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Re-Irradiation for Recurrent Gliomas: Treatment Outcomes and Prognostic Factors
이정심,조재호,장종희,서창옥 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.4
Purpose: The aim of this study was to evaluate the efficacy of re-irradiation in patients with recurrent gliomas and to identify subgroupsfor whom re-irradiation for recurrent gliomas is most beneficial. Materials and Methods: We retrospectively reviewed 36 patients with recurrent or progressive gliomas who received re-irradiationbetween January 1996 and December 2011. Re-irradiation was offered to recurrent glioma patients with good performance or at least 6 months had passed after initial radiotherapy (RT), with few exceptions. Results: Median doses of re-irradiation and initial RT were 45.0 Gy and 59.4 Gy, respectively. The median time interval between initial RT and re-irradiation was 30.5 months. Median overall survival (OS) and the 12-month OS rate were 11 months and 41.7%, respectively. In univariate analysis, Karnofsky performance status (KPS) ≥70 (p<0.001), re-irradiation dose ≥45 Gy (p=0.040), and longer time interval between initial RT and re-irradiation (p=0.040) were associated with improved OS. In multivariate analysis, KPS (p=0.030) and length of time interval between initial RT and re-irradiation (p=0.048) were important predictors of OS. A radiographicallysuspected mixture of radiation necrosis and progression after re-irradiation was seen in 5 patients. Conclusion: Re-irradiation in conjunction with surgery could be a salvage treatment for selected recurrent glioma patients with good performance status and recurrence over a long time.
이정심,김태형,김연실,김명수,박재원,김성현,김현주,이창걸 대한암학회 2020 Cancer Research and Treatment Vol.52 No.4
Purpose The benefits of reirradiation for head and neck cancer (HNC) have not been determined. This study evaluated the efficacy of reirradiation using intensity-modulated radiotherapy (IMRT) for recurrent or second primary HNC (RSPHNC) and identified subgroups for whom reirradiation for RSPHNC is beneficial. Materials and Methods A total of 118 patients from seven Korean institutions with RSPHNC who underwent IMRT-based reirradiation between 2006 and 2015 were evaluated through retrospective review of medical records. We assessed overall survival (OS) and local control (LC) within the radiotherapy (RT) field following IMRT-based reirradiation. Additionally, the OS curve according to the recursive partitioning analysis (RPA) suggested by the Multi-Institution Reirradiation (MIRI) Collaborative was determined. Results At a median follow-up period of 18.5 months, OS at 2 years was 43.1%. In multivariate analysis, primary subsite, recurrent tumor size, interval between RT courses, and salvage surgery were associated with OS. With regard to the MIRI RPA model, the class I subgroup had a significantly higher OS than class II or III subgroups. LC at 2 years was 53.5%. Multivariate analyses revealed that both intervals between RT courses and salvage surgery were prognostic factors affecting LC. Grade 3 or more toxicity and grade 5 toxicity rates were 8.5% and 0.8%, respectively. Conclusion IMRT-based reirradiation was an effective therapeutic option for patients with RSPHNC, especially those with resectable tumors and a long interval between RT courses. Further, our patients’ population validated the MIRI RPA classification by showing the difference of OS according to MIRI RPA class.
First record of Androcorys pusillus (Orchidaceae) from Mt. Baekdu
이정심,김수남,김무열 한국식물분류학회 2013 식물 분류학회지 Vol.43 No.1
Androcorys pusillus (Ohwi & Fukuy.) Masam. (Orchidaceae) was first found from Mt. Baekdu of the Korean peninsular and was known to distribute from Taiwan and Japan. This species is distinguished from the related taxa by its denticulated sepal margin, petal width which is as broad as dorsal sepal, and larger bract size.