Patterns of definitive radiotherapy practice for cervical cancer in South Korea: a survey endorsed by the Korean Radiation Oncology Group (KROG 20-06)

김나리,박원 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.3

Objective: The Korean Radiation Oncology Group conducted a nationwide questionnairesurvey to evaluate the patterns of clinical practice for patients with cervical cancer receivingdefinitive radiation therapy (RT) in South Korea. Methods: Practicing radiation oncologists from 93 centers in South Korea were administereda questionnaire survey via e-mail. The survey focused on demographic characteristics,diagnostic evaluation, indications for definitive RT, RT techniques, RT field and doseprescription, lymph node (LN) boost RT, brachytherapy, and chemotherapy. Results: The response rate was 62.4% (58/93 institutions). Of the 2,134 patients treated atthe radiation oncology department in 2019, 48.8% underwent definitive RT. The selectionof patients for definitive concurrent chemoradiation therapy and RT field, and RT doseprescription varied greatly. The upper border of the pelvis was commonly used as the bonylandmark for external beam RT (81%–88% of respondents). Most (96.6%) centers performedLN boost RT with median total doses of 59 Gy and 59.2 Gy for pelvic and retroperitoneal LN,respectively. With 50% of the centers offering brachytherapy, image-guided brachytherapyand volume-based prescription were applied in 48.3% and 37.9%, respectively. Upfrontconcurrent chemoradiation therapy with varying prescription doses was considered by 60.4%respondents in cases of supraclavicular LN metastasis. Conclusion: Most differences were noted in the indications for treatment, RT field, andprescription dose. This finding can serve as a reference for establishing practical RTguidelines for the management of locally advanced cervical cancer.

The entire structures of tmie and RN49018 are deleted in the circling mice

김나리,류재웅 한국실험동물학회 2010 한국실험동물학회 학술발표대회 논문집 Vol.2010 No.2

Overexpression of Cathepsin S Induces Atopy in Mice

김나리,류재웅 한국실험동물학회 2012 한국실험동물학회 학술발표대회 논문집 Vol.2012 No.2

Early hypopharyngeal cancer treated with different therapeutic approaches: a single-institution cohort analysis

김나리,이정심,김경환,박종원,이창걸,금기창 대한방사선종양학회 2016 Radiation Oncology Journal Vol.34 No.4

Purpose: Early hypopharyngeal squamous cell carcinoma (HPSCC) is a rarely diagnosed disease, for which the optimal treatment has not been defined yet. We assessed patterns of failure and outcomes in early HPSCC treated with various therapeutic approaches to identify its optimal treatment. Materials and Methods: Thirty-six patients with stage I (n = 10) and II (n = 26) treated between January 1992 and March 2014 were reviewed. Patients received definitive radiotherapy (RT) (R group, n = 10), surgery only (S group, n = 19), or postoperative RT (PORT group, n = 7). All patients in both the R and PORT groups received elective bilateral neck irradiation. In the S group, 7 patients had ipsilateral and 8 had bilateral dissection, while 4 patients had no elective dissection. Results: At a median follow-up of 48 months, the 5-year locoregional control (LRC) rate was 65%. Six patients had local failure, 1 regional failure (RF), 3 combined locoregional failures, and 2 distant failures. There was no difference in 5-year LRC among the R, S, and PORT groups (p = 0.17). The presence with a pyriform sinus apex extension was a prognosticator related to LRC (p = 0.01) in the multivariate analysis. Patients with a bilaterally treated neck showed a trend toward a lower RF rate (p = 0.08). Conclusion: This study shows that patients with early stage HPSCC involving the pyriform sinus apex might need a tailored approach to improve LRC. Additionally, our study confirms elective neck treatment might have an efficacious role in regional control.

위치 측정 알고리즘 및 NLOS 환경 완화 알고리즘에 대한 고찰

김나리,전현식,박현주 한국정보과학회 2007 데이타베이스 연구 Vol.23 No.3

This paper is a survey of location positioning technique of location based service known as veryimportant technique in ubiquitous environment. Most basic location positioning technique is to usesignal measurement and there are five methods using it; ROA, AOA, TOA, TDOA and hybrid thesemethod. There are several algorithms of location positioning; fingerprint, Taylor series and Chan'smethod using TDOA, and MLM including manifold method. To improve accuracy of locationmeasurement, NLOS identification and mitigation algorithms are an important tehcnique. There arevarious algorithms of NLOS identification and mitigation; Rwgh using weight, ROA and DCA forNLOS mitigation in TOA measurement environment and CRLB using probability method. 본 논문은 유비쿼터스 환경에서 가장중요한 기술로 인식되고 있는위치 기반서비스의 측위기술에 대한 조사논문이다. 가장 기본적인 측위기술은 신호측정을 이용한 방법으로 잘 알려진 ROA, AOA, TOA,TDOA 방법이 있으며 이들을 결합한 방법을 사용하기도 한다. 위치 측정 알고리즘은 fingerprint 알고리즘과 TDOA 를 이용한 Taylor series와 Chan’s method 가 있으며 MLM 이라는 다양한 방법을 포함한 방법도 있다. 위치 측정의 정확도 향상에 있어서 NLOS 를 식별하고 완화하는 알고리즘은 중요한 이슈로 떠오르고 있다. 이러한 NLOS 식별 및 알고리즘에는 가중치를 이용한 Rwgh 방법과 TOA 측정 환경에서NLOS 완화를 위해 만들어진 ROA, DCA 방법이 있으며 확률적인 방법을 사용한 CRLB 가 있다.

MZ세대 평생교육 강사의 효 인식에 관한 사례연구

김나리 한국효학회 2023 효학연구 Vol.- No.38

Background: In the field of lifelong education, a large proportion of the MZ generation is working as instructors. The study of MZ generation lifelong education instructors' perceptions of filial piety has important implications for understanding their interactions with older generations in the field of lifelong education and their influence on teaching methods. Purpose: The purpose of this study is to identify the concept of filial piety and experiences of filial piety as perceived by MZ generation lifelong education instructors, and to provide basic data on filial piety practices from the perspective of lifelong education. Methodology/Approach: For this study, 10 MZ generation lifelong education instructors in K city were selected as subjects, and data were collected through in-depth interviews and observation to apply the qualitative case study method. Findings/Conclusions: The results of the study showed that, first, the perception of the concept of filial piety was identified as honoring elders, filial piety of children, filial piety of teachers, and holistic human nature. Second, the experiences of filial behavior in direct practice were identified as enjoyment through service, overcoming generational differences, and enlightenment through filial experience. Third, the ways to practice filial piety in the field of lifelong education as perceived by MZ generation instructors were identified as developing various programs for generations to participate together, role-playing, and sensitivity training. Implications: Based on the findings of this study, practical interventions to overcome the generation gap with the older generation in the field of lifelong education and to practice filial piety in real life are suggested from the perspective of lifelong education.

치과 임플란트 수술용 고출력 초음파 수술기 설계 및 제작

김나리,전대우,김진호,김선욱,황종희,이정배,최성재,임대진,이영진,Kim, Na Ri,Jeon, Dae Woo,Kim, Jin Ho,Kim, Sun Woog,Hwang, Jong Hee,Lee, Jeong Bae,Choi, Sung Jae,Im, Dae Jin,Lee, Young Jin 한국전기전자재료학회 2017 전기전자재료학회논문지 Vol.30 No.10

This paper presents the design and fabrication of a high power piezoelectric ultrasonic surgery unit for multi-purpose dental implantation. A conventional piezoelectric ultrasonic surgery units consists of a transducer and a tip. However, the drawback of this simple structure is that the output performance of the transducer considerably changes with the change of the tips. An ultrasonic surgery unit that has an additional booster between the transducer and the tip can solve this problem to some extent; for this, an optimal structural design for the transducer is required. We used the Bolted Langevin Transducer (BLT) as the basic transducer; it consists of piezoelectric ceramics and a metal body. It's structure was optimized using mathematical methods to determine the length and radius of the tail and head masses. Additionally, the booster was also subjected to the same methods. Using these mathematical methods, optimal results in terms of the resonance frequency (24.96 kHz), displacement ($14.27{\mu}m$), and pressure (2.8 MPa), could be obtained. The validity of this proposed surgery unit was confirmed experimentally, exhibiting a cutting force of around 7% higher than that of a conventional surgery unit.

소장 결절성 림프양 증식증과 병발한 원발성 악성 림프종

김나리,김영훈,최수정,함정호,김인호,정일권,김홍수,이문호,김선주,조현득 대한소화기내시경학회 2002 Clinical Endoscopy Vol.25 No.1

결절성 림프양 증식증은 특수한 만성 자극에 대한 위장관 림프조직의 반응의 한 형태로 나타나는 양성 질환으로 중요한 임상적 의미는 없는 것으로 알려져 있으나, 중증의 경우에는 원발성 위장관 림프종으로 악성 변환을 하는 전구 병변의 형태를 보이기도 한다. 결절성 림프양 증식증과 병발 또는 속발하여 발생한 원발성 위장관 림프종에 관한 증례들이 보고되어 왔으며, 이는 결절성 림프양 증식증을 단순한 양성 질환으로만 간주하는 데는 문제가 있음을 보여주고 있다. 이에 저자 등은 결절성 림프양 증식증과 병발한 공장의 원발성 악성 림프종 1예를 경험하였기에 두 질환의 연관성에 관한 문헌고찰과 함께 보고하는 바이다. Nodular lymphoid hyperplasia is a reaction of the intestinal lymphatic tissue to specific inflammatory stimuli and may be probably of no clinical significance, but it may evolve to primary gastrointestinal lymphoma in more severe cases. Recently, several cases of nodular lymphoid hyperplasia complicated by primary gastrointestinal lymphoma have been reported, and which suggested that nodular lymphoid hyperplasia could not be considered as simple benign colon disease any more. We also experienced a case of primary jejunal malignant lymphoma associated with nodular lymphoid hyperplasia, and report this case with a brief review of relevant literatures. (Korean J Gastrointest Endosc 2002;25:52 57)

Involved-field radiation therapy for selected cases of recurrent ovarian cancer

김나리,장지석,김상운,김건민,이정윤,김용배 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.5

Objectives In our institutional experience, involved-field radiation therapy (IFRT) yields favorable outcomes in patients with recurrent epithelial ovarian cancer (EOC). This retrospective study aimed to investigate the clinical benefits of IFRT in this patient population. Methods Among patients treated with IFRT for recurrent EOC between 2010 and 2017, 61 patients with 90 treatments were included. IFRT encompassed all treatable lesions identified via imaging studies with 10–15-mm margins. Prescribed doses were ≥45 Gy (equivalent dose in 2 Gy/fraction). Results Patients were followed up for a median of 19.0 (Interquartile range, 8.6–34.9) months after IFRT. The 2-year in-field control, progression-free survival, and overall survival (OS) rates were 42.7%, 24.2%, and 78.9%, respectively. Fifty-three IFRT sessions (58.9%) were followed by systemic chemotherapy, and the median chemotherapy-free interval (CFI) was 10.5 (95% confidence interval=7.3–13.7) months. A higher carbohydrate antigen-125 (CA-125) level correlated with a worse 2-year OS (69.2% vs. 91.0%; p=0.001) and shorter median CFI (4.7 vs. 11.9 months; p<0.001). Twenty-eight (31.1%) of 90 treatments yielded a long-term CFI >12 months. For patients with a normal CA-125 level and/or platinum-sensitive tumor, IFRT prolonged CFI regardless of pre-existing carcinomatosis, gross tumor volume, and number of treatment sites. Conclusion Our early experience demonstrates the safety and feasibility of IFRT as an effective salvage therapy and enables a “chemotherapy holiday” in selected recurrent EOC settings. The CA-125 value before IFRT (within normal range) and/or platinum sensitivity could be used as selection criteria for IFRT.

글로벌화에 따른 로컬 축산업의 변동- 한우의 사회적 생산과 전략적 산업화를 중심으로

김나리,박경환 제주대학교 교육과학연구소 2016 교육과학연구 Vol.18 No.2

In many thoughts on contemporary globalization process, the ‘local’ has been often considered something pre-existing, conventional, natural, essential, and familiar, while the ‘global’ is situated as the anti-thesis of the local. In this context, Korean native cattle in South Korea have been regarded as natural, local, and traditional for many consumers. As contemporary Korean native cattle are more raised within the industrial production system, its biological attributes are socioeconomically recoded. In addition, as global standards on security and safety have been expanding, the production system of Korean native cattle are rapidly institutionalized. In this context, new local strategies, which are highly commercialized, are being developed for securing domestic beef market. Thus, Korean native cattle are becoming a ‘discursive construct’ in which various social and economic meanings are embodied. By employing Foucauldian discourse analysis, this paper aims at tracking the ways in which Korean native cattle have embodied institutionalized discourses involved in these global and local transitions. Conclusively, through this investigation, this paper reveals how knowledge system and its institutionalization involve the industrial production of Korean native cattle. 글로벌화에 의해 상품 사슬의 지리적 복잡성이 증대됨에 따라 ‘로컬한 것’에 대한 인식과 이해가 점차 중요한 과제로 부상하고 있다. 흔히 한우는 순수하고 전통적인 우리 것이라는 의미에서 ‘로컬한 것’으로 간주되어 왔다. 그러나 한우는 매우 산업적인 생산 시스템에서 ‘구성’되고 있고, 이에 따라 본연의 생물학적 속성이 사회·경제적 측면에서 새롭게 재편되고 있다. 또한, 글로벌화에 따른 표준화 현상으로 안전이나 위생과 관련된 글로벌 스탠더드가 확대됨에 따라 한우 생산 과정도 이러한 규제를 받으며 빠르게 제도화되고 있다. 또한, 쇠고기 시장 개방에 따른 국내 한우업계의 대응 전략은 한우를 단지 ‘소’라는 자연적 생물을 넘어 각종 규준과 사회적 의미가 내포된 전략적 산업화의 상품인 담론적 구성물로 만들고 있다. 본 논문은 푸코의 담론 분석을 통해 한우 담론을 추적하고 그에 내포된 의미를 발견하고자 하였으며, 한우 담론을 구성하는 지식 체계, 이의 산업화와 제도화 과정, 담론의 특징을 드러내고자 하였다. 한우를 매개로 한 로컬 축산업의 지리에 대한 이해는 현행의 국제이해교육 및 글로벌화에 대한 이해를 제고하는 데에 기여할 수 있다.