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Zipeprol(레스피렌$^{(R)}$)을 탐닉하던 노인의 급성 중독 사망례
이두환,최상천,안정환,조영신,김기운,민영기,정윤석,Lee, Doo-Hwan,Choi, Sang-Cheon,Ahn, Jung-Hwan,Cho, Young-Shin,Kim, Gi-Woon,Min, Young-Gi,Jung, Yoon-Seok 대한임상독성학회 2009 대한임상독성학회지 Vol.7 No.2
Zipeprol dihydrochloride is a non-opioid mucolytic, antitussive agent and it is frequently prescribed for respiratory symptoms such as cough and sputum. The main pharmacologic mechanisms of zipeprol are inhibition of superior laryngeal nerve stimulation and direct antagonism for stimulation of the bronchial receptors, which might have an effect for the drug's mucolytic action. Many cases of drug abuse with zipeprol have occurred world-wide due to the hallucinogenic effect of the drug. In Korea, zipeprol was reported to be the most commonly abused drug among young people for the 1990s. Zipeprol associated death was first reported since 1991 and 69 cases of death related to zipeprol abuse were further reported during 8 years (between 1991 and 1998). In addition to the hallucinogenic effect, dyspnea, extrapyramidal symptoms, seizure, cerebral edema have been reported as the signs and symptoms of toxic zipeprol overdose. However, zipeprol abuse is not common for old age people and non drug abusers. We report here on a fatal case of acute zipeprol poisoning in an eighty five year old drug addicted woman.
이두환,정명호,Jung Ae Rhee,Jin Su Choi,Ki Hong Lee,Min Goo Lee,심두선,Keun Ho Park,윤남식,윤현주,김계훈,박형욱,홍영준,김주한,안영근,조정관,박종춘,강정채 대한심장학회 2012 Korean Circulation Journal Vol.42 No.10
Background and Objectives: Predictive factors of mortality in acute coronary syndrome (ACS) patients with left ventricular dysfunction were analyzed during 5-year clinical follow-up after percutaneous coronary intervention (PCI). Subjects and Methods: A total of 329 ACS consecutive patients (64.6±11.3 years, 227 males) who underwent PCI from January 2001 to March 2006 were followed for 5 years. All patients had lower than 40% of left ventricular ejection fraction (LVEF). Patients were divided into Group I (survived longer than 5-years: n=130, 101 males) and Group II (survived shorter than 5 years: n=199, 126 males). Results: The cumulative survival rate was 88.0% at 1 month, 78.0% at 6 months, 75.0% at 1 year, 67.0% at 2 years, 62.0% at 3 years,57.0% at 4 years and 40% at 5-years. Group II was older (61.6±11.2 years vs. 66.4±11.4 years, p<0.001), and showed higher prevalence of female gender (28.4% vs. 36.7%, p=0.006) and lower LVEF (35.3±5.2 vs. 33.6±5.6) than Group I. The independent predictors for mortality were LVEF <30% {odds ratio (OR)=1.793, 95% confidence interval (CI): 1.234-2.452, p=0.002 }, serum creatinine >3.0 mg/dL (OR=2.455,95% CI: 1.306-4.614, p=0.005), older than 65 years (OR=1.594, 95% CI: 1.152-2.206, p=0.005), and female gender (OR=1.524, 95% CI:1.090-2.130, p=0.014). Conclusion: Five-year survival rate was 40% in ACS patients with left ventricular dysfunction, and the predictors for mortality were low LVEF, high serum creatinine, old age, and female gender.
한국재래산양태아 및 신생아 뇌에서 별아교세포의 전자현미경적 연구
송치원,김무강,류시윤,이강이,박일권,이미영,권효정,박미선,이경열,이두환,신현국,최윤석,장규태,Song, Chi-Won,Kim, Moo-Kang,Ryu, Si-Yoon,Lee, Kang-Lee,Park, Il-Kwon,Lee, Mi-Young,Kwon, Hyo-Jung,Park, Mi-Sun,Lee, Kyoung-Youl,Lee, Doo-Hwan,Shin, 한국현미경학회 2001 Applied microscopy Vol.31 No.2
한국재래산양의 임신60, 90, 105, 120일령 태아 및 신생아의 뇌를 대상으로 면역조직화학적방법을 통하여 면역반응을 나타낸 방사아교세포를 투과전자현미경적 방법을 이용하여 그 미세구조를 연구한 결과 임신 60일령 태아의 방사아교면역반응세포는 소수의 사립체와 많은 당원질 및 과립형질내세망이 관찰되었으며 임신90일령 태아 이후에서도 소수의 사립체, 많은 당원질 그리고 소수의 형질내세망이 관찰되었으며 임신95일령 태아에서 골지체가 관찰되었다. 그리고 임신 120일령에서 혈관에 부착되어 종말발을 뻗고 있는 GFAP 면역반응세포를 관찰할 수 있었다. This study, the ultrastructure of radial glial cells in the fetuses (the 60th, 90th, 105th 120th of gestation) and neonate brains of korean native goat were investigated by immunohistochemical method and transmisson electron microscopy. 1. In the 60th day of gestation, mitochondria and many glycogen body were observed in the radial glial cells. 2. In the 90th day of gestation, mitochondria, many glycogen body and rough endoplasmic reticulum were observed. 3. In the 95th day of gestation, Golgi's apparatus was found. 4. In the 120th day of gestation, Endfeets of radial glial cell attached vessel wall were observed.
국내 소규모 건축물의 하자 예방을 위한 시방서 개발방향에 관한 연구
이두환(Lee, Du-Hwan),김재문(Kim, Jae-Moon),전완표(Jeon, Wan-Pyo),남승훈(Nam, Seung-Hoon) 대한건축학회 2021 대한건축학회논문집 Vol.37 No.4
In this study, the development direction of specification specialized for small-sized buildings was proposed to develop measures to prevent defects and improve quality of small-sized buildings that are being built or remodeled. This is in accordance with the continuously increasing trend of small-sized buildings in the construction market. Canadian specifications used for large-sized buildings and small-sized building were chosen for comparative analysis, since its components are most similar to those in Korea. The features of small-sized building specifications were derived based on the construction classification and specification code contents. Additional improvement was proposed using the ‘General requirements for small-sized buildings (in Korea)’ as an outline. And the series of processes and results were synthesized and the ‘Application plan of domestic small-sized building specifications’ was prepared. In addition, the relevant literature was investigated and linked to reflect the visualization of specifications, and the ‘Development direction of small-sized building guide specification’ was established by compiling these results.
고주파열처리에 의한 자동차용 고강도강판의 기계적 성질변화
이두환 ( Lee Du Hwan ),윤치상 ( Yun Chi Sang ),임종대 ( Im Jong Dae ) 한국열처리공학회 2004 熱處理工學會誌 Vol.17 No.2
N/A The efforts which increase the strength of the auto-body structure and decrease its weight lead to develop a new concept of part production systems, such as Post-Form Strengthening by induction heat treatment. In this study, several cold and hot-rolled sheet steels were used to find out optimum induction heat treatment conditions. After induction heat treatment, strength of heat-treated sheet steels was increased significantly compared with that of as-rolled steels. From these results, auto-body structure which has more light and safe has been made by using this induction hardening method.
스텐트 내 재협착 병변에서 약물용출 풍선확장술 후 주요 심장사건 발생의 예측인자
이두환(Doo Hwan Lee),김인수(In Soo Kim),공창기(Chang gi Kong),한재복(Jae Bok Han) 한국방사선학회 2020 한국방사선학회 논문지 Vol.14 No.2
이 연구는 스텐트 내 재협착 병변에서 약물용출 풍선 확장술을 시행한 환자를 대상으로 주요 심장사건에 영향을 미치는 예측 인자가 무엇인지 알아보고자 하였다. 2012년 10월부터 2017년 1월까지 전남대학교병원 심혈관센터에서 경피적 관상동맥 삽입술 후 스텐트 내 재협착이 발생한 환자 중에서 약물용출 풍선 확장술을 시행 받은 환자 257명 (평균연령 66.1±10.1세, 남자 172명)을 대상으로 그룹 I (주요 심장사건 발생군, n=35명), 그룹 II (주요 심장사건 발생하지 않은 군, n=222명)로 나누어 분류 하였다. 약물용출 풍선 성형술 후 주요 심장사건의 독립적인 예측 인자를 보기 위한 다변량 분석에서 완전 폐쇄병변 형태의 재협착 형태 (HR=4.179, 95% C.I.=1.851-9.437 p= 0.001), 25 mm이상의 긴 병변 (HR=8.773, 95% C.I.=1.898-40.546 p= 0.005), 반복되는 스텐트 내 재협착 (HR=4.693, 95% C.I.=1.259-17.490 p= 0.021)이 독립적인 예측 인자로 판명되었다. The aim of this study was to investigate the predictors of major adverse cardiac events (MACE) in patients with drug-eluting balloon (DEB) for in-stent restenosis (ISR) lesion. Total of 257 patients who developed ISR on follow-up coronary angiography (66.1 ± 10.1years, 172 males) in Chonnam National University Hospital between October 2012 and January 2017 were enrolled. We divided the patients into two groups; group I (MACE group; n= 35) and group II (No MACE group; n= 222). A multivariate logistic regression analysis revealed that type IV ISR (HR=4.179, 95% C.I.=1.851-9.437 p= 0.001), lesion length > 25 mm (HR=8.773, 95% C.I.=1.898-40.546 p= 0.005), number of ISR recurrence > 2 (HR=4.693, 95% C.I.=1.259-17.490 p= 0.021) were independent factors for MACE after DEB in ISR lesions.