콘택트렌즈 소독액의 아메바 포낭에 대한 살충능력 평가

한영상,박재성,이종수,유학선,이지은 부산대학교 병원 암연구소 2007 부산대병원학술지 Vol.- No.21

Purpose: To evaluate the cysticidal effect of 5 kinds of commercially available contact lens disinfectants against 2 clinical is이ates of Acanthamoeba. Subject and Methods: Five kinds of commercially available contact lens disinfectants were soaked with cysts of Acanthamoeba ludgdunesis and castellanii at the concentration of 10³,10⁴ and lO^(S) cells/ml for land 4 or 6 hours. Cysts which were not excysted in 7 days after treatment were recognized to be killed. Morphologic changes were evaluated by electron microscopic observation. Results: Contact lens disinfectants which contain myristamidopropyl dimethylamine (MAPD) showed the best cysticidal effect. These disinfectants demonstrated a cysticidal effect on both Acanthamoeba species of all concentrations in 6-hour treatment. Contact lens disinfectants which contain polyhexamethylene biguanide (PHMB) did not demonstrate cysticidal effect, except for Acanthamoeba castellanii at the concentration of 10³ cells/ml, in either 4- or 6-hour treatment. Separation of plasma membrane from endocyst and damage of organelles were prominent in cases showing a cysticidal effect. Conclusions: Contact lens disinfectant which contains MAPD may be helpful in preventing the Acanthamoeba keratitis. A higher concentration of PHMB is required to be effective in preventing Acanthamoeba keratitis.

빛간섭단층촬영으로 발견하지 못한 국소적 망막신경섬유층 결손들의 분석

한영상,제승연,김수진,이주은,이지은,구기홍,Young Sang Han,MD,Seung Youn Jea,MD,PhD,Su Jin Kim,MD 대한안과학회 2009 대한안과학회지 Vol.50 No.4

Purpose: To analyze localized RNFL defect cases that were identified in retinal nerve fiber layer (RNFL) fundus photographs but not in optical coherence tomography (OCT). Methods: Analysis of OCT scans and images was performed for 14 eyes (17 locations) that showed localized RNFL defects in RNFL fundus photographs but not in RNFL thickness average analysis. Results: With respect to the range of RNFL defects, 41.2% were less than 10°, 47.0% were 11 to 20°, and 11.8% were 21 to 30°. In 71.4% of the RNFL cases the defects were less than 10°and the decrease of RNFL thickness was not readily observable on the OCT scan images. In all cases of RNFL defects in the 11 to 30°range the decrease in RNFL thickness could be assessed on the OCT scan images. Nonetheless, the decrease of RNFL thickness could not be seen on the OCT analysis images in which the results of the RNFL thickness made through an automated computer algorithm were displayed. Conclusions: The range of localized RNFL defects that were difficult to detect with OCT consisted of those cases that were almost less than 20°. The limitations of the OCT scan itself in patients with RNFL with an angular width defect less than 10°and the problems of RNFL thickness analysis processing in patients with an angular width of 11 to 30°may decrease the sensitivity of OCT in diagnosing RNFL defects. J Korean Ophthalmol Soc 2009;50(4):558-564

증식당뇨망막병증의 유리체절제술 후 장기시력예후

한영상 ( Han Young Sang ) , 엄부섭 ( Boo Sup Oum ) 대한안과학회 2002 대한안과학회지 Vol.43 No.9

Radiofrequency Ablation of Benign Thyroid Nodules and Recurrent Thyroid Cancers: Consensus Statement and Recommendations

나동규,이정현,정소령,김지훈,성진용,신정희,김은경,이준형,김동욱,박정선,김규선,백선미,이영흔,정세민,심정석,허정인,배재익,김경태,한송이,배민영,김윤숙,백정환,대한갑상선영상의학회,대한영상의학회 대한영상의학회 2012 Korean Journal of Radiology Vol.13 No.2

Thermal ablation using radiofrequency is a new, minimally invasive modality employed as an alternative to surgery in patients with benign thyroid nodules and recurrent thyroid cancers. The Task Force Committee of the Korean Society of Thyroid Radiology has developed recommendations for the optimal use of radiofrequency ablation for thyroid nodules. These recommendations are based on a comprehensive analysis of the current literature, the results of multicenter studies, and expert consensus.

Image Reporting and Characterization System for Ultrasound Features of Thyroid Nodules: Multicentric Korean Retrospective Study

곽진영,정인경,백정환,백선미,최나미,최윤정,정소령,김은경,김정아,김지훈,김규순,이정현,이준형,문희정,문원진,박정선,류지화,신정희,손은주,성진용,나동규,Korean Society of Thyroid Radiology,대한영상의학회 대한영상의학회 2013 Korean Journal of Radiology Vol.14 No.1

Objective: The objective of this retrospective study was to develop and validate a simple diagnostic prediction model by using ultrasound (US) features of thyroid nodules obtained from multicenter retrospective data. Materials and Methods: Patient data were collected from 20 different institutions and the data included 2000 thyroid nodules from 1796 patients. For developing a diagnostic prediction model to estimate the malignant risk of thyroid nodules using suspicious malignant US features, we developed a training model in a subset of 1402 nodules from 1260 patients. Several suspicious malignant US features were evaluated to create the prediction model using a scoring tool. The scores for such US features were estimated by calculating odds ratios, and the risk score of malignancy for each thyroid nodule was defined as the sum of these individual scores. Later, we verified the usefulness of developed scoring system by applying into the remaining 598 nodules from 536 patients. Results: Among 2000 tumors, 1268 were benign and 732 were malignant. In our multiple regression analysis models, the following US features were statistically significant for malignant nodules when using the training data set: hypoechogenicity, marked hypoechogenicity, non-parallel orientation, microlobulated or spiculated margin, ill-defined margins, and microcalcifications. The malignancy rate was 7.3% in thyroid nodules that did not have suspicious-malignant features on US. Area under the receiver operating characteristic (ROC) curve was 0.867, which shows that the US risk score help predict thyroid malignancy well. In the test data set, the malignancy rates were 6.2% in thyroid nodules without malignant features on US. Area under the ROC curve of the test set was 0.872 when using the prediction model. Conclusion: The predictor model using suspicious malignant US features may be helpful in risk stratification of thyroid nodules.

정치마케팅에서 대중매체의 효과에 관한 실증적 연구

한영상(Young Sang Han),한욱상(Uk Sang Han) 한국무역연구원 2014 무역연구 Vol.10 No.5

This paper is to analyze factors which make voters decide on candidates from the viewpoint of political marketing. In addition, this paper identifies how decision factors appear differently in accordance with the mass media contacted by voters. This will help in establishing voter market segmentation strategies and political marketing strategies in the forthcoming election by identifying the voting behavior of voters shown in the most recent election. Influential variables, are likewise defined to assist in analyzing how these affect voting behavior as well as discovering the effect of political marketing. As a result of reviewing the effect of the mass media on perception about candidates, political parties, and the election campaign from a supplier aspect, overall, the effect of an internet portal was the greatest. In the case of Jongpyeong TV, it had a positive effect on the election campaign but it had a rather a negative effect on candidate factors. As mass media that had a positive effect on involvement factors, public radio and internet portals were included. Meanwhile, public TV had a negative effect. As for relationship factors, public radio and Jongpyeon TV had a positive effect whereas podcasting had a negative effect. With respect to overall situational factors, internet portals had the greatest effect. Meanwhile, the effect of a newspaper was the greatest on public opinion or on issue factors whereas the effect of Jeongpyeon TV was more evident on public opinion factors and political factors. The political marketing techniques that may be proposed through this are as follows. First, it is use of a voter segmentation strategy. This means that above all it is necessary to select a voter class to attract and then to set up a segmentation strategy aimed at them. Second, it is a voter targeting strategy. This implies that it is effective to establish an election campaign or image strategies aimed at target voters for each candidate after segmenting voters. Third, a political marketing mix strategy should be adopted rather than using all mass media in the election. An election in Korean politics has limitations owing to ideological confrontation and regional composition; however, recently the need has grown for commending various strategies aimed at voters. Although this has a different aspect from marketing a certain product, it may be necessary to review marketing strategies from a non-profit aspect.

실리콘기름 주입안에서 점도에 따른 레이저 간섭계와 초음파로 측정된 안축장과 전방 깊이 비교

이민호,한영상,이종수,Min Ho Lee,Young Sang Han,Jong Soo Lee 대한안과학회 2008 대한안과학회지 Vol.49 No.2

`Purpose: To evaluate differences between partial coherence laser interferometry (IOL-Master, Zeiss) and A-scan measurement of axial length and anterior chamber depth in silicone oil-filled eyes according to viscosity. Methods: Using IOL-Master and A-scan, axial length and anterior chamber depth in silicone oil-filled eyes (n=54) and normal eyes (control, n=54) were measured and analyzed. In silicone oil-filled eyes, calculated axial lengths by A-scan using conversion factors, axial length multiplied by 0.71, and vitreous cavity multiplied by 0.64 (classic method) were compared with those calculated by IOL-Master. Anterior chamber depths were also analyzed., and axial lengths and anterior chamber depths were compared according to the viscosities of silicone oil for measurement by A-scan. Results: Axial length and anterior chamber depth using IOL-Master were shorter than those using A-scan by 9.45±1.81 mm (p<0.05) and 0.11±1.29 mm, respectively. In normal eyes, axial length and anterior chamber depth using IOL-Master and A-scan were not significantly different. In silicone oil-filled eyes, axial length using IOL-Master and conversion factor was also not significantly different. At the highest silicone oil viscosity the difference in measured axial length was greatest (p<0.05) while the difference in anterior chamber depths was smallest. Conclusions: In silicone oil-filled eyes, axial length by IOL-Master was more accurate than that by A-scan, regardless of silicone oil viscosity. Thus, IOL-Master is more useful than A-scan when measuring axial length in silicone oil-filled eyes.`

고안압증에서 안압과 연령, 혈압 및 비만지수와의 상관관계

이자균,한영상,이종수,김윤경 대한안과학회 2009 대한안과학회지 Vol.50 No.7

Purpose: To evaluate the relationship between intraocular pressure (IOP) and age, blood pressure and obesity index inocular hypertensive patients. Methods: A total of 2684 ocular hypertensive patients underwent automated multi-phasic testing, including fundus photography, blood pressure and assessment of obesity. The subjects were divided into six age groups by decades ranging from 20~29 years to over 70 years of age. The relationships between factors were examined using multiple regression analysis. Results: The mean participant age was 48.0±11.0 years, and 1,777 (66.3%) participants were male and 907 (33.7%) were female. The mean intraocular pressure (IOP) was 22.04±2.2 mmHg and was significantly higher in males than in females (p=0.023). The IOP was associated with mean blood pressure, gender and obesity index. After adjustment for mean blood pressure and obesity index, the relationship between IOP and age showed a significantly negative tendency (p<0.001). The relationship between IOP and obesity index adjusted for age and mean blood pressure had a significantly positive tendency (p<0.001), regardless of gender. The relationship between IOP and mean blood pressure adjusted for age and obesity index showed a significantly positive tendency (p=0.00014). Conclusions: IOP was associated with the mean blood pressure and obesity index. Regardless of gender, IOP decreased with age but increased with hypertension. It is necessary to check IOP regularly, especially in ocular hypertensive patients with systemic hypertension. 목적: 고안압증 환자에서 안압과 연령, 혈압 및 비만도의 상관관계를 알아보았다. 대상과 방법: 고안압증 환자 2,684명을 대상으로 혈압과 비만도를 측정하였다. 대상군을 20대에서 70까지 연령군으로 나누고, 안압과 성별, 혈압, 비만도와의 관계를 분석하였다. 결과: 평균연령은 48.0±11.0세로 평균안압은 22.04±2.2 mmHg였고, 평균안압, 혈압은 남성에서 여성 보다 유의하게 높았고(p=0.023, p=0.032), 비만도는 여성에서 유의하게 높았으나(p=0.002) 연령에 따른 차이는 없었다. 평균혈압 및 비만도로 보정한 연령과 안압과의 관계는 성별에 관계없이 유의하게 반비례하였다(p<0.001). 연령, 평균혈압으로 보정한 비만도와 안압과의 관계(p=0.001) 및 연령과 비만도로 보정한 혈압과 안압과의 관계는 성별에 관계없이 유의하게 비례하였다(p<0.001). 결론: 고안압증에서 안압은 혈압, 비만도와 연관성이 있었고, 성별에 상관없이 연령이 증가할수록 안압은 감소하였으나 평균혈압이 높을 때는 안압은 증가하므로 고혈압이 있는 고안압증의 경우 정기적인 안압의 경과 관찰이 필요하다고 생각된다.

Clinical applications of Doppler ultrasonography for thyroid disease: consensus statement by the Korean Society of Thyroid Radiology

정진,이유진,최영준,하은주,서종현,최미영,백정환,나동규,대한갑상선영상의학회,대한영상의학회 대한초음파의학회 2020 ULTRASONOGRAPHY Vol.39 No.4

Doppler ultrasonography (US) is widely used for the differential diagnosis of thyroid nodules, metastatic cervical lymph nodes in patients with thyroid cancer, and diffuse parenchymal disease, as well as for guidance in various US-guided procedures, including biopsy and ablation. However, controversies remain regarding the appropriate use and interpretation of Doppler US. Therefore, the Korean Society of Thyroid Radiology organized a taskforce to develop a consensus statement on the clinical use of Doppler US for thyroid disease. The review and recommendations in this article are based on a comprehensive analysis of the current literature and the consensus of experts.

원추각막의 공초점현미경 소견

이종수 ( Jong Soo Lee ),홍종욱 ( Jong Wook Hong ),한영상 ( Young Sang Han ) 대한안과학회 2002 대한안과학회지 Vol.43 No.6