신규 방사성 항암제 DW-166HC 의 소핵시험

문은이(Eun Yi Moon),이진(Jin Lee),이원용(Won Yong Lee),최청하(Chung Ha Choi),이덕근(Dug Keun Lee),유제만(Jei Man Ryu),정용호(Yong Ho Chung),윤성준(Sung June Yoon),박경배(Kyung Bae Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3

DW-166HC (^(166)Holmium (^(166)Ho)-Chitosan complex) is a new radiopharmaceutic anticancer agent with a broad anti-tumorigenic spectrum, especially against human hepatic cancer. DW-166HC was evaluated for the appearance of micronucleus in polychromatic erythrocytes (PCEs) of mouse bone marrow cells after subcutaneous arid intravenous single administration. Bone marrow cells were prepared at 24 hr and 48 hr after DW-166HC-I (^(165)Ho-Chitosan complex : cold compound) administration and at 24 hr, 72 hr and 2 weeks after DW-166HC (^(166)Ho-Chitosan complex : hot compound) administration. The results showed there was no statistically significant increase of the numbers of PCEs with micronucleus in all DW-166HC-I administered groups compared with a negative control group but there was statistically significant increase of the numbers of PCEs with micronucleus at 24 hr arid 72 hr in all DW-166HC administered groups, which was recovered after 2 weeks from the drug administration. The results also showed the ratio of normochromatic erythrocytes (NCEs) to PCEs of all DW-166HC-I administered groups was not significantly different from that of a negative controi group but there was significant difference of this ratio at 24hr and 72 hr in all DW-166HC administered groups compared with that of negative group, which was also recovered after two weeks from the drug administration. These results suggested that DW-166HC-I may not cause any chromosomal damage but DW-166HC has in vivo mutagenic potential because of its radioactivity.

8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

公務員의 意識改革과 實踐目標

朴瑾浩 동국대학교 행정대학원 1982 행정논집 Vol.11-12 No.-

한국통신 사원의 직무만족도 조사

박근호 동국대학교 행정대학원 1992 행정논집 Vol.20 No.-

폴리비닐 알코올-아조벤젠 유도체의 광 안정성에 관한 연구

朴泰坤,朴根浩 國立 昌原大學校 産業技術硏究所 1995 産技硏論文集 Vol.9 No.-

The Synthesis of long chain fatty acid containing azobenzene(Cn-Azo-PVA) was optimized, starting from Cn-Azo(C14, C16, C18) compounds and the product of reaction containing azobenzene chromophores was investigated by ultraviolet spectro-photometery in chloroform solvent at the various temperature. In addition, Reversibility and stability of azo compounds have been measured by means of Ultraviolet and the structure of these compounds were ascertained by means of FT-IR and NMR. Long chain azobenzene derivatives in chloroform solution are induced phtoisomerization by u.v. and visible light irradiation. The solution of long chain fatty acids containing azobenzene(Cn-Azo-PVA) are possible of being applied to functional molecular devices such as photomemory and light switching.

다형성 교모세포종에서 광범위 전적출술후 단기 재발된 치험 1예

박호권,강중식,조준,문창택,장상근,임정애 건국대학교 의과학연구소 2003 건국의과학학술지 Vol.13 No.-

Glioblasty/ma Multiforme(GBM) is the one of the most common malignant tumors in central nervous system(CNS). The incidence of the tumor is about 12% of all CNS tumors and about 50% of all intracranial tumors. Though the development of the microsurgical technique, radiosurgical technique, and chemotherapy works effectively, complete cure of the GBM has not been achieved. It has been known that the prognosis of GBM depends on the extent of surgical tumor removal, remained tumor volume, radiation dose, and chemotherapy. Not only patient's age but also tumor characteristics such as MRI enhancement, angiogenesis and necrosis are also very important prognostic factors. Authors experienced very aggressive GBM in aged woman, who received gross total tumor removal, but refused other therapeutic motalities postoperatively. Very rapid recurrence of GBM and global cerebral edema in aged woman should be considered fatal. This case demonstrates the effectiveness of aggressive removal and the limited usefulness of neurosurgical tools in GBM recurrence. Authors would suggest that the early diagnostic effort and the verified neurosurgical therapy for malignant tumor are still strongly requested to make better prognosis.

결핵성 육아종에서 Thioredoxin peroxidase-2 의 발현

박근호,유형륜,정영진,윤기중,한원철,유대열,문형배 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2

Background: Thioredoxin peroxidase(TPX) is a kind of recently discovered antioxidant enzyme which react as rapid hydrogen ion donor for the removal of hydroperoxide. The action and distribution of the TPX was poorly understood in the human diseases. This experiments were designed for the study about the distribution of the TPX in the chronic granulomatous inflammation and about the correlation between the expression of TPX and the site of inflammation, histological activities of tuberculous inflammation or existence of mycobacterium in the inflammatory foci. Methods: The immunohistochemical stains were performed for the localization of the TPX-2 in the epithelioid cells, giant cells and lymphocytes in the chronic granulomatous inflammation. The tissue sections were obtained from the paraffin blocks of the 54 cases of tuberculosis (lung 21 cases, lymph node 12 cases, bone and soft tissue 12 cases, kidney 9 cases; active 33 cases, inactive 21 cases by the histologic classification; presence of mycobacterium 15 cases, no mycobacterium 39 cases by PCR reaction). Results: The expression of TPX-2 was 16.7% in the giant cells, 27.8% in the epithelioid cells and 100% in the lymphocytes of tuberculous inflammations. The expression of TPX-2 in the giant cells and epithelioid cells of the tuberculosis were 28.6% and 57.1% of the pulmonary tuberculosis; 33.3% in each cells of the renal tuberculosis; 0% in each cells of the lymph node or bone and soft tissue tuberculosis. The expression of TPX-2 in the giant cells and epithelioid cells were 9.1% in each cells of the active tuberculosis and were 28.6% and 57.1% in each cells of the inactive tuberculosis by histologic classification. The expression of TPX-2 in the giant cells and epithelioid cells was 40% in each cells of tuberculosis which mycobacteria were detected and the expression of TPX-2 was 7.7% and 23.1% in each cells which mycobacteria were not detected by PCR reaction in the paraffin embedded tissue. Conclusions: The above results were summarized that the TPX-2 in the giant cells and epithelioid cells were more frequently expressed in the inactive tuberculosis than in the active tuberculosis. These results suggest that the TPX-2 is a kind of regulating or suppressing factors in the activity of the tuberculosis.

發展事業의 意思決定에 關한 硏究

朴瑾浩 동국대학교 행정대학원 1974 행정논집 Vol.5 No.-

觀光資源開發의 基準設定에 關한 考察

朴瑾浩 동국대학교 대학원 1974 大學院硏究論集-東國大學校 大學院 Vol.4 No.-

Tourism's importance was exemplified in the sponsorship by the United Nations of a Conference on International Travel and Tourism held in Rome in august september, 1963. At this conference, which was attended by over 600 persons from 84 countries, world attention was focused on international travel and tourism as "an economic and social force of major proportions in the world" Tourism is looked upon by many countries as a highly desirable and feasible method of economic development because the resources which attract and support tourism are usually abundant in undeveloped areas. Korea have also many tourism resouces for example, there are cultural attractions, scenery resources, antiquities, interesting and attractive people, and natural resource. But these abundant tourism resources did not development systematically in whole nation wide. So I attempted to study the tourism resource development and potential tourism areas with Korean Tourism Development Master Plan. The criteria of tourism resource development will be establish: 1) That sufficient potential exist to warrant large scale development 2) That sites are available that have the necessary attractiveness to warrant development 3) That physical development chracteristics necessary attract the potential tourist market 4) That the infrastructure requirements are both financially and physicically feasible 5) That economic benefit to the nation is sufficient to warrant the dedication of the required financial and natural resource. 6) Preservation of unique natural or cultural resources and traditional Korean architecture should rank hish on the tourism resource development priority.

경남지역 대기중의 부유분진 특성에 관한 연구

박점상,박근호 7개 국립대학교 환경연구 논문집 공동발행 위원회 2002 환경연구논문집 Vol.2 No.1

Suspended particles in the air were captured by high volume air sampler in the 29 sites of south Geyngsang area and measured total suspended particulate (TSP), heavy metals, and ion compounds. The results are following as; The average of TSP is 76.8㎍/㎥ throughout Gyeongnam area, and regional average is 124.9㎍/㎥ in industrial complex, 99.9㎍/㎥ road side area, and 52.9㎍/㎥ residential area. The highest level of TSP is 189.3㎍/㎥ in Yangsan industrial complex area. And the lowest is 34.1㎍/㎥ in Namhae residential area. The artificial contaminant(SO_4^2- and NO_3^-) have higher levels particularly road side area than industrial complex or residential area. Thus, it appears to be affected by emission gas of automobile. Fe is the heavy metal compound which of the highest concentration is 1.919㎍/㎥ in the air and Cd the lowest, 0.001㎍/㎥. In the regional aspect, it appesrs that industrial comples has high levels of Cl^-, Na^+, TSP, and heavry metals such as Zn, Pb and road side area has ion compounds such as SO_4^2-, NO_3^-. And there's no high level of concentration in residential area. The coefficient of correlation between Fe and Mn(P=0.000) is 0.999 in the industrial complex, that of Cr to Cd(P=0.003) is 0.997 in road side, and in the residential area that of Fe to Mn(P=0.000) is 0.867. Also, the correlation between Fe and Mn has totally the highest coefficient which is 0.995.