공급사슬관리의 전략적 과제에 관한 탐색적 연구

안병훈,이승규,정희돈,안현수 한국경영과학회 1997 經營 科學 Vol.14 No.1

This study addresses strategic issues related to the question of "how can a supply chain become more competitive?" We examine several cases of manufacturing supply chains. Results show that each constituent firm is required to maintain different manufacturing capabilities and to play different roles by its position (up/mid/down-stream) in a chain. Furthermore, there are patterns of required capabilities by the positions in a chain. These findings imply that the "position in a chain" should be treated as one of the strategic factors when discussing the buyer-seller relationship. It is also shown that different action programs are required for building different manufacturing capabilities of individual firms in a supply chain. Additionally, we argue that some programs need to be done simultaneously, by all the members of the chain, while some need to be carried out by only a small group or an individual firm. Finally, we propose a direction for a theoretical framework for analyzing supply chain structures and strategies.

월수함수 단일항전개를 이용한 추적 최적제어기 설계

안두수,오현철,김민형,이재춘,이명규 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.1

This paper presents the methode of optimal control theory and observer for time invariant system via Single Term Walsh Series. The algorithm of the optimal control theory is simulated by MATLAB.

안면비대칭에 대한 주관적 인지도와 정모두부방사선사진 분석치의 연관성

안정순,황현식,김창수,김경근 전남대학교 치의학연구소 2001 구강과학 Vol.13 No.3

This study was aimed how posteroanterior cephalometric measurements affect the perception of the patient about his/her facial asymmetry. One hundred orthodontic patients, over the age of 12, who required a posteroanterior cephalogram in the Department of Orthodontics of Chonnam National University Hospital were used as the subject. They were asked if they thought their faces are asymmetrical. Their responses were classified into 5 groups based on the level of asymmetry as follows : Definitely No, Probably No, Don't Know. Probably Yes, Definitely Yes. Nine linear and four angular measurements from each posteroanterior cephalometric radiographs were analysed on the standard of the line between crista galli and anterior nasal spine to show the extent of asymmetry. Through this comparative study, the following results were obtained. 1. As the deviation of menton and the midline discrepancy of the upper and lower jaws were greater, the perception of patients about their facial asymmetry was higher. 2. All the measurements from the group "Don't Know" showed no statistical difference with those of the groups "Definitely No" or "Probably No." 3. All the measurements from the group "Probably Yes" showed no statistical difference with those of the group "Definitely Yes." The above results suggest that it may be helpful for the orthodontic diagnosis to ask patients' perception of their own facial asymmetry.

모 컴퓨터 회사 근로자 건강증진 사업 전개를 위한 수요조사

임현우,안병용,최환석,박정일,김경수,이강숙,김정아,구정완 가톨릭대학산업의학쎈타 산업의학연구소 1997 韓國의 産業醫學 Vol.36 No.4

Before conducting the health promotion program, we surveyed the health risk appraisal(HRA) of 210 workers (186 men and 24 women) in a computer company, for the need assessment, selection of target population, priority setting, and as a standard for comparision after performing the program. The smokers were 115(88.6%), and drinkers (over 1 bottle of Soju per week) were 91(44.8%) in men. Entire women and 148(78.0%) men never or irregularly exercise. Type A personality were 73(39.2%) in men, 8(33.3%) in women, and 26(14.0%) of men and 6(25.0%) of women were high stress risk group. 53(25.2%) of men and 2(8.3%) of women were obese (BMI ≥25kg/m²), and workers who consumed exess of total calory compared with recommendation were 142(76.3%) in men and 18(75%) of women. By the health risk appraisal, it was suggested that smoking cessation program, drinking counselling, exercise prescription, stress management, and weight control program should be conducted effectively for the high risk group.

생태적 도시계획을 위한 생태기반지표의 개발과 활용에 관한 연구(Ⅱ)

김현수,안근영,장대희 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

With environmental problems and pollutions accumulated by continuous urban development projects, it is becoming necessary to develop in consideration of environmental effects. On this study, it is suggested the critical point of biotope space factor and the supplement device. Natural ground area ratio is functioned as important factor in urban area. So in region, high-rated in natural ground area ratio, or in new urban development area, it is necessary to get supplement tool for conserving preferentially natural ground area. And it is considerable to ply individual environment planning indicator in case of need. This study has main contents as follows; biotope space factor was applied to actual case, rebuilding housing complex in Cham-sil to diagnosis ecological level and to lead more ecologically sound plan. After considering all the factors there was the critical point in using as just one tool, biotope space factor, so we suggested supplement device to solve this problem for an example, by regional characteristics, biotope space factor and individual environmental planning factor will be used together.

멀티미디어 정보를 이용한 전주 박물관 안내 시스템 : 오일석

안현수,김종훈 全北大學校 敎育大學院 1995 敎育論叢 Vol.15 No.-

Recently, many a multimedia software is introduce named CD-title due to equipment of multimedia environment. This paper describes design and implement of multimedia program for guidance of cultural assets and a way of use possessed in a national Chonju museum. Our system use ToolBook as authoring tools, designs system for convenience of user to the highest degree considered. Different point from others provides image enlargement and image processing ability for more delicate observance about surface of cultural assets. Image enlargement is composed of five steps, provides image processing such as bright control and edge enhancement and implement interface through combination of C-routine and ToolBook.

대퇴동맥을 통한 경피적 관동맥 중재시술 환자의 천자부위 지혈을 위한 Angioseal^(�) 사용과 고식적 용수 압박법의 비교 : 전향적 연구

김용훈,권현철,김필호,안석진,유철웅,최진호,이상철,김준수,김덕경,전은석,이상훈,홍경표,박정의,서정돈 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 경피적 관동맥 중재술은 최근 양적 및 질적으로 급격한 발전을 보였지만 시술 시 천자부위의 혈관 합병증은 아직 해결해야 할 문제점이다. 저자들은 대퇴동맥을 통한 경피적 관동맥 중재술을 환자에게 천자부위 지혈을 위한 혈관폐쇄기구인 안지오실의 안전성과 유용성을 고식적인 용수 압박법과 비교 연구하고자 하였다. 방법 : 2002년 4월부터 2003년 5월 사이에 삼성서울병원 심장혈관센터에서 대퇴동맥을 통한 경피적 관동맥 중재술을 성공적으로 시행한 200명의 환자(안지오실 사용군: A군, 100명, 고식적 용수압박법 사용군 B군, 100명)를 대상으로 시술 후 주요 합병증 및 경한 합병증, 지혈 후 환자가 자리에 앉기까지의 시간, 보행개시 가능시간, 총 재원 기간과 시술 1주 후의 합병증을 전향적으로 조사하여 비교 연구하였다. 결론 : 두 군에서 연령, 성별, 기저질환, 심혈관 질환의 위험요소, 시술의 종류, 시술 중 사용한 헤파린의 양, clopidogrel의 양, ticlopidine의 양, 지혈 시 수축기와 확장기혈압, ACT (activated clotting time)는 차이가 없었다. A군이 B군에 비해 시술 후 자리에 앉기까지의 시간 (A군: 4.3±0.3시간, B군: 13.7±0.8시간, p=0.004) 및 보행개시까지의 시간(A군: 6.8±0.5시간, B군: 18.8±2.1시간, p=0.013)이 유의하게 짧았다. 시술 후 주요 합병증은 두군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 A군에서 유의하게 적었다(A군: 28명, B군: 19명, p=0.003). 반상출혈의 경우는 A군에서 유의하게 낮았지만(A군: 3명, B군: 12명, p=0.01), 혈종, 출혈의 발생은 두군간에 차이가 없었다. 총 재원기간에는 두 군간에 차이가 없었다(p=0.239). 시술 1주 후 경과관찰에서 주요합병증은 역시 두 군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 두 군에서 차이가 없었다(A군: 15명, B군: 13명 p=0.418), 반상출혈의 빈도는 차이가 없었지만 혈종의 발생은 A군에서 더 낮았다(A군: 2명, B군:6명, p=0.004). 두 군 모두에서 출혈은 발생하지 않았다. 결론 : 대퇴동맥을 통한 경피적 관동맥 중재술을 시행한 환자에서 안지오실의 사용은 고식적 용수 압박법에 비해 환자의 침상 안정시간을 줄여 조기 활동개시가 가능하게 하였으며 국소합병증의 위험도를 일부 낮추어, 시술에 따른 환자의 불편을 현저하게 감소시킬 수 있다고 할 수 있을 것으로 기대된다. Background : Although the number and the quality of percutaneous coronary intervention have been recently increased dramatically, the vascular complication at puncture site is still the major cause of patients' morbidity. We evaluated the safety and efficacy of newly of newly-developed collagen-based arterial closure device, Angioseal after transfemoral percuatenous coronary intervention. Methods : This study was designed as a prospective single center non-randomized comparative study. A total 200 patients undergoing transfemoral percutaneous coronary intervention were enrolled between April 2002 and May 2003. They were divided into two groups; Angioseal group (group A, n=100) and manual compression group (group B, n=100). The baseline clinical and angiographic characteristics were reviewed. The time to sit up, the time to ambulation, the duration of hospital stay, major and minor vascular puncture site complications were monitored. The patients were followed-up for 1 week after procedure by telephone. Results : The baseline clinical characteriwtics, clinical diagnosis, cardiocascular risk factors, typesof procedure, doses and numbers of anticoagulants were similar between two groups. The blood pressure and activated clotting time were also similar. The time to sit up (group A: 4.3±0.3 hours, group B: 13.7±0.8 hours, p=0.004) and the time to ambulation (group A: 6.8±0.5 hours, group B: 18.8±2.1 hours, p=0.013) were shorter in group A. No major vascular complications were noted. The incidence of hematoma and bleeding were not significantly different between two groups. The incidence of ecchymosis, however, was significantly lower in group A (group A:12%, group B: 3%, p=0.001) The duration of gospital stay was similar between groups. During 7 days of follow-up period incidence of hematoma was significantly lower in group A (p=0.004). Although the incidence of ecchymosis was not significantly different between two groups. Conclusion : The angioseal may be associated with earlier ambulation and less patients' morbidity with low incidence of local complication rate compared to manual compression after transfemoral percutaneous coronary intervention.

국소 침윤성 자궁경부암 195례 (Ia-IIb) 치료성적의 분석

안수현(Soo Hyeon Ahn),조창호(Chang Ho Cho),강은정(Eun Jeoung Kang),김기태(Ki Tae Kim),김현찬(Hyun Chan Kim) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.11

목적: 국소침윤성 자궁경부암 환자(병기 Ia기-IIb기)195례에서 치료방법을 개별화하여 근치수술, 선행항암요법 후 자궁경부암 근치수술, 수술후 재발위험군에 방사선 치료를 시행한 후 5년 생존률을 조사하고, 5년 생존률에 영향을 주는 예후인자를 평가하여, 향후 보다 나은 치료방법을 선택하는데 도움을 얻기 위하여 연구하였다. 연구방법: 1988년 1월부터 1993년 12월까지 인제 대학교 의과대학 부산 백병원 산부인과에서 자궁경부암으로 수술받은 195례의 환자를 대상으로 임상 및 병리기록을 검토하여 조사하였다. 5년 생존률은 Kaplan-Meier 의 생존곡선을 사용하였고, 예후인자에 대한 통계적 검정은 Wilcoxon test를 사용하였다. 결과: FIGO의 임상병기에 따른 5년 생존률은 Ia, Ib, IIa, IIb에서 각각 100, 86.1, 76.9, 81.1%이었다. 5년 생존률에 영향을 주는 예후인자에는 임상병기(P=0.0001), 암세포의 종류 (P=0.0001), 암침윤 깊이(≤5mm vs >5mm, P=0.0013), 종양의 크기(≤3cm vs >3cm, P=0.0035), 임파절전이(0 vs 1 vs ≥2, P=0.0001) 이었다. 예후가 좋지 않을 것으로 예상되는 경우에 선행항암요법을 시행하였으며, 선행항암요법 유무에 따른 5년 생존률은 차이가 없었다. 수술 후 재발이 예상되는 경우에 방사선 치료를 시행하였으며, 방사선 치료의 유무에 따른 5년 생존률은 방사선치료를 시행한 경우에 5년 생존률이 낮았다(P=0.0001). 결론: 자궁경부암의 5년 생존률에 영향을 주는 예후 인자는 FIGO 의 임상병기, 암세포의 조직학적 유형, 암 침윤 깊이, 종양의 크기 및 임파절 전이로 나타났고, 선행항암요법을 국소적으로 보다 진행된 병기에서 적절히 사용함으로써 5년 생존률의 개선에 도움이 될 것으로 사료되었다. Objectives: The purposes of this clinical study were 1) to assess 5-year survival rates in 195 patients with locally invasive cervical cancer(stage Ia-IIb) treated by surgery, neoadjuvant chemotherapy+surgery and postoperative radiation in selected cases, 2) to evaluate the prognostic factors affecting the survival rate, and 3) to get helpful information for the better treatment. Methods: A retrospective analysis was conducted of 195 patients. They were diagnosed and operated on during the period of Jan. 1988 - Dec. 1993 in Dept. of OB/Gyn, Pusan Paik Hospital, Inje Medical School. The 5-year survival rates were estimated using the Kaplan-Meier method, and prognostic factors were assessed using Wilcoxon test. Results: The 5-year survival rates for FIGO stages Ia, Ib, IIa, and IIb were 100, 86.1, 76.9, and 81.1%, respectively. Factors that affect the 5-year survival rates were clinical stage(P=0.0001), cell type(small cell vs other, P=0.0001), depth of invasion(≤5 mm vs >5 mm, P=0.0013), tumor size(≤3 cm vs >3cm, P=0.0035), and lymph node metastasis(0 vs 1 vs more than 2, P=0.0001). There was no difference in 5-year survival rates between without neoadjuvant chemotherapy group and with neoadjuvant chemotherapy group which had poor prognostic factors. The predicted recurrence rate of the postoperative radiation group showed a lower 5-year survival rate than the no postoperative radiation group(P=0.0001). Conclusions: We conclude that the factors affecting the prognosis were FIGO stage, cell type, depth of invasion, tumor size, and lymph node metastasis, and speculated that the survival rates could be improved by using neoadjuvant chemotherapy for more advanced locally invasive cases properly.

크고 적응적인 생략인자에 의한 비디오 영상 장면의 고속 추출

안현수(Hyeon-Soo Ahn),오일석(Il-Seok Oh) 한국정보과학회 1995 한국정보과학회 학술발표논문집 Vol.22 No.2A

본 논문은 비디오 연속영상에 크고 적응적인 생략인자를 적용하여 신속하게 장면의 변화를 찾아내는 것을 목적으로 한다. 일반적으로 기존의 방법들은 비디오 장면변화 검출을 위하여 이웃한 모든 프레임쌍을 비교 분석한다. 그러나 이러한 방법은 비디오 영상의 방대함으로 인하여 많은 계산량의 문제점을 드러낸다. 본 논문은 장면변화 검출에 있어서 바로 이웃한 프레임을 비교하는 것이 아니라, 비교적 많은 프레임을 건너뛴 다음의 프레임을 비교함으로써 신속하게 장면변화를 추출을 할 수 있는 방법을 제시한다. 이 방법은 이등분할에 의한 순환적인 처리를 함으로써 정확한 위치를 알아낸다. 또한 앞서 처리한 장면의 통계적 자료를 이용하여 다음 장면에 사용될 생략인자를 결정하는 적응적 방법도 제시한다. 실험결과는 장면변화의 추출실패없이 약 10배 이상의 속도 향상을 보여준다.

Antagonism of VEGF-A-induced increase in vascular permeability by an integrin α3β1-Shp-1-cAMP/PKA pathway

Kim, Soo Hyeon,Cho, Young-Rak,Kim, Hyeon-Ju,Oh, Joa Sub,Ahn, Eun-Kyung,Ko, Hye-Jin,Hwang, Byung Joon,Lee, Seo-Jin,Cho, Yongwan,Kim, Yong Kee,Stetler-Stevenson, William G.,Seo, Dong-Wan American Society of Hematology 2012 Blood Vol.120 No.24

<B>Abstract</B><P>In cancer, VEGF-induced increase in vascular permeability results in increased interstitial pressure, reducing perfusion and increasing hypoxia, which reduce delivery of chemotherapeutic agents and increase resistance to ionizing radiation. Here, we show that both TIMP-2 and Ala + TIMP-2, a TIMP-2 mutant without matrix metalloproteinase inhibitory activity, antagonize the VEGF-A-induced increase in vascular permeability, both in vitro and in vivo. Like other agents known to preserve endothelial barrier function, TIMP-2 elevates cytosolic levels of cAMP and increases cytoskeletal-associated vascular endothelial cadherin in human microvascular endothelial cells. All of these effects are completely ablated by selective knockdown of integrin α3β1 expression, expression of a dominant negative protein tyrosine phosphatase Shp-1 mutant, administration of the protein tyrosine phosphatase inhibitor orthovanadate, or the adenylate cyclase inhibitor SQ22536. This TIMP-2-mediated inhibition of vascular permeability involves an integrin α3β1-Shp-1-cAMP/protein kinase A-dependent vascular endothelial cadherin cytoskeletal association, as evidenced by using siRNAs to integrin α3β1 and Shp-1, or treatment with Shp-1 inhibitor NSC87877 and protein kinase A inhibitor H89. Our results demonstrate the potential utility for TIMP-2 in cancer therapy through “normalization” of vascular permeability in addition to previously described antiangiogenic effects.</P>