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- 저자 : 안정환 (검색결과 196 건)
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신경아세포종에 대한 팔보회춘탕(八寶廻春湯)의 항암 효과
안정환,조문영,우찬,신용진,신선호,An, Jung-Hwan,Cho, Mun-Young,Woo, Chan,Shin, Yong-Jin,Shin, Sun-Ho 대한한방내과학회 2014 대한한방내과학회지 Vol.35 No.1
Objectives : To investigate the anti-cancer effect of Palbohoichoon-tang (PBHCT) extracts. Methods : The cell viability was assessed by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MMT) assay and cell morphological changes were microscopically analyzed after staining with $10{\mu}M$ 2-[4-amidinophenyl]-6-indolecarbamidine dihydrochloride (DAPI) and TUNEL. We also analyzed expression of Bcl2, $Bcl_{xL}$, Bax, procaspase-3, procaspase-9, and procyclic acidic repetitive protein (PARP) by western blot method. Results : Observations showed that PBHCT induced the apoptotic cell death proved by increased sub-G1 phase cell population, apoptotic body formation and chromatin condensation. Western blot analysis of total cell lysates revealed that the PBHCT induced cleavage of caspase-9, caspase-3 and poly (ADP-ribose) polymerase (PARP). In addition, PBHCT dose-dependently increased the activity of caspase-9, caspase-3 and PARP-1. Furthermore, PBHCT reduced anti-apoptotic Bcl2, $Bcl_{xL}$ expression which contributed to the loss of mitochondrial membrane potential and the activations of caspase-9 and caspase-3. Conclusions : These findings suggest that PBHCT exerts anti-cancer effects on human neuroblastoma SH-SY5Y cells by inducing apoptotic death via down-regulation of anti-apoptotic proteins such as Bcl2 and $Bcl_{xL}$, up-regulation of pro-apoptotic proteins such as Bax, and activation of caspase cascades and PARP-1.
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대요근 근구 차단술 시행 후 발생한 요근 농양의 경험예 증례 보고
안정환,김용철,이상철,이영선 대한통증학회 2004 The Korean Journal of Pain Vol.17 No.2
Psoas compartment block (PCB) has been used for thigh, leg and lumbar area pain. It is now known to be safe and available to advocate for patients with lower extremity pain. Psoas compartment block was performed for the treatment of the lower extremity pain in a 61-year-old woman, complaining of sudden left thigh and inguinal pain. One day after the PCB, her body temperature was elevated and the leg pain aggravated by adduction of the left femur, suggestive of a psoas abscess. A huge abscess was found in the psoas major muscle on the immediate magnetic resonance image (MRI), and empirical antibiotics were administered. After a month, her left leg pain had subsided, and an MRI showed a diminished abscess pocket. Immediate laboratory check up and radiological examination are recommended for patients with fever and pain after blocks.
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안정환,정윤석,Ahn, Jung-Hwan,Jung, Yoon-Seok 대한임상독성학회 2004 대한임상독성학회지 Vol.2 No.2
Hydrogen sulfide is a colorless, and malodorous 'rotten eggs' gas that results from the decay of organic material. It is a byproduct of industry and agriculture. The mechanism of its toxicity is primarily related to inhibition of oxidative phosphorylation, which causes a decrease in available cellular energy. Because there is no rapid method of detection that is of clinical diagnostic use, management decisions must be made based on history, clinical presentation, and diagnostic tests that imply hydrogen sulfide's presence. Although there is some anecdotal evidence to suggest that the early use of hyperbaric oxygen is beneficial, supportive care remains the mainstay of therapy. We describe an occupational exposure to hydrogen sulfide gas in 51-year-old man. While cleaning the sewage of pigs. he became unconscious. When he arrived in the emergency department, he had irritability and confused mentality. The typical smell of rotten eggs on clothing and exhaled air were enough to be considered to be exposed to hydrogen sulfide. Hyperbaric oxygen therapy was performed. He had a recovery to normal function.
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Vickeres Indentation법에 의한 페라이트와 접합유리에서의 응력해석
안정환,제해준,홍국선,안재환,고경현 한국세라믹학회 1993 한국세라믹학회지 Vol.30 No.6
Residual stresses is one of the major factors to degrade the magnetic properties of VCR magnetic heads. Vicker's indentation technique was adapted to estimate the residual stresses Residual stresses and distribution in the glass and ferrite were obtained after bonding ferrite with glass, varing the cooling rate. The compressive and tensile stresses were developed in the interface and gradually decreased with increasing distance from the interface. The stresses were decreased with a cooling rate. The mean values of residual stress in ferrite were 10MN/㎡, 8MN/㎡, 5MN/㎡ with cooling rate 10℃/min, 5℃/min, 1℃/min respectively. When the bonded sample was annealed above the glass transition temperature followed by cooling at 5℃/min cooling rate, the residual stress was reduced to 6MN/㎡.
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안정환,우중원,이창규,류현열 고신대학교(의대) 고신대학교 의과대학 학술지 1998 고신대학교 의과대학 학술지 Vol.13 No.1
These studies were induced experimental overhydration in Spargue-Dawley rats to find out which of three widely used irrigating fluids is most strongly associated with survival and also investigated the changes in electrolytes. The survival and incidence of voiding was studied in 60 Sprague-Dawley rats after an intraperitoneal infusion of either 225, 250, 275 or 300 ml/kg of glycine (1.5%), mannitol (5%) and sorbitol (2.7%) plus mannitol (0.54%) over 15 minutes. Electrolyte changes was studied in 60 Sprague-Dawley rats after an intraperitoneal infusion of either 225, 250, 275 or 300 ml/kg of sorbitol plus mannitol and in 5 Sprague-Dawley rats for control. Only fifteen percent of the Sprague-Dawley rats survived the mannitol solution, whereas the overall survival rate after sorbitol plus mannitol was forty-five percents. The corresponding figure for glycine was twenty percent. The serum sodium and chloride was maximally decreased at 6 hours after infusion of sorbitol plus mannitol and then nearly returned to the normal range at 24 hours. The creatinine was slightly increased at six hours and then returned to the normal range at 24 hours. In conclusion, this experimental study in the Sprague-Dawley rats shows that sorbitol plus mannitol is the safest solution among the three solutions. At six hours after infusion of this solution, serum electrolyte changes were maximal ; serum sodium & chloride were decreased and serum creatinine was increased, and at 24 hours, serum electrolyte values were nearly returned to the normal range.
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