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보골지 추출물이 파골세포 분화 및 골흡수 관련 유전자 발현에 미치는 영향
류광현 ( Gwang-hyun Ryu ),김엄지 ( Eom Ji Kim ),김민선 ( Minsun Kim ),김재현 ( Jae-hyun Kim ),이유진 ( Yujin Lee ),진대환 ( Dae-hwan Jin ),손영주 ( Youngjoo Sohn ),정혁상 ( Hyuk-sang Jung ) 경락경혈학회 2021 Korean Journal of Acupuncture Vol.38 No.3
Objectives : The increase of osteoclasts could cause osteoporosis and bone-related diseases. Also, the inhibition of osteoclast differentiation is important in treating bone-related diseases. Traditionally, Psoraleae Semen has been used for geriatric diseases, aging and musculoskeletal diseases. The purpose of this study is to investigate the effect of Psoraleae Semen ethanol extract (PS) on osteoclast differentiation and its function. Methods : To confirm the effect of PS on osteoclastogenesis and bone resorption activity, various levels of concentrations of PS (5, 10, 20 and 40 μg/ml) were tested on RAW 264.7 cells cultured with RANKL. We measured tartarate-resistant acid phosphatase (TRAP)-positive cells, TRAP activity, pit formation and F-actin ring formation. The expressions of nuclear factor of activated T-cells (NFATc1) and c-Fos were confirmed through western blot and reverse transcription- polymerase chain reaction (RT-PCR). Also, the expression of bone resorption and fusion-related genes in osteoclast was confirmed by RT-PCR. Results : PS decreased the number of TRAP-positive cells and the TRAP activity. In addition, PS significantly inhibited the formation of pit and F-actin ring. Furthermore, PS decreased the expression of osteoclast related genes. Conclusions : PS inhibits osteoclast differentiation and bone resorption ability through inhibition of the expression of osteoclastrelated genes. This indicates that PS may be a potential therapeutic agent to osteoporosis by suppressing osteoclastogenesis.
다리움직임을 동반한 척추 가동술(SMWLM)과 통합한방치료를 활용하여 호전된 급성 하지 근력저하 4례 : 증례보고
문영주(Young-Joo Moon),신원빈(Won-Bin Shin),류광현(Gwang-Hyun Ryu),이지연(Ji-Yun Lee),전현아(Hyun-A Jeon),임수연(Su-Yeon Lim),김성현(Seong-Hyun Kim),구승혁(Seng-Hyuk, Koo),문현우(Hyun-Woo Moon) 척추신경추나의학회 2020 척추신경추나의학회지 Vol.15 No.2
Objectives The purpose of this study was to investigate the possibility of spinal mobilization with leg movement (SMWLM) using Korean Medicine treatment on acute lower limb muscle weakness through four case studies. Methods SMWLM , with other Korean Medicine treatments, was performed on four patients who underwent treatment at OOOO Korean Medicine Hospital from August 2017 to July 2018. Additionally, results of the Numerical Rate Scale(NRS), EuroQol-FiveDimensions(EQ-5D),Oswestry lowback pain disability questionnaire(ODI), Straight Leg Raise(SLR) test, and Manual Muscle Test(MMT) were evaluated. Results There was a significant increase in NRS, ODI, and EQ-5D scales with im-rovements of SLR angle and MMT figures to a normal range. Conclusions This study suggested that Korean Medicine treatment combined with SMWLM may affect treating acute lower limb muscle weakness. Further clinical studies are needed to establish a definite conclusion.
대용량 약침치료 및 한의학적 치료를 적용한 흉요추 연접부 증후군 증례 보고
송광찬 ( Kwang Chan Song ),서지연 ( Ji Yeon Seo ),송승배 ( Seung Bae Song ),류원형 ( Won Hyung Ryu ),김두리 ( Doo Ri Kim ),전용현 ( Yong Hyun Jeon ),문희영 ( Hee Young Moon ),류광현 ( Gwang Hyun Ryu ) 대한한의학회 한방재활의학과학회 2018 한방재활의학과학회지 Vol.28 No.2
The purpose of this research is to find out the effect of Megadose pharmacopuncture with Korean Medicine Treatment on patients who were diagnosed as ThoracoLumbar Junction Syndrome. Megadose pharmacopuncture was proceeded on 4 patients who received treatment at OO Korean Medicine Hospital from November, 2016 to Februrary, 2017. In addition, We also kept a record of NRS, ODI, and EQ-5D on the day of admission and discharge to find out the differences between initial and final figures. As a result, Megadose parmacopuncture showed a significant effect on alleviating pain on patients with ThoracoLumbar Junction Syndrome. There was a significant decrease in NRS, ODI scores. Not only did the scores of NRS and ODI decrease significantly,but also the figures of EQ-5D increased significantly as well. To be specific, the mean of NRS and ODI dcreased from 10 to 1.75 and 61.87 to 12.78 while the mean of EQ-5D increased from 0.258 to 0.850. This research suggests Megadose pharmacopuncture with Korean Medicine Treatment could be a remedy for ThoracoLumbar Junction Syndrome. (J Korean Med Rehabil 2018;28(2): 127-134)
Helicobacter pylori 균주의 Metronidazole 내성이 균 박멸에 미치는 영향
박경남,한동수,이민호,류광현,최호순,윤병철,강정옥,이오영,함준수,문광호,기춘석 대한소화기내시경학회 1998 Clinical Endoscopy Vol.18 No.6
Background/Aims: The success of Helicobacter pylori eradication is limited by antibiotic resistances, and the primary resistance to metranidazole seems to be high. In this study, the frequency af metronidazole resistance and the eradication rate in metronidazole-resistant H. pylori strain was evaluated. Methods: Sixty-eight patients were tested for metronidazole resistance using microdilution broth, the E test and disk diffusion method. Twenty-two patients were treated for 14 days with amoxicilline 2000 mg, metronidazole 750 mg, and tripotassium dicitrate bismuth 1200 mg. Results: Metronida-zole resistance was 46% (31/68). The eradication rates for H. pylori was 91.7% in patients with metronidazole-sensistive strains and 70% in patients with metronidazole-resistant strains. Conclusions: Metronidazole resistance was high (46%) in Korea, however, triple therapy was an efficient method of eradicating H. pylori in both metronidazole sensitive and resistant strains.
소화성 궤양 출혈에서 열탐침 지혈법 후 재출혈의 위험인자
김영호,이석호,이상구,손희정,이규택,최규완,백승운,이종균,이준혁,고광철,이종철,김재준,류광현,이풍렬 대한소화기내시경학회 2000 Clinical Endoscopy Vol.20 No.6
Background/Aims: The precise rebleeding rate and risk factors of rebleeding after heat probe thermocoagulation in peptic ulcer patients with bleeding are not clear and still need to be evaluated. If we could identify the pre-dictors for rebleeding, the mortality rate might be loweted with early retreatment or surgery in these high risk group. Methods: The 94 patients in whom heat probe was applied were enrolled and the 18 patients with bleeding tendencies. Initial hemostasis was defined as hemostasis persisting for 24 hours post-treatment and permanent hemostasis as absence of bleeding for 7 days after therapy. Rebleedig was defined as oozing or spurting hemorrhage in the ulcer base and/or unstable vital signs and continuting tarry or bloody stool or hematemesis after therapy. Results: In 35 patients with active bleeding sign, initial hemostasis was obtained in 30 (85.7%) patients. After having achieved initial hemostasis, 9 (30.0%) patients rebled. In 41 ulcer patients with non-bleeding visible vessel, 40 cases (97.6%) achieved successful pre-vention of rebleeding. No evident complication was observed. With univariate analysis, bleeding ulcer patients with spurting and oozing hemorrhage had a higher re-bleeding rate than those with non-bleeding visible vessel. Conclusions: The heat probe thermocoagulaton is relative safe and effective procedure to protect bleeding in pectic ulcer patients with non-bleeding visible vessel, but insufficient to hemostasis in bleeding peptic ulcer patients with spurting or oozing in ulcer base. Spurting and oozing hemorrhage are the only risk factors of rebleeding after initial hemostasis with heat probe thermocoagulation in peptic ulcer patients with bleeding.
이종철,이상수,이종균,이규택,최성호,김재준,최규완,백승운,고광철,이풍렬,심상군,류광현,이준혁,박철근,손태성,여규동 대한소화기학회 2000 대한소화기학회지 Vol.36 No.5
Background/Aims: Prognostic factors related to the postoperative survival of patients with peripheral cholangiocarcinoma (PCC) are not well documented. The purpose of this study was to evaluate the clinical and pathologic factors that might influence the postoperative survival of patients with PCC. Methods: Twenty-nine patients with PCC underwent laparotomy between September 1994 and September 1999. Fourteen clinicopathologic factors influencing postoperative survival were analyzed in nineteen patients who underwent hepatic resection (resection group). Ten patients had unresectable advanced tumor (unresectable group). Results: In the resection group, the overall 1-, 2-, and 3-year survival rate was 51.4%, 45.0%, and 28.1%, respectively (median survival of 17.6 months). The median survival in the unresectable group was 4.1 months and no patient lived longer than 1 year. In univariate survival analysis, tumor size and perineural invasion were correlated significantly with overall survival. The survival of patients who underwent resection with positive margin was significantly longer than that of the unresectable group. Conclusions: An aggressive surgical approach provides the best chance for long-term survival of patients with PCC. Tumor size and perineural invasion may be considered as prognostic factors for postoperative survival, but a large, long-term study is needed.