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피칸(Carya illinoensis C. KocH)으로부터 지질대사물질의 분리 및 동정
송명종,한민우,양혜정,이대영,노영덕,백남인 경희대학교식량자원개발연구소 2007 硏究論文集 Vol.26 No.1
피칸(Carya illinoensis C. Koch) 열매를 80% MeOH로 추출하고, 추출물을 극성에 따라 n-hexane, CHCl_(3), EtOAc, n-BuOH 및 물로 분배, 추출하였다. 이 중 EtOAc분획으로부터 silica gel column chromatography를 반복하여 4종의 지질화합물을 분리하였다. 분리된 화합물 화학구조는, NMR 및 MS 등의 스펙트럼을 해석하여 oleic acid methyl ester, linoleic acid methyl ester, β-sitosterol, daucosterol(3-O-β-D-glucopyaranosyl β-sitosterol)으로 동정하였다. Carya illinoensis C. Koch was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with n-hexane, CHCl_(3), EtOAc, n-BuOH and H_(2)O, successively. From the EtOAc fraction, four compounds were isolated through the repeated silica gel column chromatographies. From the results of physico-chemical data including NMR, MS and IR, the chemical structures of the compounds were determined as oleic aicd methyl ester(1), linoleic aicd methyl ester(2), β-sitosterol(3), and daucosterol(4). They were the first to be isolated from C. illinoensis.
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송명종,김모두,이효원 대한건축학회 2019 대한건축학회논문집 Vol.35 No.9
Due to the rapid increase of the elderly population, promoted desire for recreational activities in old age and so emerging importance ofLeisure welfare facilities for the elderly. Although Senior community centers playing an important role in old people leisure life arequantitative resources occupying majority of the Leisure welfare facilities for the elderly. there are many problems of managing programs,aging facilities, small spaces and so on. So, many facilities are used as simple meeting places of old people without solution aboutqualitative problem. Also, because of negative perceptions of people about Senior community center socially, desires of using Seniorcommunity center of old generation will decrease. In order to perfectly play a role of Leisure welfare facilities for the elderly, we need toreview regulations about facility and program of Senior community center and suggest ways to resolve these problems. According to thesenecessity, Integration senior community centers appeared as a new concept. These centers compensate the physical defects through integratingsmall Senior community center. Through dividing function and service of senior welfare and forming networks between Senior communitycenter and Senior welfare center, these centers set a goal of increasing quantitative and qualitative improving of leisure life of old people. 이 연구는 경로당, 노인복지관으로 구분되어 있는 노인여가복지시설 간에 네트워크를 형성하기 위해 제시된 거점경로당이라는 시설에 대한 내용을 담고 있다. 거점경로당이라는 시설의 필요성과 경로당 – 노인복지관의 중간조직적인 개념에 대해 정리하였다. 기존 경로당을 중심으로 노인여가복지시설을 연결시키려는 경로당 활성화 방안이나 노인복지서비스의 네트워크 형성에 대한 연구들을 토대로 새로운 시설의 설치기준이나 특징들을 살펴보고자 한다. 선행연구에서 제시하는 거점경로당의 특징을 분석하여 제시된 시설을 유형별로 분류한다. 분류된 유형들의 공통점과 차이점을 살펴보고, 노인여가복지시설에서 거점경로당이라는 시설의 위치와 가능성에 대해 알아보는 것을 목적으로 하고 있다.
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쑥갓(Chrysanthemum coronarium L.)으로부터 배당체의 분리
송명종,김세영,송효남,백남인 경희대학교 생명자원과학연구원 2004 硏究論文集 Vol.23 No.-
쑥갓의 지상부를 MeOH로 추출하고, 추출물을 EtOAc, n-BuOH 및 물로 분배, 추출하였다. n-BuOH분획으로부터 silica gel 및 ODS column chromatography를 반복하여 배당체를 분리하였다. 화합물의 화학구조는, MNR 및 MS 등의 스펙트럼을 해석하여 1-o-β-D-glucopyranosyl-3-hexenol으로 동정하였다. The aerial parts of Garland (Chrysanthemum coronarium L.) were extracted in MeOH and solvent fractionated with EtOAc, n-BuOH and water, successively. n-BuOH fraction gave a glycoside compound through application of silica gel column chromatographies including ODS. The chemical structure of the glycoside was determined by the interpretation of several spectral data, including NMR and MS as O-β-D-glucopyranosyl-3-hexenol (1).
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송명종,Hye-Joung Yang,정태숙,김경태,Nam-In Baek 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
The aerial parts of Chrysanthemum coronarium L. were extracted with MeOH, and the concentrated extract was partitioned using EtOAc, n-BuOH, and H2O, successively. Repeated column chromatography of the EtOAc and n-BuOH fractions gave a new heterocycle, 5,5'- dibuthoxy-2,2'-bifuran (1) along with five known compounds: methyl trans-ferulate (2), prunasin (3), sambunigrin (4), pterolactam (5), and adenosine (6), which were identified by several spectroscopic methods including NMR and MS. This paper is the first report on the isolation of these compounds from C. coronarium L. The IC50 values of compound 1 for human Acyl- CoA:cholesterol acyltransferase (hACAT)-1 and hACAT-2 were 0.16 mM and 0.19 mM, respectively. Compound 2 inhibited low-density lipoprotein (LDL) oxidation with an IC50 value of 7.7 μM
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Antioxidant and Antiatherogenic Activity of cis-Hinokiresinol from Trapa pseudoincisa
송명종,Hye-Joung Yang,방면호,김대근,정태숙,김종평,백남인 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.11
cis-Hinokiresinol, also known as (+)-nyasol, was isolated for the first time from an aquatic herbaceous plant, Trapa pseudoincisa NAKAI, via silica gel and octadecyl silica gel column chromatographies. The chemical structure was determined via analyses of the spectroscopic data, including NMR, MS and IR. cis-Hinokiresinol was also found to exhibit antioxidant and antiatherogenic activities. The IC50 values for the scavenging activities of cis-hinokiresinol on ABTS cation and superoxide anion radicals were 45.6 and 40.5 µM, respectively. The IC50 values for the inhibitory effects on Lp-PLA2, hACAT1, hACAT2 and LDL-oxidation were 284.7, 280.6, 398.9 and 5.6 µM, respectively.
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광주광역시 남구 경로당의 치매예방관련 프로그램 운영가능성
송명종,송정석,이효원 대한건축학회 2023 대한건축학회논문집 Vol.39 No.4
노인여가복지시설의 운영프로그램은 시설 및 운영주체가 위치한 지역의 특성과 노인의 여가욕구에 맞는 건강 및 정보화교육관련 프로그램을 개발하려고 노력 중이다. 하지만 현재 운영 및 개발되고 있는 프로그램은 시설의 현재상태와 이용자들의 선택보다는 공급자 중심으로 이루어지고 있다. 그렇기 때문에 보건복지부의 2020년 노인건강복지사업에서 계획한 기존 경로당의 노인 치매 예방 프로그램 운영에서 시설과 이용자측면에서의 검토가 필요하다. 본 연구는 노인 치매 예방 프로그램의 종류를 파악하고 노인의 신체활동 범위와 기존 경로당 시설의 규모와 관련하여 프로그램 운영을 위한 소요면적을 산출하여 계획한 프로그램이 운영될 수 있는지 검토하고자 한다. The operation program of leisure welfare facilities for the elderly is attempting to develop programs related to health maintenance andinformatization education that suit the characteristics of the area where a facility and operating entity are located and that address the leisureneeds of the elderly. However, the current programs being operated and developed are centered on suppliers rather than on the current statusof a facility and its users. Therefore, it is necessary to review in terms of facility status and selection of users in the operation of adementia prevention program at existing senior citizen centers planned for the 2020 Ministry of Health and Welfare project for the elderly. This study calculated the area required to operate a program concerning the scope of elderly physical activity and the size of existingfacilities in senior citizen centers. The purpose is to identify the types of dementia prevention programs for the elderly and to reviewwhether the planned program can be operated
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