황반원공과 당뇨황반부종에서 술 중 제거한 내경계막의 미세구조

구기홍,이지은,최희영,엄부섭 대한안과학회 2010 대한안과학회지 Vol.51 No.1

Purpose: To evaluate retinal damage following internal limiting membrane (ILM) peeling in macular hole and diabetic macular edema (DME) surgeries. Methods: Forty-five eyes with macular holes and thirty-five eyes with DME underwent pars plana vitrectomy with ILM peeling. The structures of the ILM were investigated using transmission electron microscopy, and the grades of retinal tissue damage were analyzed. We additionally observed the clinicopathologic association of retinal damage with the development of retinal hemorrhage during ILM peeling and that seen with indocyanine green (ICG) staining. Results: In all specimens, cellular fragments were observed on the retinal side of the ILM in both macular hole and DME patients. The thickness of the ILM in DME significantly increased (3.13±1.12 μm compared with that in patients with macular holes (2.41±0.77 μm, p=0.002). The frequency of minute retinal bleeding during ILM peeling was higher in macular hole patients (46.7%) than in those with diabetic macular edema (22.9%m p=0.028). Twenty-two eyes of 45 macular hole patients (48.9%) and 16 eyes of 35 DME patients (45.7%) had relative retinal damage. Overall, ILM performed in eyes which had minute bleeding during the peeling had more retinal damage (62.1%) than did those without hemorrhage (39.2%, p=0.049). ICG staining did not appear to influence retinal damage (p=0.81). Conclusions: ILM peeling can cause minor, but demonstrable, damage of the adjacent retina. J Korean Ophthalmol Soc 2010;51(1):42-48

당뇨병의 유병기간에 따른 안압과 각막의 형태 비교

구기홍 ( Gi Hong Koo ),제승연 ( Seung Youn Jea ),이종수 ( Jong Soo Lee ),엄부섭 ( Boo Sup Oum ) 대한안과학회 2004 대한안과학회지 Vol.45 No.8

당뇨병의 유병기간에 따른 안압과 각막의 형태 비교

구기홍 ( Gi Hong Koo ) , 제승연 ( Seung Youn Jea ) , 이종수 ( Jong Soo Lee ) , 엄부섭 ( Boo Sup Oum ) 대한안과학회 2004 대한안과학회지 Vol.45 No.8

생체신호 기반 도심 항공 모빌리티 비상 대응 시스템 개발

구기홍(Gihong Ku),이정욱(Jeongouk Lee),임한성(Hanseong Lim),조성욱(Sungwook Cho) 항공우주시스템공학회 2024 항공우주시스템공학회지 Vol.18 No.1

본 논문은 도심 항공 모빌리티 환경에서 응급상황 발생 시 비상 대응이 가능한 시스템을 제안한다. 탑승자의 심박수를 실시간으로 모니터링하고 이상 감지 시, 모스 부호화된 진동과 음성으로 경고하는 생체신호 감응형 스마트 워치를 개발하였으며. 관제시스템을 가정한 ROS 환경과 통신하여 도심 항공 모빌리티 운용 중 인근 버티포트 비상착륙을 위한 최단 경로 생성 시스템을 구현하였다. 실제 지역을 기반으로 한 고 충실도 시뮬레이션 환경 구축과 테스트로 안정성을 확인하였으며, 결과적으로 도심 항공 모빌리티의 안정과 편의를 향상시킬 수 있는 기술을 개발하였다. This paper introduces an emergency response system in urban air mobility scenarios. A biometric responsive smartwatch was designed to monitor passengers real-time heart rates. When an anomaly was detected, the system would send an alert via Morse code vibration and voice notification. It was integrated with the assumed control system of the ROS environment and communicates to implement a system for generating the shortest path for emergency landing to a nearby vertical port during urban air mobility operations. System stability was verified through high-fidelity simulation environments and testing based on actual geographic locations. Our technology improved the reliability and convenience of urban air mobility, demonstrating its effectiveness through simulations and tests in real-world scenarios.

3차원 기하학의 효과적인 통제를 위한 설계협업 전략

구기홍(Ku Ki Hong) 대한건축학회 2008 建築 Vol.52 No.4

삼출성 나이관련황반변성과 결절맥락막혈관병증에서 광역학치료와 베바시주맙 병합치료

이미현,구기홍,이지은,엄부섭,Mi Hyun Lee,MD,Gi Hong Gu,MD,Ji Eun Lee,MD,PhD,Boo Sub Oum,MD,PhD 대한안과학회 2011 대한안과학회지 Vol.52 No.7

Purpose: To compare the efficacies of photodynamic therapy (PDT) using verteporfin combined with intravitreal bevacizumab in choroidal neovascularization secondary to age-related macular degeneration and polypoidal choroidal vasculopathy (PCV). Methods: Photodynamic therapy followed by 3 monthly intravitreal injections of bevacizumab were performed for neovascular age-related macular degeneration (AMD group) and PCV (PCV group). The injections were performed within 2 weeks after PDT and then every 4 to 6 weeks. During the 12-month follow-up period, best-corrected visual acuity (BCVA), central subfield macular thickness (CSMT), and number of reinjections were reviewed retrospectively. Results: Out of 38 eyes, there were 21 eyes in the AMD group (mean age 66.8 years old) and 17 eyes in the PCV group (mean age 66.4 years old). The average follow-up duration was 17.0 months. At 12 months, the BCVA (logMAR) improved from 0.75 at baseline to 0.49 in the AMD group (p = 0.01) and from 0.81 to 0.63 in the PCV group (p = 0.03). The CSMT decreased significantly from 329 to 231 in the AMD group and from 354 to 223 in the PCV group. At 12 months, 20 eyes (95.2%) in the AMD group and 15 eyes (88.2%) in the PCV group increased or maintained BCVA. The numbers of reinjections were 4.3 in the AMD group and 3.0 in the PCV group. There were no significant differences in BCVA, BCVA changes, CSMT, or number of reinjection between the two groups. Conclusions: Combined PDT and intravitreal bevacizumab injections showed no significant difference in stabilization of vision or retreatment rates between neovascular age-related macular degeneration and PCV. J Korean Ophthalmol Soc 2011;52(7):816-824

안구뒤시신경염으로 오인된 급성대상잠재성외망막병증

김선혜,구기홍,정재호,조재욱,박경필,김대성,이재혁 대한신경과학회 2010 대한신경과학회지 Vol.28 No.3

A 27-year-old woman suffered a sudden visual disturbance in the right eye. The right eye had a visual acuity of 0.02 and a relative afferent pupillary defect. A visual-field examination revealed an inferotemporal field defect in the right eye. A fundus examination revealed no abnormalities that were responsible for the visual-field defect. Multifocal electroretinography showed decreased responses in the right eye at the corresponding area with the visual-field defect. She was diagnosed as acute zonal occult outer retinopathy.

실리콘관 삽입술에서 관의 고정을 위한 실리콘 시트와 봉합사 사용의 임상적 효과 비교

박영민,구기홍,이지은,이종수,김윤경,Young Min Park,Gi Hong Koo,Ji-Eun Lee,Jong Soo Lee,Yoon Kyung Kim 대한안과학회 2009 대한안과학회지 Vol.50 No.2

Purpose: To compare the clinical outcome of silicone tube intubation according to the tie methods. Methods: Eighty-eight eyes of 87 patients who underwent silicone tube intubation were divided into two groups based on the tie method: a silicone silastic sheet group (Group 1, n=59) and a nylon 6-0 suture knot group (Group 2, n=29). The two groups were compared according to their success rates, recurrence rates and complications. Results: No significant difference was found in the success rate between the two groups (83.0% in Group 1 and 82.7% in Group 2). However, Group 2 showed a significantly higher rate of postoperative complications than Group 1. In Group 1, 5/59 (8.4%) eyes had ocular irritation, 2/59 (3.4%) eyes exhibited tube prolapse, conjunctivitis, corneal erosion, and dacryocystitis and 1/69 (1.6%) eyes had a punctal slit after intubation. In Group 2, 3/29 (10.3%) eyes had ocular irritation, 2/29 (6.9%) eyes exhibited tube prolapse, conjunctivitis, a punctal slit, and dacryocystitis, and 1/29 (3.4%) eyes showed corneal erosion, or a granuloma after intubation. A recurrence of symptomatic tearing was found in 6/59 (10%) eyes in Group 1 and 3/29 (10%) in Group 2. Conclusions: In silicone tube intubation of incomplete NLD obstruction, the usage of silicone silastic sheets to tie both ends of the silicone tube produced a lower complication rate and a higher success rate than that of the suture knot group. Lower tension on the nasolacrimal passage in the silicone silastic sheet group allows for a significantly lower rate of punctal slit development. Therefore, the method of using silicone silasitic sheets can be considered useful in the treatment of NLD obstruction.

굴절교정레이저각막절제술 10년 후 각막조직의 공초점현미경 소견

신민규,구기홍,이종수,Min Kyu Shin,Gi Hong Koo,Jong Soo Lee 대한안과학회 2009 대한안과학회지 Vol.50 No.2

Purpose: The present study compares, using a new generation high‐resolution in vivo confocal microscope, the corneas of patients who underwent photorefractive keratectomy (PRK) 10 years previously with those of healthy persons. Case Summary: A confocal microscope (Confoscan 4.0, Fortune Technology, Italy) was used to get the data from healthy volunteers and patients. Corneal cross‐sectional images of the epithelium, Bowman's layer, stromal layer (anterior, middle and posterior keratocyte), Descemet's membrane, and endothelium were compared. In PRK corneas, the superficial epithelium was nearly intact and the subbasal nerve plexus was visible, but some hyperreflective areas were also found in the nerve plexus. Because of the absence of the Bowman's layer, some ECM and keratocytes were visualized in their optical section. Although anterior keratocytes showed uneven distribution with less cellularity, middle and posterior keratocytes looked unaffected. Likewise, there were no differences in the endothelium between the two groups. Conclusions: Ten years after PRK, the subbasal nerve plexus and anterior keratocytes showed histologic changes after corneal wound recovery.

모델기반 예측적고장결정 기법(AFD) 적용 연구

이철우 ( Cheolwoo Lee ),구기홍 ( Kihong Ku ),김대용 ( Daeyong Kim ),손명조 ( Joonyun Lee ),이중윤 ( Myeongjo Son ) 한국국방기술학회 2020 한국국방기술학회 논문지 Vol.2 No.4

종래 리스크 예측/식별 기법들이 과거 경험한 유사 사례가 없는 미지의 미래 체계에 리스크 요소를 예측/식별하는데는 많은 제한이 된다. 특히 실전 경험이 없는 미지의 미래 무인무기체계는 운용개념에 대해 예측하기가 매우 어려운데다가 유인에 의한 임기응변조차 제한되어 무인무기체계의 실전 배치시 그 임무 달성에 실패하거나 예기치 못한 사건/사고를 발생시킨 사례가 적지 않다. 이를 극복하기 위해 예측적 고장결정 기법을 모델기반 시스템 공학(MBSE)과 결합하여 최근 군에서 미래 무인 무기체계 개발사업의 일환으로 추진 중인 국방 무인OO차량개발사업의 리스크 해소방안에 적용한 사례를 소개하여 미래 무인무기체계 개발사업의 리스크 해소와 성공 가능성을 높이는데 기여하고자 하였다. Conventional risk prediction/identification techniques have many limitations in predicting/identifying risk factors in an unknown future system without similar cases experienced in the past. In particular, an unknown future unmanned weapon system with no practical experience is very difficult to predict about its operational concept, and even ad hoc response by manned is limited. There are not a few cases. In order to overcome this, we introduced a case where the predictive failure determination technique was combined with model-based system engineering (MBSE) and applied to the risk reduction plan of the defense unmanned OO vehicle development project, which is currently being promoted by the military as part of the future unmanned weapon system development project It aimed to contribute to solving the risk and increasing the possibility of success in the future unmanned weapon system development project.