Contrast-Enhanced CT with Knowledge-Based Iterative Model Reconstruction for the Evaluation of Parotid Gland Tumors: A Feasibility Study

박채정,김기욱,이호준,김명진,김진아 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.5

Objective: The purpose of this study was to determine the diagnostic utility of low-dose CT with knowledge-based iterative model reconstruction (IMR) for the evaluation of parotid gland tumors. Materials and Methods: This prospective study included 42 consecutive patients who had undergone low-dose contrastenhanced CT for the evaluation of suspected parotid gland tumors. Prior or subsequent non-low-dose CT scans within 12 months were available in 10 of the participants. Background noise (BN), signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were compared between non-low-dose CT images and images generated using filtered back projection (FBP), hybrid iterative reconstruction (iDose4; Philips Healthcare), and knowledge-based IMR. Subjective image quality was rated by two radiologists using five-point grading scales to assess the overall image quality, delineation of lesion contour, image sharpness, and noise. Results: With the IMR algorithm, background noise (IMR, 4.24 ± 3.77; iDose4, 8.77 ± 3.85; FBP, 11.73 ± 4.06; p = 0.037 [IMR vs. iDose4] and p < 0.001 [IMR vs. FBP]) was significantly lower and SNR (IMR, 23.93 ± 7.49; iDose4, 10.20 ± 3.29; FBP, 7.33 ± 2.03; p = 0.011 [IMR vs. iDose4] and p < 0.001 [IMR vs. FBP]) was significantly higher compared with the other two algorithms. The CNR was also significantly higher with the IMR compared with the FBP (25.76 ± 11.88 vs. 9.02 ± 3.18, p < 0.001). There was no significant difference in BN, SNR, and CNR between low-dose CT with the IMR algorithm and nonlow-dose CT. Subjective image analysis revealed that IMR-generated low-dose CT images showed significantly better overall image quality and delineation of lesion contour with lesser noise, compared with those generated using FBP by both reviewers 1 and 2 (4 vs. 3; 4 vs. 3; and 3–4 vs. 2; p < 0.05 for all pairs), although there was no significant difference in subjective image quality scores between IMR-generated low-dose CT and non-low-dose CT images. Conclusion: Iterative model reconstruction-generated low-dose CT is an alternative to standard non-low-dose CT without significantly affecting image quality for the evaluation of parotid gland tumors.

Reliability of Breast Ultrasound BI-RADS Final Assessment in Mammographically Negative Patients with Nipple Discharge and Radiologic Predictors of Malignancy

박채정,김은경,문희정,윤정현,김민정 한국유방암학회 2016 Journal of breast cancer Vol.19 No.3

Purpose: The purpose of this study was to retrospectively investigate the reliability of breast ultrasound (US) Breast Imaging Reporting and Data System (BI-RADS) final assessment in mammographically negative patients with pathologic nipple discharge, and to determine the clinical and ultrasonographic variables associated with malignancy in this group of patients. Methods: A total of 65 patients with 67 mammographically negative breast lesions that were pathologically confirmed through US-guided biopsy were included. Results: Of the 53 BI-RADS category 4 and 5 lesions, eight (15.1%) were malignant (six ductal carcinomas in situ, one invasive ductal carcinoma, and one solid papillary carcinoma). There was no malignancy among the remaining 14 category 3 lesions. Malignant lesions more frequently displayed a round or irregular shape (75.0%, 6/8; p=0.030) and nonparallel orientation (33.3%, 4/12; p=0.029) compared to the benign lesions. The increase in the BI-RADS category corresponded with a rise in the malignancy rate (p=0.004). Conclusion: The BI-RADS lexicon and final assessment of breast US reliably detect and characterize malignancy in mammographically negative patients with pathologic nipple discharge.

Botryoid Wilms’ Tumor in a Child Presenting with Gross Hematuria: A Case Report

박채정,임영재,신현주,김명준,이미정 대한영상의학회 2016 대한영상의학회지 Vol.75 No.3

We report a unique case of botryoid Wilms’ tumor with its characteristic imaging findings in a 5-month-old boy presenting with gross hematuria. In our case, ultrasonography revealed lobulated hyperechoic lesions filling the pelvicalyceal system without parenchymal invasion, mimicking a blood clot. However, magnetic resonance imaging (MRI) demonstrated the exact extent of the lesion with diffusion restriction and delayed enhancement suggestive of a tumor. Despite their rarity, botryoid Wilms’ tumors should be included in the differential diagnosis of lobulated renal pelvic lesions presenting as gross hematuria in children, and MRI can suggest the diagnosis.

Breast Cancer Arising Adjacent to an Involuting Fibroadenoma: Serial Changes in Radiologic Features

박채정,김은경,우하영,문희정,윤정현,김민정 한국유방암학회 2015 Journal of breast cancer Vol.18 No.3

Fibroadenoma is a common benign breast lesion and its malignant transformation is rare. There have been several case reports and studies that retrospectively reviewed breast cancers that arose within fibroadenomas; however, none of these studies reported serial changes in radiologic features of the cancer, including findings from mammography and ultrasound (US). We report a case of breast cancer arising adjacent to an involuting fibro adenoma in a 39-year-old woman who was undergoing serial follow-up after her fibroadenoma was diagnosed. Seven years after her diagnosis, the lesion showed evidence of coarse calcifications, a typical sign of involution. Four years later, US revealed a newly developed hypoechoic lesion with irregular margins and peripherally located calcifications adjacent to the fibroadenoma. A core biopsy was performed, and histopathological examination resulted in a diagnosis of invasive ductal carcinoma. When new suspicious features are observed in a fibroadenoma, radiologists should raise the concern for breast cancer and proceed with diagnosis and treatment accordingly.

EEG Source Imaging in Partial Epilepsy in Comparison with Presurgical Evaluation and Magnetoencephalography

박채정,서지혜,김대영,Berdakh Abibullaev,권혁찬,이용호,김민영,안경민,김종식,주은연,홍승봉 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.4

Background and Purpose Te aim of this study was to determine the usefulness of threedimensional (3D) scalp EEG source imaging (ESI) in partial epilepsy in comparison with the results of presurgical evaluation, magnetoencephalography (MEG), and electrocorticography (ECoG). Methods Te epilepsy syndrome of 27 partial epilepsy patients was determined by presurgical evaluations. EEG recordings were made using 70 scalp electrodes, and the 3D coordinates of the electrodes were digitized. ESI images of individual and averaged spikes were analyzed by Curry sofware with a boundary element method. MEG and ECoG were performed in 23 and 9 patients, respectively. Results ESI and MEG source imaging (MSI) results were well concordant with the results of presurgical evaluations (in 96.3% and 100% cases for ESI and MSI, respectively) at the lobar level. However, there were no spikes in the MEG recordings of three patients. Te ESI results were well concordant with MSI results in 90.0% of cases. Compared to ECoG, the ESI results tended to be localized deeper than the cortex, whereas the MSI results were generally localized on the cortical surface. ESI was well concordant with ECoG in 8 of 9 (88.9%) cases, and MSI was also well concordant with ECoG in 4 of 5 (80.0%) cases. Te EEG single dipoles in one patient with mesial temporal lobe epilepsy were tightly clustered with the averaged dipole when a 3 Hz high-pass flter was used. Conclusions Te ESI results were well concordant with the results of the presurgical evaluation, MSI, and ECoG. Te ESI analysis was found to be useful for localizing the seizure focus and is recommended for the presurgical evaluation of intractable epilepsy patients.

기초지방자치단체의 주민청구조례안 수용요인에 관한 연구: 로컬거버넌스의 맥락을 중심으로

박채정 ( Park Chae Jeong ) 한국행정학회 2021 韓國行政學報 Vol.55 No.1

점차적으로 지방자치와 주민참여가 강조되어 가는 현실에서 기존 주민조례제정개폐청구제도에 관한 연구는 주로 법학 분야에서 현황이나 의의 및 제도적 개선점 등과 같이 서술적 설명에 초점을 맞추어 온 반면, 행정학 및 정책학 분야에서는 제도 자체보다는 규범적인 측면이나 개별 사례연구에 초점을 맞추면서, 주민청구조례안의 수용 요인에 대한 체계적 연구는 미흡하였다. 이 연구는 로컬거버넌스 관점에서 전국 지방자치단체에서 실시하고 있는 주민조례제정개폐청구제도의 정책산물인 주민청구조례안의 수용에 영향을 미치는 요인들을 실증적으로 분석하였다. 기존 법률안 결정에 관한 연구에서 주로 선정되는 가결뿐만 아니라 반영을 함께 고려하였으며, 이에 영향을 미치는 요인으로서 정책내용, 주민참여, 재정측면, 정치측면의 가설을 수립한 후 이항 로짓분석을 실시하였다. 분석결과, 정책유형 중 배분정책과 지방선거투표율 및 지방선거 시기가 통계적으로 유의미한 것으로 나타났으며, 해당 제도가 주민들의 참여를 통한 주민의 물질적 권익 실현에 주로 작용하고 있음을 보여주었다. 이 연구는 보다 다양한 배분정책 유형 및 주민참여 지표 개발을 통해 제도의 로컬거버넌스 위상에 대한 추가적 연구가 필요함을 제시하였다. In the reality that the participation of local governments and residents is gradually emphasized, a systematic study of the factors that affect acceptance of residents' claimed ordinances was lacking. In the field of law the focus has been mainly on descriptive explanations, such as current status and significance and institutional improvements, whereas in the fields of public administration and policy the focus has been on normative aspects and individual case studies rather than on the system itself. This study analyzed the factors that affect acceptance of residents' claimed municipal ordinances by local governments nationwide from the viewpoint of local governance. The dependent variables were not only whether residents' claimed ordinances were passed or not, but also whether they were reflected or not. After formulation of the hypothesis on policy content, residents' participation, and the financial and political aspects, the logistic regression method was applied to identify factors that affected the acceptance of residents' claimed ordinances. The findings revealed that distributive policy, voter turnout in local elections, and the timing of local elections are statistically significant. They also showed that the system plays a major role in the realization of the material rights and interests of residents. This study presents the need for additional research on the status of local governance as systems through the development of more diverse distributive policy types and resident participation indicators.

양극성 장애 입원 환자에서 약물 사용 경향의 변화 : 일 병원 4년 자연 연구

박원명,이경욱,이원희,박여진,채정호,전태연,김광수,유태열 대한정신약물학회 2004 대한정신약물학회지 Vol.15 No.1

SCADE 를 이용한 CBTC 지상장치 소프트웨어 ATO 기능 모델링 기법

박채정 ( Chae-jung Park ),이덕희 ( Duk-hee Lee ),유성호 ( Sung-ho Yoo ),최선아 ( Sun-ah Choi ),조동래 ( Dong-rae Cho ) 한국정보처리학회 2010 한국정보처리학회 학술대회논문집 Vol.17 No.2

본 논문은 통신기반 열차제어방식으로 주목 받고 있는 CBTC 시스템의 지상장치 소프트웨어 기능을 모델기반 개발도구인 SCADE 를 이용하여 설계하는 기법을 제시한다. CBTC 지상장치의 ATO 기능은 모델링 후 다양한 테스트 케이스를 통해서 기능을 검증하였다. 수행된 모델링을 통해서 SCADE 가 CBTC 소프트웨어 시스템을 개발하는데 효과적으로 사용될 수 있음을 제시한다.

땅과 사람의 관계로서 주민주권 개념과 제도의 모색

박채정 ( Chaejeong Park ),최태현 ( Taehyon Choi ) 서울대학교 한국행정연구소 2021 行政論叢 Vol.59 No.4

지방자치제도의 꾸준한 혁신으로 지방자치가 새로운 수준에 진입하려는 가운데 지방자치 관련 학문적 논의는 주로 정치·행정제도에 초점이 맞춰지면서 현시대의 문제와 직면하는 철학적 기반에 대한 보다 근원적인 논의는 상대적으로 부족하였다. 이 논문의 목적은 전지구적 위기 및 국가거버넌스의 한계를 지적하는 흐름에서 지난 10여 년간 논의되어 온 주민주권이라는 개념을 ‘땅과 사람의 관계 맺음’의 관점에서 구성함으로써, 지방자치적 오리엔탈리즘을 극복하는 이념적 기초로서 주민주권 개념을 모색하는 것이다. 생태론, 비판적 공간이론, 토라 등이 공통적으로 내포하는 땅과 사람의 역동적 관계에 기반하여 이 논문에서는 주민주권을 “땅이 제공하는 삶의 가능성의 실현을 둘러싼 땅과 사람간의 계약적 권능”으로 정의한다. 이러한 개념을 바탕으로 지난 70년간 지방자치법의 목적, 주민의 정의와 권리, 주민투표의 대상을 중심으로 한 지방자치법제의 변화과정을 비판적으로 분석한 후 향후 제도 개선의 시사점을 제시한다. South Korea has developed institutional local autonomy to an impressive level since 1987, and is now ready to take a next step toward an enhanced level of local autonomy. However, the academic discourse on local autonomy has focused on political and administrative institutions, leaving the discourse on the political-philosophical foundation required to cope with contemporary issues behind. The purpose of this article is to propose a definition of resident sovereignty based on ecological perspectives, critical space theory, and the law of the Torah, emphasizing the relationship between land and people. Accordingly, we define resident sovereignty as the ability derived from the contract between land and people to realize the potential of life offered by the land. The history of the South Korean Local Autonomy Act is critically analyzed based on this conceptualization by focusing on changes in purpose, definition of residents, and referendums. It is suggested that facing global challenges and the limits of national governance requires a radical philosophical foundation for local autonomy that puts the relationship between land and people at the center.

Olanzapine으로 유발된 체중증가에 대한 Amantadine의 효과

박원명,이경욱,채정호,이원희,전태연,김광수 대한정신약물학회 2003 대한정신약물학회지 Vol.14 No.1

본 연구는 amantadine이 olanzapine에 의해유발된 체중 증가를 유의하게 감소시키지는 않으나, 대부 분의 경우 정신병적인 증상이나 추체외로 증상을 악화 시키지 않고 안전하게 사용할 수 있음을 시사하였다. 추후 보다 잘 설계된 전향적 위약 통제 대조군 연구가 필요할 것으로 생각된다. 요 약 목 적:olanzapine은 정신분열병의 치료에 효과적이면 서도 부작용이 적은 약으로 알려져 있다. 그러나, 여러 부작용 가운데 특히 체중 증가는 약물 비순응을 유발하고 삶의 질을 떨어뜨리는 주요 원인이 되고 있으나 체중 증가를 뚜렷하게 조절할 수 있는 효과적인 방법은 없는 박원명 등 27 실정이다. 이에 저자들은 olanzapine으로 체중이 증가된 환자들에게 도파민 효현제인 amantadine을 투여하여 체중에 미치는 효과와 안전성을 조사하였다. 방 법:가톨릭대학교 성모병원에 내원하여 olanza -pine을 투여 받고 체중이 증가한 환자를 대상으로 olan -zapine을 투여하기 전, amantadine을 투여하기 직전, 2002년 7월 세 시점에서 체중, BMI, BPRS, ESRS를 측정하였고, olanzapine과 amantadine의 평균 용량 및 투여 기간을 조사하여 체중의 변화와 BPRS, ESRS의 변화를 비교하였다. 결 과:대상군의 평균나이는 38.7 ± 12.0세였고, 남자 는 4명, 여자는 17명이었다. olanzapine을 투여하기 전의 평균 체중 및 BMI는 각각 60.60 ± 1.04 kg, 23.13 ± 7.51 kg/m2였다. amantadine을 투여하기 직전의 olan -zapine의 평균용량은 1.94 ± 4.58 mg, 평균 투여 기간은 123.1 ± 174.6일이었으며, 체중은 평균 6.3 ± 4.45 kg, BMI는 평균 4.94 ± 0.75 kg/m2가 유의하게 증가하였다 (Z=-3.839, p<0.001;Z=-3.724, p<0.001). 투여한 amantadine의 평균 용량은 161.90 ± 58.96 mg, 평균 투여 기간은 10.2 ± 78.7일이었으며, amantadine을 투여 한 이후 체중은 0.96 ± 3.44 kg, BMI는 0.71 ± 2.7 kg/m2 이 감소하였으나 유의하지는 않았다. BPRS의 평균값은 amantadine을 투여하기 전과 연구 종료 시점에서 각 23.19 ± 6.41, 19.62 ± 7.63점으로 유의하게 감소하였고 (F=15.70, df=1, p<0.001), ESRS는 유의한 변화가 없었다.