는 대용량의 데이터가 생성되었다. 대용량 데이터를 식별하고 가려내는 작업은 가까운 미래에 오늘날의 컴퓨터 과학의 상당 부분을 새롭게 정의할 것으로 예상된다. 여러 관련 분야에서 반복되는 중요한 과제는 재식별의 문제이다. 광범위한 정의에서, 재식별 문제는 과거에 인식된 객체를 다시 식별하는 문제이다. 예를 들면, 여러 장소에 설치된 감시 카메라에 포착된 어떤 사람을 추적하는 문제가 이에 해당한다. 본 논문에서는 서로 다른 분야에서 이 과제를 어떻게 정의하고,이 과제를 어떻게 해결하는가에 대해 비교 분석한다. 비디오 감시에서 사람 재식별, 텍스트 샘플에서 저자 식별, 사진선호도에 따른 사용자 식별 등이 이에 포함된다. 본 논문은 또한 학제간 해결 방안이 장점을 지니는 상황에 대한 비전을 제시한다. The wide diffusion of internet and the overall increased reliance on technology for information communication, dissemination and gathering have created an unparalleled mass of data. Sifting through this data is defining and will define in the foreseeable future a big part of contemporary computer science. Within this data, a growing proportion is given by personal information, which represents a unique opportunity to study human activities extensively and live. One important recurring challenge in many disciplines is the problem of people re-identification. In its broadest definition, re-identification is the problem of newly recognizing previously identified people, such as following an unknown person while he walks through many different surveillance cameras in different locations. Our goals is to review how several diverse disciplines define and meet this challenge, from person re-identification in video-surveillance to authorship attribution in text samples to distinguishing users based on their preferences of pictures. We further envision a situation where multidisciplinary solutions might be beneficial.

식품 중 Nisin의 항균력 상승을 위한 양이온의 효과

정동선 서울여자대학교 자연과학연구소 1997 자연과학연구논문집 Vol.9 No.-

천연 항균물질인 nisin이 특정의 고지방 식품에서는 항균력이 높지 않음이 확인되었기 때문에 특정 식품내에서 nisin의 역가 감소를 억제하거나 역가의 상승효과를 얻기 위한 방안으로 양이온의 영향을 조사하였다. nisin의 역가가 현저히 감소되었던 half-and-half milk와 red wine에 calcium chloride를 첨가하였을 경우 nisin의 역가가 상승하였으며, Ca 이온 농도가 높을수록 nisin의 역가가 높게 나타났다. 그러나 Na이온은 역가에 거의 영향을 미치지 않았다. Model foods로 사용한 beef, ham, chicken, or turkey 등의 식품에 calcium choride or magnesium choride를 첨가하였을 경우 nisin activity가 훨씬 높게 나타났으며, 상승효과는 Ca ion이 Mg ion보다 뛰어났다. 특정 식품내에서 양이온이 nisin activity의 감소를 억제하거나 향상시키는 기작은 아마도 양이온이 식품 중 특정성분과 결합함으로서, 양이온을 띠고 있는 Nisin분자와 반응하지 않았기 때문으로 해석된다. Nisin as an antimicrobial agent has been observed to be less active in certain high fat containing foods. To investigate the enhancement effect of the reduced efficacy of nisin in certain foods, cations were added into model foods which retained less nisin activity. Calcium ions enhanced nisin activity in half-and-half milk and wine. Nisin activity was decreased significantly in high fat containing foods such as beef, ham, chicken, and turkey. However, nisin with calcium ions or magnesium ions retained much higher activity in these foods. The recovery effect of magnesium ions on nisin activity in food system was intermediate between that of calcium ions and sodium ions. It suggest that the mechanism of enhancement of nisin activity is likely by masking negatively charged sites in the food components which might bind to positively charged nisin molecules by metal ions.

여자 정신분열병 환자에서 혈중 에스트로겐 농도와 추체외로 증상과의 관계

정동선,정희연,권영준,박인준,한선호,정한용,Chung, Dong Seon,Jung, Hee Yeon,Kwon, Young Joon,Park, In Joon,Han, Sun Ho,Jung, Han Yong 대한생물정신의학회 2001 생물정신의학 Vol.8 No.1

Objective : It has been thought that estrogen has neuroleptic like effect in women schizophrenic patients. This study aimed to investigate neuroleptic side-effects severity in women with schizophrenia and to investigate their putative association with variations in sex steroids over menstrual cycle. Based on the estrogen theory, The author hypothesized that parkinsonian side-effects would be exacerbated when estrogen levels were high. Method : 26 schizophrenic women were assessed using the ESRS(Extrapyramidal Symptom Rating Scale) and estrogen analysis. Tests were conducted twice, in the mid luteal and mid follicular phase. Result : It was hypothesized that high level of estrogen would lead to an exacerbation of parkinsonian side-effects but the results indicated that parkinsonian side effects decreased overall when estrogen levels were high. This effects were more marked for the group taking typical neuroleptics than those taking atypical neuroleptics. Conclusion : The results of this study suggest that estrogen and progesteron may reduce the severity of neuroleptic induced extrapyramidal side effects over menstrual cycle in women with schizophrenia. It was concluded that estrogen has different effects on dopamine dynamics in the mesolimbic and mesostriatal pathways according to estrogen, progesteron, catecol estrogen, prolactine.

Alternaria brassicicola SW-3에 의해 생산되는 항암 및 항균성 대사산물의 생산 및 효율적 분리를 위한 연구

정동선,라여정 서울여자대학교 자연과학연구소 2005 자연과학연구논문집 Vol.17 No.-

Alternaria brassicicola SW-3은 배양조건 및 시기에 따라 다양한 대사산물을 생성하는 것으로서, 본 연구에서는 항암성 대사산물(SW-301, depudecin)과 항균성 대사산물(SW-302)의 생산 조건과 분리 정제 방법을 수립하였다. A. brassicicola SW-3에 의한 2차 대사산물의 생성은 탄소원과 질소원이 충분한 고영양 배지에서는, 항균성 대사산물은 증가하고 depudecin의 생산이 감소한 반면, 무기염류를 함유한 영양 제한 배지 또는 생합성 전구체로 sodium acetate를 첨가한 배지에서는 포자 형성이 촉진되어 depudecin의 농도가 증가한 것을 알 수 있었다. Fungal metabolite가 혼합되어 있는 배양액에서 항암활성물질인 depudecin은 흡착크로마토그래피인 HP-20 Diaioin column을 이용하여 극성성분을 흡착시킨 후, 비극성의 depudecin 성분을 효율적으로 분리할 수 있었다. 또한 항균성 대사산물은 silica gel chromatography로 분리한 후, RP-HPLC를 사용하여 효율적으로 분리할 수 있었다. Studies of the secondary metabolites produced by the phytopathogenic fungus Alternaria brassicicola have lead to the isolation of two bioactive metabolites, SW301 and SW302. The metabolite SW301 is identified as depudecin, which posesses antitumor activity. The compound SW302 showed no antitumor activity but potent antimicrobial activity. The production of depudecin was increased by addition of 0.02% sodium acetate, but decreased in nutrient rich media. However, the antimicrobial metabolite SW-302 was increased by supplement of sodium nitrate at 0.2%. We also developed a procedure to separate and purify two bioactive metabolites from the fermentation broth. The SW-301(depudecin) was separated from the culture broth by Diaion HP-20 and further silica gel chromatography. The antmjcroial metabolite(SW-302) was purified by silica gel column chromatography and semi-preparative HPLC.

병원의 진료비청구 및 누락방지책<I>

정동선,Jeong, Dong-Seon 대한병원협회 1986 대한병원협회지 Vol.15 No.9

주의력결핍/과잉행동장애와 양극성장애 공존 환아군과 주의력결핍/과잉행동장애 환아군의 비교연구

정동선,하규섭,정희연,구훈정,황준원,김붕년,신민섭,조수철,홍강의 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6

Objective : Attention deficit hyperactivity disorder (ADHD) is frequently comorbid with a variety of psychiatric disorders. Among them, bipolar disorder (BPD) has especially attracted growing interest. This is partly due to the fact that early onset BPD has been frequently misdiagnosed as ADHD because of symptomatic overlap. The aim of the present study is to find the differences in demographic data and clinical features of ADHD+BPD and ADHD in children and adolescents. Method : Children and adolescents patients participating in the present study have been enrolled at the child psychiatric clinic since 2004. 14 patients meeting the DSM-IV chteria for ADHD+BPD and 19 patients meeting the criteria for ADHD and 15 healthy comparison subjects were recruited. All groups were evaluated through the Schedule for Affective disorders and Schizophrenia for School-Age Children-Present and Life Time version-Korean version (K-SADS-PL-K). Demographic data and clinical charactehstics of the subjects were also collected. Parents were asked to complete the Child Behavior Check List(CBCL) and the Toddler Temperamental Scale (TTS) clinical ratings were obtained using the Young Mania Rating Scale(YMRS), the Children's Depression Iventory (CDI) and the Dupaul ADHD scale. Clinical variables between ADHD+BPD and ADHD were analyzed using the Mann-Whitney U test. YMRS, CDI, Dupaul ADHD scale (inattention and hyperactivity), CBCL, and TTS among the three groups were analyzed using the Kruskal-Wallis test with post-hoc Mann-Whitney U test. Results : 1) ADHD+BPD group had an earlier onset age of ADHD than ADHD group 2) ADHD+BPD group had more co-morbid psychiathc disorders than ADHD group. 3) Compared to ADHD group, ADHD+BPD had more psychiathc family history, especially mood disorders. 4) ADHD+BPD group had prodromal symptoms such as irritability, anger dyscontrol and academic dysfunction, compared to ADHD group who rarely showed prodromal symptoms. 5) ADHD+BPD group had higher ADHD scores than the ADHD group in the Dupaul ADHD inattentive scale. 6) In global functions of CBCL, ADHD+BPD group showed more impaired functions at home and school than ADHD group. 7) In Attention diagnostic system (ADS), ADHD+BPD group had more omission and commission errors than ADHD group, especially in the visual system. 8) In the subtests of the IQ profile, ADHD+BPD group had lower arithmetic and block design scores than ADHD group. Conclusion : Clinicians have to rule out underlying bipolarity in children and adolescents with ADHD who show earlier age of onset and severe clinical features. Bipolarity should be explored intensively in ADHD children and adolescents who have early onset of symptoms and severe functional impairment.

지방산 생합성효소(FabH)에 대한 Nocardia sp.대사산물의 저해효과

정동선,나여정 서울여자대학교 자연과학연구소 2004 자연과학연구논문집 Vol.16 No.-

Fatty acid biosynthesis catalyzed by the type Ⅱ fatty acid synthase (FAS) system in most bacteria but catalyzed by the type Ⅰ FAS system in mammalian. FAS may be a potential target for antibacterial drug development. We screened antibacterial substances and measured inhibitory activity on the type Ⅱ FAS (FabH) to obtain the new antibacterial substances from Actinomycetes. Nocardia sp. produced antibacterial substances after 7days of cultivation in modified glycerol medium. The metabolites exhibits a broad antibacterial spectrum, particularly potent activity against Staphylococcus eureus. The antibacterial compounds extracted from the culture broth of Nocardia sp. using ethyl acetate, and purified by silica gel column chromatography. Four fractions purified from culture broth of Nocardia sp. were measured for inhibitory activity on FabH enzyme. Two fractions (Fl and F4) showed the inhibitory activity on the type Ⅱ FAS. The structural analysis of bio-active metabolites is now under investigation.

Alternaria brassicicola SW-3의 항진균 활성

정동선,라여정,변한나,정은영 서울여자대학교 자연과학연구소 2003 자연과학연구논문집 Vol.15 No.-

The fungus Alternaria brassicicola is a causal agent of black leaf spot in. several cruciferous plants. We found A. brassicicola SW-3 produced antifungal metabolite, in addition to depudecin, reported as a histone deacetylase inhibitor. The metabolite produced by A. brassicicola SW-3 exhibited antifungal activity against various filamentous fungi such as Rhizopus, Mucor, Aspergillus, Microsporium, and Trichophyton. The antifungal metabolite was extracted with ethyl acetate from the culture filtrate of A. brassicicola, and purified through silica gel column chromatography. The purified compound exhibited a broad antifungal spectrum, particularly potent activity against Microsporum canis and Trichophyton rubrum which are dermatophytes associated with cutaneous Mycosiscause. The purified metabolite showed very complex spectral data from proton and carbon-13 NMR analysis, indicating the compound contains both lipid and carbohydrate moiety. Although structure of the antifungal metabolite is not elucidated yet, these preliminary results suggest that the antifungal metabolite from A. brassicicola could be used as a lead compound for treatment of skin diseases caused by filamentous fungi.

저온저장과 Nisin처리가 물김치(개량 동치미)의 저장성에 미치는 영향

정동선,임경화,정원철 서울여자대학교 자연과학연구소 1997 자연과학연구논문집 Vol.9 No.-

천연항균물질인 nisin에 의한 물김치의 신선도 유지 효과를 조사하기 위하여 숙성된 물김치에 nisin을 첨가 후 저온저장하며 pH, 총산함량, 젖산균수, 대장균군수 등의 변화를 측정하였다. Nisin을 첨가한 물김치는 저장 20일까지 pH 감소 현상이 거의 나타나지 않은 반면, 4℃에 저장한 시험구의 pH는 서서히 낮아져 저장 20일에는 pH 3.41이었고, 2℃에 저장한 시험구의 pH도 약간씩 감소하였다. 물김치내 젖산균수는 4℃에서도 지속적으로 증가함과 더불어 산도도 증가하여 저장 20일에는 초기의 2배에 달하였다. Nisin첨가구의 젖산균수는 첨가 직후 균수의 급격한 감소현상이 있었으나 저장기간이 길어짐에 따라 서서히 증식하여 저장 13일 이후에는 초기 균수 보다 많아졌다. 그러나 nisin첨가구에서의 총산함량은 거의 증가하지 않은 것으로 보아, 물김치내 젖산균이 nisin에 대한 내성이 생겨 nisin에 의한 생육저해효과가 높지는 않으나 내성균주에 의한 산생성능은 약해진 것으로 보인다. 물김치의 저장 중 대장균군수는 산도가 높아짐에 따라 감소하여 4℃ 저장 13일이후에는 대장균군이 나타나지 않은 반면, nisin 처리구에서는 대장균군의 사멸속도가 매우 완만하게 나타난 점으로 보아 nisin 처리에 의해 산생성이 억제되어 신선도는 오래 유지되나 대장균군 억제효과는 낮은 것으로 나타났다. Effect of nisin to extend the freshness of mul-kimchi was investigated by measuring the change in pH, Total acidity, and microbial counts of mul-kimchi during preservation at low temperature. Preservation of mul-kimchi at 2℃ reduced the rate of pH decrease, but preservation at 4℃ resulted in a significant decrease in the rate of pH decrease and Total acidity increase in mul-kimchi. However, nisin treatment into mul-kimchi reduced acid production by lactic acid bacteria, and kept the freshness much longer than that of 2℃ preservation. Lactic acid bacteria in mul-kimchi contained nisin was significantly decreased in number right after addition of nisin, but it started to grow slowly and reached to the original number after 13days of preservation. Nisin also allowed coliforms to survive in mul-kimchi longer than in control. Therefore, nisin can be used to control the over-acidification of mul-kimchi, if only the initial contamination of colifoms is low.

시판 샐러드용 채소와 아파트 발코니에서 재배한 채소의 미생물 오염도 비교

정동선,강민주 서울여자대학교 자연과학연구소 2008 자연과학연구논문집 Vol.20 No.-